CA1083141A - Cephalosporin displacement reaction - Google Patents

Cephalosporin displacement reaction

Info

Publication number
CA1083141A
CA1083141A CA298,070A CA298070A CA1083141A CA 1083141 A CA1083141 A CA 1083141A CA 298070 A CA298070 A CA 298070A CA 1083141 A CA1083141 A CA 1083141A
Authority
CA
Canada
Prior art keywords
methyl
acetamido
thio
cephem
thiol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA298,070A
Other languages
English (en)
French (fr)
Inventor
Lowell D. Hatfield
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/862,871 external-priority patent/US4144391A/en
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of CA1083141A publication Critical patent/CA1083141A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA298,070A 1977-03-07 1978-03-02 Cephalosporin displacement reaction Expired CA1083141A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US77501877A 1977-03-07 1977-03-07
US862,871 1977-12-27
US05/862,871 US4144391A (en) 1977-03-07 1977-12-27 Cephalosporin displacement reaction
US775,018 1991-10-11

Publications (1)

Publication Number Publication Date
CA1083141A true CA1083141A (en) 1980-08-05

Family

ID=27118982

Family Applications (1)

Application Number Title Priority Date Filing Date
CA298,070A Expired CA1083141A (en) 1977-03-07 1978-03-02 Cephalosporin displacement reaction

Country Status (30)

Country Link
JP (1) JPS53130689A (ja)
AT (1) AT366696B (ja)
AU (1) AU515428B2 (ja)
BG (1) BG31379A3 (ja)
CA (1) CA1083141A (ja)
CH (1) CH637964A5 (ja)
CS (1) CS205115B2 (ja)
CY (1) CY1196A (ja)
DD (1) DD137356A5 (ja)
DE (1) DE2809058A1 (ja)
DK (1) DK97378A (ja)
EG (1) EG13454A (ja)
ES (1) ES467637A1 (ja)
FI (1) FI69309C (ja)
FR (1) FR2383189A1 (ja)
GB (1) GB1597036A (ja)
GR (1) GR68893B (ja)
HK (1) HK49083A (ja)
HU (1) HU179967B (ja)
IE (1) IE46437B1 (ja)
IL (1) IL54181A (ja)
IT (1) IT1093504B (ja)
MX (1) MX5142E (ja)
NL (1) NL190703C (ja)
NZ (1) NZ186610A (ja)
PH (1) PH14596A (ja)
PL (1) PL122152B1 (ja)
PT (1) PT67732A (ja)
SE (1) SE437991B (ja)
YU (1) YU51478A (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011103686A1 (en) * 2010-02-26 2011-09-01 Viswanatha , Sundaramma CEPHALOSPORIN DERIVATIVES USEFUL AS β-LACTAMASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5543043A (en) * 1978-09-22 1980-03-26 Sankyo Co Ltd Preparation of 3-substituted thiomethylcephalosporin derivative
US4576937A (en) * 1984-02-29 1986-03-18 Smithkline Beckman Corporation 7-D-Mandelamido-3(1-sulfomethyltetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid monosodium salt
GB8519606D0 (en) * 1985-08-05 1985-09-11 Fujisawa Pharmaceutical Co 3 7-d substituted-3-cephem compounds
JP2503500B2 (ja) * 1986-04-14 1996-06-05 萬有製薬株式会社 新規セフアロスポリン誘導体及びその製造法
JPS62281881A (ja) * 1986-09-08 1987-12-07 Sankyo Co Ltd ３−置換チオメチルセフアロスポリン誘導体の製法
GB201818410D0 (en) * 2018-11-12 2018-12-26 Imperial Innovations Ltd Compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3641021A (en) * 1969-04-18 1972-02-08 Lilly Co Eli 3 7-(ring-substituted) cephalosporin compounds
JPS5116436B1 (ja) * 1971-05-31 1976-05-24
JPS5143785A (en) * 1974-10-11 1976-04-14 Yamanouchi Pharma Co Ltd Shinsefuarosuhorinkanrenkagobutsuno goseiho
JPS612674B2 (ja) * 1974-06-20 1986-01-27 Meiji Seika Co
CA1100129A (en) * 1974-08-02 1981-04-28 William H.W. Lunn Cephalosporin compounds
FI761035A (ja) * 1975-04-21 1976-10-22 Erba Carlo Spa

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011103686A1 (en) * 2010-02-26 2011-09-01 Viswanatha , Sundaramma CEPHALOSPORIN DERIVATIVES USEFUL AS β-LACTAMASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF

Also Published As

Publication number Publication date
PL122152B1 (en) 1982-06-30
CS205115B2 (en) 1981-04-30
CY1196A (en) 1983-12-31
HU179967B (en) 1983-01-28
IL54181A (en) 1981-03-31
PL205135A1 (pl) 1979-06-04
GR68893B (ja) 1982-03-15
JPH025758B2 (ja) 1990-02-05
EG13454A (en) 1981-12-31
NL190703C (nl) 1994-07-01
SE437991B (sv) 1985-03-25
DE2809058A1 (de) 1978-09-14
PT67732A (en) 1978-04-01
AT366696B (de) 1982-04-26
FR2383189A1 (fr) 1978-10-06
FR2383189B1 (ja) 1981-06-26
GB1597036A (en) 1981-09-03
IT7820912A0 (it) 1978-03-06
SE7802530L (sv) 1978-09-08
IT1093504B (it) 1985-07-19
AU3382878A (en) 1979-09-06
AU515428B2 (en) 1981-04-02
BG31379A3 (en) 1981-12-15
NL7802376A (nl) 1978-09-11
NL190703B (nl) 1994-02-01
HK49083A (en) 1983-11-04
ATA150778A (de) 1981-09-15
DK97378A (da) 1978-09-08
FI69309C (fi) 1986-01-10
DD137356A5 (de) 1979-08-29
ES467637A1 (es) 1980-04-01
PH14596A (en) 1981-10-02
IE780453L (en) 1978-09-07
FI69309B (fi) 1985-09-30
DE2809058C2 (ja) 1989-02-09
IL54181A0 (en) 1978-06-15
JPS53130689A (en) 1978-11-14
YU51478A (en) 1982-10-31
CH637964A5 (en) 1983-08-31
MX5142E (es) 1983-03-30
IE46437B1 (en) 1983-06-15
FI780716A (fi) 1978-09-08
NZ186610A (en) 1979-11-01

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Legal Events

Date Code Title Description
MKEX Expiry