CA1175745A - Methods of producing hb sag - Google Patents

Methods of producing hb sag

Info

Publication number
CA1175745A
CA1175745A CA000394009A CA394009A CA1175745A CA 1175745 A CA1175745 A CA 1175745A CA 000394009 A CA000394009 A CA 000394009A CA 394009 A CA394009 A CA 394009A CA 1175745 A CA1175745 A CA 1175745A
Authority
CA
Canada
Prior art keywords
temperature
hbsag
cells
hollow fiber
hepatitis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000394009A
Other languages
English (en)
French (fr)
Inventor
Henry Z. Markus
William J. Mcaleer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of CA1175745A publication Critical patent/CA1175745A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CA000394009A 1981-01-16 1982-01-12 Methods of producing hb sag Expired CA1175745A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US225,555 1981-01-16
US06/225,555 US4416986A (en) 1981-01-16 1981-01-16 Methods of producing HBsAg

Publications (1)

Publication Number Publication Date
CA1175745A true CA1175745A (en) 1984-10-09

Family

ID=22845332

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000394009A Expired CA1175745A (en) 1981-01-16 1982-01-12 Methods of producing hb sag

Country Status (10)

Country Link
US (1) US4416986A (show.php)
EP (1) EP0056761B1 (show.php)
JP (1) JPS57141294A (show.php)
AT (1) ATE6402T1 (show.php)
CA (1) CA1175745A (show.php)
DE (1) DE3260046D1 (show.php)
DK (1) DK15382A (show.php)
ES (1) ES508742A0 (show.php)
GR (1) GR74755B (show.php)
PT (1) PT74246B (show.php)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4393133A (en) * 1980-06-12 1983-07-12 The Wistar Institute Of Anatomy And Biology Human hepatoma derived cell line, process for preparation thereof, and uses therefor
US5223428A (en) * 1982-12-14 1993-06-29 Baxter International Inc. Method for in vitro culture of mammalian cells
US4742158A (en) * 1986-04-25 1988-05-03 Merck & Co., Inc. Purification of hepatitis pre-S antigens by polymerized serum albumin affinity binding
US5567612A (en) * 1986-11-20 1996-10-22 Massachusetts Institute Of Technology Genitourinary cell-matrix structure for implantation into a human and a method of making
CA1340581C (en) * 1986-11-20 1999-06-08 Joseph P. Vacanti Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices
US6309635B1 (en) 1986-11-20 2001-10-30 Children's Medical Center Corp. Seeding parenchymal cells into compression resistant porous scaffold after vascularizing in vivo
US6022742A (en) 1986-11-26 2000-02-08 Kopf; Henry B. Culture device and method
ATE136582T1 (de) * 1990-05-16 1996-04-15 Baylor College Medicine Eine permanente menschliche hepatogene zellinie und seine verwendung in der unterstützung der leberfunktion
AU2900792A (en) * 1991-10-24 1993-05-21 Children's Medical Center Corporation Neomorphogenesis of urological structures in vivo from cell culture
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US5498537A (en) * 1994-03-09 1996-03-12 Cellco, Inc. Serum-free production of packaged viral vector
US5716404A (en) * 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
US6123727A (en) 1995-05-01 2000-09-26 Massachusetts Institute Of Technology Tissue engineered tendons and ligaments
US5855610A (en) 1995-05-19 1999-01-05 Children's Medical Center Corporation Engineering of strong, pliable tissues
US5741685A (en) * 1995-06-07 1998-04-21 Children's Medical Center Corporation Parenchymal cells packaged in immunoprotective tissue for implantation
US6129761A (en) * 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
US6872549B2 (en) * 2002-03-27 2005-03-29 Immunex Corporation Methods for increasing polypeptide production
JP5327793B2 (ja) * 2006-09-26 2013-10-30 国立大学法人京都大学 肝炎ウイルスの増殖方法、及びその利用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3883393A (en) * 1972-05-18 1975-05-13 Us Health Education & Welfare Cell culture on semi-permeable tubular membranes
US4220725A (en) * 1978-04-03 1980-09-02 United States Of America Capillary cell culture device
CA1164799A (en) * 1979-09-04 1984-04-03 Paula A. Giesa Cell culture of hepatitis a virus
US4301250A (en) * 1979-11-02 1981-11-17 Merck & Co., Inc. Method of producing hepatitis B surface antigen
PT72015B (en) * 1979-11-13 1982-06-20 Merck & Co Inc Process for preparing "invitro" cultures of hepatitis b virus
IE51173B1 (en) * 1980-03-27 1986-10-29 Merck & Co Inc Method of growing hepatitis b surface antigen

Also Published As

Publication number Publication date
DK15382A (da) 1982-07-17
EP0056761A1 (en) 1982-07-28
ES8300473A1 (es) 1982-11-16
PT74246A (en) 1982-02-01
EP0056761B1 (en) 1984-02-29
US4416986A (en) 1983-11-22
ATE6402T1 (de) 1984-03-15
PT74246B (en) 1984-05-29
JPS57141294A (en) 1982-09-01
GR74755B (show.php) 1984-07-11
DE3260046D1 (en) 1984-04-05
ES508742A0 (es) 1982-11-16

Similar Documents

Publication Publication Date Title
CA1175745A (en) Methods of producing hb sag
US4301249A (en) High titer production of hepatitis A virus
US4335215A (en) Method of growing anchorage-dependent cells
WO1995024468A1 (en) Hepatitis a virus culture process
US4301250A (en) Method of producing hepatitis B surface antigen
JPH0748277A (ja) Ａ型肝炎ウィルスワクチン
Vagi Cultivation and characterization of BALB/cfC3H mammary tumor cell lines
CN1970080A (zh) 用悬浮的Vero细胞生产病毒疫苗的方法
CN100374552C (zh) 大规模生产甲型肝炎病毒的方法
US4169761A (en) Process for the cultivation of viruses
US9932562B2 (en) Drain down and re-feed of microcarrier bioreactor
JP2633391B2 (ja) 付着的に結合した細胞を有するマトリックスおよびウイルス／ウイルス抗原の製造方法
EP0192705A1 (en) Detachment of anchorage-dependent cells from microcarriers
US5719051A (en) Perfusion system and a method for the large scale production of virus or virus antigen
CA1177753A (en) Method of growing hepatitis b surface antigen background of the invention
McAleer et al. Production of purified hepatitis B surface antigen from Alexander hepatoma cells grown in artificial capillary units
Manousos et al. Feasibility studies of oncornavirus production in microcarrier cultures
Nicholson Growth of fish cell lines on microcarriers
CN111662881B (zh) 新型冠状病毒Vero细胞灭活疫苗病毒液及其生产方法
EP0028987B1 (en) Process for the in vitro culture of hepatitis b virus
BACHRACH THE purpose of this report is to review pro
RU1806190C (ru) Штамм VIRUS нератIтIS А номINIS дл приготовлени вакцинных и диагностических препаратов
Thomson et al. Growth of rubella virus in a glass bead propagator
CN107523534B (zh) 重组cho细胞的贴壁微载体悬浮培养方法
SU1317021A1 (ru) Штамм диплоидных клеток кожи и мышц эмбриона человека,используемый дл культивировани вирусов

Legal Events

Date Code Title Description
MKEC Expiry (correction)
MKEX Expiry