CA1206668A - Polymer surfaces for blood-contacting surfaces of a biomedical device, and methods for forming - Google Patents
Polymer surfaces for blood-contacting surfaces of a biomedical device, and methods for formingInfo
- Publication number
- CA1206668A CA1206668A CA000371214A CA371214A CA1206668A CA 1206668 A CA1206668 A CA 1206668A CA 000371214 A CA000371214 A CA 000371214A CA 371214 A CA371214 A CA 371214A CA 1206668 A CA1206668 A CA 1206668A
- Authority
- CA
- Canada
- Prior art keywords
- polymer
- component
- additive
- admixture
- base polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229920000642 polymer Polymers 0.000 title claims abstract description 190
- 238000000034 method Methods 0.000 title claims abstract description 49
- 239000000654 additive Substances 0.000 claims abstract description 105
- 230000000996 additive effect Effects 0.000 claims abstract description 105
- 229920005601 base polymer Polymers 0.000 claims abstract description 97
- 229920001519 homopolymer Polymers 0.000 claims abstract description 43
- 229920001400 block copolymer Polymers 0.000 claims abstract description 24
- 229920002635 polyurethane Polymers 0.000 claims abstract description 21
- 239000004814 polyurethane Substances 0.000 claims abstract description 20
- 229920000578 graft copolymer Polymers 0.000 claims abstract description 7
- 210000000416 exudates and transudate Anatomy 0.000 claims abstract description 6
- -1 poly(dimethylsiloxane) Polymers 0.000 claims description 24
- 239000008280 blood Substances 0.000 claims description 22
- 210000004369 blood Anatomy 0.000 claims description 22
- 239000012530 fluid Substances 0.000 claims description 16
- 229920001577 copolymer Polymers 0.000 claims description 15
- 239000002904 solvent Substances 0.000 claims description 9
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 8
- 239000001257 hydrogen Substances 0.000 claims description 5
- 229910052739 hydrogen Inorganic materials 0.000 claims description 5
- 229920006294 polydialkylsiloxane Polymers 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 4
- 125000005376 alkyl siloxane group Chemical group 0.000 claims description 3
- 229920000098 polyolefin Polymers 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 102000004169 proteins and genes Human genes 0.000 claims description 3
- 238000000137 annealing Methods 0.000 claims description 2
- 238000001816 cooling Methods 0.000 claims description 2
- 239000000306 component Substances 0.000 claims 50
- 241001367053 Autographa gamma Species 0.000 claims 18
- 239000000758 substrate Substances 0.000 claims 4
- 239000006185 dispersion Substances 0.000 claims 2
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims 2
- 238000011065 in-situ storage Methods 0.000 claims 1
- 229920006030 multiblock copolymer Polymers 0.000 claims 1
- 229920001187 thermosetting polymer Polymers 0.000 claims 1
- 229920002959 polymer blend Polymers 0.000 abstract description 2
- 239000000463 material Substances 0.000 description 12
- 229920001296 polysiloxane Polymers 0.000 description 10
- 239000004205 dimethyl polysiloxane Substances 0.000 description 9
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 9
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 6
- 150000002500 ions Chemical class 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 229920001169 thermoplastic Polymers 0.000 description 5
- 239000004416 thermosoftening plastic Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 239000004698 Polyethylene Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 229920000573 polyethylene Polymers 0.000 description 4
- 101150039033 Eci2 gene Proteins 0.000 description 3
- 239000004721 Polyphenylene oxide Substances 0.000 description 3
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000005859 coupling reaction Methods 0.000 description 3
- 230000009477 glass transition Effects 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 238000002844 melting Methods 0.000 description 3
- 230000008018 melting Effects 0.000 description 3
- 229920000570 polyether Polymers 0.000 description 3
- 229920001897 terpolymer Polymers 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 230000023555 blood coagulation Effects 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000001746 injection moulding Methods 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 239000004800 polyvinyl chloride Substances 0.000 description 2
- 229920000915 polyvinyl chloride Polymers 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- QOXOZONBQWIKDA-UHFFFAOYSA-N 3-hydroxypropyl Chemical group [CH2]CCO QOXOZONBQWIKDA-UHFFFAOYSA-N 0.000 description 1
- UPMLOUAZCHDJJD-UHFFFAOYSA-N 4,4'-Diphenylmethane Diisocyanate Chemical compound C1=CC(N=C=O)=CC=C1CC1=CC=C(N=C=O)C=C1 UPMLOUAZCHDJJD-UHFFFAOYSA-N 0.000 description 1
- 239000007991 ACES buffer Substances 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 208000010496 Heart Arrest Diseases 0.000 description 1
- 206010022528 Interactions Diseases 0.000 description 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
- 241000353097 Molva molva Species 0.000 description 1
- 239000005062 Polybutadiene Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920002367 Polyisobutene Polymers 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 241000193803 Therea Species 0.000 description 1
- 239000004433 Thermoplastic polyurethane Substances 0.000 description 1
- ZJCCRDAZUWHFQH-UHFFFAOYSA-N Trimethylolpropane Chemical compound CCC(CO)(CO)CO ZJCCRDAZUWHFQH-UHFFFAOYSA-N 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- LUTSRLYCMSCGCS-BWOMAWGNSA-N [(3s,8r,9s,10r,13s)-10,13-dimethyl-17-oxo-1,2,3,4,7,8,9,11,12,16-decahydrocyclopenta[a]phenanthren-3-yl] acetate Chemical compound C([C@@H]12)C[C@]3(C)C(=O)CC=C3[C@@H]1CC=C1[C@]2(C)CC[C@H](OC(=O)C)C1 LUTSRLYCMSCGCS-BWOMAWGNSA-N 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 210000002376 aorta thoracic Anatomy 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- JLQUFIHWVLZVTJ-UHFFFAOYSA-N carbosulfan Chemical compound CCCCN(CCCC)SN(C)C(=O)OC1=CC=CC2=C1OC(C)(C)C2 JLQUFIHWVLZVTJ-UHFFFAOYSA-N 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229920000891 common polymer Polymers 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- JJCFRYNCJDLXIK-UHFFFAOYSA-N cyproheptadine Chemical compound C1CN(C)CCC1=C1C2=CC=CC=C2C=CC2=CC=CC=C21 JJCFRYNCJDLXIK-UHFFFAOYSA-N 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000011067 equilibration Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 238000005227 gel permeation chromatography Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- IQPQWNKOIGAROB-UHFFFAOYSA-N isocyanate Chemical compound [N-]=C=O IQPQWNKOIGAROB-UHFFFAOYSA-N 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229940099990 ogen Drugs 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 229920002857 polybutadiene Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920001195 polyisoprene Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920000346 polystyrene-polyisoprene block-polystyrene Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- CMXPERZAMAQXSF-UHFFFAOYSA-M sodium;1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonate;1,8-dihydroxyanthracene-9,10-dione Chemical compound [Na+].O=C1C2=CC=CC(O)=C2C(=O)C2=C1C=CC=C2O.CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC CMXPERZAMAQXSF-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 229920000468 styrene butadiene styrene block copolymer Polymers 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 229920002803 thermoplastic polyurethane Polymers 0.000 description 1
- SRVJKTDHMYAMHA-WUXMJOGZSA-N thioacetazone Chemical compound CC(=O)NC1=CC=C(\C=N\NC(N)=S)C=C1 SRVJKTDHMYAMHA-WUXMJOGZSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- JFALSRSLKYAFGM-UHFFFAOYSA-N uranium(0) Chemical compound [U] JFALSRSLKYAFGM-UHFFFAOYSA-N 0.000 description 1
- 230000002861 ventricular Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
- C08L83/10—Block- or graft-copolymers containing polysiloxane sequences
- C08L83/12—Block- or graft-copolymers containing polysiloxane sequences containing polyether sequences
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/06—Use of macromolecular materials
- A61L33/062—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/06—Use of macromolecular materials
- A61L33/068—Use of macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/08—Processes
- C08G18/10—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/40—High-molecular-weight compounds
- C08G18/61—Polysiloxanes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/42—Block-or graft-polymers containing polysiloxane sequences
- C08G77/452—Block-or graft-polymers containing polysiloxane sequences containing nitrogen-containing sequences
- C08G77/455—Block-or graft-polymers containing polysiloxane sequences containing nitrogen-containing sequences containing polyamide, polyesteramide or polyimide sequences
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/42—Block-or graft-polymers containing polysiloxane sequences
- C08G77/458—Block-or graft-polymers containing polysiloxane sequences containing polyurethane sequences
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/42—Block-or graft-polymers containing polysiloxane sequences
- C08G77/46—Block-or graft-polymers containing polysiloxane sequences containing polyether sequences
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L75/00—Compositions of polyureas or polyurethanes; Compositions of derivatives of such polymers
- C08L75/04—Polyurethanes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA000473726A CA1211878A (en) | 1980-02-29 | 1985-02-07 | Polymer surfaces for blood-contacting surfaces of a biomedical device |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12584580A | 1980-02-29 | 1980-02-29 | |
| US125,845 | 1980-02-29 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000473726A Division CA1211878A (en) | 1980-02-29 | 1985-02-07 | Polymer surfaces for blood-contacting surfaces of a biomedical device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1206668A true CA1206668A (en) | 1986-06-24 |
Family
ID=22421689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000371214A Expired CA1206668A (en) | 1980-02-29 | 1981-02-18 | Polymer surfaces for blood-contacting surfaces of a biomedical device, and methods for forming |
Country Status (12)
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4675361A (en) * | 1980-02-29 | 1987-06-23 | Thoratec Laboratories Corp. | Polymer systems suitable for blood-contacting surfaces of a biomedical device, and methods for forming |
| US4861830A (en) * | 1980-02-29 | 1989-08-29 | Th. Goldschmidt Ag | Polymer systems suitable for blood-contacting surfaces of a biomedical device, and methods for forming |
| DE68385T1 (de) * | 1981-06-22 | 1983-09-15 | Kanegafuchi Kagaku Kogyo K.K., Osaka | Antithrombogenes elastomer |
| JPS57211358A (en) * | 1981-06-22 | 1982-12-25 | Kanegafuchi Chemical Ind | Anti-thrombus elastomer and method |
| DE3130646C2 (de) * | 1981-07-28 | 1983-09-15 | Wilfried Dr.-Ing. 1000 Berlin Lemm | Verfahren zum Herstellen von Gegenständen aus Polyurethan, die in gewissen Oberflächenbereichen mit Polydimethylsiloxan angereichert sind |
| JPS58185647A (ja) * | 1982-03-17 | 1983-10-29 | Nippon Zeon Co Ltd | 抗血栓表面を与える安定な重合体エマルジョン組成物 |
| DK103483A (da) * | 1982-04-15 | 1983-10-16 | Ethicon Inc | Siliconebelagt kirurgisk haefteklamme |
| JPS6045357A (ja) * | 1983-08-23 | 1985-03-11 | 日本ゼオン株式会社 | 血液接触医療器具の製造方法 |
| JPH0622591B2 (ja) * | 1983-10-13 | 1994-03-30 | 日本ゼオン株式会社 | 血液接触医療器具の製造方法 |
| CA1257425A (en) * | 1984-05-21 | 1989-07-11 | Th. Goldschmidt Ag | Moisture vapor permeable materials |
| US4883699A (en) * | 1984-09-21 | 1989-11-28 | Menlo Care, Inc. | Polymeric article having high tensile energy to break when hydrated |
| US4911691A (en) * | 1984-09-21 | 1990-03-27 | Menlo Care, Inc. | Assembly for adminstering IV solution |
| JPS6176152A (ja) * | 1984-09-25 | 1986-04-18 | 学校法人東京女子医科大学 | 医療用チユ−ブ |
| JPS61154674A (ja) * | 1984-12-28 | 1986-07-14 | 日本ゼオン株式会社 | 抗血栓性材料 |
| US5512650A (en) * | 1986-06-20 | 1996-04-30 | Minnesota Mining And Manufacturing Company | Block copolymer, method of making the same, diamine precursors of the same, method of making such diamines and end products comprising the block copolymer |
| US5214119A (en) * | 1986-06-20 | 1993-05-25 | Minnesota Mining And Manufacturing Company | Block copolymer, method of making the same, dimaine precursors of the same, method of making such diamines and end products comprising the block copolymer |
| US5221724A (en) * | 1987-08-12 | 1993-06-22 | Wisconsin Alumni Research Foundation | Polysiloxane polyurea urethanes |
| US4906465A (en) * | 1987-10-19 | 1990-03-06 | Massachusetts Institute Of Technology | Antithrombogenic devices containing polysiloxanes |
| US4939007A (en) * | 1988-03-07 | 1990-07-03 | Becton, Dickinson And Company | Article having a hemocompatible surface |
| US4840796A (en) * | 1988-04-22 | 1989-06-20 | Dow Corning Corporation | Block copolymer matrix for transdermal drug release |
| US4951657A (en) * | 1988-04-22 | 1990-08-28 | Dow Corning Corporation | Heat sealable membrane for transdermal drug release |
| GB8811868D0 (en) * | 1988-05-19 | 1988-06-22 | Ici Plc | Release film |
| DE3922079C2 (de) * | 1989-07-05 | 1996-06-13 | Hanse Chemie Gmbh | Polysiloxandispersion, Verfahren zu ihrer Herstellung und ihre Verwendung |
| JP3857306B2 (ja) * | 1992-04-24 | 2006-12-13 | ザ ポリマー テクノロジー グループ，インコーポレイティド | 所定分子量レンジの分子を透過させるためのコポリマー及びそれらの非細孔性，半透過性膜並びにその使用 |
| DE4217165C1 (enrdf_load_stackoverflow) * | 1992-05-23 | 1993-08-19 | Rehau Ag + Co, 8673 Rehau, De | |
| US5670598A (en) * | 1995-03-24 | 1997-09-23 | Minnesota Mining And Manufacturing Company | Diblock and triblock polydiorganosiloxane-polyurea block copolymers |
| DE19641335A1 (de) * | 1996-10-08 | 1998-04-09 | Inst Textil & Faserforschung | Triblockterpolymer, seine Verwendung für chirurgisches Nahtmaterial und Verfahren zur Herstellung |
| AUPO251096A0 (en) | 1996-09-23 | 1996-10-17 | Cardiac Crc Nominees Pty Limited | Polysiloxane-containing polyurethane elastomeric compositions |
| DE19641334A1 (de) * | 1996-10-08 | 1998-04-09 | Inst Textil & Faserforschung | Triblockterpolymer, seine Verwendung für medizinische Produkte und Verfahren zur Herstellung |
| US5863627A (en) * | 1997-08-26 | 1999-01-26 | Cardiotech International, Inc. | Hydrolytically-and proteolytically-stable polycarbonate polyurethane silicone copolymers |
| AU9284198A (en) * | 1998-01-30 | 1999-08-16 | Kaneka Corporation | Balloon catheter, catheter shaft used for the catheter and method of production of balloon |
| US20050220835A1 (en) * | 2004-03-30 | 2005-10-06 | Jayaraman Ramesh B | Agent eluting bioimplantable devices and polymer systems for their preparation |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3562352A (en) * | 1968-09-06 | 1971-02-09 | Avco Corp | Polysiloxane-polyurethane block copolymers |
| JPS5314103B2 (enrdf_load_stackoverflow) * | 1972-07-15 | 1978-05-15 | ||
| US4002794A (en) * | 1975-07-18 | 1977-01-11 | Nashua Corporation | Adhesive material and articles incorporating same |
| US4100309A (en) * | 1977-08-08 | 1978-07-11 | Biosearch Medical Products, Inc. | Coated substrate having a low coefficient of friction hydrophilic coating and a method of making the same |
| US4196731A (en) * | 1978-03-17 | 1980-04-08 | Baxter Travenol Laboratories, Inc. | Silicone-containing thermoplastic polymers for medical uses |
-
1981
- 1981-02-18 CA CA000371214A patent/CA1206668A/en not_active Expired
- 1981-02-19 ZA ZA00811107A patent/ZA811107B/xx unknown
- 1981-02-20 IL IL62183A patent/IL62183A/xx unknown
- 1981-02-23 GB GB8105685A patent/GB2073219B/en not_active Expired
- 1981-02-23 AU AU67551/81A patent/AU548194B2/en not_active Ceased
- 1981-02-24 AT AT0083581A patent/AT385041B/de not_active IP Right Cessation
- 1981-02-24 MX MX186106A patent/MX159062A/es unknown
- 1981-02-25 JP JP2670781A patent/JPS56136565A/ja active Granted
- 1981-02-27 IT IT8120027A patent/IT1210997B/it active
- 1981-02-27 DE DE3153664A patent/DE3153664C2/de not_active Expired - Lifetime
- 1981-02-27 NL NL8100975A patent/NL8100975A/nl not_active Application Discontinuation
- 1981-02-27 FR FR8103961A patent/FR2491938B1/fr not_active Expired
-
1982
- 1982-02-08 FR FR8201981A patent/FR2497217B1/fr not_active Expired
-
1984
- 1984-03-22 GB GB08407417A patent/GB2140444B/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB2140444A (en) | 1984-11-28 |
| GB2073219A (en) | 1981-10-14 |
| MX159062A (es) | 1989-04-14 |
| NL8100975A (nl) | 1981-10-01 |
| IT1210997B (it) | 1989-09-29 |
| ATA83581A (de) | 1987-07-15 |
| DE3153664C2 (enrdf_load_stackoverflow) | 1991-07-25 |
| IL62183A0 (en) | 1981-03-31 |
| GB2073219B (en) | 1985-02-27 |
| AT385041B (de) | 1988-02-10 |
| IL62183A (en) | 1984-10-31 |
| FR2491938B1 (fr) | 1985-10-25 |
| AU6755181A (en) | 1981-09-03 |
| FR2497217B1 (fr) | 1986-05-23 |
| FR2497217A1 (fr) | 1982-07-02 |
| AU548194B2 (en) | 1985-11-28 |
| GB2140444B (en) | 1985-06-05 |
| JPS56136565A (en) | 1981-10-24 |
| FR2491938A1 (fr) | 1982-04-16 |
| JPH0214062B2 (enrdf_load_stackoverflow) | 1990-04-06 |
| GB8407417D0 (en) | 1984-05-02 |
| IT8120027A0 (it) | 1981-02-27 |
| ZA811107B (en) | 1982-03-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA1206668A (en) | Polymer surfaces for blood-contacting surfaces of a biomedical device, and methods for forming | |
| US4861830A (en) | Polymer systems suitable for blood-contacting surfaces of a biomedical device, and methods for forming | |
| US4675361A (en) | Polymer systems suitable for blood-contacting surfaces of a biomedical device, and methods for forming | |
| KR100423068B1 (ko) | 폴리디오르가노실록산폴리우레아단편화된공중합체및이것의제조방법 | |
| US5059269A (en) | Method of making an article having a hemocompatible surface | |
| US6355759B1 (en) | Polydiorganosiloxane polyurea segmented copolymers and a process for making same | |
| US4939007A (en) | Article having a hemocompatible surface | |
| US5061424A (en) | Method for applying a lubricious coating to an article | |
| EP0396431B1 (en) | Elastomeric segmented hydrophilic polyetherurethane based lubricious coatings | |
| Aggarwal | Structure and properties of block polymers and multiphase polymer systems: an overview of present status and future potential | |
| Park et al. | PDMS-based polyurethanes with MPEG grafts: synthesis, characterization and platelet adhesion study | |
| EP0822952B1 (en) | Polydiorganosiloxane oligourea segmented copolymers and a process for making same | |
| EP0758349B1 (en) | Surface-modifying endgroups for biomedical polymers | |
| Kozakiewicz | Polysiloxaneurethanes: new polymers for potential coating applications | |
| US5998551A (en) | Crosslinked nylon block copolymers | |
| JPH0632652B2 (ja) | 湿潤時に潤滑性のある医療用物品 | |
| WO1986007541A1 (en) | Composition which can impart antithrombotic ability and medical apparatus to be in contact with blood | |
| WO1995026993A9 (en) | Surface-modifying endgroups for biomedical polymers | |
| JPH0317178A (ja) | 付加硬化型シリコーン感圧接着剤 | |
| CN110885550B (zh) | 一种有机硅改性热塑性聚氨酯弹性体及其制备方法 | |
| CA1277062C (en) | Multiple release mold coating | |
| GB2140437A (en) | Polymer surfaces for blood-contacting surfaces of a biomedical device and methods for forming | |
| CN106715503A (zh) | 自润滑聚合物组合物 | |
| Mitzner et al. | Modification of poly (ether urethane) elastomers by incorporation of poly (isobutylene) glycol. Relation between polymer properties and thrombogenicity | |
| JPS60238315A (ja) | 抗血栓性ポリウレタン又はポリウレタンウレア及びその製造方法、ならびに血液接触医療器具 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |