CA1166133A - Systeme de substrat pour l'amplification de la chemoluminescence en immunochimie - Google Patents

Systeme de substrat pour l'amplification de la chemoluminescence en immunochimie

Info

Publication number
CA1166133A
CA1166133A CA000366110A CA366110A CA1166133A CA 1166133 A CA1166133 A CA 1166133A CA 000366110 A CA000366110 A CA 000366110A CA 366110 A CA366110 A CA 366110A CA 1166133 A CA1166133 A CA 1166133A
Authority
CA
Canada
Prior art keywords
fluorescer
catalyst
biological
species
interest
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000366110A
Other languages
English (en)
Inventor
Richard M. Mandle
Yuan N. Wong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alfa Wassermann Inc
Original Assignee
Alfa Wassermann Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wassermann Inc filed Critical Alfa Wassermann Inc
Application granted granted Critical
Publication of CA1166133A publication Critical patent/CA1166133A/fr
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
CA000366110A 1979-12-19 1980-12-04 Systeme de substrat pour l'amplification de la chemoluminescence en immunochimie Expired CA1166133A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10525779A 1979-12-19 1979-12-19
US105,257 1979-12-19

Publications (1)

Publication Number Publication Date
CA1166133A true CA1166133A (fr) 1984-04-24

Family

ID=22304836

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000366110A Expired CA1166133A (fr) 1979-12-19 1980-12-04 Systeme de substrat pour l'amplification de la chemoluminescence en immunochimie

Country Status (6)

Country Link
BE (1) BE886751A (fr)
CA (1) CA1166133A (fr)
ES (1) ES8203152A1 (fr)
IT (1) IT1151457B (fr)
WO (1) WO1981001883A1 (fr)
ZA (1) ZA807274B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4372745A (en) * 1979-12-19 1983-02-08 Electro-Nucleonics, Inc. Chemical luminescence amplification substrate system for immunochemistry involving microencapsulated fluorescer
CA1180647A (fr) * 1981-07-17 1985-01-08 Cavit Akin Methode de diagnostic d'hybridation de polynucleotides par emission de lumiere
US4517303A (en) * 1982-10-20 1985-05-14 E. I. Du Pont De Nemours And Company Specific binding assays utilizing analyte-cytolysin conjugates
DK487784A (da) * 1983-10-13 1985-04-14 Univ Georgia Immunoassay
US4695554A (en) * 1984-02-14 1987-09-22 Becton Dickinson And Company Sac or liposome containing dye (sulforhodamine) for immunoassay
EP0165072A3 (fr) * 1984-06-15 1986-12-30 Mast Immunosystems, Inc. Milieu de réactif pour un essai de liaison spécifique, trousse d'essai et procédé
US4681859A (en) * 1984-09-21 1987-07-21 Ortho Diagnostic Systems Inc. Fluorescence polarization immunoassay for heavy antigens
US5221605A (en) * 1984-10-31 1993-06-22 Igen, Inc. Luminescent metal chelate labels and means for detection
US5310687A (en) * 1984-10-31 1994-05-10 Igen, Inc. Luminescent metal chelate labels and means for detection
US5238808A (en) * 1984-10-31 1993-08-24 Igen, Inc. Luminescent metal chelate labels and means for detection
US5422266A (en) * 1984-12-31 1995-06-06 University Of Georgia Research Foundation, Inc. Recombinant DNA vectors capable of expressing apoaequorin
FR2596048B1 (fr) * 1986-03-18 1988-07-08 Sanofi Sa Derives du phenyl-(methoxy) phenyl-pyrenylmethane, procede d'obtention, intermediaires de synthese et application au marquage fluorescent de nucleosides, nucleotides et polynucleotides
US6165729A (en) * 1986-04-30 2000-12-26 Hyperion Catalysis International, Inc. Electrochemiluminescent reaction utilizing amine-derived reductant
US6451225B1 (en) 1986-04-30 2002-09-17 Igen International, Inc. Electrochemiluminescent reaction utilizing amine-derived reductant
JPH0737464B2 (ja) * 1986-04-30 1995-04-26 イゲン，インコーポレーテッド エレクトロ化学ルミネセンスアツセイ
US6702986B1 (en) 1988-04-29 2004-03-09 Igen International, Inc. Electrochemiluminescent reaction utilizing amine-derived reductant
AU2965200A (en) * 1999-01-11 2000-08-01 Lightsense Corporation Method and material for ratiometric fluorescent determination of analyte concentration

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3935074A (en) * 1973-12-17 1976-01-27 Syva Company Antibody steric hindrance immunoassay with two antibodies
US4199559A (en) * 1974-08-12 1980-04-22 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4169137A (en) * 1974-12-20 1979-09-25 Block Engineering, Inc. Antigen detecting reagents
US4011219A (en) * 1975-03-28 1977-03-08 Chugai Seiyaku Kabushiki Kaisha Phthalazine derivatives and salts thereof
US4018884A (en) * 1975-06-26 1977-04-19 Hoffmann-La Roche Inc. Fluorogenic materials and labeling techniques
US4181650A (en) * 1975-08-25 1980-01-01 Maier Charles L Jr Procedure for the assay of pharmacologically immunologically and biochemically active compounds in biological fluids
US4201763A (en) * 1975-10-09 1980-05-06 Bio-Rad Laboratories, Inc. Solid phase immunofluorescent assay method
US4036946A (en) * 1975-10-20 1977-07-19 Marcos Kleinerman Immunofluorometric method for measuring minute quantities of antigens, antibodies and other substances
US4020151A (en) * 1976-02-17 1977-04-26 International Diagnostic Technology, Inc. Method for quantitation of antigens or antibodies on a solid surface
US4160818A (en) * 1976-04-15 1979-07-10 Technicon Instruments Corporation Fluorimetric immunoassay for diphenylhydantoin
US4220450A (en) * 1978-04-05 1980-09-02 Syva Company Chemically induced fluorescence immunoassay
US4238195A (en) * 1979-01-18 1980-12-09 Miles Laboratories, Inc. Fluorescer-labeled specific binding assays

Also Published As

Publication number Publication date
ZA807274B (en) 1982-06-30
BE886751A (fr) 1981-04-16
IT8026043A0 (it) 1980-11-17
ES497867A0 (es) 1982-02-16
ES8203152A1 (es) 1982-02-16
WO1981001883A1 (fr) 1981-07-09
IT1151457B (it) 1986-12-17

Similar Documents

Publication Publication Date Title
US4372745A (en) Chemical luminescence amplification substrate system for immunochemistry involving microencapsulated fluorescer
CA1166133A (fr) Systeme de substrat pour l'amplification de la chemoluminescence en immunochimie
FI70728C (fi) Foerbaettrad luminescent eller luminometriskt bestaemning av en substans
US5464741A (en) Palladium (II) octaethylporphine alpha-isothiocyanate as a phosphorescent label for immunoassays
US6140138A (en) Electrochemiluminescent metal chelates and means for detection
EP0606422B1 (fr) Methode d'analyse biospecifique portant sur plusieurs parametres
US4478817A (en) Detecting or quantifying substances using labelling techniques
US5756011A (en) Detecting or quantifying multiple analytes using labelling techniques
EP0137515A2 (fr) Immunoessais bioluminescents
CN107449771B (zh) 酶促化学发光底物
US5736320A (en) Method of detecting substances by chemiluminescence
US4835101A (en) Luminescent analyses with enhanced storage stability
Patel et al. Chemiluminescence energy transfer: a new technique applicable to the study of ligand-ligand interactions in living systems
JPS62174637A (ja) 化学発光反応成分検出感度増大法
CN113504371B (zh) 基于环糊精包合的免分离化学发光免疫分析的方法
Dakubu et al. Time-resolved pulsed fluorescence immunometric assays of carcinoembryonic antigen.
US5017475A (en) Fluorescent detection method based on enzyme activated conversion of a fluorophore precursor substrate
AU582341B2 (en) Assay for immobilized reporter groups
CN114152740A (zh) 一种酶促化学发光试剂盒、制备方法及检测方法
Lidofsky et al. Enzyme-linked sandwich immunoassay for insulin using laser fluorimetric detection.
CA2053120A1 (fr) Determination quantitative par chimiluminescence a substance photosensible
EP0653638B1 (fr) Composé d'oxydation sous forme de poudre et méthode pour mesurer la luminescence utilisant ce composé
CN115629208A (zh) 采用电中性金属配合物增强电化学发光免疫分析性能的方法
JPS58500084A (ja) 免疫化学のための化学ルミネセンス増巾基質システム
CN111007256A (zh) 钙调素化学发光免疫检测试剂盒及其制备方法

Legal Events

Date Code Title Description
MKEX Expiry