CA1239345A - Method for the production of pertussis component vaccine and combined vaccine of pertussis antigen, diphtheria toxoid and tetanus toxoid - Google Patents
Method for the production of pertussis component vaccine and combined vaccine of pertussis antigen, diphtheria toxoid and tetanus toxoidInfo
- Publication number
- CA1239345A CA1239345A CA000482469A CA482469A CA1239345A CA 1239345 A CA1239345 A CA 1239345A CA 000482469 A CA000482469 A CA 000482469A CA 482469 A CA482469 A CA 482469A CA 1239345 A CA1239345 A CA 1239345A
- Authority
- CA
- Canada
- Prior art keywords
- gel
- sulfate
- lpf
- crosslinked
- cellulose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- HQPCSDADVLFHHO-LTKCOYKYSA-N all-cis-8,11,14,17-icosatetraenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/CCCCCCC(O)=O HQPCSDADVLFHHO-LTKCOYKYSA-N 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 150000005747 fulminates Chemical class 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 102000050796 human HP Human genes 0.000 description 1
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- RGCLLPNLLBQHPF-HJWRWDBZSA-N phosphamidon Chemical compound CCN(CC)C(=O)C(\Cl)=C(/C)OP(=O)(OC)OC RGCLLPNLLBQHPF-HJWRWDBZSA-N 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- UFWWAKOWSBGGCP-UHFFFAOYSA-N pyridine;sulfurochloridic acid Chemical compound OS(Cl)(=O)=O.C1=CC=NC=C1 UFWWAKOWSBGGCP-UHFFFAOYSA-N 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- VGTPCRGMBIAPIM-UHFFFAOYSA-M sodium thiocyanate Chemical compound [Na+].[S-]C#N VGTPCRGMBIAPIM-UHFFFAOYSA-M 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 150000003567 thiocyanates Chemical class 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/099—Bordetella
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP198899/1984 | 1984-05-30 | ||
| JP59198899A JPS6176422A (ja) | 1984-09-22 | 1984-09-22 | 百日ぜきコンポ−ネントワクチンおよび百日ぜき・ジフテリア・破傷風混合ワクチンの製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1239345A true CA1239345A (en) | 1988-07-19 |
Family
ID=16398788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000482469A Expired CA1239345A (en) | 1984-09-22 | 1985-05-27 | Method for the production of pertussis component vaccine and combined vaccine of pertussis antigen, diphtheria toxoid and tetanus toxoid |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0175841B1 (en, 2012) |
| JP (1) | JPS6176422A (en, 2012) |
| KR (1) | KR920009730B1 (en, 2012) |
| AT (1) | ATE61230T1 (en, 2012) |
| AU (1) | AU568743B2 (en, 2012) |
| CA (1) | CA1239345A (en, 2012) |
| DE (1) | DE3581993D1 (en, 2012) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU571078B2 (en) * | 1984-04-14 | 1988-03-31 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Purification of filamentous hemagglutinin |
| FR2597605B1 (fr) * | 1986-04-16 | 1989-06-23 | Merieux Inst | Nouveau materiau pour chromatographie d'affinite et son application a la separation et a la purification des antigenes proteiques des bacteries du genre bordetella |
| EP0267998A1 (en) * | 1986-11-17 | 1988-05-25 | Institut Pasteur | Means for protecting against bordetella infections and toxic processes |
| US5139776A (en) * | 1987-04-24 | 1992-08-18 | The Research Foundation For Microbial Diseases Of Osaka University | Method for culturing Bordetella pertussis, a pertussis toxoid and a pertussis vaccine |
| CA1337859C (en) * | 1987-04-24 | 1996-01-02 | Masashi Chazono | Method for culturing bordetella pertussis, a pertussis toxoid and a pertussis vaccine |
| GB8807860D0 (en) * | 1988-04-05 | 1988-05-05 | Connaught Lab | Pertussis vaccine |
| JP2849632B2 (ja) * | 1988-04-08 | 1999-01-20 | 社団法人北里研究所 | ワクチン製剤 |
| CA1341123C (en) * | 1988-10-27 | 2000-10-17 | David A. Relman | Filamentous hemagglutinin of b. pertussis |
| GB8910570D0 (en) * | 1989-05-08 | 1989-06-21 | Wellcome Found | Acellular vaccine |
| IT1248735B (it) * | 1990-06-21 | 1995-01-26 | Sclavo Spa | Vaccini acellulari contro la pertosse |
| EP0471177B1 (en) * | 1990-08-13 | 1995-10-04 | American Cyanamid Company | Filamentous hemagglutinin of bordetella pertussis as a carrier molecule for conjugate vaccines |
| US6124432A (en) * | 1994-06-10 | 2000-09-26 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Process for purifying dermonecrotic toxin produced by Bordetella and toxoid |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4247452A (en) * | 1978-03-01 | 1981-01-27 | The Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland | Purification of pertussis haemagglutinins |
| US4500639A (en) * | 1981-10-15 | 1985-02-19 | Teijin Limited | Culturing Bordetella in media containing etherified cyclodextrin |
| US4515714A (en) * | 1983-03-09 | 1985-05-07 | Juridicial Foundation, The Chemo-Semo-Sero-Therapeutic Research Institute | Method for purification of hepatitis B virus surface antigen |
| CA1213234A (en) * | 1983-03-30 | 1986-10-28 | Akihiro Ginnaga | Method for the production of ha fraction containing protective antigens of bordetella pertussis and pertussis vaccine |
| JPS6098988A (ja) * | 1983-11-01 | 1985-06-01 | Chemo Sero Therapeut Res Inst | Ｌｐｆ−ｈａの精製法 |
| AU571078B2 (en) * | 1984-04-14 | 1988-03-31 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Purification of filamentous hemagglutinin |
| KR890001003B1 (ko) * | 1984-07-19 | 1989-04-18 | 자이단 호오진 까가꾸 오요비 겟세이 료오호 겐뀨쇼 | Lpf-ha의 정제방법 |
-
1984
- 1984-09-22 JP JP59198899A patent/JPS6176422A/ja active Granted
-
1985
- 1985-05-14 AU AU42459/85A patent/AU568743B2/en not_active Expired
- 1985-05-22 EP EP85106303A patent/EP0175841B1/en not_active Expired - Lifetime
- 1985-05-22 AT AT85106303T patent/ATE61230T1/de not_active IP Right Cessation
- 1985-05-22 DE DE8585106303T patent/DE3581993D1/de not_active Expired - Lifetime
- 1985-05-27 CA CA000482469A patent/CA1239345A/en not_active Expired
- 1985-05-30 KR KR1019850003773A patent/KR920009730B1/ko not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0574576B2 (en, 2012) | 1993-10-18 |
| DE3581993D1 (de) | 1991-04-11 |
| AU4245985A (en) | 1986-03-27 |
| EP0175841B1 (en) | 1991-03-06 |
| EP0175841A3 (en) | 1987-08-19 |
| KR860002570A (ko) | 1986-04-26 |
| AU568743B2 (en) | 1988-01-07 |
| JPS6176422A (ja) | 1986-04-18 |
| KR920009730B1 (ko) | 1992-10-22 |
| EP0175841A2 (en) | 1986-04-02 |
| ATE61230T1 (de) | 1991-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |