CA1148546A - Uracil derivatives, process for preparing the same and a pharmaceutical composition containing the same - Google Patents

Uracil derivatives, process for preparing the same and a pharmaceutical composition containing the same

Info

Publication number
CA1148546A
CA1148546A CA000383943A CA383943A CA1148546A CA 1148546 A CA1148546 A CA 1148546A CA 000383943 A CA000383943 A CA 000383943A CA 383943 A CA383943 A CA 383943A CA 1148546 A CA1148546 A CA 1148546A
Authority
CA
Canada
Prior art keywords
group
formula
process according
fluorouracil
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000383943A
Other languages
English (en)
French (fr)
Inventor
Kiyoshige Ochi
Katsuhito Miyamoto
Hiroki Mitsui
Shigeru Takanashi
Takashi Matsuno
Yumiko Tsuruma
Isao Matsunaga
Minoru Shindo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of CA1148546A publication Critical patent/CA1148546A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
CA000383943A 1980-08-19 1981-08-14 Uracil derivatives, process for preparing the same and a pharmaceutical composition containing the same Expired CA1148546A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP11299380A JPS5738774A (en) 1980-08-19 1980-08-19 Uracil derivative and its preparation
JP112993/1980 1980-08-19

Publications (1)

Publication Number Publication Date
CA1148546A true CA1148546A (en) 1983-06-21

Family

ID=14600731

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000383943A Expired CA1148546A (en) 1980-08-19 1981-08-14 Uracil derivatives, process for preparing the same and a pharmaceutical composition containing the same

Country Status (6)

Country Link
US (1) US4415573A (OSRAM)
EP (1) EP0046307B1 (OSRAM)
JP (1) JPS5738774A (OSRAM)
AT (1) ATE10368T1 (OSRAM)
CA (1) CA1148546A (OSRAM)
DE (1) DE3167320D1 (OSRAM)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5839672A (ja) * 1981-09-03 1983-03-08 Chugai Pharmaceut Co Ltd ウラシル誘導体
JPS5980620A (ja) * 1982-09-17 1984-05-10 グラクソ・グル−プ・リミテツド ５−ハロビニル−２′−デオキシウリジン誘導体
SU1235864A1 (ru) * 1983-03-11 1986-06-07 Отделение ордена Ленина института химической физики АН СССР Нитроксильные производные 5-фторурацила,обладающие противоопухолевой активностью
JPS61204190A (ja) * 1985-03-06 1986-09-10 Kanto Ishi Pharma Co Ltd グリコシド及びその製造方法
US4719214A (en) * 1985-07-25 1988-01-12 Southern Research Institute Carbocyclic analogues of thymine nucleosides
US4613604A (en) * 1985-07-31 1986-09-23 Brown University Research Foundation Hydroxymethyl derivatives of 5-benzylacyclouridine and 5-benzoyloxybenzylacyclouridine and their use as potentiators for 5-fluoro-2'-deoxyuridine
JPS62174060A (ja) * 1985-10-11 1987-07-30 Terumo Corp ５−フルオロウラシル誘導体およびこれを含有する医薬製剤
ATE112767T1 (de) * 1988-03-31 1994-10-15 Mitsubishi Chem Ind Acyclische 6-substituierte pyrimidin nukleosid- abkömmlinge und antivirale mittel, die dieselben als aktive mittel enthalten.
US6350753B1 (en) 1988-04-11 2002-02-26 Biochem Pharma Inc. 2-Substituted-4-substituted-1,3-dioxolanes and use thereof
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
US5466806A (en) * 1989-02-08 1995-11-14 Biochem Pharma Inc. Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
US5041449A (en) * 1988-04-11 1991-08-20 Iaf Biochem International, Inc. 4-(nucleoside base)-substituted-1,3-dioxolanes useful for treatment of retroviral infections
US7119202B1 (en) 1989-02-08 2006-10-10 Glaxo Wellcome Inc. Substituted-1,3-oxathiolanes and substituted-1,3-dioxolanes with antiviral properties
US6903224B2 (en) 1988-04-11 2005-06-07 Biochem Pharma Inc. Substituted 1,3-oxathiolanes
US5684164A (en) * 1988-04-11 1997-11-04 Biochem Pharma Inc. Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
US5252576A (en) * 1988-07-18 1993-10-12 Yamasa Shoyu Kabushiki Kaisha 1-amino-5-halogenouracils, process for their preparation, and central nervous system depressants containing same as active ingredient
DE3905725A1 (de) * 1989-02-24 1990-09-06 Boehringer Mannheim Gmbh Seco-nucleosid-derivate, verfahren zu deren herstellung sowie deren verwendung als antivirale mittel
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
US5476855A (en) * 1993-11-02 1995-12-19 Mahmoud H. el Kouni Enzyme inhibitors, their synthesis and methods for use
AU693107B2 (en) * 1994-02-28 1998-06-25 Sunkyong Industries Co., Ltd. Pyrimidine acyclonucleoside derivatives
JP2002533470A (ja) * 1998-12-23 2002-10-08 シャイアー・バイオケム・インコーポレイテッド 抗ウイルス性ヌクレオシド類似体

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947444A (en) * 1973-06-21 1976-03-30 Solomon Aronovich Giller Process for producing N1 -(Dihydroxyalkyl)-5-substituted uracils
JPS606943B2 (ja) * 1975-04-01 1985-02-21 三井製薬工業株式会社 １−（α−アルコキシアルキル）−ウラシル類の製造法
JPS609505B2 (ja) * 1976-04-20 1985-03-11 大鵬薬品工業株式会社 ５−フルオルウラシル誘導体
JPS52153977A (en) * 1976-06-11 1977-12-21 Daikin Ind Ltd Synthesis of 5-fluorouracil and its derivatives
JPS6011704B2 (ja) * 1976-07-30 1985-03-27 大鵬薬品工業株式会社 ５−フルオルウラシル誘導体の製造法
JPS5331676A (en) * 1976-09-06 1978-03-25 Mitsui Toatsu Chem Inc Uracil derivatives and their preparation
CH633280A5 (de) * 1978-03-09 1982-11-30 Elkawi Ag 5-fluoruracil-derivate und diese verbindungen enthaltende arzneimittel.

Also Published As

Publication number Publication date
EP0046307B1 (en) 1984-11-21
JPH0140830B2 (OSRAM) 1989-08-31
US4415573A (en) 1983-11-15
ATE10368T1 (de) 1984-12-15
JPS5738774A (en) 1982-03-03
DE3167320D1 (en) 1985-01-03
EP0046307A1 (en) 1982-02-24

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Legal Events

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