CA1106686A - Process and apparatus for the production of frozen granulates - Google Patents

Process and apparatus for the production of frozen granulates

Info

Publication number
CA1106686A
CA1106686A CA293,821A CA293821A CA1106686A CA 1106686 A CA1106686 A CA 1106686A CA 293821 A CA293821 A CA 293821A CA 1106686 A CA1106686 A CA 1106686A
Authority
CA
Canada
Prior art keywords
liquid
cooling agent
product liquid
granulate
product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA293,821A
Other languages
English (en)
French (fr)
Inventor
Klaus D. Heck
Gotthilf Naher
Eberhard Pahl
Klaus Beuerle
Svenn Kittelsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Application granted granted Critical
Publication of CA1106686A publication Critical patent/CA1106686A/en
Expired legal-status Critical Current

Links

Classifications

    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26DRYING
    • F26BDRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
    • F26B5/065Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing the product to be freeze-dried being sprayed, dispersed or pulverised
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23BPRESERVING, e.g. BY CANNING, MEAT, FISH, EGGS, FRUIT, VEGETABLES, EDIBLE SEEDS; CHEMICAL RIPENING OF FRUIT OR VEGETABLES; THE PRESERVED, RIPENED, OR CANNED PRODUCTS
    • A23B4/00General methods for preserving meat, sausages, fish or fish products
    • A23B4/03Drying; Subsequent reconstitution
    • A23B4/037Freeze-drying, i.e. cryodessication, lyophilisation; Apparatus therefor
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23BPRESERVING, e.g. BY CANNING, MEAT, FISH, EGGS, FRUIT, VEGETABLES, EDIBLE SEEDS; CHEMICAL RIPENING OF FRUIT OR VEGETABLES; THE PRESERVED, RIPENED, OR CANNED PRODUCTS
    • A23B4/00General methods for preserving meat, sausages, fish or fish products
    • A23B4/06Freezing; Subsequent thawing; Cooling
    • A23B4/062Freezing; Subsequent thawing; Cooling the materials being transported through or in the apparatus with or without shaping, e.g. in the form of powder, granules or flakes
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/36Freezing; Subsequent thawing; Cooling
    • A23L3/37Freezing; Subsequent thawing; Cooling with addition of or treatment with chemicals
    • A23L3/375Freezing; Subsequent thawing; Cooling with addition of or treatment with chemicals with direct contact between the food and the chemical, e.g. liquid nitrogen, at cryogenic temperature
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/40Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by drying or kilning; Subsequent reconstitution
    • A23L3/44Freeze-drying
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25CPRODUCING, WORKING OR HANDLING ICE
    • F25C1/00Producing ice
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25DREFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D3/00Devices using other cold materials; Devices using cold-storage bodies
    • F25D3/10Devices using other cold materials; Devices using cold-storage bodies using liquefied gases, e.g. liquid air

Landscapes

  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Thermal Sciences (AREA)
  • Nutrition Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Combustion & Propulsion (AREA)
  • Drying Of Solid Materials (AREA)
  • Freezing, Cooling And Drying Of Foods (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Confectionery (AREA)
  • Non-Alcoholic Beverages (AREA)
  • Glanulating (AREA)
CA293,821A 1976-12-30 1977-12-23 Process and apparatus for the production of frozen granulates Expired CA1106686A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19762659546 DE2659546A1 (de) 1976-12-30 1976-12-30 Verfahren zur herstellung von gefrorenen granulaten
DEP2659546.0 1976-12-30

Publications (1)

Publication Number Publication Date
CA1106686A true CA1106686A (en) 1981-08-11

Family

ID=5997030

Family Applications (1)

Application Number Title Priority Date Filing Date
CA293,821A Expired CA1106686A (en) 1976-12-30 1977-12-23 Process and apparatus for the production of frozen granulates

Country Status (18)

Country Link
JP (1) JPS53114783A (it)
AR (1) AR214108A1 (it)
AT (1) AT356498B (it)
AU (1) AU506746B2 (it)
BE (1) BE862370A (it)
CA (1) CA1106686A (it)
CH (1) CH625332A5 (it)
DD (1) DD133295A5 (it)
DE (1) DE2659546A1 (it)
FI (1) FI773941A (it)
FR (1) FR2375901A1 (it)
GB (1) GB1559920A (it)
IE (1) IE46022B1 (it)
IL (1) IL53695A0 (it)
IT (1) IT1089419B (it)
NL (1) NL7714401A (it)
SE (1) SE7714822L (it)
ZA (1) ZA777184B (it)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3042955A1 (de) * 1980-11-14 1982-10-21 Helmut 7702 Gottmadingen Ruh Verfahren und vorrichtung zum aufbereiten frischer kraeuter oder kraeutermischungen sowie formkoerper daraus
FR2566515B1 (fr) * 1984-06-22 1987-03-27 Air Liquide Procede et installation de refroidissement, au moyen d'un fluide frigorigene d'une poudre
US4704873A (en) * 1985-11-14 1987-11-10 Taiyo Sanso Co., Ltd. Method and apparatus for producing microfine frozen particles
WO1990010183A1 (en) * 1989-03-01 1990-09-07 Andrew Boyd French Snowmaking method and device
DE69005800T2 (de) * 1989-05-01 1994-05-19 Alkermes Inc Verfahren zur herstellung von kleinen partikeln von biologisch aktiven molekülen.
JPH0753704Y2 (ja) * 1989-06-05 1995-12-13 大陽酸素株式会社 凍結粒製造装置
JPH089582Y2 (ja) * 1990-08-31 1996-03-21 大陽酸素株式会社 凍結粒製造装置
DE4112890A1 (de) * 1991-04-19 1992-10-22 Abony Szuecs Eva Verfahren und vorrichtung zum reinigen von oberflaechen, insbesondere von empfindlichen oberflaechen
JPH05115853A (ja) * 1991-04-19 1993-05-14 Eva Abony Szucs 鋭敏な表面を洗浄する方法および装置
JPH06323712A (ja) * 1993-04-20 1994-11-25 E I Du Pont De Nemours & Co 霧化した極低温液滴の閉じ込め帯域を用いて凍結粒子を製造する方法および装置
DE4344393C2 (de) * 1993-12-24 1998-10-01 Ftd Foam Tech Dev Gmbh Einrichtung zum Herstellen von Speiseeis, gefrorenen Dessert- und Fruchtmassen, Tortenmassen, Teigmassen, aus mehreren schwer mischbaren fluiden Matrizes, welche aus wenigstens einer Stoffkomponente bestehen
US5737928A (en) * 1995-03-09 1998-04-14 The Boc Group, Inc. Process fluid cooling means and apparatus
DE19813101A1 (de) * 1998-03-25 1999-09-30 Herbert Dressler Vorrichtung zum Versprühen chemisch-technischer Produkte und Verfahren hierzu
NO311164B1 (no) * 1998-06-02 2001-10-22 Leiv Eiriksson Nyfotek As Fremgangsmåte for frysetörking av lösninger
MXPA02003230A (es) 1999-09-30 2004-04-21 Saitec Srl Metodo y sistema para enfriar y efectuar un cambio de estado en una mezcla liquida.
DE10243483A1 (de) * 2002-09-19 2004-04-08 Messer Griesheim Gmbh System zum Mikropelletieren von Lösungen bzw. Schmelzen
ITMI20032367A1 (it) * 2003-12-03 2005-06-04 Air Liquide Italia S P A Metodo ed impianto per il raffreddamento di fluidi
JP5183068B2 (ja) 2003-12-22 2013-04-17 フィンレイ,ウォーレン,エイチ 大気噴出凍結乾燥法による粉末形成
EP1794524B1 (en) 2004-07-23 2012-01-18 Bayer Technology Services GmbH Sterile freezing, drying, storing, assaying and filling process (sfd-saf process) (pellet freeze-drying process for parenteral biopharmaceuticals)
NZ550563A (en) * 2006-10-16 2009-01-31 Agres Ltd Improvements in spray freeze drying
US7861551B2 (en) * 2007-11-30 2011-01-04 Whirlpool Corporation Method and device for producing ice droplets on demand
MX2010008799A (es) 2008-03-05 2010-09-07 Sanofi Pasteur Proceso para estabilizar una composicion de vacuna que contiene adyuvante.
EP2143440A1 (fr) 2008-07-09 2010-01-13 Sanofi Pasteur Agent stabilisant et composition vaccinale comprenant un ou plusieurs flavivirus vivants atténués
US9945611B2 (en) 2010-08-04 2018-04-17 Ima Life North America Inc. Bulk freeze drying using spray freezing and agitated drying
ITBS20110076A1 (it) * 2011-05-25 2012-11-26 K190 S R L Apparato e procedimento per la preparazione di gelato o prodotti alimentari affini
FR2983286B1 (fr) * 2011-11-24 2018-04-13 L'air Liquide,Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges Claude Dispositif de refroidissement de produits en vrac
CN103123196B (zh) * 2013-02-06 2015-08-26 邹杰 一种蓄冷设备
JP5837670B2 (ja) * 2014-10-24 2015-12-24 アイエムエー ライフ ノース アメリカ インコーポレーテッド 噴霧凍結および撹拌乾燥を使用するバルク・フリーズドライ
CN105597622B (zh) * 2016-03-09 2017-11-21 苏州大学 结冰温度可控的用于制备微米级冰球颗粒的喷雾冷冻塔
CN106113314B (zh) * 2016-08-15 2019-06-21 浙江心源科技有限公司 一种喷雾结晶造粒装置及其造粒方法
DE202016106243U1 (de) * 2016-09-21 2016-11-17 Dressler Group GmbH & Co. KG Vorrichtung zur Herstellung von pulverförmigen Kunststoffen mit möglichst kugelförmiger Struktur
DE102018002750B8 (de) * 2018-04-06 2020-09-24 Messer France S.A.S. Vorrichtung zum Kühlen von Produkten
CN108709369A (zh) * 2018-04-20 2018-10-26 大连工业大学 一种超声波喷雾冷冻干燥装置
CN109820130B (zh) * 2019-04-03 2022-09-16 河南工业大学 一种可溶性膳食纤维提取装置
WO2022047366A1 (en) * 2020-08-31 2022-03-03 Cornell University Systems and methods for rapidly freezing a liquid
CN112774571A (zh) * 2020-12-26 2021-05-11 深圳万和制药有限公司 高均匀性大粒径微丸的分散冷凝生产工艺

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2751687A (en) * 1952-05-21 1956-06-26 Proctor Drying And Freezing Co Process and apparatus for producing stabilized products

Also Published As

Publication number Publication date
JPS53114783A (en) 1978-10-06
FI773941A (fi) 1978-07-01
ZA777184B (en) 1978-10-25
IE46022B1 (en) 1983-01-26
AU506746B2 (en) 1980-01-24
BE862370A (fr) 1978-06-27
SE7714822L (sv) 1978-07-01
IT1089419B (it) 1985-06-18
AR214108A1 (es) 1979-04-30
NL7714401A (nl) 1978-07-04
DD133295A5 (de) 1978-12-27
DE2659546A1 (de) 1978-07-13
ATA940677A (de) 1979-09-15
IE46022L (en) 1978-06-30
IL53695A0 (en) 1978-03-10
FR2375901A1 (fr) 1978-07-28
CH625332A5 (en) 1981-09-15
GB1559920A (en) 1980-01-30
AU3192277A (en) 1979-06-28
AT356498B (de) 1980-04-25

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Legal Events

Date Code Title Description
MKEX Expiry