CA1161032A - Cephalosporin derivatives, their production and use as antimicrobial agents - Google Patents
Cephalosporin derivatives, their production and use as antimicrobial agentsInfo
- Publication number
- CA1161032A CA1161032A CA000345659A CA345659A CA1161032A CA 1161032 A CA1161032 A CA 1161032A CA 000345659 A CA000345659 A CA 000345659A CA 345659 A CA345659 A CA 345659A CA 1161032 A CA1161032 A CA 1161032A
- Authority
- CA
- Canada
- Prior art keywords
- formula
- pyrazolyl
- group
- acid
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1545/79 | 1979-02-16 | ||
| CH154579A CH641810A5 (en) | 1979-02-16 | 1979-02-16 | Acetamidocephalosporanic acid derivatives, process for their preparation and pharmaceutical forms which contain them |
| CH17480A CH645378A5 (en) | 1980-01-10 | 1980-01-10 | Acetamidocephalosporanic acid derivatives, process for their preparation and pharmaceutical forms which contain them |
| CH174/80 | 1980-01-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1161032A true CA1161032A (en) | 1984-01-24 |
Family
ID=25683752
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000345659A Expired CA1161032A (en) | 1979-02-16 | 1980-02-14 | Cephalosporin derivatives, their production and use as antimicrobial agents |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4477448A (es) |
| AT (1) | AT374806B (es) |
| CA (1) | CA1161032A (es) |
| DE (1) | DE3005012A1 (es) |
| DK (1) | DK53780A (es) |
| ES (2) | ES488651A0 (es) |
| FI (1) | FI800381A (es) |
| FR (1) | FR2449093A1 (es) |
| GB (2) | GB2046734B (es) |
| IE (1) | IE49395B1 (es) |
| IL (1) | IL59391A (es) |
| IT (1) | IT8047922A0 (es) |
| MY (1) | MY8500128A (es) |
| NL (1) | NL8000894A (es) |
| NZ (1) | NZ192873A (es) |
| PH (1) | PH17926A (es) |
| PT (1) | PT70834A (es) |
| SE (2) | SE8000982L (es) |
| YU (1) | YU40280A (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0037380B1 (en) * | 1980-03-28 | 1984-09-12 | BIOCHEMIE Gesellschaft m.b.H. | New process for the production of cephalosporin antibiotics, and novel intermediates used in such process and their production |
| CH648038A5 (de) * | 1981-01-19 | 1985-02-28 | Sandoz Ag | 7-((carboxymethoxyimino)-1h-pyrazol-3-yl-acetyl)amino-3-desacetoxy-3-(1-methyl-1h-tetrazol-5-yl-thio)cephalosporansaeure und salze, verfahren zur herstellung und verwendung. |
| GB2125033B (en) * | 1982-07-23 | 1985-08-29 | Servipharm Ltd | Cephalosporins |
| US4698338A (en) * | 1986-02-19 | 1987-10-06 | Eli Lilly And Company | 7[2-(2-aminothiazol-4-yl)-2-benzyloximino]acetamido-3[4-alkyl-5-oxo-6-hydroxy-3,4-dihydro-1,2,4-triazin-3-yl]thiomethyl cephalosporins |
| US5688964A (en) * | 1996-02-13 | 1997-11-18 | Eastman Kodak Company | Process for preparing a acylhyrazino pyrazole derivative |
| KR100770419B1 (ko) * | 1999-09-24 | 2007-10-26 | 니혼노야쿠가부시키가이샤 | 살충, 살진드기제 |
| ATE445838T1 (de) | 2001-07-25 | 2009-10-15 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
| DK1889198T3 (da) | 2005-04-28 | 2015-02-09 | Proteus Digital Health Inc | Farma-informatiksystem |
| WO2008036682A2 (en) | 2006-09-18 | 2008-03-27 | Raptor Pharmaceutical Inc. | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
| ES2728225T3 (es) | 2009-02-20 | 2019-10-23 | 2 Bbb Medicines B V | Sistema de administración de fármacos a base de glutatión |
| US8445002B2 (en) | 2009-05-06 | 2013-05-21 | Laboratory Skin Care, Inc. | Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4024137A (en) * | 1971-05-14 | 1977-05-17 | Glaxo Laboratories Limited | 7β-[2-Etherified oximino-2-(phenyl- or naphthylacetamido)] cephalosporins |
-
1980
- 1980-02-07 FI FI800381A patent/FI800381A/fi not_active Application Discontinuation
- 1980-02-07 SE SE8000982A patent/SE8000982L/xx not_active Application Discontinuation
- 1980-02-07 DK DK53780A patent/DK53780A/da not_active Application Discontinuation
- 1980-02-11 DE DE19803005012 patent/DE3005012A1/de not_active Withdrawn
- 1980-02-12 GB GB8004696A patent/GB2046734B/en not_active Expired
- 1980-02-13 FR FR8003143A patent/FR2449093A1/fr active Granted
- 1980-02-13 NL NL8000894A patent/NL8000894A/nl not_active Application Discontinuation
- 1980-02-14 CA CA000345659A patent/CA1161032A/en not_active Expired
