CA1132542A - Derivatives of polyene macrolide antibiotics containing an amino sugar moiety, process for the preparation thereof and pharmaceutical compositions containing them - Google Patents

Derivatives of polyene macrolide antibiotics containing an amino sugar moiety, process for the preparation thereof and pharmaceutical compositions containing them

Info

Publication number
CA1132542A
CA1132542A CA338,013A CA338013A CA1132542A CA 1132542 A CA1132542 A CA 1132542A CA 338013 A CA338013 A CA 338013A CA 1132542 A CA1132542 A CA 1132542A
Authority
CA
Canada
Prior art keywords
hydrogen
group
carbon atoms
zero
amphotericin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA338,013A
Other languages
English (en)
French (fr)
Inventor
John J. Wright
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of CA1132542A publication Critical patent/CA1132542A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA338,013A 1978-10-23 1979-10-19 Derivatives of polyene macrolide antibiotics containing an amino sugar moiety, process for the preparation thereof and pharmaceutical compositions containing them Expired CA1132542A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95382478A 1978-10-23 1978-10-23
US953,824 1978-10-23

Publications (1)

Publication Number Publication Date
CA1132542A true CA1132542A (en) 1982-09-28

Family

ID=25494578

Family Applications (1)

Application Number Title Priority Date Filing Date
CA338,013A Expired CA1132542A (en) 1978-10-23 1979-10-19 Derivatives of polyene macrolide antibiotics containing an amino sugar moiety, process for the preparation thereof and pharmaceutical compositions containing them

Country Status (14)

Country Link
EP (1) EP0010297B1 (instruction)
JP (1) JPS5557600A (instruction)
AT (1) ATE3046T1 (instruction)
AU (1) AU5190079A (instruction)
CA (1) CA1132542A (instruction)
DE (1) DE2965212D1 (instruction)
DK (1) DK439879A (instruction)
FI (1) FI793236A7 (instruction)
GR (1) GR74128B (instruction)
HU (1) HU181506B (instruction)
IL (1) IL58490A (instruction)
NO (1) NO147840C (instruction)
PT (1) PT70341A (instruction)
ZA (1) ZA795508B (instruction)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59104326A (ja) * 1982-12-04 1984-06-16 Toyo Jozo Co Ltd マクロライド抗生物質の安定な経口用製剤および安定化法
FR2574075B1 (fr) * 1984-12-04 1987-09-18 Poudres & Explosifs Ste Nale Procede de synthese d'esters actifs d'acides carboxyliques, nouveaux carbonates alpha-halogenes utiles pour cette synthese et leur mode d'obtention
CA2213285A1 (en) * 1996-08-19 1998-02-19 Hoechst Aktiengesellschaft Novel polyene antibiotics, 3874 h1 to h6, processes for their preparation and use
AU7549198A (en) * 1997-06-03 1998-12-21 Ajinomoto Co., Inc. Process for preparing antifungal v-28-3m
US5981721A (en) * 1997-10-23 1999-11-09 Karykion Corporation Polyene macrolide schiff bases, their alkyl esters and processes for preparing polyene macrolide alkyl ester salts thereof
JP2010534688A (ja) * 2007-07-30 2010-11-11 上海医薬工業研究院 ポリエン類抗生物質ジエステル化合物
WO2020119773A1 (zh) * 2018-12-13 2020-06-18 上海医药工业研究院 两性霉素b肽衍生物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3244590A (en) * 1960-12-23 1966-04-05 Rutgers Res And Educational Fo Polyenic compounds and procedures related thereto
GB1399139A (en) 1972-07-24 1975-06-25 Prodotti Antibiotici Spa Alkyl esters of polyene antibiotics
US4038382A (en) 1972-07-24 1977-07-26 Spa-Societe Prodotti Antibiotici S.P.A. Alkyl esters of polyene antibiotics
US4041232A (en) * 1976-02-23 1977-08-09 E. R. Squibb & Sons, Inc. Amphotericin B methyl ester salts

Also Published As

Publication number Publication date
JPS5557600A (en) 1980-04-28
ATE3046T1 (de) 1983-04-15
DE2965212D1 (en) 1983-05-19
AU5190079A (en) 1980-05-01
NO147840C (no) 1983-06-22
FI793236A7 (fi) 1981-01-01
ZA795508B (en) 1981-05-27
EP0010297B1 (en) 1983-04-13
IL58490A (en) 1983-07-31
NO147840B (no) 1983-03-14
GR74128B (instruction) 1984-06-06
EP0010297A1 (en) 1980-04-30
PT70341A (en) 1979-11-01
HU181506B (en) 1983-10-28
DK439879A (da) 1980-04-24
IL58490A0 (en) 1980-01-31
NO793354L (no) 1980-04-24

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