CA1078846A - Derivatives of 2-iminothiazolidines and thiazolines - Google Patents

Derivatives of 2-iminothiazolidines and thiazolines

Info

Publication number
CA1078846A
CA1078846A CA277,184A CA277184A CA1078846A CA 1078846 A CA1078846 A CA 1078846A CA 277184 A CA277184 A CA 277184A CA 1078846 A CA1078846 A CA 1078846A
Authority
CA
Canada
Prior art keywords
carbon atoms
compound
lower alkyl
formula
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA277,184A
Other languages
English (en)
French (fr)
Inventor
Clarence S. Rooney
Joshua Rokach
Edward J. Cragoe (Jr.)
George Gal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of CA1078846A publication Critical patent/CA1078846A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/18—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/39—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
    • C07C205/42—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/43—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/16—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CA277,184A 1976-05-03 1977-04-27 Derivatives of 2-iminothiazolidines and thiazolines Expired CA1078846A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68287676A 1976-05-03 1976-05-03

Publications (1)

Publication Number Publication Date
CA1078846A true CA1078846A (en) 1980-06-03

Family

ID=24741558

Family Applications (1)

Application Number Title Priority Date Filing Date
CA277,184A Expired CA1078846A (en) 1976-05-03 1977-04-27 Derivatives of 2-iminothiazolidines and thiazolines

Country Status (24)

Country Link
JP (1) JPS52133981A (enExample)
AU (1) AU508889B2 (enExample)
BE (1) BE854172A (enExample)
CA (1) CA1078846A (enExample)
CH (1) CH629490A5 (enExample)
DE (1) DE2719577A1 (enExample)
DK (1) DK173777A (enExample)
ES (2) ES458237A1 (enExample)
FI (1) FI771285A7 (enExample)
FR (1) FR2350351A1 (enExample)
GB (1) GB1534242A (enExample)
HU (1) HU180504B (enExample)
IE (1) IE46011B1 (enExample)
IL (1) IL51935A (enExample)
IT (1) IT1082657B (enExample)
LU (1) LU77243A1 (enExample)
NL (1) NL7704322A (enExample)
NO (1) NO146061C (enExample)
NZ (1) NZ183941A (enExample)
PH (1) PH14030A (enExample)
PL (1) PL123449B1 (enExample)
SE (1) SE7704594L (enExample)
YU (1) YU111677A (enExample)
ZA (1) ZA772614B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU188852B (en) * 1983-03-16 1986-05-28 Richter Gedeon Vegyeszeti Gyar Rt,Hu Process for producing thiazolidine derivatives active against gastric ulcer and intestinal ulcer
US5555162A (en) * 1994-04-26 1996-09-10 Sylvan R. Shemitz Designs, Inc. Compact fluorescent luminaire
USRE37310E1 (en) 1994-12-06 2001-08-07 Sylvan R. Shemitz Designs, Inc. Compact fluorescent luminaire
FR2748023B1 (fr) * 1996-04-30 1998-07-24 Rhone Poulenc Chimie Hydrogenofluorosulfonates de base organique, leur utilisation pour liberer les bases organiques de leur fluorhydrate, leur procede de preparation, compositions les comportant

Also Published As

Publication number Publication date
JPS52133981A (en) 1977-11-09
BE854172A (fr) 1977-11-03
IT1082657B (it) 1985-05-21
CH629490A5 (en) 1982-04-30
IE46011L (en) 1977-11-03
HU180504B (en) 1983-03-28
NO146061C (no) 1982-07-28
SE7704594L (sv) 1977-11-04
FR2350351B1 (enExample) 1979-03-02
ES468377A1 (es) 1978-12-16
DE2719577A1 (de) 1977-11-24
NO146061B (no) 1982-04-13
FI771285A7 (enExample) 1977-11-04
GB1534242A (en) 1978-11-29
ZA772614B (en) 1978-12-27
LU77243A1 (enExample) 1977-12-13
YU111677A (en) 1983-01-21
PL123449B1 (en) 1982-10-30
IL51935A0 (en) 1977-06-30
NZ183941A (en) 1980-12-19
IE46011B1 (en) 1983-01-26
AU2463077A (en) 1978-11-02
NL7704322A (nl) 1977-11-07
PH14030A (en) 1980-12-12
DK173777A (da) 1977-11-04
FR2350351A1 (fr) 1977-12-02
NO771375L (no) 1977-11-04
AU508889B2 (en) 1980-04-03
ES458237A1 (es) 1978-07-01
IL51935A (en) 1981-07-31

Similar Documents

Publication Publication Date Title
JP3179515B2 (ja) ２−クロロチアゾール類の製造方法
US4443466A (en) 4-Benzyl- and 4-benzoyl-substituted imidazole derivatives and use as medicaments
EP0052442B1 (en) Heterocyclic compounds
CA1248110A (en) Piperazine derivatives, processes for production thereof, and pharmaceutical compositions comprising said compounds as active ingredient
US4174397A (en) Thiazolidine derivatives
US4181661A (en) Derivatives of 2-iminothiazolidines and thiazolines
IE911439A1 (en) Therapeutic N-(2-Biphenylyl)guanidine derivatives
CA1078846A (en) Derivatives of 2-iminothiazolidines and thiazolines
HU200322B (en) Process for producing new alkane sulfonanilide derivatives
HU211520A9 (en) Tetrazole derivatives and aldose reductase inhibition therewith
US4022783A (en) Piperazinyl-imidazolines
US3957772A (en) Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2h-1,2-benzothiazine 1,1-dioxide
Belwal et al. Synthesis and antifungal activity of some novel thiazolidinone derivatives of 4-(4-oxo-2-phenylthiazolidin-3-yl) benzoic acid
US4378366A (en) 2-[Trifluoroethylamine]oxazolines
HU176820B (en) Process for preparing phenyl-piperazine derivatives
US4049650A (en) 1-[[[5-(Substituted phenyl)-2-oxazolyl]methylene]amino]-2,4-imidazolidinediones
US3574210A (en) 2,4-disubstituted-6-nitro-and 6-a minoquinazolines
US3187001A (en) Certain 2, 1-benzisothiazole compounds
US4022766A (en) Pharmacologically active pyrrolodiazepines
JPS59225172A (ja) 新規グアニジノチアゾ−ル誘導体及びその製法
US3211746A (en) Guanylhydrazones of biguanidoarylketones
US3413303A (en) Aralkenyloxyguanidines
US3136764A (en) Tetrahalocyclopentadienyldiamine compounds
US4975462A (en) Antiarthritic α-arylcarbamoyl cyanoacetic acid derivatives
HU196064B (en) Process for production of 1,3,4-tiadiasole-derivatives and medical preparatives containing such compositions

Legal Events

Date Code Title Description
MKEX Expiry