- 1980-02-14 PT PT70834A patent/PT70834A/pt unknown
- 1980-02-14 IL IL59391A patent/IL59391A/xx unknown
- 1980-02-14 AT AT0078780A patent/AT374806B/de not_active IP Right Cessation
- 1980-02-14 NZ NZ192873A patent/NZ192873A/en unknown
- 1980-02-14 YU YU00402/80A patent/YU40280A/xx unknown
- 1980-02-14 IE IE284/80A patent/IE49395B1/en unknown
- 1980-02-15 IT IT8047922A patent/IT8047922A0/it unknown
- 1980-02-15 ES ES488651A patent/ES488651A0/es active Granted
- 1980-02-15 PH PH23650A patent/PH17926A/en unknown
- 1980-11-20 ES ES497002A patent/ES497002A0/es active Granted
-
1982
- 1982-06-21 US US06/390,323 patent/US4477448A/en not_active Expired - Fee Related
-
1983
- 1983-04-11 GB GB08309730A patent/GB2117774B/en not_active Expired
-
1985
- 1985-02-08 SE SE8500589A patent/SE8500589D0/xx unknown
- 1985-12-30 MY MY128/85A patent/MY8500128A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2449093B1 (es) | 1983-07-29 |
| ES8203848A1 (es) | 1982-04-01 |
| PH17926A (en) | 1985-01-31 |
| SE8500589D0 (sv) | 1985-02-08 |
| IE49395B1 (en) | 1985-10-02 |
| SE8000982L (sv) | 1980-08-17 |
| GB2046734B (en) | 1983-09-01 |
| US4477448A (en) | 1984-10-16 |
| GB8309730D0 (en) | 1983-05-18 |
| FI800381A (fi) | 1980-08-17 |
| ES8102134A1 (es) | 1980-12-16 |
| NL8000894A (nl) | 1980-08-19 |
| DE3005012A1 (de) | 1980-11-27 |
| IL59391A0 (en) | 1980-05-30 |
| ATA78780A (de) | 1983-10-15 |
| YU40280A (en) | 1983-06-30 |
| IL59391A (en) | 1983-05-15 |
| ES497002A0 (es) | 1982-04-01 |
| PT70834A (en) | 1980-03-01 |
| AT374806B (de) | 1984-06-12 |
| FR2449093A1 (fr) | 1980-09-12 |
| IE800284L (en) | 1980-08-16 |
| ES488651A0 (es) | 1980-12-16 |
| GB2046734A (en) | 1980-11-19 |
| GB2117774B (en) | 1984-03-21 |
| NZ192873A (en) | 1984-07-31 |
| MY8500128A (en) | 1985-12-31 |
| GB2117774A (en) | 1983-10-19 |
| IT8047922A0 (it) | 1980-02-15 |
| DK53780A (da) | 1980-08-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4264595A (en) | 7-[2-(2-Imino-4-thiazolin-4-yl)-2-(syn)-hydroxy-iminoacetamido]-cephalosporins | |
| CA1161032A (en) | Cephalosporin derivatives, their production and use as antimicrobial agents | |
| JPH0255437B2 (es) | ||
| JPH0313237B2 (es) | ||
| CA1120923A (en) | Cephalosporanic acid derivatives and processes for the preparation thereof | |
| PL85513B1 (es) | ||
| CA1103237A (en) | Unsaturated derivatives of 7-acylamido-3-cephem-4- carboxylic acid and process for their preparation | |
| US4048311A (en) | 7-Acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolyl thiomethyl)cephalosporins | |
| NZ245200A (en) | Cephalosporin derivatives, medicaments and intermediate compounds | |
| US3907786A (en) | 7-{8 {60 -(2-aminomethyl-1,4-cyclohexadienyl)acetamido{9 -3-heterocyclic-thiomethyl-3-cephem-4-carboxylic acids and salts | |
| US4609654A (en) | Derivatives of cephalosporins substituted in 3 position by a thiomethyl heterocycle group; and pharmaceutical compositions containing them | |
| SE444682B (sv) | Nya 7alfa-metoxicefalosporiner | |
| US4140694A (en) | Intermediates for preparing 7-acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolylthiomethyl)cephalosporins | |
| CA1185598A (en) | 7-¬(carboxymethoxyimino)-1h-pyrazol-3-yl-acetyl| amino-3-desacetoxy-3-(1-methyl-1h-tetrazol-5-yl- thio) cephalosporanic acid | |
| US4159373A (en) | 7-Acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolyl thiomethyl) cephalosporins | |
| US4311699A (en) | Aminoacid derivatives of cephalosporin compounds | |
| US3996216A (en) | 3-Heterothio derivatives of (formylamino)acetylamino-7-alpha-methoxy cephalosporins | |
| IE45392B1 (en) | Cephalosporin compounds | |
| AT378371B (de) | Verfahren zur herstellung neuer cephalosporin -derivate | |
| US4092480A (en) | Intermediates for preparing substituted phenylglycylcephalosporins | |
| US5484928A (en) | 2-(2-aminothiazol-4-yl)-2-oxoacetic acid derivatives | |
| CA1064019A (en) | Cepham derivatives and preparation thereof | |
| US4044047A (en) | Intermediates for preparing substituted phenylglycylcephalosporins | |
| US4404376A (en) | Cephalosporanic acid derivatives | |
| CA1146553A (en) | Intermediates for cephalosporanic acid derivatives and processes for their preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |