CA1198672A - Fibrinolytically active agent and a method for the preparation thereof - Google Patents

Fibrinolytically active agent and a method for the preparation thereof

Info

Publication number
CA1198672A
CA1198672A CA000422034A CA422034A CA1198672A CA 1198672 A CA1198672 A CA 1198672A CA 000422034 A CA000422034 A CA 000422034A CA 422034 A CA422034 A CA 422034A CA 1198672 A CA1198672 A CA 1198672A
Authority
CA
Canada
Prior art keywords
solution
aqueous
earthworms
tissues
extract solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000422034A
Other languages
English (en)
French (fr)
Inventor
Hiroyuki Sumi
Hisashi Mihara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HISAHI MIHARA
Amano Enzyme Inc
Original Assignee
HISAHI MIHARA
Amano Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HISAHI MIHARA, Amano Pharmaceutical Co Ltd filed Critical HISAHI MIHARA
Application granted granted Critical
Publication of CA1198672A publication Critical patent/CA1198672A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA000422034A 1982-02-27 1983-02-21 Fibrinolytically active agent and a method for the preparation thereof Expired CA1198672A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP57031467A JPS58148824A (ja) 1982-02-27 1982-02-27 線溶活性物質の製造法
JP31467/1982 1982-02-27

Publications (1)

Publication Number Publication Date
CA1198672A true CA1198672A (en) 1985-12-31

Family

ID=12332056

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000422034A Expired CA1198672A (en) 1982-02-27 1983-02-21 Fibrinolytically active agent and a method for the preparation thereof

Country Status (6)

Country Link
JP (1) JPS58148824A (no)
CA (1) CA1198672A (no)
DE (1) DE3306944A1 (no)
FR (1) FR2522266B1 (no)
GB (1) GB2116565B (no)
IT (1) IT1197586B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1629383A (en) * 1982-10-02 1984-04-05 Amano Seiyaku K.K. Earthworm tissue protease thrombolytic agents
DE3519736C2 (de) * 1985-06-01 1995-11-16 Haeusler Gerd Mittel zur Behandlung von Rheuma und Polyarthritis
US5024844A (en) * 1987-08-18 1991-06-18 Eimei Company, Ltd. Process for the production of dried earthworm powder and antihyperlipemic, antidiabetic, antihypertensive and antihypotensive preparations containing dried earthworm powder as active ingredient
KR900012617A (ko) * 1987-10-28 1990-09-01 요오이찌 이시이 혈전증 치료제 및 그 제조방법
IT1230719B (it) * 1988-04-19 1991-10-29 Eimei Co Ltd Procedimento per la produzione di polvere di lombrichi secca e preparazioni anti iperlipemiche, anti diabetiche, anti ipertensive ed anti ipotensive contenenti, come ingrediente attivo, polvere secca di lombrichi.
US5186944A (en) * 1989-02-15 1993-02-16 Eimei Company Ltd. Therapeutic medicament for thrombosis
JP2006096673A (ja) * 2004-09-28 2006-04-13 Mihara Lr Kenkyusho:Kk ミミズ製品の製造方法
JP2009143845A (ja) * 2007-12-14 2009-07-02 Mihara Lr Kenkyusho:Kk ミミズ抽出液の製造方法及びミミズ乾燥粉末の製造方法
EP2255819A1 (en) * 2009-05-26 2010-12-01 Inmobiliaria Algeciras Ltda Extract of annelid and use thereof for the regeneration of the skin

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1629383A (en) * 1982-10-02 1984-04-05 Amano Seiyaku K.K. Earthworm tissue protease thrombolytic agents

Also Published As

Publication number Publication date
GB2116565B (en) 1985-02-27
IT8347795A0 (it) 1983-02-25
JPS645576B2 (no) 1989-01-31
GB2116565A (en) 1983-09-28
DE3306944A1 (de) 1983-09-15
DE3306944C2 (no) 1989-04-13
IT1197586B (it) 1988-12-06
JPS58148824A (ja) 1983-09-05
FR2522266A1 (fr) 1983-09-02
GB8305359D0 (en) 1983-03-30
FR2522266B1 (fr) 1987-07-31

Similar Documents

Publication Publication Date Title
US4568545A (en) Thrombolytic agent
US4505893A (en) Purified plasminogen activator, process for its production and thrombolytic composition containing it
EP0217341B2 (en) Process for preparing an anticoagulating substance
JPS62108821A (ja) アルフア−１−プロテイナ−ゼ阻害剤の製造方法
CA1198672A (en) Fibrinolytically active agent and a method for the preparation thereof
KR960007922B1 (ko) 조직단백질 pp4의 저온살균법
JPH0424360B2 (no)
CA1283048C (en) Therapeutic agent for treating hematopoietic diseases
Wuepper et al. Plasma kinin system: proenzyme components
CA1297634C (en) Anticoagulating substance and preparation process thereof
US4067964A (en) Antihemophilic agent and process for its manufacture
US3555000A (en) Plasminogen activator and isolation thereof from stromata of human erythrocytes
US4056614A (en) Immunity depressant medicine
JPH0694420B2 (ja) 血栓溶解剤
JPS62153224A (ja) プラスミノゲン製剤
JPS61171431A (ja) アミラ−ゼ阻害物質およびその製造法
KR100261657B1 (ko) 룸부로키나제의 제조방법
EP0112940B1 (en) Method of producing a tissue plasminogen activator and composition comprising same
Morishita Studies on Human Gastric Intrinsic Factor I. Purification of Intrinsic Factor from Human Gastric Juice
CA1189788A (en) Method of producing a tissue plasminogen activator and composition comprising same
US2847349A (en) Plasma preparation
JPS6333666B2 (no)
Miller et al. Prothrombin activation by encephalitogenic brain protein
JPH0259840B2 (no)
JPS608226A (ja) 低分子蛋白質を有効成分とする制ガン剤

Legal Events

Date Code Title Description
MKEX Expiry