CA1132371A - Chromatographic apparatus and method - Google Patents
Chromatographic apparatus and methodInfo
- Publication number
- CA1132371A CA1132371A CA321,124A CA321124A CA1132371A CA 1132371 A CA1132371 A CA 1132371A CA 321124 A CA321124 A CA 321124A CA 1132371 A CA1132371 A CA 1132371A
- Authority
- CA
- Canada
- Prior art keywords
- chromatographic
- column
- fractions
- chromatographic column
- passing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title claims abstract description 28
- 238000000926 separation method Methods 0.000 claims abstract description 29
- 239000000470 constituent Substances 0.000 claims description 46
- 150000001875 compounds Chemical group 0.000 claims description 16
- 238000004587 chromatography analysis Methods 0.000 claims description 11
- 238000004458 analytical method Methods 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 8
- 238000010828 elution Methods 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 6
- 239000002699 waste material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 230000000717 retained effect Effects 0.000 claims description 3
- 239000000523 sample Substances 0.000 claims 7
- 238000005070 sampling Methods 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 2
- 238000005086 pumping Methods 0.000 abstract description 2
- 238000010586 diagram Methods 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 230000001360 synchronised effect Effects 0.000 description 3
- 238000009835 boiling Methods 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000007670 refining Methods 0.000 description 2
- PCLIRWBVOVZTOK-UHFFFAOYSA-M 2-(1-methylpyrrolidin-1-ium-1-yl)ethyl 2-hydroxy-2,2-diphenylacetate;iodide Chemical compound [I-].C=1C=CC=CC=1C(O)(C=1C=CC=CC=1)C(=O)OCC[N+]1(C)CCCC1 PCLIRWBVOVZTOK-UHFFFAOYSA-M 0.000 description 1
- 101100008046 Caenorhabditis elegans cut-2 gene Proteins 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 230000012447 hatching Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000029305 taxis Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/46—Flow patterns using more than one column
- G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N30/20—Injection using a sampling valve
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/44—Flow patterns using recycling of the fraction to be distributed
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
- B01D15/1871—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in series
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N30/20—Injection using a sampling valve
- G01N2030/201—Injection using a sampling valve multiport valves, i.e. having more than two ports
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/44—Flow patterns using recycling of the fraction to be distributed
- G01N2030/445—Flow patterns using recycling of the fraction to be distributed heart cut
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/24—Automatic injection systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/46—Flow patterns using more than one column
- G01N30/466—Flow patterns using more than one column with separation columns in parallel
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/46—Flow patterns using more than one column
- G01N30/468—Flow patterns using more than one column involving switching between different column configurations
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sustainable Development (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/922,712 US4204952A (en) | 1978-07-07 | 1978-07-07 | Chromatographic apparatus and method |
| US922,712 | 1992-07-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1132371A true CA1132371A (en) | 1982-09-28 |
Family
ID=25447483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA321,124A Expired CA1132371A (en) | 1978-07-07 | 1979-02-08 | Chromatographic apparatus and method |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4204952A (en, 2012) |
| JP (1) | JPS5512486A (en, 2012) |
| AU (1) | AU518102B2 (en, 2012) |
| BE (1) | BE877273A (en, 2012) |
| CA (1) | CA1132371A (en, 2012) |
| CH (1) | CH639000A5 (en, 2012) |
| DE (1) | DE2926521A1 (en, 2012) |
| FR (1) | FR2430614A1 (en, 2012) |
| GB (1) | GB2024647B (en, 2012) |
| IT (1) | IT1119074B (en, 2012) |
| NL (1) | NL7901754A (en, 2012) |
| SE (1) | SE7901263L (en, 2012) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4392873A (en) * | 1981-06-12 | 1983-07-12 | Brockington Francis R | Continuous vapor phase chromatography |
| JPS60219554A (ja) * | 1984-04-16 | 1985-11-02 | Yokogawa Hokushin Electric Corp | 多量成分中の微量成分を測定する方法およびその装置 |
| EP0207537B1 (en) * | 1985-06-28 | 1993-01-13 | Shell Internationale Researchmaatschappij B.V. | Chromatographic analyzer |
| US4630469A (en) * | 1985-09-30 | 1986-12-23 | Phillips Petroleum Company | Sample homogenizer |
| US4724081A (en) * | 1986-04-28 | 1988-02-09 | Soken Kagaku Kabushiki Kaisha | Process and apparatus for separation by liquid chromatography |
| DE3717456C1 (de) * | 1987-05-23 | 1988-07-21 | Eberhard Gerstel | Gaschromatograph und Verfahren zur gaschromatographischen Trennung |
| US5057437A (en) * | 1988-07-27 | 1991-10-15 | Bio-Rad Laboratories, Inc. | Method for broad spectrum drug detection |
| GB2223692A (en) * | 1988-09-16 | 1990-04-18 | Philips Nv | Liquid chromatography |
| FI82553C (fi) * | 1989-07-04 | 1991-03-11 | Valtion Teknillinen | Foerfarande och anordning foer kromatografisk separation. |
| JP2834224B2 (ja) * | 1989-10-18 | 1998-12-09 | 株式会社日立製作所 | 液体クロマトグラフィーによる試料の分析装置 |
| US5071547A (en) * | 1990-03-23 | 1991-12-10 | Separations Technology, Inc. | Column chromatographic column apparatus with switching capability |
| US5281256A (en) * | 1990-09-28 | 1994-01-25 | Regents Of The University Of Michigan | Gas chromatography system with column bifurcation and tunable selectivity |
| JPH06138115A (ja) * | 1991-04-25 | 1994-05-20 | Shimadzu Corp | 試料成分分取装置 |
| US5288310A (en) * | 1992-09-30 | 1994-02-22 | The Regents Of The University Of Michigan | Adsorbent trap for gas chromatography |
| US5346622A (en) * | 1993-03-04 | 1994-09-13 | Hewlett-Packard Company | Hydrocarbon class separation and quantitation by split column effluent analysis |
| US5352585A (en) * | 1993-06-29 | 1994-10-04 | Bio-Rad Laboratories, Inc. | System for benzodiazepine detection |
| DE19711173A1 (de) * | 1997-03-18 | 1998-09-24 | Sartorius Gmbh | Verfahren und Anlage für die adsorptive Stofftrennung |
| FR2787576B1 (fr) | 1998-12-22 | 2001-01-12 | Inst Francais Du Petrole | Procede et dispositif d'analyse integree pour la caracterisation d'hydrocarbures, par simulation de distillation |
| GB0025018D0 (en) * | 2000-10-12 | 2000-11-29 | Micromass Ltd | Apparatus method for isotopically analysing samples |
| US6632268B2 (en) * | 2001-02-08 | 2003-10-14 | Oakland University | Method and apparatus for comprehensive two-dimensional gas chromatography |
| US7089763B2 (en) * | 2002-02-25 | 2006-08-15 | Worldwide Water, L.L.C. | Portable, potable water recovery and dispensing apparatus |
| US10948483B2 (en) | 2013-04-08 | 2021-03-16 | Chromacon Ag | Method for control, monitoring and/or optimization of a chromatographic process |
| US10099156B2 (en) | 2013-04-08 | 2018-10-16 | Chromacon Ag | Chromatographic purification method |
| EP3519807B1 (en) | 2016-09-28 | 2024-08-14 | Evosep ApS | System for subjecting a sample to chromatographic analysis |
| CN110178027A (zh) * | 2016-09-28 | 2019-08-27 | 埃沃赛普私人有限责任公司 | 使用低压双重梯度再集中的色谱分析 |
| CN109923413A (zh) * | 2016-11-15 | 2019-06-21 | 株式会社资生堂 | 多级色谱分析方法及分析系统 |
| WO2024238315A1 (en) * | 2023-05-12 | 2024-11-21 | Wayne State University | Process for using modified dtpa-associated organosilica media for producing individually separated high purity rare earth elements |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3002583A (en) * | 1957-06-10 | 1961-10-03 | Phillips Petroleum Co | Fluid separation by gas chromatography |
| US3159019A (en) * | 1959-07-17 | 1964-12-01 | Phillips Petroleum Co | Chromatographic analysis method |
| US3263488A (en) * | 1963-03-04 | 1966-08-02 | Hewlett Packard Co | Method for gas chromatography |
| DE1598205B1 (de) * | 1964-04-13 | 1971-05-19 | Ceskoslovenska Akademie Ved | Einrichtung zur chromatographie von aminosaeuren und derglei chen enthaltenden gemischen |
| US3385101A (en) * | 1964-11-16 | 1968-05-28 | Phillips Petroleum Co | Chromatographic analyzer |
| SE326056B (en, 2012) * | 1966-01-07 | 1970-07-13 | Ceskoslovenska Akademie Ved | |
| FR1546865A (fr) * | 1966-11-21 | 1968-11-22 | Shell Int Research | Procédé et appareil de séparation chromatographique d'un mélange |
| US4001112A (en) * | 1972-06-14 | 1977-01-04 | Philip Edwin Barker | Method of operating a chromatographic apparatus |
| US3897213A (en) * | 1973-08-06 | 1975-07-29 | Dow Chemical Co | Automated quantitative analysis of ionic species |
| US3918906A (en) * | 1973-08-06 | 1975-11-11 | Dow Chemical Co | Determining total ionic content |
| US4070284A (en) * | 1973-08-20 | 1978-01-24 | Hitachi, Ltd. | Liquid chromatography and apparatus for the same |
| US3992175A (en) * | 1974-02-11 | 1976-11-16 | Toe Jokhannesovich Klementi | Method of and device for chromatographic separation of fluid mixtures into fractions |
| FR2300607A1 (fr) * | 1975-02-13 | 1976-09-10 | Erap | Proce |
-
1978
- 1978-07-07 US US05/922,712 patent/US4204952A/en not_active Expired - Lifetime
-
1979
- 1979-02-08 CA CA321,124A patent/CA1132371A/en not_active Expired
- 1979-02-13 SE SE7901263A patent/SE7901263L/xx not_active Application Discontinuation
- 1979-03-06 NL NL7901754A patent/NL7901754A/nl not_active Application Discontinuation
- 1979-03-09 JP JP2680979A patent/JPS5512486A/ja active Pending
- 1979-03-27 AU AU45423/79A patent/AU518102B2/en not_active Ceased
- 1979-03-30 GB GB7911178A patent/GB2024647B/en not_active Expired
- 1979-04-27 IT IT67901/79A patent/IT1119074B/it active
- 1979-06-26 BE BE0/195961A patent/BE877273A/xx unknown
- 1979-06-28 FR FR7916708A patent/FR2430614A1/fr active Granted
- 1979-06-30 DE DE19792926521 patent/DE2926521A1/de active Granted
- 1979-07-03 CH CH621179A patent/CH639000A5/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| GB2024647A (en) | 1980-01-16 |
| AU4542379A (en) | 1980-01-10 |
| DE2926521C2 (en, 2012) | 1989-05-11 |
| US4204952A (en) | 1980-05-27 |
| AU518102B2 (en) | 1981-09-10 |
| GB2024647B (en) | 1982-09-29 |
| IT1119074B (it) | 1986-03-03 |
| FR2430614B1 (en, 2012) | 1984-10-19 |
| CH639000A5 (de) | 1983-10-31 |
| DE2926521A1 (de) | 1980-01-17 |
| FR2430614A1 (fr) | 1980-02-01 |
| NL7901754A (nl) | 1980-01-09 |
| IT7967901A0 (it) | 1979-04-27 |
| JPS5512486A (en) | 1980-01-29 |
| SE7901263L (sv) | 1980-01-08 |
| BE877273A (fr) | 1979-12-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |