CA1159835A - 5-(pyridinyl)-benzoxazol-2(3h)-ones, their preparation and cardiotonic use - Google Patents

5-(pyridinyl)-benzoxazol-2(3h)-ones, their preparation and cardiotonic use

Info

Publication number
CA1159835A
CA1159835A CA000390671A CA390671A CA1159835A CA 1159835 A CA1159835 A CA 1159835A CA 000390671 A CA000390671 A CA 000390671A CA 390671 A CA390671 A CA 390671A CA 1159835 A CA1159835 A CA 1159835A
Authority
CA
Canada
Prior art keywords
pyridinyl
phenol
benzoxazol
acid
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000390671A
Other languages
English (en)
French (fr)
Inventor
Baldev Singh
George Y. Lesher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Application granted granted Critical
Publication of CA1159835A publication Critical patent/CA1159835A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CA000390671A 1980-11-24 1981-11-23 5-(pyridinyl)-benzoxazol-2(3h)-ones, their preparation and cardiotonic use Expired CA1159835A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US209,416 1980-11-24
US06/209,416 US4310531A (en) 1980-11-24 1980-11-24 5-(Pyridinyl)-benzoxazol-2(3H)-ones and their use as cardiotonics

Publications (1)

Publication Number Publication Date
CA1159835A true CA1159835A (en) 1984-01-03

Family

ID=22778673

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000390671A Expired CA1159835A (en) 1980-11-24 1981-11-23 5-(pyridinyl)-benzoxazol-2(3h)-ones, their preparation and cardiotonic use

Country Status (26)

Country Link
US (1) US4310531A (enExample)
JP (1) JPS57116068A (enExample)
KR (1) KR830007637A (enExample)
AR (1) AR231139A1 (enExample)
AT (1) AT379808B (enExample)
AU (1) AU545707B2 (enExample)
BE (1) BE891017A (enExample)
CA (1) CA1159835A (enExample)
CH (1) CH652124A5 (enExample)
DE (1) DE3145847A1 (enExample)
DK (1) DK510881A (enExample)
ES (1) ES8304568A1 (enExample)
FI (1) FI813550A7 (enExample)
FR (1) FR2494690A1 (enExample)
GB (1) GB2098594B (enExample)
GR (1) GR78020B (enExample)
IL (1) IL64129A (enExample)
IT (1) IT1144937B (enExample)
LU (1) LU83770A1 (enExample)
NL (1) NL8105204A (enExample)
NO (1) NO813911L (enExample)
NZ (1) NZ198819A (enExample)
PH (1) PH17977A (enExample)
PT (1) PT73986B (enExample)
SE (1) SE8106871L (enExample)
ZA (1) ZA817487B (enExample)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1183046A (en) * 1966-06-28 1970-03-04 Allen & Hanburys Ltd Novel Heterocyclic Compounds
CH532077A (de) * 1968-05-31 1972-12-31 Robapharm A G Verfahren zur Herstellung von neuen basischen Derivaten des Benzoxazolin-2-ons

Also Published As

Publication number Publication date
SE8106871L (sv) 1982-05-25
PH17977A (en) 1985-02-22
FR2494690B1 (enExample) 1985-05-17
CH652124A5 (fr) 1985-10-31
ATA498981A (de) 1985-07-15
FI813550L (fi) 1982-05-25
US4310531A (en) 1982-01-12
GB2098594B (en) 1984-08-22
AU545707B2 (en) 1985-07-25
ES507383A0 (es) 1983-03-01
NZ198819A (en) 1984-07-06
PT73986A (en) 1981-12-01
FR2494690A1 (fr) 1982-05-28
DK510881A (da) 1982-05-25
LU83770A1 (fr) 1982-06-30
IL64129A0 (en) 1982-01-31
IL64129A (en) 1985-02-28
DE3145847A1 (de) 1982-08-19
IT8125143A0 (it) 1981-11-17
NO813911L (no) 1982-05-25
GR78020B (enExample) 1984-09-26
IT1144937B (it) 1986-10-29
PT73986B (en) 1983-04-18
AT379808B (de) 1986-03-10
ZA817487B (en) 1982-10-27
JPS57116068A (en) 1982-07-19
ES8304568A1 (es) 1983-03-01
AU7741781A (en) 1982-06-03
NL8105204A (nl) 1982-06-16
KR830007637A (ko) 1983-11-04
BE891017A (fr) 1982-05-06
FI813550A7 (fi) 1982-05-25
AR231139A1 (es) 1984-09-28
GB2098594A (en) 1982-11-24

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Legal Events

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