CA1236357A - Disposable spermicide-releasing diaphragm - Google Patents
Disposable spermicide-releasing diaphragmInfo
- Publication number
- CA1236357A CA1236357A CA000457835A CA457835A CA1236357A CA 1236357 A CA1236357 A CA 1236357A CA 000457835 A CA000457835 A CA 000457835A CA 457835 A CA457835 A CA 457835A CA 1236357 A CA1236357 A CA 1236357A
- Authority
- CA
- Canada
- Prior art keywords
- spermicide
- elastomer
- barrier
- diaphragm
- nonoxynol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000934 spermatocidal agent Substances 0.000 title claims abstract description 69
- 239000000203 mixture Substances 0.000 claims abstract description 35
- 230000004888 barrier function Effects 0.000 claims abstract description 34
- 238000000034 method Methods 0.000 claims abstract description 32
- 229920003169 water-soluble polymer Polymers 0.000 claims abstract description 23
- 229920001169 thermoplastic Polymers 0.000 claims abstract description 19
- 239000003433 contraceptive agent Substances 0.000 claims abstract description 16
- 230000002254 contraceptive effect Effects 0.000 claims abstract description 16
- 229920004918 nonoxynol-9 Polymers 0.000 claims description 45
- 229940087419 nonoxynol-9 Drugs 0.000 claims description 45
- FBWNMEQMRUMQSO-UHFFFAOYSA-N tergitol NP-9 Chemical group CCCCCCCCCC1=CC=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCO)C=C1 FBWNMEQMRUMQSO-UHFFFAOYSA-N 0.000 claims description 45
- 210000001215 vagina Anatomy 0.000 claims description 20
- 239000002202 Polyethylene glycol Substances 0.000 claims description 19
- 239000010408 film Substances 0.000 claims description 19
- 229920001223 polyethylene glycol Polymers 0.000 claims description 19
- 229920000642 polymer Polymers 0.000 claims description 19
- 239000000806 elastomer Substances 0.000 claims description 18
- 229920001971 elastomer Polymers 0.000 claims description 17
- 238000004519 manufacturing process Methods 0.000 claims description 16
- 239000004416 thermosoftening plastic Substances 0.000 claims description 16
- 229920002725 thermoplastic elastomer Polymers 0.000 claims description 11
- 229920003225 polyurethane elastomer Polymers 0.000 claims description 10
- 238000009792 diffusion process Methods 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 238000007598 dipping method Methods 0.000 claims description 6
- 229920002635 polyurethane Polymers 0.000 claims description 6
- 239000004814 polyurethane Substances 0.000 claims description 6
- 230000001150 spermicidal effect Effects 0.000 claims description 6
- 230000006872 improvement Effects 0.000 claims description 5
- 238000001746 injection moulding Methods 0.000 claims description 5
- 238000007789 sealing Methods 0.000 claims description 4
- 230000015556 catabolic process Effects 0.000 claims description 3
- 238000006731 degradation reaction Methods 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 238000001125 extrusion Methods 0.000 claims description 3
- 239000013536 elastomeric material Substances 0.000 claims description 2
- 230000002209 hydrophobic effect Effects 0.000 claims description 2
- 239000011159 matrix material Substances 0.000 claims description 2
- 238000007493 shaping process Methods 0.000 claims description 2
- 239000010409 thin film Substances 0.000 claims description 2
- 238000005096 rolling process Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 description 10
- 239000003814 drug Substances 0.000 description 10
- 239000000463 material Substances 0.000 description 10
- 229940079593 drug Drugs 0.000 description 9
- 238000003780 insertion Methods 0.000 description 8
- 230000037431 insertion Effects 0.000 description 8
- 230000035699 permeability Effects 0.000 description 7
- 210000003679 cervix uteri Anatomy 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 5
- 238000001727 in vivo Methods 0.000 description 5
- 238000013270 controlled release Methods 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 4
- 238000010348 incorporation Methods 0.000 description 4
- 238000011068 loading method Methods 0.000 description 4
- -1 polyethylene Polymers 0.000 description 4
- 241000282520 Papio Species 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 230000005012 migration Effects 0.000 description 3
- 238000013508 migration Methods 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N EtOH Substances CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241001504519 Papio ursinus Species 0.000 description 2
- 239000004721 Polyphenylene oxide Substances 0.000 description 2
- 239000004599 antimicrobial Substances 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 238000005266 casting Methods 0.000 description 2
- 230000001113 coital effect Effects 0.000 description 2
- 238000003618 dip coating Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 238000005567 liquid scintillation counting Methods 0.000 description 2
- 230000001050 lubricating effect Effects 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 229920000570 polyether Polymers 0.000 description 2
- 239000012815 thermoplastic material Substances 0.000 description 2
- NMXDTPBZWZGMMO-UHFFFAOYSA-N 4-(2-methyl-5-propan-2-ylcyclohexyl)phenol Chemical compound C1C(C(C)C)CCC(C)C1C1=CC=C(O)C=C1 NMXDTPBZWZGMMO-UHFFFAOYSA-N 0.000 description 1
- DYDCUQKUCUHJBH-UWTATZPHSA-N D-Cycloserine Chemical compound N[C@@H]1CONC1=O DYDCUQKUCUHJBH-UWTATZPHSA-N 0.000 description 1
- RYECOJGRJDOGPP-UHFFFAOYSA-N Ethylurea Chemical compound CCNC(N)=O RYECOJGRJDOGPP-UHFFFAOYSA-N 0.000 description 1
- 206010018612 Gonorrhoea Diseases 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- 229920002633 Kraton (polymer) Polymers 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 229920001054 Poly(ethylene‐co‐vinyl acetate) Polymers 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 239000002174 Styrene-butadiene Substances 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- MTAZNLWOLGHBHU-UHFFFAOYSA-N butadiene-styrene rubber Chemical compound C=CC=C.C=CC1=CC=CC=C1 MTAZNLWOLGHBHU-UHFFFAOYSA-N 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229940126523 co-drug Drugs 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 229940124558 contraceptive agent Drugs 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- GHLKSLMMWAKNBM-UHFFFAOYSA-N dodecane-1,12-diol Chemical compound OCCCCCCCCCCCCO GHLKSLMMWAKNBM-UHFFFAOYSA-N 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- KVFIJIWMDBAGDP-UHFFFAOYSA-N ethylpyrazine Chemical compound CCC1=CN=CC=N1 KVFIJIWMDBAGDP-UHFFFAOYSA-N 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 208000001786 gonorrhea Diseases 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 229960001112 menfegol Drugs 0.000 description 1
- 230000003821 menstrual periods Effects 0.000 description 1
- 229920000847 nonoxynol Polymers 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 229920002113 octoxynol Polymers 0.000 description 1
- 229940066429 octoxynol Drugs 0.000 description 1
- 229940127234 oral contraceptive Drugs 0.000 description 1
- 239000003539 oral contraceptive agent Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- CWEFIMQKSZFZNY-UHFFFAOYSA-N pentyl 2-[4-[[4-[4-[[4-[[4-(pentoxycarbonylamino)phenyl]methyl]phenyl]carbamoyloxy]butoxycarbonylamino]phenyl]methyl]phenyl]acetate Chemical compound C1=CC(CC(=O)OCCCCC)=CC=C1CC(C=C1)=CC=C1NC(=O)OCCCCOC(=O)NC(C=C1)=CC=C1CC1=CC=C(NC(=O)OCCCCC)C=C1 CWEFIMQKSZFZNY-UHFFFAOYSA-N 0.000 description 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000003345 scintillation counting Methods 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000011115 styrene butadiene Substances 0.000 description 1
- 229920003048 styrene butadiene rubber Polymers 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
- A61F6/08—Pessaries, i.e. devices worn in the vagina to support the uterus, remedy a malposition or prevent conception, e.g. combined with devices protecting against contagion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/14—Topical contraceptives and spermacides
Landscapes
- Health & Medical Sciences (AREA)
- Reproductive Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/513,773 US4589880A (en) | 1983-07-14 | 1983-07-14 | Disposable spermicide-releasing diaphragm |
| US513,773 | 1983-07-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1236357A true CA1236357A (en) | 1988-05-10 |
Family
ID=24044628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000457835A Expired CA1236357A (en) | 1983-07-14 | 1984-06-29 | Disposable spermicide-releasing diaphragm |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4589880A (enExample) |
| EP (1) | EP0135283B1 (enExample) |
| JP (1) | JPS6036050A (enExample) |
| AT (1) | ATE46816T1 (enExample) |
| AU (2) | AU3025984A (enExample) |
| CA (1) | CA1236357A (enExample) |
| DE (1) | DE3479959D1 (enExample) |
| NZ (1) | NZ208886A (enExample) |
| ZA (1) | ZA845233B (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61503003A (ja) * | 1984-04-19 | 1986-12-25 | ユニバ−シテイ− オブ クイ−ンスランド | 避妊方法、避妊用製剤及び避妊具 |
| NL8600250A (nl) * | 1986-02-01 | 1987-09-01 | Fundatech Sa | Vaginaal anticonceptiemiddel. |
| US4834113A (en) * | 1987-08-11 | 1989-05-30 | Reddy A V K | Prophylactic device |
| US4735621A (en) * | 1987-02-03 | 1988-04-05 | Lasse Hessel | Tubular protective device for protection against transfer of infectious matter during sexual intercourse |
| US5094250A (en) * | 1987-03-02 | 1992-03-10 | Chartex International Plc | Tubular protective device for protection against transfer of infectious matter during sexual intercourse |
| DE8708879U1 (de) * | 1987-06-26 | 1987-10-22 | Büttner-Frank GmbH, 8520 Erlangen | Schalenförmiger Stützpessar mit biegsamer Faltzone |
| US5545615A (en) * | 1987-09-18 | 1996-08-13 | Zymogenetics, Inc. | A method of inhibiting fertilization by alpha-1-antitrypsin or antithrombin III |
| JPH01170452A (ja) * | 1987-12-25 | 1989-07-05 | Marugo Kogyo Kk | ダッチペッサリーの製造方法 |
| US5044376A (en) * | 1988-08-22 | 1991-09-03 | Shields Jack W | Vaginal diaphragms with medicament dispensing foam pads |
| US5181505A (en) * | 1989-03-08 | 1993-01-26 | Lew Chel W | Method and apparatus for delivery of a medicament in the oral cavity |
| US5002540A (en) * | 1989-05-22 | 1991-03-26 | Warren Kirschbaum | Intravaginal device and method for delivering a medicament |
| US5295984A (en) * | 1989-12-07 | 1994-03-22 | Ultrafem, Inc. | Vaginal discharge collection device and intravaginal drug delivery system |
| US6264638B1 (en) * | 1989-12-07 | 2001-07-24 | Ultrafem, Inc. | Intravaginal drug delivery system and discharge collection device |
| US5163448A (en) * | 1991-04-30 | 1992-11-17 | Family Health International | Condom comprising dispensing structure, and method of making and using the same |
| JP2737567B2 (ja) * | 1992-09-16 | 1998-04-08 | 三菱電機株式会社 | ガス遮断器 |
| EP0665733B1 (en) * | 1992-10-21 | 2003-05-07 | Gynetech Laboratories, Inc. | Vaginal sponge delivery system |
| FR2698781B1 (fr) * | 1992-12-07 | 1995-04-07 | Chanez Jean Francois | Dispositif destiné à remédier aux incontinences urinaires légères chez la femme. |
| EP0688822B1 (en) * | 1994-06-21 | 1999-12-15 | The BFGOODRICH COMPANY | Degradable blend of composition |
| US5851188A (en) * | 1994-10-12 | 1998-12-22 | Bullard; Kelli M. | Device for holding medical instrumentation sensors at and upon the cervix os of a human female, particularly for holding the ultrasonic transducers of an ultrasonic transit time, real-time, cervical effacement and dilatation monitor |
| TW280920B (enExample) * | 1995-01-20 | 1996-07-11 | Hitachi Seisakusyo Kk | |
| AU732781B2 (en) | 1996-07-03 | 2001-04-26 | Ultrafem, Inc. | Method and system for manufacturing elastomeric articles |
| US5819742A (en) * | 1996-11-06 | 1998-10-13 | Family Health International | Vaginal device for preventing conception or the transmission of sexually transmitted diseases, or both |
| US5857959A (en) * | 1997-02-03 | 1999-01-12 | Veos France Eurl | Conception kit |
| US8133501B2 (en) * | 2002-02-08 | 2012-03-13 | Boston Scientific Scimed, Inc. | Implantable or insertable medical devices for controlled drug delivery |
| US8685427B2 (en) * | 2002-07-31 | 2014-04-01 | Boston Scientific Scimed, Inc. | Controlled drug delivery |
| US7485102B2 (en) * | 2002-04-12 | 2009-02-03 | Yamuna Zake | Method and device for foot therapy |
| US8920826B2 (en) * | 2002-07-31 | 2014-12-30 | Boston Scientific Scimed, Inc. | Medical imaging reference devices |
| US20050025847A1 (en) * | 2003-02-26 | 2005-02-03 | Program For Appropriate Technology In Health | Microbicidal compositions and method of use |
| WO2004105662A1 (en) * | 2003-05-23 | 2004-12-09 | Program For Appropriate Technology In Health | Microbicidal compositions and methods of use |
| JP2006007799A (ja) * | 2004-06-22 | 2006-01-12 | Shimano Inc | 自転車用スプロケット |
| UA93354C2 (ru) | 2004-07-09 | 2011-02-10 | Гилиад Сайенсиз, Инк. | Местный противовирусный препарат |
| US8454493B2 (en) * | 2007-03-28 | 2013-06-04 | Conceivex, Inc. | Conception device and related methods |
| US20080242919A1 (en) * | 2007-03-28 | 2008-10-02 | Melrock Ltd. | Conception cap and related methods |
| KR20110003534A (ko) * | 2008-04-16 | 2011-01-12 | 시플라 리미티드 | 항진균제 및 항바이러스제를 포함하는 국소 조합물 |
| US20100040671A1 (en) * | 2008-08-12 | 2010-02-18 | Ahmed Salah U | Intravaginal Devices With a Rigid Support, Methods of Making, and Uses Thereof |
| EP2506841A1 (en) | 2009-12-01 | 2012-10-10 | Seprox Biotech, S.L. | Topical use of hydroxytyrosol and derivatives for the prevention of hiv infection |
| US8580294B2 (en) | 2010-10-19 | 2013-11-12 | International Partnership For Microbicides | Platinum-catalyzed intravaginal rings |
| EP2546358A1 (en) | 2011-07-15 | 2013-01-16 | Laboratorios Del. Dr. Esteve, S.A. | Methods and reagents for efficient control of HIV progression |
| US10137031B2 (en) | 2013-11-14 | 2018-11-27 | International Partnership For Microbicides, Inc. | Combination therapy intravaginal rings |
| US11077008B2 (en) | 2014-08-06 | 2021-08-03 | Polar Fusion Llc | Massage device and system |
| US10226387B2 (en) | 2014-09-19 | 2019-03-12 | Gwynne Marie Hite | Cervical pad |
| US9474885B2 (en) | 2015-01-10 | 2016-10-25 | Nine Medical, Inc. | Methods and devices to prevent premature birth |
| USD827146S1 (en) * | 2016-06-24 | 2018-08-28 | Polar Fusion Llc | Massage device |
| USD826417S1 (en) * | 2016-06-24 | 2018-08-21 | Polar Fusion Llc | Massage device with a rounded body and a flange member |
| USD837980S1 (en) * | 2017-12-22 | 2019-01-08 | Filip Sedic | Menstrual cup |
| US10874432B2 (en) | 2018-05-01 | 2020-12-29 | Conceivex, Inc. | Conception device and related methods |
| US12303425B2 (en) * | 2018-12-28 | 2025-05-20 | Nine Medical, Inc. | Methods and devices to prevent premature birth, stillbirth, miscarriage, infection, or pregnancy |
| CN115066239A (zh) * | 2019-11-18 | 2022-09-16 | 戴尔生物科学公司 | 阴道内环装置 |
| US11298375B2 (en) * | 2021-10-12 | 2022-04-12 | Terry Earl Brady | Halogenated fullerene functionalized as a biocidal and chemotactic spermicide to vaginally harbor and neutralize spermatozoa for use as a safe and effective contraceptive |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2234495A (en) * | 1940-03-18 | 1941-03-11 | Willard V Lay | Pessary |
| US2697057A (en) * | 1948-12-23 | 1954-12-14 | Ortho Pharma Corp | Method of making a diaphragm |
| GB892386A (en) * | 1958-10-25 | 1962-03-28 | Sture Edvard Randstrom | Pessary, particularly a uterus pessary |
| US3015598A (en) * | 1958-11-03 | 1962-01-02 | Jones John Leslie | Manufacturing absorbent diaphragms |
| GB1019854A (en) * | 1959-07-29 | 1966-02-09 | Flair Plastics Corp | Plastic container and process and apparatus for producing same |
| US3117575A (en) * | 1961-08-22 | 1964-01-14 | Ross M Carrell | Ear protector |
| US3545439A (en) * | 1968-01-04 | 1970-12-08 | Upjohn Co | Medicated devices and methods |
| US3920805A (en) * | 1971-12-09 | 1975-11-18 | Upjohn Co | Pharmaceutical devices and method |
| US3975350A (en) * | 1972-08-02 | 1976-08-17 | Princeton Polymer Laboratories, Incorporated | Hydrophilic or hydrogel carrier systems such as coatings, body implants and other articles |
| US4007249A (en) * | 1974-07-15 | 1977-02-08 | The Franklin Institute Research Laboratories | Method of forming a removable cervical cap |
| IL48277A (en) * | 1974-10-18 | 1978-03-10 | Schering Ag | Vaginal ring |
| US3991760A (en) * | 1975-12-02 | 1976-11-16 | The Procter & Gamble Company | Vaginal medicament dispensing means |
| US3995633A (en) * | 1975-12-02 | 1976-12-07 | The Procter & Gamble Company | Vaginal Medicament dispensing device |
| US4219016A (en) * | 1978-12-07 | 1980-08-26 | The Procter & Gamble Company | Vaginal contraceptive |
| US4093490A (en) * | 1977-04-29 | 1978-06-06 | Ortho Pharmaceutical Corporation | Method of making vaginal diaphragm |
| US4198976A (en) * | 1977-10-11 | 1980-04-22 | The Procter & Gamble Company | Vaginal contraceptive |
| US4198965A (en) * | 1978-07-17 | 1980-04-22 | Fournier E P | Disposable contraceptive cervical barrier |
| US4311543A (en) * | 1978-07-17 | 1982-01-19 | Strickman Robert L | Method of manufacturing a disposable contraceptive intravaginal cervical barrier |
| US4286587A (en) * | 1978-10-11 | 1981-09-01 | Alza Corporation | Vaginal drug delivery system made from polymer |
| US4215691A (en) * | 1978-10-11 | 1980-08-05 | Alza Corporation | Vaginal contraceptive system made from block copolymer |
| JPS5560450A (en) * | 1978-10-30 | 1980-05-07 | Procter & Gamble | Contraceptive appliance for vagina |
| US4292965A (en) * | 1978-12-29 | 1981-10-06 | The Population Council, Inc. | Intravaginal ring |
| US4187286A (en) * | 1979-01-02 | 1980-02-05 | G&W Laboratories, Inc. | Contraceptive suppository |
| US4200090A (en) * | 1979-01-15 | 1980-04-29 | The Procter & Gamble Company | Vaginal contraceptive and method of using |
| US4304226A (en) * | 1980-03-03 | 1981-12-08 | The Procter & Gamble Company | Vaginal contraceptive |
| US4286593A (en) * | 1980-05-05 | 1981-09-01 | Place Virgil A | Vaginal contraceptive shield |
| US4369773A (en) * | 1980-11-05 | 1983-01-25 | Milos Chvapil | Contraceptive sponge - diaphragm bilayer |
| AU9131982A (en) * | 1981-12-07 | 1983-06-16 | Syntex (U.S.A.) Inc. | Contraceptive device releasing 1-substituted imadazoles |
| US4469671A (en) * | 1983-02-22 | 1984-09-04 | Eli Lilly And Company | Contraceptive device |
-
1983
- 1983-07-14 US US06/513,773 patent/US4589880A/en not_active Expired - Lifetime
-
1984
- 1984-06-29 CA CA000457835A patent/CA1236357A/en not_active Expired
- 1984-07-04 AU AU30259/84A patent/AU3025984A/en not_active Abandoned
- 1984-07-06 ZA ZA845233A patent/ZA845233B/xx unknown
- 1984-07-12 EP EP84304772A patent/EP0135283B1/en not_active Expired
- 1984-07-12 AT AT84304772T patent/ATE46816T1/de not_active IP Right Cessation
- 1984-07-12 DE DE8484304772T patent/DE3479959D1/de not_active Expired
- 1984-07-13 JP JP59144535A patent/JPS6036050A/ja active Granted
- 1984-07-13 NZ NZ208886A patent/NZ208886A/en unknown
-
1988
- 1988-11-11 AU AU25060/88A patent/AU620350B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP0135283A2 (en) | 1985-03-27 |
| US4589880A (en) | 1986-05-20 |
| ATE46816T1 (de) | 1989-10-15 |
| DE3479959D1 (en) | 1989-11-09 |
| AU620350B2 (en) | 1992-02-20 |
| ZA845233B (en) | 1985-02-27 |
| JPH0356734B2 (enExample) | 1991-08-29 |
| EP0135283B1 (en) | 1989-10-04 |
| NZ208886A (en) | 1987-10-30 |
| JPS6036050A (ja) | 1985-02-25 |
| EP0135283A3 (en) | 1986-03-19 |
| AU2506088A (en) | 1989-03-02 |
| AU3025984A (en) | 1985-01-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |