CA1112567A - Disodium cromoglycate self-propelling compositions - Google Patents
Disodium cromoglycate self-propelling compositionsInfo
- Publication number
- CA1112567A CA1112567A CA307,480A CA307480A CA1112567A CA 1112567 A CA1112567 A CA 1112567A CA 307480 A CA307480 A CA 307480A CA 1112567 A CA1112567 A CA 1112567A
- Authority
- CA
- Canada
- Prior art keywords
- sorbitan
- propellant
- composition according
- weight
- lecithin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 31
- 229960000265 cromoglicic acid Drugs 0.000 title claims description 9
- IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 title claims 4
- 239000006185 dispersion Substances 0.000 claims abstract description 25
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims abstract description 24
- 235000019404 dichlorodifluoromethane Nutrition 0.000 claims abstract description 23
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims abstract description 15
- -1 sorbitol ester Chemical class 0.000 claims abstract description 15
- 239000000725 suspension Substances 0.000 claims abstract description 12
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 11
- 235000010445 lecithin Nutrition 0.000 claims abstract description 11
- 239000000787 lecithin Substances 0.000 claims abstract description 11
- 229940067606 lecithin Drugs 0.000 claims abstract description 11
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims abstract description 9
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 8
- 239000000600 sorbitol Substances 0.000 claims abstract description 8
- DDMOUSALMHHKOS-UHFFFAOYSA-N 1,2-dichloro-1,1,2,2-tetrafluoroethane Chemical compound FC(F)(Cl)C(F)(F)Cl DDMOUSALMHHKOS-UHFFFAOYSA-N 0.000 claims description 21
- 239000003380 propellant Substances 0.000 claims description 16
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 claims description 7
- 239000004147 Sorbitan trioleate Substances 0.000 claims description 6
- 235000019337 sorbitan trioleate Nutrition 0.000 claims description 6
- 229960000391 sorbitan trioleate Drugs 0.000 claims description 6
- 239000004338 Dichlorodifluoromethane Substances 0.000 claims description 4
- CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical group OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 claims description 3
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 claims description 2
- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 claims description 2
- 229940035044 sorbitan monolaurate Drugs 0.000 claims description 2
- 239000001593 sorbitan monooleate Substances 0.000 claims description 2
- 235000011069 sorbitan monooleate Nutrition 0.000 claims description 2
- 229940035049 sorbitan monooleate Drugs 0.000 claims description 2
- 229960005078 sorbitan sesquioleate Drugs 0.000 claims description 2
- 229940029284 trichlorofluoromethane Drugs 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 8
- 238000009472 formulation Methods 0.000 abstract description 6
- 239000004094 surface-active agent Substances 0.000 description 8
- 150000002148 esters Chemical class 0.000 description 5
- VLARUOGDXDTHEH-UHFFFAOYSA-L disodium cromoglycate Chemical compound [Na+].[Na+].O1C(C([O-])=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C([O-])=O)O2 VLARUOGDXDTHEH-UHFFFAOYSA-L 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 3
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 3
- 239000010419 fine particle Substances 0.000 description 3
- 229910021653 sulphate ion Inorganic materials 0.000 description 3
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 description 2
- AWRLZJJDHWCYKN-UHFFFAOYSA-N 5-bromo-2-ethoxy-3-nitropyridine Chemical compound CCOC1=NC=C(Br)C=C1[N+]([O-])=O AWRLZJJDHWCYKN-UHFFFAOYSA-N 0.000 description 2
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 description 2
- MKFFGUZYVNDHIH-UHFFFAOYSA-N [2-(3,5-dihydroxyphenyl)-2-hydroxyethyl]-propan-2-ylazanium;sulfate Chemical compound OS(O)(=O)=O.CC(C)NCC(O)C1=CC(O)=CC(O)=C1.CC(C)NCC(O)C1=CC(O)=CC(O)=C1 MKFFGUZYVNDHIH-UHFFFAOYSA-N 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 229960004311 betamethasone valerate Drugs 0.000 description 2
- SNHRLVCMMWUAJD-SUYDQAKGSA-N betamethasone valerate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(OC(=O)CCCC)[C@@]1(C)C[C@@H]2O SNHRLVCMMWUAJD-SUYDQAKGSA-N 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 229960001037 fenoterol hydrobromide Drugs 0.000 description 2
- 229960001317 isoprenaline Drugs 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229960001802 phenylephrine Drugs 0.000 description 2
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 description 2
- 229960002052 salbutamol Drugs 0.000 description 2
- QPYZEEKXUYXZBK-KATIXKQHSA-N 4-[(s)-hydroxy-[(2r)-piperidin-2-yl]methyl]benzene-1,2-diol;hydrobromide Chemical compound Br.C([C@@H]1[C@@H](O)C=2C=C(O)C(O)=CC=2)CCCN1 QPYZEEKXUYXZBK-KATIXKQHSA-N 0.000 description 1
- LSLYOANBFKQKPT-DIFFPNOSSA-N 5-[(1r)-1-hydroxy-2-[[(2r)-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]benzene-1,3-diol Chemical compound C([C@@H](C)NC[C@H](O)C=1C=C(O)C=C(O)C=1)C1=CC=C(O)C=C1 LSLYOANBFKQKPT-DIFFPNOSSA-N 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 description 1
- IROWCYIEJAOFOW-UHFFFAOYSA-N DL-Isoprenaline hydrochloride Chemical compound Cl.CC(C)NCC(O)C1=CC=C(O)C(O)=C1 IROWCYIEJAOFOW-UHFFFAOYSA-N 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 229950000210 beclometasone dipropionate Drugs 0.000 description 1
- 229940124630 bronchodilator Drugs 0.000 description 1
- 239000000168 bronchodilator agent Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 229940042935 dichlorodifluoromethane Drugs 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 229960001022 fenoterol Drugs 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- LMOINURANNBYCM-UHFFFAOYSA-N metaproterenol Chemical compound CC(C)NCC(O)C1=CC(O)=CC(O)=C1 LMOINURANNBYCM-UHFFFAOYSA-N 0.000 description 1
- 229960002657 orciprenaline Drugs 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 229960001457 rimiterol Drugs 0.000 description 1
- IYMMESGOJVNCKV-SKDRFNHKSA-N rimiterol Chemical compound C([C@@H]1[C@@H](O)C=2C=C(O)C(O)=CC=2)CCCN1 IYMMESGOJVNCKV-SKDRFNHKSA-N 0.000 description 1
- 229960001953 rimiterol hydrobromide Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 229960002117 triamcinolone acetonide Drugs 0.000 description 1
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
- 229940070710 valerate Drugs 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/124—Aerosols; Foams characterised by the propellant
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dispersion Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB30169/77 | 1977-07-19 | ||
| GB3016977 | 1977-07-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1112567A true CA1112567A (en) | 1981-11-17 |
Family
ID=10303374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA307,480A Expired CA1112567A (en) | 1977-07-19 | 1978-07-17 | Disodium cromoglycate self-propelling compositions |
Country Status (15)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6284287B1 (en) | 1994-07-16 | 2001-09-04 | Asta Medica Ag | Particulate formulation for administration by inhalation |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8501015D0 (en) * | 1985-01-16 | 1985-02-20 | Riker Laboratories Inc | Drug |
| HU205249B (en) * | 1990-11-09 | 1992-04-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing suspensive aerosole composition |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB367276A (en) * | 1931-06-20 | 1932-02-18 | Schmidt Sche Heissdampf | Improvements in or relating to independently fired steam superheaters |
