CA1233749A - Method for the therapeutic occlusion of blood vessels - Google Patents
Method for the therapeutic occlusion of blood vesselsInfo
- Publication number
- CA1233749A CA1233749A CA000450019A CA450019A CA1233749A CA 1233749 A CA1233749 A CA 1233749A CA 000450019 A CA000450019 A CA 000450019A CA 450019 A CA450019 A CA 450019A CA 1233749 A CA1233749 A CA 1233749A
- Authority
- CA
- Canada
- Prior art keywords
- chitosan
- chitin
- solution
- blood vessels
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 210000004204 blood vessel Anatomy 0.000 title claims abstract description 10
- 230000001225 therapeutic effect Effects 0.000 title claims description 4
- 238000000034 method Methods 0.000 title abstract description 16
- 229920001661 Chitosan Polymers 0.000 claims abstract description 45
- 229920002101 Chitin Polymers 0.000 claims abstract description 15
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000012153 distilled water Substances 0.000 claims abstract description 4
- 239000000243 solution Substances 0.000 claims description 15
- 238000002347 injection Methods 0.000 claims description 5
- 239000007924 injection Substances 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000008280 blood Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 241000282472 Canis lupus familiaris Species 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 208000032843 Hemorrhage Diseases 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 241000238557 Decapoda Species 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 3
- 229960000583 acetic acid Drugs 0.000 description 3
- 238000006640 acetylation reaction Methods 0.000 description 3
- 125000003277 amino group Chemical group 0.000 description 3
- 210000001367 artery Anatomy 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- 230000002439 hemostatic effect Effects 0.000 description 3
- 239000011343 solid material Substances 0.000 description 3
- 206010061216 Infarction Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 2
- 230000001054 cortical effect Effects 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 230000007574 infarction Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
- 241000238421 Arthropoda Species 0.000 description 1
- 241000282465 Canis Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241000238424 Crustacea Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 159000000021 acetate salts Chemical class 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 229960002442 glucosamine Drugs 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000011344 liquid material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229950006780 n-acetylglucosamine Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Materials Engineering (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/522,492 US4452785A (en) | 1982-11-08 | 1983-08-12 | Method for the therapeutic occlusion |
| US522,492 | 1983-08-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1233749A true CA1233749A (en) | 1988-03-08 |
Family
ID=24081086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000450019A Expired CA1233749A (en) | 1983-08-12 | 1984-03-20 | Method for the therapeutic occlusion of blood vessels |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US4452785A (enExample) |
| JP (1) | JPS6042326A (enExample) |
| CA (1) | CA1233749A (enExample) |
| GB (1) | GB2144630B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0684309B2 (ja) * | 1986-03-24 | 1994-10-26 | ライオン株式会社 | 人工唾液組成物 |
| DE3855777T2 (de) * | 1987-11-12 | 1997-06-26 | Canon Kk | Flüssigkristallgerät |
| US5180426A (en) * | 1987-12-28 | 1993-01-19 | Asahi Kogaku Kogyo K.K. | Composition for forming calcium phosphate type setting material and process for producing setting material |
| JP2798287B2 (ja) * | 1989-02-08 | 1998-09-17 | ユニチカ株式会社 | 抗炎症剤 |
| US6150581A (en) * | 1995-06-07 | 2000-11-21 | United States Surgical Corporation | Chitosan/alginate anti-adhesion barrier |
| EP0879068A4 (en) * | 1996-02-02 | 1999-04-21 | Transvascular Inc | METHODS AND APPARATUS FOR STOPPING BLOOD FLOW IN VESSELS |
| US20060004314A1 (en) * | 2001-06-14 | 2006-01-05 | Hemcon, Inc. | Antimicrobial barriers, systems, and methods formed from hydrophilic polymer structures such as chistosan |
| BR0210406A (pt) * | 2001-06-14 | 2006-04-04 | Providence Health Sys Oregon | curativo de ferimento, e, métodos de controle de sangramento severo, e de produção de um curativo de ferimento capaz de controlar o sangramento severo |
| US8741335B2 (en) | 2002-06-14 | 2014-06-03 | Hemcon Medical Technologies, Inc. | Hemostatic compositions, assemblies, systems, and methods employing particulate hemostatic agents formed from hydrophilic polymer foam such as Chitosan |
| US7371403B2 (en) | 2002-06-14 | 2008-05-13 | Providence Health System-Oregon | Wound dressing and method for controlling severe, life-threatening bleeding |
| US20050147656A1 (en) * | 2001-06-14 | 2005-07-07 | Hemcon, Inc. | Tissue dressing assemblies, systems, and methods formed from hydrophilic polymer sponge structures such as chitosan |
| US7897832B2 (en) * | 2001-06-14 | 2011-03-01 | Hemcon Medical Technologies, Inc. | Compositions, assemblies, and methods applied during or after a dental procedure to ameliorate fluid loss and/or promote healing, using a hydrophilic polymer sponge structure such as chitosan |
| US20050137512A1 (en) * | 2003-12-23 | 2005-06-23 | Campbell Todd D. | Wound dressing and method for controlling severe, life-threatening bleeding |
| US8269058B2 (en) * | 2002-06-14 | 2012-09-18 | Hemcon Medical Technologies, Inc. | Absorbable tissue dressing assemblies, systems, and methods formed from hydrophilic polymer sponge structures such as chitosan |
| CN1938036B (zh) | 2004-02-23 | 2011-05-11 | 洛马林达大学医学中心 | 局部和内部使用的止血剂 |
| WO2006089167A1 (en) * | 2005-02-18 | 2006-08-24 | Cartilix, Inc. | Glucosamine materials |
| US9204957B2 (en) * | 2005-03-17 | 2015-12-08 | Hemcon Medical Technologies, Inc. | Systems and methods for hemorrhage control and or tissue repair |
| JP2009538192A (ja) | 2006-05-23 | 2009-11-05 | プロビデンス ヘルス システム−オレゴン ディー／ビー／エー プロビデンス セント ビンセント メディカル センター | 体の内腔または体の中空器官内に包帯構造を導入および適用するシステムおよび方法 |
| WO2009134447A1 (en) * | 2008-05-02 | 2009-11-05 | Providence Health System-Oregon D/B/A Providence St. Vincent Medical Center | Wound dressing devices and methods |
| EP2340002B1 (en) | 2008-10-06 | 2015-03-25 | Providence Health System - Oregon | Foam medical devices and methods |
| US8623274B2 (en) | 2009-11-25 | 2014-01-07 | Loma Linda University Medical Center | Chitosan-based hemostatic textile |
| AU2012284048B2 (en) * | 2011-07-19 | 2017-03-02 | Takeda Pharmaceutical Company Limited | Resorption enhancers as additives to improve the oral formulation of non-anticoagulant sulfated polysaccharides |
| US9192692B2 (en) | 2013-10-24 | 2015-11-24 | Medtronic Xomed, Inc. | Chitosan stenting paste |
| US9192574B2 (en) | 2013-10-24 | 2015-11-24 | Medtronic Xomed, Inc. | Chitosan paste wound dressing |
| US9259357B2 (en) | 2014-04-16 | 2016-02-16 | Loma Linda University | Composition, preparation, and use of chitosan shards for biomedical applications |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3911116A (en) * | 1970-04-13 | 1975-10-07 | Leslie L Balassa | Process for promoting wound healing with chitin derivatives |
| US3989535A (en) * | 1974-02-11 | 1976-11-02 | American Cyanamid Company | Solution of poly(N-acetyl-D-glucosamine) |
| JPS5626049A (en) * | 1979-08-06 | 1981-03-13 | Mitsubishi Rayon Co | Chitine or chitine derivative nonwoven fabric and method |
| JPS56106901A (en) * | 1980-01-30 | 1981-08-25 | Mitsubishi Rayon Co Ltd | Production of formed product of chitosan |
| US4532134A (en) * | 1981-04-06 | 1985-07-30 | Malette William Graham | Method of achieving hemostasis, inhibiting fibroplasia, and promoting tissue regeneration in a tissue wound |
| US4394373A (en) * | 1981-04-06 | 1983-07-19 | Malette William Graham | Method of achieving hemostasis |
-
1983
- 1983-08-12 US US06/522,492 patent/US4452785A/en not_active Expired - Fee Related
-
1984
- 1984-03-20 CA CA000450019A patent/CA1233749A/en not_active Expired
- 1984-03-28 GB GB08408036A patent/GB2144630B/en not_active Expired
- 1984-04-24 JP JP59081261A patent/JPS6042326A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| GB8408036D0 (en) | 1984-05-10 |
| GB2144630A (en) | 1985-03-13 |
| US4452785A (en) | 1984-06-05 |
| GB2144630B (en) | 1988-03-30 |
| JPS6042326A (ja) | 1985-03-06 |
| JPH054370B2 (enExample) | 1993-01-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |