CA1228354A - Procede de preparation de derives de 4-alkyl 2-hydroxy 3-methyl 2-phenyl morpholine et les derives ainsi obtenus - Google Patents

Procede de preparation de derives de 4-alkyl 2-hydroxy 3-methyl 2-phenyl morpholine et les derives ainsi obtenus

Info

Publication number
CA1228354A
CA1228354A CA000464758A CA464758A CA1228354A CA 1228354 A CA1228354 A CA 1228354A CA 000464758 A CA000464758 A CA 000464758A CA 464758 A CA464758 A CA 464758A CA 1228354 A CA1228354 A CA 1228354A
Authority
CA
Canada
Prior art keywords
formula
acids
cul
organic
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000464758A
Other languages
English (en)
French (fr)
Inventor
Louis Lafon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon France SAS
Original Assignee
Laboratoire L Lafon SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoire L Lafon SA filed Critical Laboratoire L Lafon SA
Application granted granted Critical
Publication of CA1228354A publication Critical patent/CA1228354A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA000464758A 1983-10-17 1984-10-04 Procede de preparation de derives de 4-alkyl 2-hydroxy 3-methyl 2-phenyl morpholine et les derives ainsi obtenus Expired CA1228354A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8316485 1983-10-17
FR8316485A FR2553413B1 (fr) 1983-10-17 1983-10-17 Derives de 4-alkyl-2-hydroxy-3-methyl-2-phenyl-morpholine, procede de preparation et utilisation en therapeutique

Publications (1)

Publication Number Publication Date
CA1228354A true CA1228354A (fr) 1987-10-20

Family

ID=9293216

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000464758A Expired CA1228354A (fr) 1983-10-17 1984-10-04 Procede de preparation de derives de 4-alkyl 2-hydroxy 3-methyl 2-phenyl morpholine et les derives ainsi obtenus

Country Status (13)

Country Link
US (1) US4576944A (en, 2012)
EP (1) EP0139590B1 (en, 2012)
JP (1) JPS6097969A (en, 2012)
AT (1) ATE35261T1 (en, 2012)
AU (1) AU565778B2 (en, 2012)
CA (1) CA1228354A (en, 2012)
DE (1) DE3472256D1 (en, 2012)
DK (1) DK157682C (en, 2012)
ES (1) ES8507123A1 (en, 2012)
FR (1) FR2553413B1 (en, 2012)
GR (1) GR80658B (en, 2012)
IE (1) IE57773B1 (en, 2012)
ZA (1) ZA848024B (en, 2012)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8417170D0 (en) * 1984-07-05 1984-08-08 Wellcome Found Heterocyclic pharmaceutical compounds
GB8924528D0 (en) * 1989-10-31 1989-12-20 Wellcome Found Heterocyclic pharmaceutical compounds,preparation and use
GB9108629D0 (en) * 1991-04-23 1991-06-12 Wellcome Found Heterocyclic pharmaceutical compounds,preparation and use
EP2474308A1 (en) * 2005-06-27 2012-07-11 Valeant International (Barbados) SRL Pharmaceutical formulations containing bupropion hydrobromide
WO2011146821A2 (en) 2010-05-21 2011-11-24 Research Triangle Institute 1 - phenylmorpholine derivatives as hydroxybupropion analogues for treating drug dependence
ES2687095T3 (es) 2010-05-21 2018-10-23 Research Triangle Institute Fenilimorfolinas y análogos de las mismas

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB791416A (en) * 1956-04-09 1958-03-05 Albert Boehringer Improvements in or relating to the production of substituted tetrahydrooxazines
US3117967A (en) * 1962-04-02 1964-01-14 Smith Kline French Lab 2-biphenylyl-2-hydroxy-morpholinium halides
US3225042A (en) * 1962-07-31 1965-12-21 Lilly Co Eli Hydroxymorpholines
US4044131A (en) * 1975-11-24 1977-08-23 American Home Products Corporation 2-Morpholinol derivatives

Also Published As

Publication number Publication date
DK484684D0 (da) 1984-10-10
DK157682B (da) 1990-02-05
IE57773B1 (en) 1993-04-07
EP0139590B1 (fr) 1988-06-22
US4576944A (en) 1986-03-18
ES536991A0 (es) 1985-08-16
EP0139590A3 (en) 1985-06-26
ES8507123A1 (es) 1985-08-16
JPS6097969A (ja) 1985-05-31
FR2553413B1 (fr) 1986-03-21
DE3472256D1 (en) 1988-07-28
GR80658B (en) 1985-02-18
AU3409184A (en) 1985-04-26
IE842552L (en) 1985-04-17
AU565778B2 (en) 1987-09-24
JPH0522704B2 (en, 2012) 1993-03-30
DK484684A (da) 1985-04-18
EP0139590A2 (fr) 1985-05-02
DK157682C (da) 1990-07-09
ZA848024B (en) 1985-06-26
FR2553413A1 (fr) 1985-04-19
ATE35261T1 (de) 1988-07-15

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Legal Events

Date Code Title Description
MKEX Expiry