CA1100855A - Substrate coated with receptor and labeled ligand for assays - Google Patents
Substrate coated with receptor and labeled ligand for assaysInfo
- Publication number
- CA1100855A CA1100855A CA282,095A CA282095A CA1100855A CA 1100855 A CA1100855 A CA 1100855A CA 282095 A CA282095 A CA 282095A CA 1100855 A CA1100855 A CA 1100855A
- Authority
- CA
- Canada
- Prior art keywords
- ligand
- receptor
- labelled
- article
- assayed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- 229960000258 corticotropin Drugs 0.000 description 1
- 229960004544 cortisone Drugs 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- ZOOGRGPOEVQQDX-UHFFFAOYSA-N cyclic GMP Natural products O1C2COP(O)(=O)OC2C(O)C1N1C=NC2=C1NC(N)=NC2=O ZOOGRGPOEVQQDX-UHFFFAOYSA-N 0.000 description 1
- 229940095074 cyclic amp Drugs 0.000 description 1
- PDRGHUMCVRDZLQ-UHFFFAOYSA-N d-equilenin Natural products OC1=CC=C2C(CCC3(C4CCC3=O)C)=C4C=CC2=C1 PDRGHUMCVRDZLQ-UHFFFAOYSA-N 0.000 description 1
- 229960000648 digitoxin Drugs 0.000 description 1
- WDJUZGPOPHTGOT-XUDUSOBPSA-N digitoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)CC5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O WDJUZGPOPHTGOT-XUDUSOBPSA-N 0.000 description 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
- PDRGHUMCVRDZLQ-WMZOPIPTSA-N equilenin Chemical compound OC1=CC=C2C(CC[C@]3([C@H]4CCC3=O)C)=C4C=CC2=C1 PDRGHUMCVRDZLQ-WMZOPIPTSA-N 0.000 description 1
- PROQIPRRNZUXQM-ZXXIGWHRSA-N estriol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)C4)O)[C@@H]4[C@@H]3CCC2=C1 PROQIPRRNZUXQM-ZXXIGWHRSA-N 0.000 description 1
- 229960001348 estriol Drugs 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
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- 229960000304 folic acid Drugs 0.000 description 1
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- 239000011724 folic acid Substances 0.000 description 1
- 229940028334 follicle stimulating hormone Drugs 0.000 description 1
- GZZJHPZDXZCDDA-MBJUQXSJSA-N gitaloxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(C[C@@H]([C@@H]([C@@]6(C)CC5)C=5COC(=O)C=5)OC=O)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O GZZJHPZDXZCDDA-MBJUQXSJSA-N 0.000 description 1
- 229950001952 gitaloxin Drugs 0.000 description 1
- LKRDZKPBAOKJBT-CNPIRKNPSA-N gitoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(C[C@H](O)[C@@H]([C@@]6(C)CC5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LKRDZKPBAOKJBT-CNPIRKNPSA-N 0.000 description 1
- 229950000974 gitoxin Drugs 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- RFDAIACWWDREDC-FRVQLJSFSA-N glycocholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 RFDAIACWWDREDC-FRVQLJSFSA-N 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 239000002622 gonadotropin Substances 0.000 description 1
- 239000000122 growth hormone Substances 0.000 description 1
- 208000002672 hepatitis B Diseases 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- 125000003835 nucleoside group Chemical group 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 description 1
- 229960001723 oxytocin Drugs 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 230000001817 pituitary effect Effects 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229960000249 pregnenolone Drugs 0.000 description 1
- ORNBQBCIOKFOEO-QGVNFLHTSA-N pregnenolone Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 ORNBQBCIOKFOEO-QGVNFLHTSA-N 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000000186 progesterone Substances 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 235000017709 saponins Nutrition 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229930002534 steroid glycoside Natural products 0.000 description 1
- 150000008143 steroidal glycosides Chemical class 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 229940034208 thyroxine Drugs 0.000 description 1
- 229940035722 triiodothyronine Drugs 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 201000001862 viral hepatitis Diseases 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2470/00—Immunochemical assays or immunoassays characterised by the reaction format or reaction type
- G01N2470/10—Competitive assay format
- G01N2470/12—Displacement or release-type competition
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/804—Radioisotope, e.g. radioimmunoassay
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/81—Tube, bottle, or dipstick
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/702,691 US4120945A (en) | 1976-07-06 | 1976-07-06 | Substrate coated with receptor and labeled ligand for assays |
| US702,691 | 1976-07-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1100855A true CA1100855A (en) | 1981-05-12 |
Family
ID=24822215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA282,095A Expired CA1100855A (en) | 1976-07-06 | 1977-07-05 | Substrate coated with receptor and labeled ligand for assays |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4120945A (enExample) |
| JP (1) | JPS5331191A (enExample) |
| AU (1) | AU2671077A (enExample) |
| BE (1) | BE856548A (enExample) |
| CA (1) | CA1100855A (enExample) |
| DE (1) | DE2729268A1 (enExample) |
| FR (1) | FR2357900A1 (enExample) |
| GB (1) | GB1560859A (enExample) |
| IT (1) | IT1143739B (enExample) |
| SE (1) | SE7707813L (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5622871A (en) * | 1987-04-27 | 1997-04-22 | Unilever Patent Holdings B.V. | Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents |
| IT1114861B (it) * | 1977-05-12 | 1986-01-27 | Sclavo Inst Sieroterapeut | Metodo per la determinazione del contenuto di costituenti di fluidi biologici e mezzi adatti allo scopo |
| USRE34394E (en) * | 1978-01-23 | 1993-09-28 | Baxter Diagnostics Inc. | Method and composition for double receptor, specific binding assays |
| US4271140A (en) * | 1978-01-23 | 1981-06-02 | Baxter Travenol Laboratories, Inc. | Method and composition for double receptor, specific binding assays |
| US4292296A (en) * | 1978-09-12 | 1981-09-29 | Baxter Travenol Laboratories, Inc. | Diagnostic method |
| US4363634A (en) * | 1980-07-18 | 1982-12-14 | Akzona Incorporated | Glass support coated with synthetic polymer for bioprocess |
| US4357142A (en) * | 1980-07-18 | 1982-11-02 | Akzona Incorporated | Glass support coated with synthetic polymer for bioprocess |
| JPS585659A (ja) * | 1981-06-24 | 1983-01-13 | ハイブリテツク インコ−ポレ−テツド | 単クロ−ン性抗体を使用する免疫学的、抑制試験 |
| US4994373A (en) | 1983-01-27 | 1991-02-19 | Enzo Biochem, Inc. | Method and structures employing chemically-labelled polynucleotide probes |
| EP0141818A1 (en) * | 1983-04-18 | 1985-05-22 | Quidel | Removal of self-binding and staph a cross-reactivity of anti-strep antibody |
| WO1984004170A1 (en) * | 1983-04-18 | 1984-10-25 | Quidel | Protection of antibody during chemical modification |
| GB8317124D0 (en) * | 1983-06-23 | 1983-07-27 | Ekins R P | Free ligand assay |
| FR2585367B1 (fr) * | 1985-07-26 | 1987-10-02 | Lyonnaise Eaux | Procede de dosage immunologique en continu de composes organiques dans un fluide en circulation, et dispositif de mise en oeuvre |
| US6881536B1 (en) * | 1986-04-30 | 2005-04-19 | Bioveris Corporation | Particle based electrochemiluminescent assays |
| CA1289872C (en) * | 1986-06-18 | 1991-10-01 | David L. Woodrum | Reversible immobilization of assay reagents in a multizone test device |
| US4959305A (en) * | 1986-06-18 | 1990-09-25 | Miles Inc. | Reversible immobilization of assay reagents in a multizone test device |
| DK289686A (da) * | 1986-06-19 | 1987-12-20 | Immuntech As | Fremgangsmaade til fremstilling af overfladebaserede immunanalyser |
| JPS6321560A (ja) * | 1986-07-16 | 1988-01-29 | Matsushita Electric Ind Co Ltd | 酵素免疫測定法およびそれに使用する測定素子 |
| DE1248112T1 (de) | 1987-04-27 | 2003-03-20 | Inverness Medical Switzerland | Immunochromatographische Spezifischebindungsassayvorrichtung |
| US5334513A (en) * | 1988-05-17 | 1994-08-02 | Syntex (U.S.A.) Inc. | Method for immunochromatographic analysis |
| US5039607A (en) * | 1988-05-17 | 1991-08-13 | Syntex (U.S.A.) Inc. | Method for immunochromatographic analysis |
| US5028535A (en) * | 1989-01-10 | 1991-07-02 | Biosite Diagnostics, Inc. | Threshold ligand-receptor assay |
| US6352862B1 (en) | 1989-02-17 | 2002-03-05 | Unilever Patent Holdings B.V. | Analytical test device for imuno assays and methods of using same |
| AU1272292A (en) * | 1990-10-30 | 1992-05-26 | Immulogic Pharmaceutical Corporation | Peptide binding assays with mhc antigens |
| US5580741A (en) * | 1994-06-29 | 1996-12-03 | General Electric Company | Chemiluminescence immunoassay for chlorinated aromatic compound detection |
| WO1997022367A1 (en) * | 1995-12-20 | 1997-06-26 | Merck & Co., Inc. | Radiolabeled growth hormone secretagogue |
| CA2303855A1 (en) | 1998-07-22 | 2000-02-03 | Jin Po Lee | Multiple analyte assay device |
| US20040072262A1 (en) * | 2002-10-11 | 2004-04-15 | Montero-Julian Felix A. | Methods and systems for detecting MHC class I binding peptides |
| WO2005069006A1 (en) * | 2004-01-06 | 2005-07-28 | Bwt Property Inc. | Novel antibody mediated surface enhanced raman scattering (sers) immunoassay and multiplexing schemes |
| JP2007536522A (ja) * | 2004-05-07 | 2007-12-13 | ベックマン コールター インコーポレーティッド | Ｃｔｌの媒介による抗原提示細胞の溶解を検出するためのｍｈｃ架橋系 |
| US7678379B2 (en) * | 2004-06-17 | 2010-03-16 | Beckman Coulter, Inc. | Mycobacterium tuberculosis epitopes and methods of use thereof |
| US8455263B2 (en) | 2008-12-30 | 2013-06-04 | Jin Po Lee | Quantitative analyte assay device and method |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3646346A (en) * | 1968-12-26 | 1972-02-29 | Pharmacia Ab | Antibody-coated tube system for radioimmunoassay |
| US3790663A (en) * | 1970-07-07 | 1974-02-05 | Us Health | Preparation of dry antiserum coated solid-phase for radioimmunoassay of antigens |
| US4012494A (en) * | 1971-12-21 | 1977-03-15 | Abbott Laboratories | Direct radioimmunoassay for antigens and their antibodies |
| US3867517A (en) * | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
| US4017597A (en) * | 1974-10-30 | 1977-04-12 | Monsanto Company | Unitized solid phase immunoassay kit and method |
-
1976
- 1976-07-06 US US05/702,691 patent/US4120945A/en not_active Expired - Lifetime
-
1977
- 1977-06-29 DE DE19772729268 patent/DE2729268A1/de not_active Withdrawn
- 1977-06-30 IT IT25290/77A patent/IT1143739B/it active
- 1977-07-04 AU AU26710/77A patent/AU2671077A/en active Pending
- 1977-07-05 CA CA282,095A patent/CA1100855A/en not_active Expired
- 1977-07-05 SE SE7707813A patent/SE7707813L/xx unknown
- 1977-07-06 BE BE179129A patent/BE856548A/xx unknown
- 1977-07-06 JP JP8087577A patent/JPS5331191A/ja active Pending
- 1977-07-06 GB GB28398/77A patent/GB1560859A/en not_active Expired
- 1977-07-06 FR FR7720834A patent/FR2357900A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| AU2671077A (en) | 1979-01-11 |
| BE856548A (fr) | 1977-10-31 |
| JPS5331191A (en) | 1978-03-24 |
| FR2357900B3 (enExample) | 1980-05-16 |
| GB1560859A (en) | 1980-02-13 |
| SE7707813L (sv) | 1978-01-07 |
| IT1143739B (it) | 1986-10-22 |
| DE2729268A1 (de) | 1978-02-02 |
| US4120945A (en) | 1978-10-17 |
| FR2357900A1 (fr) | 1978-02-03 |
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