| BE555319A (enrdf_load_stackoverflow) * | 1956-03-21 | 1900-01-01 | ||
| BE556587A (enrdf_load_stackoverflow) * | 1957-01-31 | 1957-04-11 | ||
| GB1144905A (en) * | 1965-03-25 | 1969-03-12 | Fisons Pharmaceuticals Ltd | Substituted bis-(2-carboxy-chromonyl-oxy) derivatives and preparation and pharmaceutical compositions thereof |
| US3513104A (en) * | 1965-03-26 | 1970-05-19 | Colgate Palmolive Co | Self-propelling powder compositions |
| US3560507A (en) * | 1968-02-27 | 1971-02-02 | Millmaster Onyx Corp | Quaternary ammonium alkenyl succinates |
| ZA72434B (en) * | 1971-01-25 | 1973-09-26 | Colgate Palmolive Co | Fabric conditioning |
| DE2151706B1 (en) * | 1971-10-18 | 1973-05-03 | Cegla, Ulrich, Dr med , 600 0 Frank fürt Niederrad | Tantalum-contg x-ray contrast agents - in aerosol form for bronchography |
| IL44022A0 (en) * | 1973-01-23 | 1974-05-16 | Fisons Ltd | Novel salts of anti-inflammatory quinoline derivatives,their preparation and pharmaceutical compositions containing them |
| IT1039699B (it) * | 1975-07-03 | 1979-12-10 | Prephar | Composizione spermicida a base di derivati benzisotiazolici |
| GB1562901A (en) * | 1976-01-30 | 1980-03-19 | Fisons Ltd | Disodium cromoglycate |
| FI770215A7 (enrdf_load_stackoverflow) * | 1976-01-30 | 1977-07-31 | Fisons Ltd | |
| GB2001334B (en) | 1977-07-19 | 1982-03-03 | Fisons Ltd | Pressurised aerosol formulation |
| GB1590126A (en) | 1977-11-23 | 1981-05-28 | Booth B H | Method of bulking yarns |
-
1978
- 1978-07-14 AU AU38057/78A patent/AU522792B2/en not_active Expired
- 1978-07-17 IE IE1432/78A patent/IE47128B1/en not_active IP Right Cessation
- 1978-07-17 BE BE189326A patent/BE869055A/xx not_active IP Right Cessation
- 1978-07-17 CA CA307,480A patent/CA1112567A/en not_active Expired
- 1978-07-17 NL NL7807625A patent/NL7807625A/xx active Search and Examination
- 1978-07-17 FR FR7821172A patent/FR2397833A1/fr active Granted
- 1978-07-18 SE SE7807934A patent/SE443087B/sv not_active IP Right Cessation
- 1978-07-18 IL IL55161A patent/IL55161A/xx unknown
- 1978-07-18 DE DE19782831419 patent/DE2831419A1/de active Granted
- 1978-07-18 CH CH774178A patent/CH627075A5/fr not_active IP Right Cessation
- 1978-07-18 JP JP8682578A patent/JPS5435209A/ja active Granted
- 1978-07-18 IT IT25845/78A patent/IT1158890B/it active Protection Beyond IP Right Term
- 1978-07-18 NZ NZ187894A patent/NZ187894A/en unknown
-
1984
- 1984-12-30 MY MY252/84A patent/MY8400252A/xx unknown
-
1985
- 1985-07-04 HK HK515/85A patent/HK51585A/xx not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6284287B1 (en) | 1994-07-16 | 2001-09-04 | Asta Medica Ag | Particulate formulation for administration by inhalation |
Also Published As
| Publication number | Publication date |
|---|---|
| IL55161A0 (en) | 1978-09-29 |
| SE7807934L (sv) | 1979-01-20 |
| IL55161A (en) | 1981-12-31 |
| IE47128B1 (en) | 1983-12-28 |
| BE869055A (fr) | 1979-01-17 |
| IE781432L (en) | 1979-01-19 |
| JPS6411615B2 (enrdf_load_stackoverflow) | 1989-02-27 |
| IT7825845A0 (it) | 1978-07-18 |
| FR2397833A1 (fr) | 1979-02-16 |
| NZ187894A (en) | 1984-05-31 |
| AU3805778A (en) | 1980-01-17 |
| FR2397833B1 (enrdf_load_stackoverflow) | 1982-06-25 |
| JPS5435209A (en) | 1979-03-15 |
| SE443087B (sv) | 1986-02-17 |
| NL7807625A (nl) | 1979-01-23 |
| IT1158890B (it) | 1987-02-25 |
| HK51585A (en) | 1985-07-12 |
| CH627075A5 (en) | 1981-12-31 |
| MY8400252A (en) | 1984-12-31 |
| DE2831419A1 (de) | 1979-02-01 |
| AU522792B2 (en) | 1982-06-24 |
| DE2831419C2 (enrdf_load_stackoverflow) | 1989-01-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |