CA1175825A - Antihypertensive derivatives of 1,4-dihydropyridine - Google Patents

Antihypertensive derivatives of 1,4-dihydropyridine

Info

Publication number
CA1175825A
CA1175825A CA000370606A CA370606A CA1175825A CA 1175825 A CA1175825 A CA 1175825A CA 000370606 A CA000370606 A CA 000370606A CA 370606 A CA370606 A CA 370606A CA 1175825 A CA1175825 A CA 1175825A
Authority
CA
Canada
Prior art keywords
compound
alkyl
formula
acid addition
addition salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000370606A
Other languages
English (en)
French (fr)
Inventor
Bernard Loev
James R. Shroff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
USV Pharmaceutical Corp
Original Assignee
USV Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by USV Pharmaceutical Corp filed Critical USV Pharmaceutical Corp
Application granted granted Critical
Publication of CA1175825A publication Critical patent/CA1175825A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
CA000370606A 1980-04-11 1981-02-11 Antihypertensive derivatives of 1,4-dihydropyridine Expired CA1175825A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/139,367 US4258042A (en) 1980-04-11 1980-04-11 Antihypertensive pyridines and compositions
US139,367 1993-10-20

Publications (1)

Publication Number Publication Date
CA1175825A true CA1175825A (en) 1984-10-09

Family

ID=22486280

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000370606A Expired CA1175825A (en) 1980-04-11 1981-02-11 Antihypertensive derivatives of 1,4-dihydropyridine

Country Status (23)

Country Link
US (1) US4258042A (enExample)
JP (1) JPS56158762A (enExample)
AR (2) AR227306A1 (enExample)
AU (1) AU6941181A (enExample)
BE (1) BE888327A (enExample)
CA (1) CA1175825A (enExample)
CH (1) CH647519A5 (enExample)
DE (1) DE3109794A1 (enExample)
DK (1) DK162581A (enExample)
ES (1) ES8202001A1 (enExample)
FI (1) FI810981L (enExample)
FR (1) FR2480284A1 (enExample)
GB (1) GB2073739B (enExample)
IL (1) IL62362A (enExample)
IT (1) IT1137539B (enExample)
LU (1) LU83293A1 (enExample)
NL (1) NL8100745A (enExample)
NO (1) NO811240L (enExample)
NZ (1) NZ196787A (enExample)
PH (1) PH15278A (enExample)
SE (1) SE8101211L (enExample)
ZA (1) ZA81802B (enExample)
ZW (1) ZW8281A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3208628A1 (de) * 1982-03-10 1983-09-22 Bayer Ag, 5090 Leverkusen Neue verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4656181A (en) * 1982-11-24 1987-04-07 Cermol S.A. Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same
US4435395A (en) 1983-03-03 1984-03-06 Usv Pharmaceutical Corporation N-Substituted 1,4-dihydropyridazines and pharmaceutical compositions
US4500528A (en) * 1983-03-03 1985-02-19 Usv Pharmaceutical Corporation N-Substituted 1,4-dihydropyridines and pharmaceutical compositions
US4491582A (en) * 1983-03-03 1985-01-01 Usv Pharmaceutical Corporation N-(substituted piperazino)-1,4-dihydropyridine-3,5-carboxylic acid
US4503223A (en) * 1983-08-11 1985-03-05 Usv Pharmaceutical Corporation Process for the purification of N-morpholinoalkyl dihydropyridines
IE57810B1 (en) * 1984-03-27 1993-04-21 Delagrange Lab 1,4-dihydropyridine derivatives,their preparation and their use
US4757071A (en) * 1984-12-14 1988-07-12 Nisshin Flour Milling Co., Ltd. 1,4-dihydropyridine derivatives, and pharmaceutical compositions containing same, useful for treating cardiovascular diseases
US4833150A (en) * 1985-03-14 1989-05-23 Nelson Research & Development Co. 1,4-dihydropyridines
US4659717A (en) * 1985-08-21 1987-04-21 Eli Lilly And Company Dihydropyridines useful in the treatment of angina and stroke
DE3544211A1 (de) * 1985-12-13 1987-06-19 Bayer Ag Neue, fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4780538A (en) * 1986-02-12 1988-10-25 Merck & Co., Inc. Process for 1,4-dihydropyridine compounds using a titanamine catalyst
US4849436A (en) * 1986-03-11 1989-07-18 Nelson Research & Development Co. 1,4-dihydropyridines

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5170767A (en) * 1974-12-17 1976-06-18 Yamanouchi Pharma Co Ltd Shinki nn chikan 1*44 jihidoropirijinjudotaino goseiho

Also Published As

Publication number Publication date
IL62362A0 (en) 1981-05-20
CH647519A5 (de) 1985-01-31
SE8101211L (sv) 1981-10-12
PH15278A (en) 1982-11-02
IT1137539B (it) 1986-09-10
AR227306A1 (es) 1982-10-15
FI810981A7 (fi) 1981-10-12
FI810981L (fi) 1981-10-12
NL8100745A (nl) 1981-11-02
DK162581A (da) 1981-10-12
IL62362A (en) 1984-12-31
LU83293A1 (fr) 1981-12-02
ES499667A0 (es) 1982-02-01
GB2073739B (en) 1984-07-11
BE888327A (fr) 1981-10-08
JPS56158762A (en) 1981-12-07
US4258042A (en) 1981-03-24
DE3109794A1 (de) 1982-01-28
ZA81802B (en) 1982-02-24
IT8121078A0 (it) 1981-04-10
ES8202001A1 (es) 1982-02-01
AR229435A1 (es) 1983-08-15
NZ196787A (en) 1984-04-27
GB2073739A (en) 1981-10-21
FR2480284A1 (fr) 1981-10-16
NO811240L (no) 1981-10-12
FR2480284B1 (enExample) 1984-01-06
AU6941181A (en) 1981-10-15
ZW8281A1 (en) 1981-07-01

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Legal Events

Date Code Title Description
MKEX Expiry
MKEX Expiry

Effective date: 20011009