CA1175838A - N-hydroxy-1,2-dihydro-2-oxo- 5(pyridinyl)nicotinimidamides, their cardiotonic use, their preparation and conversion to corresponding 3- amino-5-(pyridinyl)-2(1h)-pyridinones - Google Patents

N-hydroxy-1,2-dihydro-2-oxo- 5(pyridinyl)nicotinimidamides, their cardiotonic use, their preparation and conversion to corresponding 3- amino-5-(pyridinyl)-2(1h)-pyridinones

Info

Publication number
CA1175838A
CA1175838A CA000390670A CA390670A CA1175838A CA 1175838 A CA1175838 A CA 1175838A CA 000390670 A CA000390670 A CA 000390670A CA 390670 A CA390670 A CA 390670A CA 1175838 A CA1175838 A CA 1175838A
Authority
CA
Canada
Prior art keywords
pyridinyl
oxo
dihydro
methyl
ketone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000390670A
Other languages
English (en)
French (fr)
Inventor
George Y. Lesher
Monte D. Gruett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis US LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA000448189A priority Critical patent/CA1185242A/en
Application granted granted Critical
Publication of CA1175838A publication Critical patent/CA1175838A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA000390670A 1980-12-22 1981-11-23 N-hydroxy-1,2-dihydro-2-oxo- 5(pyridinyl)nicotinimidamides, their cardiotonic use, their preparation and conversion to corresponding 3- amino-5-(pyridinyl)-2(1h)-pyridinones Expired CA1175838A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA000448189A CA1185242A (en) 1980-12-22 1984-02-23 3-amino-5-(pyridinyl)-2(1h)-pyridinone derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/218,616 US4305948A (en) 1980-12-22 1980-12-22 N-Hydroxy-1,2-dihydro-2-oxo-5-(pyridinyl)-nicotinimidamide and their cardiotonic use
US218,616 1980-12-22

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA000448189A Division CA1185242A (en) 1980-12-22 1984-02-23 3-amino-5-(pyridinyl)-2(1h)-pyridinone derivatives

Publications (1)

Publication Number Publication Date
CA1175838A true CA1175838A (en) 1984-10-09

Family

ID=22815795

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000390670A Expired CA1175838A (en) 1980-12-22 1981-11-23 N-hydroxy-1,2-dihydro-2-oxo- 5(pyridinyl)nicotinimidamides, their cardiotonic use, their preparation and conversion to corresponding 3- amino-5-(pyridinyl)-2(1h)-pyridinones

Country Status (20)

Country Link
US (1) US4305948A (OSRAM)
JP (1) JPS57140767A (OSRAM)
AU (1) AU7793981A (OSRAM)
BE (1) BE891493A (OSRAM)
CA (1) CA1175838A (OSRAM)
DE (1) DE3150062A1 (OSRAM)
DK (1) DK557681A (OSRAM)
ES (1) ES8502434A1 (OSRAM)
FI (1) FI813913A7 (OSRAM)
FR (1) FR2496659A1 (OSRAM)
GB (1) GB2089791B (OSRAM)
GR (1) GR76987B (OSRAM)
IL (1) IL64439A0 (OSRAM)
IT (1) IT1142099B (OSRAM)
LU (1) LU83840A1 (OSRAM)
NL (1) NL8105667A (OSRAM)
NO (1) NO814294L (OSRAM)
PT (1) PT74114B (OSRAM)
SE (1) SE8107551L (OSRAM)
ZA (1) ZA818277B (OSRAM)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4361569A (en) * 1981-08-26 1982-11-30 Sterling Drug Inc. 3-(Hydroxy or hydroxymethyl)-6-methyl-5-(4-pyridinyl)-2(1H)-pyridinone and cardiotonic use thereof
ZA848428B (en) * 1983-11-03 1985-06-26 Merrell Pharma Inc Novel alkoxyimino ether derivatives of 5-acyl-2(1h)-pyridiones
US4849522A (en) * 1983-11-03 1989-07-18 Merrell Dow Pharmaceuticals Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
US5212314A (en) * 1983-11-03 1993-05-18 Merrell Dow Pharmaceuticals Inc. Alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
CN104326975A (zh) * 2014-10-20 2015-02-04 郑州四环医药用品有限公司 一种高纯度米力农的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4072746A (en) * 1975-10-14 1978-02-07 Sterling Drug Inc. 3-Amino-5-(pyridinyl)-2(1H)-pyridinones
US4004012A (en) * 1975-10-14 1977-01-18 Sterling Drug Inc. 3-Cyano-5-(pyridinyl)-2(1H)-pyridinones
IL61501A (en) * 1979-11-26 1984-06-29 Sterling Drug Inc 5-(pyridinyl)-2(1h)-pyridinones,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
ES508020A0 (es) 1985-01-01
BE891493A (fr) 1982-06-16
NL8105667A (nl) 1982-07-16
GB2089791A (en) 1982-06-30
GR76987B (OSRAM) 1984-09-04
PT74114A (en) 1982-01-01
PT74114B (en) 1983-06-06
IL64439A0 (en) 1982-03-31
FR2496659A1 (fr) 1982-06-25
US4305948A (en) 1981-12-15
DK557681A (da) 1982-06-23
ES8502434A1 (es) 1985-01-01
AU7793981A (en) 1982-07-01
SE8107551L (sv) 1982-06-23
FI813913L (fi) 1982-06-23
JPS57140767A (en) 1982-08-31
FI813913A7 (fi) 1982-06-23
IT8125585A0 (it) 1981-12-14
DE3150062A1 (de) 1982-07-22
GB2089791B (en) 1984-08-30
ZA818277B (en) 1982-10-27
IT1142099B (it) 1986-10-08
NO814294L (no) 1982-06-23
LU83840A1 (fr) 1982-07-07

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Legal Events

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MKEX Expiry