CA1077842A - Albumin medicament carrier system - Google Patents
Albumin medicament carrier systemInfo
- Publication number
- CA1077842A CA1077842A CA260,288A CA260288A CA1077842A CA 1077842 A CA1077842 A CA 1077842A CA 260288 A CA260288 A CA 260288A CA 1077842 A CA1077842 A CA 1077842A
- Authority
- CA
- Canada
- Prior art keywords
- medicament
- spherules
- drug
- albumin
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- 108010088751 Albumins Proteins 0.000 title claims description 47
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- 230000002792 vascular Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- SYOKIDBDQMKNDQ-XWTIBIIYSA-N vildagliptin Chemical compound C1C(O)(C2)CC(C3)CC1CC32NCC(=O)N1CCC[C@H]1C#N SYOKIDBDQMKNDQ-XWTIBIIYSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2989—Microcapsule with solid core [includes liposome]
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62114575A | 1975-10-09 | 1975-10-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1077842A true CA1077842A (en) | 1980-05-20 |
Family
ID=24488920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA260,288A Expired CA1077842A (en) | 1975-10-09 | 1976-08-31 | Albumin medicament carrier system |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4147767A (enExample) |
| JP (1) | JPS5247912A (enExample) |
| AU (1) | AU513080B2 (enExample) |
| CA (1) | CA1077842A (enExample) |
| CH (1) | CH629666A5 (enExample) |
| DE (1) | DE2645553C2 (enExample) |
| FR (1) | FR2326934A1 (enExample) |
| GB (1) | GB1567763A (enExample) |
| SE (1) | SE443086B (enExample) |
Cited By (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5401516A (en) * | 1992-12-21 | 1995-03-28 | Emisphere Technologies, Inc. | Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof |
| US5447728A (en) * | 1992-06-15 | 1995-09-05 | Emisphere Technologies, Inc. | Desferrioxamine oral delivery system |
| US5451410A (en) * | 1993-04-22 | 1995-09-19 | Emisphere Technologies, Inc. | Modified amino acids for encapsulating active agents |
| US5541155A (en) | 1994-04-22 | 1996-07-30 | Emisphere Technologies, Inc. | Acids and acid salts and their use in delivery systems |
| US5578323A (en) | 1992-06-15 | 1996-11-26 | Emisphere Technologies, Inc. | Proteinoid carriers and methods for preparation and use thereof |
| US5601846A (en) | 1992-06-15 | 1997-02-11 | Emisphere Technologies, Inc. | Proteinoid microspheres and methods for preparation and use thereof |
| US5629020A (en) * | 1994-04-22 | 1997-05-13 | Emisphere Technologies, Inc. | Modified amino acids for drug delivery |
| US5643957A (en) | 1993-04-22 | 1997-07-01 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5650386A (en) | 1995-03-31 | 1997-07-22 | Emisphere Technologies, Inc. | Compositions for oral delivery of active agents |
| US5667806A (en) | 1995-06-07 | 1997-09-16 | Emisphere Technologies, Inc. | Spray drying method and apparatus |
| US5693338A (en) | 1994-09-29 | 1997-12-02 | Emisphere Technologies, Inc. | Diketopiperazine-based delivery systems |
| US5709861A (en) | 1993-04-22 | 1998-01-20 | Emisphere Technologies, Inc. | Compositions for the delivery of antigens |
| US5714167A (en) | 1992-06-15 | 1998-02-03 | Emisphere Technologies, Inc. | Active agent transport systems |
| US5750147A (en) | 1995-06-07 | 1998-05-12 | Emisphere Technologies, Inc. | Method of solubilizing and encapsulating itraconazole |
| US5766633A (en) | 1993-04-22 | 1998-06-16 | Emisphere Technologies, Inc. | Oral drug delivery compositions and methods |
| USRE35862E (en) * | 1986-08-18 | 1998-07-28 | Emisphere Technologies, Inc. | Delivery systems for pharmacological agents encapsulated with proteinoids |
| US5792451A (en) | 1994-03-02 | 1998-08-11 | Emisphere Technologies, Inc. | Oral drug delivery compositions and methods |
| US5804688A (en) | 1997-02-07 | 1998-09-08 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5811127A (en) | 1992-06-15 | 1998-09-22 | Emisphere Technologies, Inc. | Desferrioxamine oral delivery system |
| US5820881A (en) | 1995-04-28 | 1998-10-13 | Emisphere Technologies, Inc. | Microspheres of diamide-dicarboxylic acids |
| US5824345A (en) | 1995-06-07 | 1998-10-20 | Emisphere Technologies, Inc. | Fragrances and flavorants |
| US5863944A (en) | 1997-04-30 | 1999-01-26 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5866536A (en) | 1995-03-31 | 1999-02-02 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5876710A (en) | 1997-02-07 | 1999-03-02 | Emisphere Technologies Inc. | Compounds and compositions for delivering active agents |
| US5879681A (en) | 1997-02-07 | 1999-03-09 | Emisphere Technolgies Inc. | Compounds and compositions for delivering active agents |
| US5939381A (en) | 1997-02-07 | 1999-08-17 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5958457A (en) | 1993-04-22 | 1999-09-28 | Emisphere Technologies, Inc. | Compositions for the delivery of antigens |
| US5962710A (en) | 1997-05-09 | 1999-10-05 | Emisphere Technologies, Inc. | Method of preparing salicyloylamino acids |
| US5965121A (en) | 1995-03-31 | 1999-10-12 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5990166A (en) | 1997-02-07 | 1999-11-23 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5989539A (en) | 1995-03-31 | 1999-11-23 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US6001347A (en) | 1995-03-31 | 1999-12-14 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US6051258A (en) | 1995-06-07 | 2000-04-18 | Emisphere Technologies, Inc. | Proteinoid emulsions and methods for preparation and use thereof |
| US6060513A (en) | 1997-02-07 | 2000-05-09 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US6071510A (en) | 1995-03-31 | 2000-06-06 | Emisphere Technologies, Inc. | Modified amino acids and compositions comprising the same for delivering active agents |
| US6084112A (en) | 1995-09-11 | 2000-07-04 | Emisphere Technologies, Inc. | Method for preparing ω-aminoalkanoic acid derivatives from cycloalkanones |
| US6090958A (en) | 1995-03-31 | 2000-07-18 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US6099856A (en) | 1992-06-15 | 2000-08-08 | Emisphere Technologies, Inc. | Active agent transport systems |
| US6221367B1 (en) | 1992-06-15 | 2001-04-24 | Emisphere Technologies, Inc. | Active agent transport systems |
| US6242495B1 (en) | 1997-02-07 | 2001-06-05 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US6331318B1 (en) | 1994-09-30 | 2001-12-18 | Emisphere Technologies Inc. | Carbon-substituted diketopiperazine delivery systems |
| US6375983B1 (en) | 1996-06-14 | 2002-04-23 | Emisphere Technologies, Inc. | Microencapsulated fragrances and method for preparation |
| US7553872B2 (en) | 1997-02-07 | 2009-06-30 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
Families Citing this family (107)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4357259A (en) * | 1977-08-01 | 1982-11-02 | Northwestern University | Method of incorporating water-soluble heat-sensitive therapeutic agents in albumin microspheres |
| US4129659A (en) * | 1977-08-08 | 1978-12-12 | The University Of Miami | Method for improving cardiovascular function with salinomycin |
| US4345588A (en) * | 1979-04-23 | 1982-08-24 | Northwestern University | Method of delivering a therapeutic agent to a target capillary bed |
| US4247406A (en) | 1979-04-23 | 1981-01-27 | Widder Kenneth J | Intravascularly-administrable, magnetically-localizable biodegradable carrier |
| US4331654A (en) | 1980-06-13 | 1982-05-25 | Eli Lilly And Company | Magnetically-localizable, biodegradable lipid microspheres |
| JPS5726625A (en) * | 1980-07-24 | 1982-02-12 | Japan Atom Energy Res Inst | Sustained release type composite material entrapping medical enzyme and its preparation |
| US4349530A (en) | 1980-12-11 | 1982-09-14 | The Ohio State University | Implants, microbeads, microcapsules, preparation thereof and method of administering a biologically-active substance to an animal |
| JPS57144082U (enExample) * | 1981-03-04 | 1982-09-09 | ||
| JPS5811833A (ja) * | 1981-07-15 | 1983-01-22 | Hitachi Zosen Corp | スラリ−濃度計測装置 |
| FR2520229A1 (fr) * | 1982-01-26 | 1983-07-29 | Japan Atomic Energy Res Inst | Procede de production d'un compose a degagement lent |
| DE3360633D1 (en) * | 1982-02-12 | 1985-10-03 | Unitika Ltd | Anti-cancer device |
| JPS58162595A (ja) * | 1982-03-19 | 1983-09-27 | Green Cross Corp:The | 徐放性アルブミン複合体の製法 |
| US4798786A (en) * | 1982-05-06 | 1989-01-17 | Stolle Research And Development Corporation | Living cells encapsulated in crosslinked protein |
| US4622219A (en) * | 1983-06-17 | 1986-11-11 | Haynes Duncan H | Method of inducing local anesthesia using microdroplets of a general anesthetic |
| DE3376660D1 (en) * | 1983-06-22 | 1988-06-23 | Stolle Res & Dev | Encapsulated cells, their method of preparation and use |
| US4671954A (en) * | 1983-12-13 | 1987-06-09 | University Of Florida | Microspheres for incorporation of therapeutic substances and methods of preparation thereof |
| GB2160312B (en) * | 1984-04-13 | 1987-09-16 | South African Inventions | Adjuvant for immunisation |
| FR2565102B1 (fr) * | 1984-06-05 | 1987-03-20 | Paris Sud Universite | Microcapsules biodegradables a base de serumalbumine, leur preparation et leur application a la liberation in situ de medicuments |
| US4789501A (en) * | 1984-11-19 | 1988-12-06 | The Curators Of The University Of Missouri | Glass microspheres |
| CS255758B1 (en) * | 1985-12-11 | 1988-03-15 | Frantisek Rypacek | Preparat for the diagnostic of transportion function of oviduct and process for preparing thereof |
| US5055300A (en) * | 1988-06-17 | 1991-10-08 | Basic Bio Systems, Inc. | Time release protein |
| US5023080A (en) * | 1988-06-17 | 1991-06-11 | Basic Bio Systems, Inc. | Time release protein |
| FR2635459B1 (fr) * | 1988-08-17 | 1992-06-19 | Cird | Procede de fabrication de microspheres par reticulation de proteines, microspheres ainsi obtenues et leurs utilisations |
| US5084276A (en) * | 1990-01-05 | 1992-01-28 | Abbott Laboratories | Quinolone carboxylic acid compositions with polymeric additive to reduce vein irritation |
| FR2663224B1 (fr) * | 1990-06-14 | 1995-01-20 | Applicationes Farmaceuticas Sa | Forme galenique parenterale. |
| FR2663223B1 (fr) * | 1990-06-14 | 1994-12-02 | Af Aplicaciones Far Lab | Forme galenique parenterale. |
| US5725804A (en) * | 1991-01-15 | 1998-03-10 | Hemosphere, Inc. | Non-crosslinked protein particles for therapeutic and diagnostic use |
| US5616311A (en) * | 1991-01-15 | 1997-04-01 | Hemosphere, Inc. | Non-crosslinked protein particles for therapeutic and diagnostic use |
| US6391343B1 (en) | 1991-01-15 | 2002-05-21 | Hemosphere, Inc. | Fibrinogen-coated particles for therapeutic use |
| US5993805A (en) * | 1991-04-10 | 1999-11-30 | Quadrant Healthcare (Uk) Limited | Spray-dried microparticles and their use as therapeutic vehicles |
| GB9107628D0 (en) * | 1991-04-10 | 1991-05-29 | Moonbrook Limited | Preparation of diagnostic agents |
| AU2572692A (en) | 1991-09-09 | 1993-04-05 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Methods and devices for treating hemophilia and aids |
| US5429822A (en) * | 1992-03-13 | 1995-07-04 | Cambridge Scientific, Inc. | Biodegradable bursting release system |
| US6916489B2 (en) * | 1992-06-15 | 2005-07-12 | Emisphere Technologies, Inc. | Active agent transport systems |
| US7425543B2 (en) * | 1992-11-16 | 2008-09-16 | The Corporation Of Mercer University | Microencapsulated materials and method of making same |
| WO1994010980A1 (en) | 1992-11-16 | 1994-05-26 | Corporation Of Mercer University | Compositions using microencapsulated neutralizing antibodies |
| US5340614A (en) * | 1993-02-11 | 1994-08-23 | Minnesota Mining And Manufacturing Company | Methods of polymer impregnation |
| US20070117862A1 (en) * | 1993-02-22 | 2007-05-24 | Desai Neil P | Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
| US20030133955A1 (en) * | 1993-02-22 | 2003-07-17 | American Bioscience, Inc. | Methods and compositions useful for administration of chemotherapeutic agents |
| US20030068362A1 (en) * | 1993-02-22 | 2003-04-10 | American Bioscience, Inc. | Methods and formulations for the delivery of pharmacologically active agents |
| ES2113094T3 (es) * | 1993-03-09 | 1998-04-16 | Epic Therapeutics Inc | Las microparticulas macromoleculares y metodos de obtencion. |
| US6090925A (en) * | 1993-03-09 | 2000-07-18 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
| US5456917A (en) * | 1993-04-12 | 1995-10-10 | Cambridge Scientific, Inc. | Method for making a bioerodible material for the sustained release of a medicament and the material made from the method |
| US6461643B2 (en) | 1993-04-22 | 2002-10-08 | Emisphere Technologies, Inc. | Oral drug delivery compositions and methods |
| US20010003001A1 (en) * | 1993-04-22 | 2001-06-07 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5739004A (en) * | 1993-05-20 | 1998-04-14 | Minnesota Mining And Manufacturing Company | Biological sterilization indication for use with or without test pack materials or devices |
| AU697044B2 (en) * | 1993-06-14 | 1998-09-24 | Emisphere Technologies, Inc. | Proteinoid carriers |
| GB9423419D0 (en) | 1994-11-19 | 1995-01-11 | Andaris Ltd | Preparation of hollow microcapsules |
| US6214331B1 (en) | 1995-06-06 | 2001-04-10 | C. R. Bard, Inc. | Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained |
| AU6100296A (en) * | 1995-06-06 | 1996-12-24 | Hemosphere, Inc. | Protein particles for therapeutic and diagnostic use |
| ATE386506T1 (de) | 1995-10-17 | 2008-03-15 | Jagotec Ag | Verabreichung unlöslicher arzneistoffe |
| IL126318A (en) | 1996-03-29 | 2004-09-27 | Emisphere Tech Inc | Compounds and compositions for delivering active agents and some novel carrier compounds |
| US6465016B2 (en) | 1996-08-22 | 2002-10-15 | Research Triangle Pharmaceuticals | Cyclosporiine particles |
| US7255877B2 (en) * | 1996-08-22 | 2007-08-14 | Jagotec Ag | Fenofibrate microparticles |
| US6017310A (en) * | 1996-09-07 | 2000-01-25 | Andaris Limited | Use of hollow microcapsules |
| US8137684B2 (en) | 1996-10-01 | 2012-03-20 | Abraxis Bioscience, Llc | Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
| WO1998021951A1 (en) | 1996-11-18 | 1998-05-28 | Emisphere Technologies, Inc. | Methods and compositions for inducing oral tolerance in mammals |
| US6068600A (en) * | 1996-12-06 | 2000-05-30 | Quadrant Healthcare (Uk) Limited | Use of hollow microcapsules |
| EP0964676A1 (en) * | 1997-01-30 | 1999-12-22 | Quadrant Healthcare (UK) Limited | Microparticles and their use in cancer treatment |
| JP2002503254A (ja) | 1997-06-05 | 2002-01-29 | ヘモスフィア，インコーポレイテッド | フィブリノゲンをコーティングしたミクロスフィア |
| PT1023050E (pt) * | 1997-06-27 | 2013-12-04 | Abraxis Bioscience Llc | Novas formulações de agentes farmacológicos, métodos para a sua preparação e métodos para a sua utilização |
| US20030199425A1 (en) * | 1997-06-27 | 2003-10-23 | Desai Neil P. | Compositions and methods for treatment of hyperplasia |
| US6150505A (en) * | 1997-09-19 | 2000-11-21 | Hadasit Medical Research Services & Development Ltd. | Fibrin microbeads prepared from fibrinogen, thrombin and factor XIII |
| DE69908304T2 (de) * | 1998-02-11 | 2004-02-19 | Rtp Pharma Corp. | Ungesättigte fettsäure und steroide enthaltende kombinationspräparate zur behandlung von entzündungen |
| US6979456B1 (en) | 1998-04-01 | 2005-12-27 | Jagotec Ag | Anticancer compositions |
| KR100635456B1 (ko) | 1998-05-29 | 2006-10-18 | 스키에파마 캐나다 인코포레이티드 | 열보호화 마이크로입자 조성물 및 그의 말단의 스팀멸균방법 |
| JP5144861B2 (ja) | 1998-07-27 | 2013-02-13 | エミスフェアー・テクノロジーズ・インク | 活性剤のデリバリーのための化合物及び組成物 |
| US6440929B1 (en) | 1998-07-27 | 2002-08-27 | Emisphere Technologies, Inc. | Pulmonary delivery of active agents |
| US6991798B1 (en) | 1998-08-07 | 2006-01-31 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| IL140930A0 (en) * | 1998-08-07 | 2002-02-10 | Emisphere Tech Inc | Compounds and compositions for delivering active agents |
| DE69912441T2 (de) | 1998-08-19 | 2004-08-19 | Skyepharma Canada Inc., Verdun | Injizierbare wässerige propofoldispersionen |
| GB9819272D0 (en) * | 1998-09-03 | 1998-10-28 | Andaris Ltd | Microparticles |
| IL143197A0 (en) * | 1998-11-20 | 2002-04-21 | Rtp Pharma Inc | Dispersible phospholipid stabilized microparticles |
| DE19858188A1 (de) * | 1998-12-17 | 2000-07-06 | Centeon Pharma Gmbh | Verfahren zum Auflösen von Albuminflocken in einer Flüssigkeit sowie Einrichtung zur Durchführung des Verfahrens |
| JP2002534363A (ja) * | 1999-01-08 | 2002-10-15 | エミスフェアー・テクノロジーズ・インク | ポリマー性デリバリー剤及びデリバリー剤化合物 |
| MXPA01008611A (es) | 1999-02-26 | 2003-06-24 | Emisphere Tech Inc | Compuestos y composiciones para suministrar agentes activos. |
| ES2235854T3 (es) * | 1999-04-05 | 2005-07-16 | Emisphere Technologies, Inc. | Sales disodicas, monohidratos y solvatos etanolicos para aportar agentes activos. |
| AU7984200A (en) * | 1999-09-21 | 2001-04-24 | Skyepharma Canada Inc. | Surface modified particulate compositions of biologically active substances |
| US7129274B1 (en) | 1999-11-05 | 2006-10-31 | Emisphere Technologies Inc. | Phenoxy carboxylic acid compounds and compositions for delivering active agents |
| US7279597B1 (en) | 1999-11-05 | 2007-10-09 | Emisphere Technologies, Inc. | Phenyl amine carboxylic acid compounds and compositions for delivering active agents |
| ES2298168T3 (es) * | 1999-12-16 | 2008-05-16 | Emisphere Technologies, Inc. | Compuestos y composiciones para suministrar agentes activos. |
| EP1276465B1 (en) | 2000-04-20 | 2014-03-12 | Jagotec AG | Improved water-insoluble drug particle process |
| JP4969761B2 (ja) | 2000-08-31 | 2012-07-04 | オバン・エナジー・リミテッド | 所望粒度を持つ固体基材の小粒子および第一材料の小粒状物を含む相乗作用性混合物を製造する方法 |
| EP1320362B1 (en) * | 2000-09-20 | 2011-08-31 | Jagotec AG | Stabilised fibrate microparticles |
| US8586094B2 (en) * | 2000-09-20 | 2013-11-19 | Jagotec Ag | Coated tablets |
| NZ527408A (en) * | 2001-02-22 | 2005-04-29 | Skyepharma Canada Inc | Hydroxymethylglutarylcoenzyme A (HMG CoA) reductase inhibitor (or a statin) and a fibrate in a single effective oral dosage form to treat dyslipidaemia and dyslipoproteinaemia |
| DE10113884B4 (de) * | 2001-03-21 | 2005-06-02 | Basf Coatings Ag | Verfahren zum Beschichten mikroporöser Oberflächen und Verwendung des Verfahrens |
| US20030225300A1 (en) * | 2001-04-19 | 2003-12-04 | Emisphere Technologies Inc. | Compounds and compositions for delivering active agents |
| US6552172B2 (en) | 2001-08-30 | 2003-04-22 | Habto Biotech, Inc. | Fibrin nanoparticles and uses thereof |
| JP2005209106A (ja) * | 2004-01-26 | 2005-08-04 | Nec Corp | 携帯通信端末、受信メール管理方法、プログラムおよび記録媒体 |
| EP1831373A2 (en) * | 2004-12-22 | 2007-09-12 | Novozymes A/S | Recombinant production of serum albumin |
| CN101370634A (zh) * | 2005-02-16 | 2009-02-18 | 亚历山大·R·瓦卡若 | 供植入与药物传递的再吸收中空装置 |
| US11524058B2 (en) | 2008-09-29 | 2022-12-13 | The Corporation Of Mercer University | Oral dissolving films containing microencapsulated vaccines and methods of making same |
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| WO2010037142A1 (en) * | 2008-09-29 | 2010-04-01 | The Corporation Of Mercer University | Nanospheres encapsulating bioactive material and method for formulation of nanospheres |
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| HRP20171364T1 (hr) * | 2012-11-15 | 2017-11-03 | Utah-Inha Dds & Advanced Therapeutics Research Center | Biorazgradive mikrogranule s poboljšanim kapacitetom adsorpcije lijekova protiv raka, koji sadržava albumin i dekstran sulfat, i postupak njihove pripreme |
| EP2926806B1 (en) | 2012-11-27 | 2019-07-03 | Utah-Inha DDS & Advanced Therapeutics Research Center | Biodegradable microbead comprising anionic polymer for improving adsorptive power to anticancer drugs, and method for preparing same |
| US12239822B2 (en) | 2013-03-15 | 2025-03-04 | Windgap Medical, Inc. | Portable drug mixing and delivery device and associated methods |
| EP3082419A4 (en) * | 2013-12-18 | 2017-09-20 | Windgap Medical, Inc. | Drug mixing and delivery system and method |
| US9474834B2 (en) * | 2014-04-11 | 2016-10-25 | Abbott Cardiovascular Systems Inc. | Stent with albumin coating for enhanced thromboresistance |
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| WO2017062463A1 (en) | 2015-10-05 | 2017-04-13 | The Corporation Of Mercer University | Nanospheres encapsulating bioactive material and method for formulation of nanospheres |
| US11628208B2 (en) | 2015-10-05 | 2023-04-18 | The Corporation Of Mercer University | System and method for microneedle delivery of microencapsulated vaccine and bioactive proteins |
| CN109311802B (zh) * | 2016-05-26 | 2022-02-08 | 珠海贝海生物技术有限公司 | 苯丁酸氮芥制剂 |
| CN115887677B (zh) * | 2022-11-03 | 2024-04-12 | 嘉兴学院 | 一种蛋白质仿生胶囊的制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3265630A (en) * | 1958-12-22 | 1966-08-09 | Ncr Co | Encapsulating lipophilic material by coacervation |
| US3265629A (en) * | 1958-12-22 | 1966-08-09 | Ncr Co | Coating by phase separation |
| US3043782A (en) * | 1958-12-22 | 1962-07-10 | Upjohn Co | Process for preparing a more impermeable coating by liquid-liquid phase separation |
| US3533958A (en) * | 1966-07-22 | 1970-10-13 | Ncr Co | Process for making minute capsules |
| US3663685A (en) * | 1968-04-01 | 1972-05-16 | Minnesota Mining & Mfg | Biodegradable radioactive particles |
| US3663686A (en) * | 1968-04-24 | 1972-05-16 | Minnesota Mining & Mfg | Biodegradable radioactive particles |
| US3663687A (en) * | 1968-06-26 | 1972-05-16 | Minnesota Mining & Mfg | Biodegradable parenteral microspherules |
| US3541201A (en) * | 1968-12-18 | 1970-11-17 | Ethan Alan Brown | Novel sodium chloride encapsulated injectionable substances |
| US3937668A (en) * | 1970-07-15 | 1976-02-10 | Ilse Zolle | Method for incorporating substances into protein microspheres |
-
1976
- 1976-08-31 CA CA260,288A patent/CA1077842A/en not_active Expired
- 1976-10-06 SE SE7611064A patent/SE443086B/xx not_active IP Right Cessation
- 1976-10-08 CH CH1276476A patent/CH629666A5/de not_active IP Right Cessation
- 1976-10-08 FR FR7630396A patent/FR2326934A1/fr active Granted
- 1976-10-08 GB GB42007/76A patent/GB1567763A/en not_active Expired
- 1976-10-08 JP JP51121183A patent/JPS5247912A/ja active Granted
- 1976-10-08 DE DE2645553A patent/DE2645553C2/de not_active Expired
- 1976-10-08 AU AU18506/76A patent/AU513080B2/en not_active Expired
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1977
- 1977-09-30 US US05/838,355 patent/US4147767A/en not_active Expired - Lifetime
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Also Published As
| Publication number | Publication date |
|---|---|
| FR2326934A1 (fr) | 1977-05-06 |
| SE443086B (sv) | 1986-02-17 |
| AU513080B2 (en) | 1980-11-13 |
| SE7611064L (sv) | 1977-04-10 |
| CH629666A5 (de) | 1982-05-14 |
| AU1850676A (en) | 1978-04-13 |
| GB1567763A (en) | 1980-05-21 |
| JPS5247912A (en) | 1977-04-16 |
| DE2645553A1 (de) | 1977-04-21 |
| FR2326934B1 (enExample) | 1979-07-20 |
| US4147767A (en) | 1979-04-03 |
| JPH0133445B2 (enExample) | 1989-07-13 |
| DE2645553C2 (de) | 1986-11-06 |
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