CA1236038A - Complex of biologically active protein with reactive high polymer having bonded thereto bifunctional chelate - Google Patents

Complex of biologically active protein with reactive high polymer having bonded thereto bifunctional chelate

Info

Publication number
CA1236038A
CA1236038A CA000454813A CA454813A CA1236038A CA 1236038 A CA1236038 A CA 1236038A CA 000454813 A CA000454813 A CA 000454813A CA 454813 A CA454813 A CA 454813A CA 1236038 A CA1236038 A CA 1236038A
Authority
CA
Canada
Prior art keywords
group
polysuccinimide
biologically active
protein
active protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000454813A
Other languages
English (en)
French (fr)
Inventor
Yoshiaki Murakami
Kunio Shiba
Akira Yoshitake
Keietsu Takahashi
Nobuo Ueda
Masaaki Hazue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Application granted granted Critical
Publication of CA1236038A publication Critical patent/CA1236038A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • C08G73/10—Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors
    • C08G73/1092—Polysuccinimides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/48—Polymers modified by chemical after-treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
CA000454813A 1983-05-23 1984-05-22 Complex of biologically active protein with reactive high polymer having bonded thereto bifunctional chelate Expired CA1236038A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP58091217A JPS59215321A (ja) 1983-05-23 1983-05-23 二官能性配位子化合物を結合した反応性高分子
JP91217/83 1983-05-23

Publications (1)

Publication Number Publication Date
CA1236038A true CA1236038A (en) 1988-05-03

Family

ID=14020251

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000454813A Expired CA1236038A (en) 1983-05-23 1984-05-22 Complex of biologically active protein with reactive high polymer having bonded thereto bifunctional chelate

Country Status (6)

Country Link
US (1) US4556689A (enExample)
EP (1) EP0131361B1 (enExample)
JP (1) JPS59215321A (enExample)
AU (1) AU562504B2 (enExample)
CA (1) CA1236038A (enExample)
DE (1) DE3480204D1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2148901A (en) * 1983-10-04 1985-06-05 Johnson & Johnson Protein/polysaccharide complexes
US4837003A (en) * 1984-09-13 1989-06-06 Mallinckrodt, Inc. Radiolabeled antibody fragments
US4659839A (en) * 1984-10-10 1987-04-21 Mallinckrodt, Inc. Coupling agents for radiolabeled antibody fragments
US5217998A (en) * 1985-07-02 1993-06-08 Biomedical Frontiers, Inc. Composition for the stabilization of deferoxamine to chelate free ions in physiological fluid
US5223242A (en) * 1985-11-05 1993-06-29 The General Hospital Corporation Negatively charged specific affinity reagents
JPS62181229A (ja) * 1985-11-05 1987-08-08 ザ・ゼネラル・ホスピタル・コ−ポレ−シヨン 負に荷電した特異親和性試薬
CA1266344A (en) * 1986-02-14 1990-02-27 Miki Kurami High molecular compounds having amino groups, and their utilization
EP0438527A4 (en) * 1988-10-14 1992-07-01 Mallinckrodt, Inc. Radiolabelled particulate composition
GB9007384D0 (en) * 1990-04-02 1990-05-30 Duncan Ruth Coupling between polymers and other organic molecular entities utilising thiol-specific reactive groups
US5268165A (en) * 1990-10-16 1993-12-07 Biomedical Frontiers, Inc. Polymer-deferoxamine-ferric iron adducts for use in magnetic resonance imaging
ES2105332T3 (es) * 1992-10-14 1997-10-16 Nycomed Imaging As Polimeros quelantes.
US5817292A (en) * 1992-10-14 1998-10-06 Nycomed Imaging As MR imaging compositions and methods
DE69327659T2 (de) * 1992-10-14 2000-09-21 Nycomed Imaging As, Oslo Therapeutische und diagnostische bilderzeugungzusammensetzung und verfahren zur herstellung
US6174530B1 (en) 1993-05-05 2001-01-16 Gryphon Sciences Homogeneous polyoxime compositions and their preparation by parallel assembly
ES2146649T3 (es) 1993-05-05 2000-08-16 Keith Rose Compuestos de polioximas y su preparacion.
US6001364A (en) 1993-05-05 1999-12-14 Gryphon Sciences Hetero-polyoxime compounds and their preparation by parallel assembly
US5889072A (en) * 1997-02-24 1999-03-30 Solutia Inc. Process for preparing superabsorbing crosslinked polyaspartate salt
US5834568A (en) * 1997-03-17 1998-11-10 Solutia, Inc. Forming crosslinked polysuccinimide
US5859179A (en) * 1997-03-17 1999-01-12 Solutia Inc. Forming superabsorbent polymer
US5981761A (en) * 1997-03-27 1999-11-09 Solutia Inc. Crosslinked polyaspartate salts a process for their production
US6759127B1 (en) * 2001-09-27 2004-07-06 Precision Fabrics Group, Inc. Treated inherently flame resistant polyester fabrics
KR100560107B1 (ko) 2004-10-14 2006-03-13 한국화학연구원 주사제용 다기능성 폴리숙신이미드계 고분자
US20070087059A1 (en) * 2005-10-17 2007-04-19 Frank Everaerts Bioactive delivery matrix compositions and methods
KR100634381B1 (ko) 2005-11-23 2006-10-16 한국화학연구원 다기능성 폴리숙신이미드계 고분자 및 이를 이용한 조영제

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3927204A (en) * 1969-07-03 1975-12-16 Sclavo Inst Sieroterapeut Use of {60 ,{62 -poly-(aspartic acid)-hydroxyalkylamides as a plasma expander
EP0040506B1 (en) * 1980-05-21 1986-08-20 Teijin Limited Reactive polymer and process for the preparation thereof
JPS58167519A (ja) * 1982-03-30 1983-10-03 Teijin Ltd 細胞毒性複合体及びその製造法

Also Published As

Publication number Publication date
AU562504B2 (en) 1987-06-11
EP0131361A2 (en) 1985-01-16
DE3480204D1 (en) 1989-11-23
US4556689A (en) 1985-12-03
AU2841184A (en) 1984-11-29
JPH0333176B2 (enExample) 1991-05-16
EP0131361A3 (en) 1987-02-04
JPS59215321A (ja) 1984-12-05
EP0131361B1 (en) 1989-10-18

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