CA1184518A - Reversible microencapsulation - Google Patents

Reversible microencapsulation

Info

Publication number
CA1184518A
CA1184518A CA000398210A CA398210A CA1184518A CA 1184518 A CA1184518 A CA 1184518A CA 000398210 A CA000398210 A CA 000398210A CA 398210 A CA398210 A CA 398210A CA 1184518 A CA1184518 A CA 1184518A
Authority
CA
Canada
Prior art keywords
polymer
membrane
solution
stripping
plural
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000398210A
Other languages
English (en)
French (fr)
Inventor
Franklin Lim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Damon Corp
Original Assignee
Damon Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Damon Corp filed Critical Damon Corp
Application granted granted Critical
Publication of CA1184518A publication Critical patent/CA1184518A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/20—After-treatment of capsule walls, e.g. hardening
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0012—Cell encapsulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
    • A61K2035/128—Immunoprotecting barriers, e.g. jackets, diffusion chambers capsules, e.g. microcapsules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/74—Alginate

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
CA000398210A 1981-03-13 1982-03-12 Reversible microencapsulation Expired CA1184518A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24358481A 1981-03-13 1981-03-13
US243,584 1981-03-13

Publications (1)

Publication Number Publication Date
CA1184518A true CA1184518A (en) 1985-03-26

Family

ID=22919328

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000398210A Expired CA1184518A (en) 1981-03-13 1982-03-12 Reversible microencapsulation

Country Status (11)

Country Link
JP (1) JPS57197031A (de)
BE (1) BE892477A (de)
CA (1) CA1184518A (de)
CH (1) CH651579A5 (de)
DE (1) DE3209045C2 (de)
DK (1) DK112382A (de)
FR (1) FR2501528A1 (de)
GB (1) GB2094750B (de)
IT (1) IT1150681B (de)
NO (1) NO158284C (de)
SE (1) SE454181B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD160393A3 (de) * 1980-11-14 1983-07-27 Horst Dautzenberg Mikrokapseln und verfahren zu ihrer herstellung
NO161446C (no) * 1981-03-13 1989-08-16 Damon Biotech Inc Fremgangsmaate for dyrking av celler som er avhengige av forankring.
NO163060C (no) * 1981-03-13 1990-03-28 Damon Biotech Inc Fremgangsmaate for fremstilling av substanser som dannes av levende celler som produserer interferoner eller antistoffer.
US4582799A (en) * 1983-04-15 1986-04-15 Damon Biotech, Inc. Process for recovering nonsecreted substances produced by cells
CA1196862A (en) * 1983-06-01 1985-11-19 Anthony M.F. Sun Microencapsulation of living tissue and cells
EP0127989A3 (de) * 1983-06-01 1986-03-26 Connaught Laboratories Limited Mikroverkapselung von lebenden Gewebe und Zellen
IL72787A (en) * 1983-09-01 1987-12-31 Damon Biotech Inc Polyionic microencapsulation of viable cells
US4663286A (en) * 1984-02-13 1987-05-05 Damon Biotech, Inc. Encapsulation of materials
DE3575375D1 (de) * 1984-02-15 1990-02-22 Massachusetts Inst Technology Verfahren zur verkapselung und systeme mit verkapseltem aktivmaterial.
US4686098A (en) * 1984-05-14 1987-08-11 Merck & Co., Inc. Encapsulated mouse cells transformed with avian retrovirus-bovine growth hormone DNA, and a method of administering BGH in vivo
GB8500121D0 (en) * 1985-01-03 1985-02-13 Connaught Lab Microencapsulation of living cells
AU589438B2 (en) * 1985-08-26 1989-10-12 Hana Biologics, Inc. Transplantable artificial tissue and process
JPS62166891A (ja) * 1986-01-20 1987-07-23 Snow Brand Milk Prod Co Ltd 細胞培養による有用物質の製造方法
US4952506A (en) * 1986-04-28 1990-08-28 Rohm And Haas Company Immobilization of nonanchorage-dependent cells
JPS6348039U (de) * 1986-09-12 1988-04-01
JPS6379587A (ja) * 1986-09-22 1988-04-09 Saburo Senoo 細胞培養用基材
US5069831A (en) * 1988-12-22 1991-12-03 The Mead Corporation Method for separation of microcapsules and preparation of printing inks
US5800829A (en) * 1991-04-25 1998-09-01 Brown University Research Foundation Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core
ES2107537T3 (es) * 1991-04-25 1997-12-01 Univ Brown Res Found Vehiculo inmunoaislante biocompatible implantable para suministrar productos terapeuticos seleccionados.
IL102785A (en) * 1991-08-20 1998-06-15 Univ Leicester Method for removing protein from a water- soluble gum and a method of making biocompatible capsules using said gum
CN100408098C (zh) * 1999-12-08 2008-08-06 范赛尔生物技术有限公司 聚丙烯酰胺凝胶在哺乳动物的机体组织中形成胶囊的应用、培养细胞的方法和治疗肿瘤和糖尿病的方法
GB201408233D0 (en) 2014-05-09 2014-06-25 Austrianova Singapore Pte Ltd Use of polyanionic composition
JP7159334B2 (ja) * 2018-09-28 2022-10-24 富士フイルム株式会社 細胞構造体、細胞構造体の製造方法、細胞培養方法及びマイクロ流路
CN114504561B (zh) * 2022-03-01 2023-08-11 陕西科技大学 一种用于制备药物渗透泵制剂的水性包衣方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL129921C (de) * 1958-12-31
FR1542881A (fr) * 1966-10-10 1968-10-18 Ncr Co Procédé de préparation de capsules minuscules à base de polymère
CH573212A5 (en) * 1973-06-29 1976-03-15 Feller Marc Rech Tech Et Et Sc Delayed release agricultural formulations - of herbicide or insecticide absorbed on porous carrier and coed with isolating layer
US4352883A (en) * 1979-03-28 1982-10-05 Damon Corporation Encapsulation of biological material

Also Published As

Publication number Publication date
JPS6152737B2 (de) 1986-11-14
DE3209045C2 (de) 1986-06-19
NO820795L (no) 1982-09-14
JPS57197031A (en) 1982-12-03
DK112382A (da) 1982-09-14
CH651579A5 (de) 1985-09-30
IT8220139A0 (it) 1982-03-12
NO158284B (no) 1988-05-09
SE454181B (sv) 1988-04-11
IT1150681B (it) 1986-12-17
FR2501528A1 (fr) 1982-09-17
GB2094750A (en) 1982-09-22
FR2501528B1 (de) 1984-06-15
GB2094750B (en) 1984-08-22
NO158284C (no) 1988-08-17
DE3209045A1 (de) 1982-09-30
BE892477A (fr) 1982-07-01
SE8201557L (sv) 1982-09-14

Similar Documents

Publication Publication Date Title
CA1184518A (en) Reversible microencapsulation
US4407957A (en) Reversible microencapsulation of a core material
US4409331A (en) Preparation of substances with encapsulated cells
CA1172961A (en) Process for producing substances produced by cells
US4352883A (en) Encapsulation of biological material
US4391909A (en) Microcapsules containing viable tissue cells
US4495288A (en) Method of culturing anchorage dependent cells
US5429821A (en) Non-fibrogenic high mannuronate alginate coated transplants, processes for their manufacture, and methods for their use
US5084350A (en) Method for encapsulating biologically active material including cells
US4933185A (en) System for controlled release of biologically active compounds
US5916790A (en) Encapsulation compositions, and methods
CA2223417C (en) Method for the manufacture of minimal volume capsules containing biological material
US5470731A (en) Coated transplant and method for making same
CA1172586A (en) Method of culturing anchorage dependent cells
EP1011518A4 (de) Mit mehrschichtigem alginat beschichtetes biologisches gewebetransplantat, geeignet für transplantationen und verfahren zu seiner herstellung
CA1230054A (en) Sustained release semi-permeable capsule
US4582799A (en) Process for recovering nonsecreted substances produced by cells
GB2145992A (en) Microencapsulation of viable cells
AU705108B2 (en) Novel encapsulation process by a gelling polymer
WO1988000237A1 (en) Covalent membranes
Iwata et al. Microencapsulation of Langerhans islets in agarose microbeads and their application for a bioartificial pancreas
WO1987004367A1 (en) Covalent membranes
GB2119734A (en) Encapsulated living tissue
Wen et al. Microcapsules through polymer complexation: Part 3: Encapsulation and culture of human burkitt lymphoma cells in vitro
GB2119737A (en) Encapsulation of viable tissue

Legal Events

Date Code Title Description
MKEX Expiry