CA1082179A - Amide derivatives of vlb, leurosidine, leurocristine and related dimeric alkaloids - Google Patents
Amide derivatives of vlb, leurosidine, leurocristine and related dimeric alkaloidsInfo
- Publication number
- CA1082179A CA1082179A CA284,711A CA284711A CA1082179A CA 1082179 A CA1082179 A CA 1082179A CA 284711 A CA284711 A CA 284711A CA 1082179 A CA1082179 A CA 1082179A
- Authority
- CA
- Canada
- Prior art keywords
- desacetyl vlb
- vlb
- formula
- desacetyl
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72165076A | 1976-09-08 | 1976-09-08 | |
| US721,650 | 1976-09-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1082179A true CA1082179A (en) | 1980-07-22 |
Family
ID=24898757
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA284,711A Expired CA1082179A (en) | 1976-09-08 | 1977-08-15 | Amide derivatives of vlb, leurosidine, leurocristine and related dimeric alkaloids |
Country Status (27)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE30561E (en) * | 1976-12-06 | 1981-03-31 | Eli Lilly And Company | Vinca alkaloid intermediates |
| US4199504A (en) * | 1978-05-15 | 1980-04-22 | Eli Lilly And Company | Bridged cathranthus alkaloid dimers |
| AR225153A1 (es) * | 1978-10-10 | 1982-02-26 | Lilly Co Eli | Un procedimiento para la preparacion de sulfato de vindesina |
| US4357334A (en) | 1980-03-20 | 1982-11-02 | Eli Lilly And Company | Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms |
| OA06421A (fr) * | 1980-06-10 | 1981-09-30 | Omnium Chimique Sa | Procédé de préparation de dérivés N-(vinblastinoyl-23) d'acides aminés et de peptides. |
| US4362664A (en) * | 1980-12-29 | 1982-12-07 | Eli Lilly And Company | Vinblastine oxazolidinedione disulfides and related compounds |
| CA1335686C (fr) * | 1986-01-13 | 1995-05-23 | Rao K. S. P. Bhushana | Vinblastine et composition pharmaceutique les contenant |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR204004A1 (es) * | 1973-04-02 | 1975-11-12 | Lilly Co Eli | Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina |
| IL48685A (en) * | 1975-01-09 | 1980-03-31 | Lilly Co Eli | Amides of vincadioline and vinblastine |
-
1977
- 1977-08-10 GR GR54126A patent/GR69783B/el unknown
- 1977-08-15 IE IE1700/77A patent/IE45558B1/en not_active IP Right Cessation
- 1977-08-15 CA CA284,711A patent/CA1082179A/en not_active Expired
- 1977-08-15 IL IL52731A patent/IL52731A0/xx not_active IP Right Cessation
- 1977-08-16 NZ NZ184932A patent/NZ184932A/xx unknown
- 1977-08-17 ZA ZA00774988A patent/ZA774988B/xx unknown
- 1977-08-19 AU AU28039/77A patent/AU511055B2/en not_active Expired
- 1977-09-01 DE DE19772739443 patent/DE2739443A1/de active Granted
- 1977-09-01 PL PL1977200607A patent/PL104309B1/pl not_active IP Right Cessation
- 1977-09-01 PT PT66984A patent/PT66984B/pt unknown
- 1977-09-01 AR AR269062A patent/AR226411A1/es active
- 1977-09-02 PH PH20192A patent/PH14771A/en unknown
- 1977-09-02 GB GB36691/77A patent/GB1586709A/en not_active Expired
- 1977-09-02 YU YU02097/77A patent/YU209777A/xx unknown
- 1977-09-06 RO RO7798857A patent/RO77922A/ro unknown
- 1977-09-06 RO RO7798856A patent/RO77921A/ro unknown
- 1977-09-06 NL NL7709806A patent/NL7709806A/xx not_active Application Discontinuation
- 1977-09-06 CH CH1089377A patent/CH631990A5/de not_active IP Right Cessation
- 1977-09-07 DK DK398577A patent/DK146822C/da not_active IP Right Cessation
- 1977-09-07 RO RO7791544A patent/RO72474A/ro unknown
- 1977-09-07 SE SE7710059A patent/SE434953B/xx not_active IP Right Cessation
- 1977-09-07 HU HU77EI762A patent/HU180722B/hu unknown
- 1977-09-07 AT AT644277A patent/AT360513B/de not_active IP Right Cessation
- 1977-09-07 MX MX776104U patent/MX4740E/es unknown
- 1977-09-07 BE BE1008362A patent/BE858451A/xx not_active IP Right Cessation
- 1977-09-07 FR FR7727080A patent/FR2364220A1/fr active Granted
- 1977-09-08 ES ES462229A patent/ES462229A1/es not_active Expired
- 1977-09-08 JP JP10834477A patent/JPS5340799A/ja active Granted
- 1977-09-08 DD DD7700200940A patent/DD133055A5/xx unknown
-
1979
- 1979-07-25 AR AR277455A patent/AR230642A1/es active
- 1979-07-25 AR AR277456A patent/AR231643A1/es active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4203898A (en) | Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids | |
| US4166810A (en) | Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide | |
| CA1042428A (en) | Amide derivatives of vlb and leurocristine | |
| CA1082179A (en) | Amide derivatives of vlb, leurosidine, leurocristine and related dimeric alkaloids | |
| CA1067073A (en) | Amide derivatives of vlb, leurosidine, leurocristine and related dimeric alkaloid | |
| US4191688A (en) | Amides of leurosine, leuroformine, desacetylleurosine and desacetylleuroformine | |
| US4096148A (en) | Oxazolidinedione derivatives of Vinca alkaloids | |
| IL42730A (en) | D-6-methyl-2,8-disubstituted ergolines,their preparation and pharmaceutical compositions containing them | |
| US4115388A (en) | 3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds | |
| US4199504A (en) | Bridged cathranthus alkaloid dimers | |
| KR810001453B1 (ko) | 인돌-디하이드로인돌 카복스 아마이드 이량체의 제조방법 | |
| USRE30561E (en) | Vinca alkaloid intermediates | |
| US4160767A (en) | Vinca alkaloid intermediates | |
| FR2517680A1 (fr) | Derives n-(vinblastinoyl-23) d'acides amines, leur preparation et leur application therapeutique | |
| USRE30560E (en) | Oxazolidinedione derivatives of Vinca alkaloids | |
| CH641803A5 (fr) | 2-azaergolines et 2-aza-8(ou 9)ergolenes, et composition pharmaceutique les contenant. | |
| US4110330A (en) | 5'-Acetonylvincristine and related compounds | |
| KR790000810B1 (ko) | 빈브라스틴 유도체의 제조방법 | |
| CA1121815A (en) | Bridged catharanthus alkaloid dimers | |
| IE42132B1 (en) | Novel derivatives of vinblastine,vincristine and leurosidine | |
| KR820001241B1 (ko) | 4-데스아세틸 vlb c-3카복스하이드라지드의 항종양유도체 제조방법 | |
| KR820001240B1 (ko) | 4-데스 아세틸 vlb c-3카복스하이드라지드의 항종양 유도체 제조방법 | |
| CA1127153A (en) | Bridged catharanthus alkaloid dimers | |
| US4357334A (en) | Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms | |
| US4159269A (en) | Preparation of oxazolidinedione derivatives of Vinca alkaloids |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |