CA1144552A - Antiinflammatory 4,5-diaryl-a-polyfluoroalkyl-1h- imidazole-2-methanamines - Google Patents

Antiinflammatory 4,5-diaryl-a-polyfluoroalkyl-1h- imidazole-2-methanamines

Info

Publication number
CA1144552A
CA1144552A CA000381924A CA381924A CA1144552A CA 1144552 A CA1144552 A CA 1144552A CA 000381924 A CA000381924 A CA 000381924A CA 381924 A CA381924 A CA 381924A CA 1144552 A CA1144552 A CA 1144552A
Authority
CA
Canada
Prior art keywords
alkyl
compound
prepared
independently
pyridyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000381924A
Other languages
English (en)
French (fr)
Inventor
Joel G. Whitney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Application granted granted Critical
Publication of CA1144552A publication Critical patent/CA1144552A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA000381924A 1980-07-21 1981-07-16 Antiinflammatory 4,5-diaryl-a-polyfluoroalkyl-1h- imidazole-2-methanamines Expired CA1144552A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US17087180A 1980-07-21 1980-07-21
US170,871 1980-07-21
US06/271,276 US4348404A (en) 1980-07-21 1981-06-15 Antiinflammatory 4,5-diaryl-α-polyfluoroalkyl-1H-imidazole-2-methanamines
US271,276 1981-06-15

Publications (1)

Publication Number Publication Date
CA1144552A true CA1144552A (en) 1983-04-12

Family

ID=26866505

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000381924A Expired CA1144552A (en) 1980-07-21 1981-07-16 Antiinflammatory 4,5-diaryl-a-polyfluoroalkyl-1h- imidazole-2-methanamines

Country Status (16)

Country Link
US (1) US4348404A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0044486B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU7312581A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1144552A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3166949D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK323981A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES8301218A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI812270L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR76541B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU185938B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL63368A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO812484L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ197762A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (1) PH16513A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT73388B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
YU (1) YU180181A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA826501B (en) * 1982-09-06 1984-04-25 Du Pont Anti-hypertensive imidazole derivative
US4478845A (en) * 1983-01-19 1984-10-23 E. I. Du Pont De Nemours And Company Antiinflammatory and/or analgesic imidazoimidazoles
US4632930A (en) * 1984-11-30 1986-12-30 E. I. Du Pont De Nemours And Company Antihypertensive alkyl-arylimidazole, thiazole and oxazole derivatives
NZ238688A (en) * 1990-06-28 1992-05-26 Smithkline Beecham Corp Substituted histidines: pharmaceutical compositions, preparation and uses thereof
US6426360B1 (en) * 1994-07-28 2002-07-30 G D Searle & Co. 4,5-substituted imidazolyl compounds for the treatment of inflammation
US5620999A (en) * 1994-07-28 1997-04-15 Weier; Richard M. Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation
US5700826A (en) * 1995-06-07 1997-12-23 Ontogen Corporation 1,2,4,5-tetra substituted imidazoles as modulators of multi-drug resistance
KR20010014288A (ko) * 1997-06-30 2001-02-26 오르토-맥네일 파마슈티칼, 인코퍼레이티드 염증성 질환의 치료에 유용한 2-치환된 이미다졸
US5840721A (en) * 1997-07-09 1998-11-24 Ontogen Corporation Imidazole derivatives as MDR modulators
NZ526958A (en) 1998-05-22 2004-12-24 Smithkline Beecham Corp Novel 2-alkyl substituted imidazole compounds
TWI283577B (en) * 1999-10-11 2007-07-11 Sod Conseils Rech Applic Pharmaceutical composition of imidazole derivatives acting as modulators of sodium channels and the use thereof
DE60015594T2 (de) 1999-11-22 2005-10-27 Smithkline Beecham P.L.C., Brentford Imidazolderivate und deren verwendung als raf kinase inhibitoren
AU2096901A (en) * 1999-12-17 2001-06-25 Procter & Gamble Company, The N-(1-phenylethyl)-5-phenyl-imidazole-2-amine compounds, their compositions and uses
US6596739B2 (en) 2000-03-29 2003-07-22 The Procter & Gamble Company N-(1-phenylethyl)-5-phenyl-imidazole-2-amine compounds, their compositions and uses
GB0112348D0 (en) * 2001-05-19 2001-07-11 Smithkline Beecham Plc Compounds
WO2003022837A1 (en) * 2001-09-05 2003-03-20 Smithkline Beecham P.L.C. Heterocycle-carboxamide derivatives as raf kinase inhibitors
DE60304778T2 (de) 2002-08-30 2006-09-21 Ishida Co., Ltd. Display-Streifen

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2532547A (en) * 1950-12-05 Z-aminoalkyl-glyoxaline derivatives
US3197480A (en) * 1962-12-12 1965-07-27 Du Pont 2 and 2, 4-(alpha hydroxypolyperhalocycloalkyl)-thiophenes, pyrroles, and furans; 2 and 2, 4-[(alpha hydroxyalpha, alpha dipolyperhalo hydrocarbon) methyl]-thiophenes, pyrroles and furans and process for making them
US3707475A (en) * 1970-11-16 1972-12-26 Pfizer Antiinflammatory imidazoles
US3929807A (en) * 1971-05-10 1975-12-30 Ciba Geigy Corp 2-Substituted-4(5)-(aryl)-5(4)-(2,3 or -4-pyridyl)-imidazoles
BE793407A (fr) 1971-12-28 1973-06-28 Hoechst Ag Imidazolyl - (2) -carbinols ayant une activite hypolipidemique et leur procede de preparation
US4190666A (en) * 1975-08-11 1980-02-26 E. I. Du Pont De Nemours And Company Anti-inflammatory 4,5-diarly-2-(substituted-thio)imidazoles and their corresponding sulfoxides and sulfones
US4159338A (en) * 1977-02-09 1979-06-26 E. I. Du Pont De Nemours And Company Antiinflammatory-4,5-dicyclic-2-(substituted thio)-imidazoles and their corresponding sulfoxides and sulfones
EP0005219B1 (en) * 1978-04-24 1981-07-22 A/S Dumex (Dumex Ltd.) Arylimidazoles, their synthesis and pharmaceutical or veterinary preparations containing them
US4199592A (en) * 1978-08-29 1980-04-22 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-2-nitroimidazoles

Also Published As

Publication number Publication date
US4348404A (en) 1982-09-07
PT73388A (en) 1981-08-01
NZ197762A (en) 1984-09-28
EP0044486B1 (en) 1984-10-31
AU7312581A (en) 1982-01-28
IL63368A0 (en) 1981-10-30
DE3166949D1 (de) 1984-12-06
YU180181A (en) 1984-02-29
ES504121A0 (es) 1982-12-01
NO812484L (no) 1982-01-22
ES8301218A1 (es) 1982-12-01
DK323981A (da) 1982-01-22
GR76541B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1984-08-10
EP0044486A1 (en) 1982-01-27
FI812270A7 (fi) 1982-01-22
HU185938B (en) 1985-04-28
FI812270L (fi) 1982-01-22
PT73388B (en) 1983-09-14
PH16513A (en) 1983-11-08

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Legal Events

Date Code Title Description
MKEX Expiry