CA1157776A - Directly compressible acetaminophen granulation - Google Patents

Directly compressible acetaminophen granulation

Info

Publication number
CA1157776A
CA1157776A CA000392780A CA392780A CA1157776A CA 1157776 A CA1157776 A CA 1157776A CA 000392780 A CA000392780 A CA 000392780A CA 392780 A CA392780 A CA 392780A CA 1157776 A CA1157776 A CA 1157776A
Authority
CA
Canada
Prior art keywords
acetaminophen
granulation
weight
lubricant
nacmc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000392780A
Other languages
English (en)
French (fr)
Inventor
Stephen H. Vogel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Application granted granted Critical
Publication of CA1157776A publication Critical patent/CA1157776A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA000392780A 1980-12-22 1981-12-21 Directly compressible acetaminophen granulation Expired CA1157776A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21929080A 1980-12-22 1980-12-22
US219,290 1980-12-22

Publications (1)

Publication Number Publication Date
CA1157776A true CA1157776A (en) 1983-11-29

Family

ID=22818680

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000392780A Expired CA1157776A (en) 1980-12-22 1981-12-21 Directly compressible acetaminophen granulation

Country Status (10)

Country Link
JP (1) JPS57130913A (xx)
AR (1) AR226763A1 (xx)
AU (1) AU545475B2 (xx)
BE (1) BE891557A (xx)
CA (1) CA1157776A (xx)
DE (1) DE3150557A1 (xx)
FR (1) FR2496461B1 (xx)
GB (1) GB2090739B (xx)
MY (1) MY8600144A (xx)
PH (1) PH18488A (xx)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4600579A (en) * 1983-06-07 1986-07-15 Mallinckrodt, Inc. N-acetyl-p-aminophenol compositions containing partially gelatinized starch and method for preparing same
US4661521A (en) * 1984-04-30 1987-04-28 Mallinckrodt, Inc. Direct tableting acetaminophen compositions
JPS61145111A (ja) * 1984-12-20 1986-07-02 Lion Corp アセトアミノフェン含有錠剤の製造方法
US4757090A (en) * 1986-07-14 1988-07-12 Mallinckrodt, Inc. Direct tableting acetaminophen compositions
DE3636209A1 (de) * 1986-10-24 1988-04-28 Lentia Gmbh Verfahren zur herstellung eines bindemittelfreien tablettierfaehigen celiprololhydrochlorid-granulates
DE3883098T2 (de) * 1987-07-08 1993-12-02 American Home Prod Sprühgetrocknete Ibuprofen-Zusammensetzungen.
IT1227336B (it) * 1987-09-11 1991-04-08 Squibb & Sons Inc Composizione farmaceutica contenente un carico elevato di medicamento e procedimento per la sua preparazione
FR2638971B1 (fr) * 1988-11-15 1993-01-08 Vacher Dominique Comprime a delitement et/ou dissolution instantane
FR2672212B1 (fr) * 1991-02-04 1993-05-28 Lille Ii Universite Cristaux de paracetamol pour compression directe, procede de preparation de ces cristaux et comprime obtenu avec ces cristaux.
JPH0656659A (ja) * 1992-06-10 1994-03-01 Natl Sci Council 直接打錠できる薬学組成物及びその錠剤の製造法
DE4327462A1 (de) * 1993-08-16 1995-02-23 Carl Heinrich Dr Weischer Neue N-Acetyl-p-Aminophenol-Derivate zur Bekämpfung von Schmerzzuständen

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1390032A (en) * 1971-08-27 1975-04-09 Sterling Winthrop Group Ltd Pharmaceutical compositions
JPS535725B2 (xx) * 1973-03-05 1978-03-01
US3873694A (en) * 1973-09-27 1975-03-25 Cpc International Inc Direct compression tabletting composition and pharmaceutical tablets produced therefrom
US4097606A (en) * 1975-10-08 1978-06-27 Bristol-Myers Company APAP Tablet containing an alkali metal carboxymethylated starch and processes for manufacturing same
JPS5344618A (en) * 1976-10-04 1978-04-21 Takeda Chem Ind Ltd Preparation of tablet
DE2713197A1 (de) * 1977-03-25 1978-10-05 Bayer Ag Neues paracetamol-granulat

Also Published As

Publication number Publication date
AU7872081A (en) 1982-07-01
AR226763A1 (es) 1982-08-13
MY8600144A (en) 1986-12-31
DE3150557A1 (de) 1982-09-02
BE891557A (fr) 1982-06-21
JPH044297B2 (xx) 1992-01-27
FR2496461B1 (fr) 1985-07-12
JPS57130913A (en) 1982-08-13
AU545475B2 (en) 1985-07-18
FR2496461A1 (fr) 1982-06-25
GB2090739A (en) 1982-07-21
GB2090739B (en) 1984-09-19
DE3150557C2 (xx) 1991-10-02
PH18488A (en) 1985-08-02

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Legal Events

Date Code Title Description
MKEX Expiry
MKEX Expiry

Effective date: 20001129