CA1186305A - 16-methoxy-16-methyl-prostagland in e.sub.1 derivatives, a process for preparing them and their use as gastroprotective agents - Google Patents

16-methoxy-16-methyl-prostagland in e.sub.1 derivatives, a process for preparing them and their use as gastroprotective agents

Info

Publication number
CA1186305A
CA1186305A CA000349411A CA349411A CA1186305A CA 1186305 A CA1186305 A CA 1186305A CA 000349411 A CA000349411 A CA 000349411A CA 349411 A CA349411 A CA 349411A CA 1186305 A CA1186305 A CA 1186305A
Authority
CA
Canada
Prior art keywords
formula
compound
methyl
methoxy
chirality
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000349411A
Other languages
English (en)
French (fr)
Inventor
Umberto Guzzi
Romeo Ciabatti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruppo Lepetit SpA
Original Assignee
Gruppo Lepetit SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruppo Lepetit SpA filed Critical Gruppo Lepetit SpA
Priority to CA000436820A priority Critical patent/CA1186306A/en
Application granted granted Critical
Publication of CA1186305A publication Critical patent/CA1186305A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA000349411A 1979-04-10 1980-04-09 16-methoxy-16-methyl-prostagland in e.sub.1 derivatives, a process for preparing them and their use as gastroprotective agents Expired CA1186305A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA000436820A CA1186306A (en) 1979-04-10 1983-09-15 Optically active 16-methoxy-16-methyl-prostaglandin e derivatives and a process for preparing them

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT21707/79A IT1162731B (it) 1979-04-10 1979-04-10 16-metil-16-metossi-5,6-diidro-prosta-glandine della serie e1 ad attivita'antisecretoria
IT21707A/79 1979-04-10

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA000436820A Division CA1186306A (en) 1979-04-10 1983-09-15 Optically active 16-methoxy-16-methyl-prostaglandin e derivatives and a process for preparing them

Publications (1)

Publication Number Publication Date
CA1186305A true CA1186305A (en) 1985-04-30

Family

ID=11185708

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000349411A Expired CA1186305A (en) 1979-04-10 1980-04-09 16-methoxy-16-methyl-prostagland in e.sub.1 derivatives, a process for preparing them and their use as gastroprotective agents

Country Status (22)

Country Link
US (1) US4547521A (OSRAM)
JP (1) JPS55149246A (OSRAM)
AT (1) AT370725B (OSRAM)
AU (1) AU534150B2 (OSRAM)
BE (1) BE882734A (OSRAM)
CA (1) CA1186305A (OSRAM)
CH (1) CH647503A5 (OSRAM)
DE (1) DE3012306A1 (OSRAM)
DK (1) DK155937C (OSRAM)
FR (2) FR2453850B1 (OSRAM)
GB (1) GB2046750B (OSRAM)
HK (1) HK66283A (OSRAM)
IE (1) IE49675B1 (OSRAM)
IT (1) IT1162731B (OSRAM)
MX (1) MX6595E (OSRAM)
MY (1) MY8400336A (OSRAM)
NL (1) NL8002073A (OSRAM)
NO (1) NO151363C (OSRAM)
NZ (1) NZ193370A (OSRAM)
SE (1) SE465126B (OSRAM)
SG (1) SG44483G (OSRAM)
ZA (1) ZA801822B (OSRAM)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1190400B (it) * 1985-10-04 1988-02-16 Istituto Biochimico Italiano Derivati dell'acido 19,20-bis,nor-prostanoico ad attivita' antiulcera e anoressivca,procedimento per la loro preparazione e composizioni farmaceutiche
EP0325869B1 (en) * 1988-01-28 1992-11-25 Merrell Dow Pharmaceuticals Inc. Novel processes and intermediates
WO1999062877A1 (fr) * 1998-06-04 1999-12-09 Asahi Glass Company Ltd. Procede de production d'un derive de prostaglandine purifie

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1495152A (en) * 1974-08-16 1977-12-14 Ici Ltd Prostanoic acid derivatives
GB1538871A (en) * 1975-01-24 1979-01-24 Lepetit Spa Prostaglandins
US4064350A (en) * 1976-11-22 1977-12-20 G. D. Searle & Co. 15,16-Dihydroxyprostaglandins

Also Published As

Publication number Publication date
FR2510567B1 (fr) 1985-09-06
ZA801822B (en) 1981-03-25
MY8400336A (en) 1984-12-31
JPH0141625B2 (OSRAM) 1989-09-06
HK66283A (en) 1983-12-23
SE465126B (sv) 1991-07-29
NZ193370A (en) 1984-08-24
DK155937C (da) 1989-10-16
IT1162731B (it) 1987-04-01
DE3012306A1 (de) 1980-10-23
FR2453850B1 (fr) 1985-11-22
AU5656080A (en) 1980-10-16
SE8002689L (sv) 1980-10-11
JPS55149246A (en) 1980-11-20
NO151363C (no) 1985-03-27
SG44483G (en) 1984-02-17
AU534150B2 (en) 1984-01-05
BE882734A (fr) 1980-10-10
AT370725B (de) 1983-04-25
IE49675B1 (en) 1985-11-27
FR2510567A1 (fr) 1983-02-04
FR2453850A1 (fr) 1980-11-07
GB2046750B (en) 1983-04-20
IE800723L (en) 1980-10-10
NL8002073A (nl) 1980-10-14
NO151363B (no) 1984-12-17
GB2046750A (en) 1980-11-19
MX6595E (es) 1985-08-14
ATA192680A (de) 1982-09-15
CH647503A5 (fr) 1985-01-31
US4547521A (en) 1985-10-15
DK155937B (da) 1989-06-05
DK151480A (da) 1980-10-11
IT7921707A0 (it) 1979-04-10
DE3012306C2 (OSRAM) 1990-03-22
NO800998L (no) 1980-10-13

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Legal Events

Date Code Title Description
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