CA1089359A - Blood cell typing and compatibility test by solid phase immunoadsorbtion - Google Patents
Blood cell typing and compatibility test by solid phase immunoadsorbtionInfo
- Publication number
- CA1089359A CA1089359A CA259,042A CA259042A CA1089359A CA 1089359 A CA1089359 A CA 1089359A CA 259042 A CA259042 A CA 259042A CA 1089359 A CA1089359 A CA 1089359A
- Authority
- CA
- Canada
- Prior art keywords
- cells
- layer
- antibodies
- solution
- extent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 210000000601 blood cell Anatomy 0.000 title claims abstract description 42
- 239000007790 solid phase Substances 0.000 title abstract description 19
- 238000012360 testing method Methods 0.000 title description 78
- 210000004027 cell Anatomy 0.000 claims abstract description 243
- 239000010410 layer Substances 0.000 claims abstract description 157
- 239000000427 antigen Substances 0.000 claims abstract description 91
- 102000036639 antigens Human genes 0.000 claims abstract description 90
- 108091007433 antigens Proteins 0.000 claims abstract description 90
- 239000011159 matrix material Substances 0.000 claims abstract description 88
- 238000000034 method Methods 0.000 claims abstract description 87
- 239000002356 single layer Substances 0.000 claims abstract description 63
- 239000007787 solid Substances 0.000 claims abstract description 63
- 230000000295 complement effect Effects 0.000 claims abstract description 29
- 210000002966 serum Anatomy 0.000 claims abstract description 29
- 230000009089 cytolysis Effects 0.000 claims abstract description 23
- 239000000243 solution Substances 0.000 claims description 90
- 210000003743 erythrocyte Anatomy 0.000 claims description 85
- 239000000725 suspension Substances 0.000 claims description 57
- 210000004369 blood Anatomy 0.000 claims description 26
- 239000008280 blood Substances 0.000 claims description 26
- 230000027455 binding Effects 0.000 claims description 19
- 238000009739 binding Methods 0.000 claims description 19
- 230000000890 antigenic effect Effects 0.000 claims description 17
- 239000000758 substrate Substances 0.000 claims description 16
- 125000003636 chemical group Chemical group 0.000 claims description 15
- 239000004793 Polystyrene Substances 0.000 claims description 13
- 229940012952 fibrinogen Drugs 0.000 claims description 13
- 239000013553 cell monolayer Substances 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 12
- 229920002223 polystyrene Polymers 0.000 claims description 12
- 102000008946 Fibrinogen Human genes 0.000 claims description 11
- 108010049003 Fibrinogen Proteins 0.000 claims description 11
- 108010039918 Polylysine Proteins 0.000 claims description 10
- 229920000656 polylysine Polymers 0.000 claims description 10
- 239000000910 agglutinin Substances 0.000 claims description 9
- 238000001179 sorption measurement Methods 0.000 claims description 9
- 238000005406 washing Methods 0.000 claims description 9
- 230000015572 biosynthetic process Effects 0.000 claims description 7
- 238000005259 measurement Methods 0.000 claims description 7
- 230000002860 competitive effect Effects 0.000 claims description 6
- 230000006957 competitive inhibition Effects 0.000 claims description 6
- 239000002344 surface layer Substances 0.000 claims description 6
- 230000002101 lytic effect Effects 0.000 claims description 5
- 239000012528 membrane Substances 0.000 claims description 5
- 102000007327 Protamines Human genes 0.000 claims description 4
- 108010007568 Protamines Proteins 0.000 claims description 4
- 229940048914 protamine Drugs 0.000 claims description 3
- 101710186708 Agglutinin Proteins 0.000 claims description 2
- 101710146024 Horcolin Proteins 0.000 claims description 2
- 101710189395 Lectin Proteins 0.000 claims description 2
- 101710179758 Mannose-specific lectin Proteins 0.000 claims description 2
- 101710150763 Mannose-specific lectin 1 Proteins 0.000 claims description 2
- 101710150745 Mannose-specific lectin 2 Proteins 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 2
- 239000003153 chemical reaction reagent Substances 0.000 claims description 2
- 239000012153 distilled water Substances 0.000 claims description 2
- 230000002829 reductive effect Effects 0.000 claims description 2
- 229910021653 sulphate ion Inorganic materials 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 6
- 102000018358 immunoglobulin Human genes 0.000 claims 6
- 229940072221 immunoglobulins Drugs 0.000 claims 6
- 108010069112 Complement System Proteins Proteins 0.000 claims 3
- 102000000989 Complement System Proteins Human genes 0.000 claims 3
- 230000002391 anti-complement effect Effects 0.000 claims 2
- 108010008730 anticomplement Proteins 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 230000004520 agglutination Effects 0.000 abstract description 25
- 238000006243 chemical reaction Methods 0.000 abstract description 16
- 238000009582 blood typing Methods 0.000 abstract description 8
- 210000000170 cell membrane Anatomy 0.000 abstract description 3
- 238000011158 quantitative evaluation Methods 0.000 abstract description 2
- 238000009740 moulding (composite fabrication) Methods 0.000 description 13
- 239000012071 phase Substances 0.000 description 9
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- 102000004169 proteins and genes Human genes 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 7
- 102000001554 Hemoglobins Human genes 0.000 description 5
- 108010054147 Hemoglobins Proteins 0.000 description 5
- 238000000326 densiometry Methods 0.000 description 5
- 238000001514 detection method Methods 0.000 description 5
- 230000035945 sensitivity Effects 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 230000001464 adherent effect Effects 0.000 description 4
- 210000001772 blood platelet Anatomy 0.000 description 4
- 238000009826 distribution Methods 0.000 description 4
- 230000008105 immune reaction Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 4
- 108091005804 Peptidases Proteins 0.000 description 3
- 239000004365 Protease Substances 0.000 description 3
- 230000003190 augmentative effect Effects 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 230000006037 cell lysis Effects 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 210000003714 granulocyte Anatomy 0.000 description 3
- 230000035931 haemagglutination Effects 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 238000004220 aggregation Methods 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- -1 antibodies Proteins 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 238000002306 biochemical method Methods 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 108010018927 conglutinin Proteins 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- QCUFYOBGGZSFHY-UHFFFAOYSA-N depsidomycin Chemical compound O=C1C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(NC=O)C(C)CC)C(C)OC(=O)C2CCCNN2C(=O)C(CC(C)C)NC(=O)C2CCCNN21 QCUFYOBGGZSFHY-UHFFFAOYSA-N 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 208000007475 hemolytic anemia Diseases 0.000 description 2
- 230000002452 interceptive effect Effects 0.000 description 2
- 230000003834 intracellular effect Effects 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920000136 polysorbate Polymers 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 230000009870 specific binding Effects 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- MEXAGTSTSPYCEP-NUBCRITNSA-N (2r)-2,6-diaminohexanoic acid;hydrobromide Polymers Br.NCCCC[C@@H](N)C(O)=O MEXAGTSTSPYCEP-NUBCRITNSA-N 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 101710088235 Envelope glycoprotein C homolog Proteins 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- 102000006395 Globulins Human genes 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical group O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 206010022822 Intravascular haemolysis Diseases 0.000 description 1
- 108090001090 Lectins Proteins 0.000 description 1
- 102000004856 Lectins Human genes 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 102100038567 Properdin Human genes 0.000 description 1
- 108010005642 Properdin Proteins 0.000 description 1
- 238000005411 Van der Waals force Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000003416 augmentation Effects 0.000 description 1
- 238000013142 basic testing Methods 0.000 description 1
- HODFCFXCOMKRCG-UHFFFAOYSA-N bitolterol mesylate Chemical compound CS([O-])(=O)=O.C1=CC(C)=CC=C1C(=O)OC1=CC=C(C(O)C[NH2+]C(C)(C)C)C=C1OC(=O)C1=CC=C(C)C=C1 HODFCFXCOMKRCG-UHFFFAOYSA-N 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 230000009137 competitive binding Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical group BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 229960000587 glutaral Drugs 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000016178 immune complex formation Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 229940088592 immunologic factor Drugs 0.000 description 1
- 239000000367 immunologic factor Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 239000002523 lectin Substances 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 231100000355 lymphocytotoxic Toxicity 0.000 description 1
- 230000001391 lymphocytotoxic effect Effects 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000003068 molecular probe Substances 0.000 description 1
- 238000009828 non-uniform distribution Methods 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 238000000424 optical density measurement Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000012017 passive hemagglutination assay Methods 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229920000867 polyelectrolyte Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 229950008679 protamine sulfate Drugs 0.000 description 1
- 229940070376 protein Drugs 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 230000000405 serological effect Effects 0.000 description 1
- 229940076279 serotonin Drugs 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Optical Measuring Cells (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60480875A | 1975-08-14 | 1975-08-14 | |
| US604,808 | 1975-08-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1089359A true CA1089359A (en) | 1980-11-11 |
Family
ID=24421139
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA259,042A Expired CA1089359A (en) | 1975-08-14 | 1976-08-13 | Blood cell typing and compatibility test by solid phase immunoadsorbtion |
Country Status (14)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0015473A1 (de) * | 1979-02-28 | 1980-09-17 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Verfahren zum Immobilisieren von Zellen |
| NZ194251A (en) * | 1979-07-13 | 1983-06-17 | Ortho Diagnostics | Rapid determination of antigens on red blood cells and reagent therefor |
| DE8137962U1 (de) * | 1981-12-28 | 1982-06-16 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | Mikrotiterplatte zur blutgruppendiagnostik |
| JPS63172963A (ja) * | 1986-11-14 | 1988-07-16 | ロバート エイ．レビン | 生物学的粒子の検出方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL89406C (enrdf_load_stackoverflow) * | 1951-07-28 | |||
| SE341239B (enrdf_load_stackoverflow) * | 1967-09-06 | 1971-12-20 | Pharmacia Ab | |
| US3732410A (en) * | 1969-12-22 | 1973-05-08 | Postmaster Department Res Labo | Self adaptive filter and control circuit therefor |
| US3666421A (en) * | 1971-04-05 | 1972-05-30 | Organon | Diagnostic test slide |
| US3770380A (en) * | 1971-04-19 | 1973-11-06 | Us Army | Article and method for multiple immune adherence assay |
| CA1025772A (en) * | 1972-06-26 | 1978-02-07 | Ivar Giaever | Method and apparatus for detection and purification of proteins and antibodies |
| BR7405744D0 (pt) * | 1973-08-15 | 1975-05-27 | Gen Electric | Processo para aperfeicoamento da detectacao da sensibilidade de laminas de diagnostico imunologico |
| US3904367A (en) * | 1973-08-15 | 1975-09-09 | Gen Electric | Contrast enhancement for immunological film detection |
-
1976
- 1976-08-10 GB GB33231/76A patent/GB1555142A/en not_active Expired
- 1976-08-12 NO NO762801A patent/NO153987C/no unknown
- 1976-08-12 DK DK364876AA patent/DK153425B/da not_active Application Discontinuation
- 1976-08-13 DE DE19762636616 patent/DE2636616A1/de active Granted
- 1976-08-13 SE SE7609089A patent/SE7609089L/ not_active Application Discontinuation
- 1976-08-13 AT AT604776A patent/AT357686B/de not_active IP Right Cessation
- 1976-08-13 CA CA259,042A patent/CA1089359A/en not_active Expired
- 1976-08-13 CH CH1034176A patent/CH631550A5/de not_active IP Right Cessation
- 1976-08-13 ZA ZA00764880A patent/ZA764880B/xx unknown
- 1976-08-13 AU AU16840/76A patent/AU510384B2/en not_active Expired
- 1976-08-13 FR FR7624793A patent/FR2321127A1/fr active Granted
- 1976-08-13 NL NL7609061A patent/NL7609061A/xx not_active Application Discontinuation
- 1976-08-13 BE BE169825A patent/BE845201A/xx not_active IP Right Cessation
- 1976-08-13 IT IT50901/76A patent/IT1076463B/it active
-
1984
- 1984-01-13 NO NO840135A patent/NO153988C/no unknown
-
1985
- 1985-07-10 SE SE8503429A patent/SE8503429D0/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO762801L (enrdf_load_stackoverflow) | 1977-02-15 |
| FR2321127A1 (fr) | 1977-03-11 |
| SE8503429L (sv) | 1985-07-10 |
| NO153987B (no) | 1986-03-17 |
| NO153987C (no) | 1986-06-25 |
| NO153988C (no) | 1986-06-25 |
| DE2636616C2 (enrdf_load_stackoverflow) | 1987-10-29 |
| NL7609061A (nl) | 1977-02-16 |
| IT1076463B (it) | 1985-04-27 |
| AU1684076A (en) | 1978-02-16 |
| ZA764880B (en) | 1978-03-29 |
| DK364876A (da) | 1977-02-15 |
| SE7609089L (sv) | 1977-02-15 |
| NO840135L (no) | 1977-02-15 |
| SE8503429D0 (sv) | 1985-07-10 |
| AT357686B (de) | 1980-07-25 |
| BE845201A (fr) | 1977-02-14 |
| ATA604776A (de) | 1979-12-15 |
| FR2321127B1 (enrdf_load_stackoverflow) | 1982-02-26 |
| DK153425B (da) | 1988-07-11 |
| CH631550A5 (en) | 1982-08-13 |
| DE2636616A1 (de) | 1977-02-24 |
| NO153988B (no) | 1986-03-17 |
| GB1555142A (en) | 1979-11-07 |
| AU510384B2 (en) | 1980-06-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |