JPS5726625A - Sustained release type composite material entrapping medical enzyme and its preparation - Google Patents
Sustained release type composite material entrapping medical enzyme and its preparationInfo
- Publication number
- JPS5726625A JPS5726625A JP10146380A JP10146380A JPS5726625A JP S5726625 A JPS5726625 A JP S5726625A JP 10146380 A JP10146380 A JP 10146380A JP 10146380 A JP10146380 A JP 10146380A JP S5726625 A JPS5726625 A JP S5726625A
- Authority
- JP
- Japan
- Prior art keywords
- composite material
- medical
- protein
- sustained release
- type composite
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PURPOSE: To obtain the titled composite material capable of dissolving a medical enzyme at a controlled rate for a long term, by mixing the medical enzyme with a matrix material containing a protein essentially, denaturing the protein by a physical and chemical means, and irradiating the resultant mixture with light or ionizing radiation.
CONSTITUTION: (A) One or more types of medical enzymes, e.g. uricase or asparaginase, are mixed with (B) a matrix material consisting of one or more types of proteins, e.g. γ-globulin or bovine blood serum albumin, containing 0.01W80wt% physiological medium solution, e.g. physiological saline solution, essentially. The resultant system is then subjected to the chemical treatment, e.g. the addition of an acid or surfactant, or physical treatment, e.g. heating, ultraviolet light irradiation or shaking, to denature the protein. The mixture is then irradiated with light or ionizing radiation to give the aimed sustained release type composite material.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10146380A JPS5726625A (en) | 1980-07-24 | 1980-07-24 | Sustained release type composite material entrapping medical enzyme and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10146380A JPS5726625A (en) | 1980-07-24 | 1980-07-24 | Sustained release type composite material entrapping medical enzyme and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5726625A true JPS5726625A (en) | 1982-02-12 |
JPH0217527B2 JPH0217527B2 (en) | 1990-04-20 |
Family
ID=14301395
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10146380A Granted JPS5726625A (en) | 1980-07-24 | 1980-07-24 | Sustained release type composite material entrapping medical enzyme and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5726625A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5192743A (en) * | 1992-01-16 | 1993-03-09 | Genentech, Inc. | Reconstitutable lyophilized protein formulation |
US5597802A (en) * | 1990-06-07 | 1997-01-28 | Genentech, Inc. | Method of formulating IGF-I with growth hormone |
FR2810336A1 (en) * | 2000-06-19 | 2001-12-21 | Prod Oenologiques J Laffort & | METHOD FOR MANUFACTURING AN ADJUSTED CLARIFICATION PRODUCT OF A WINE AND CLARIFICATION PRODUCT OBTAINED |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5247912A (en) * | 1975-10-09 | 1977-04-16 | Minnesota Mining & Mfg | Solid serum albumin circles and its production |
-
1980
- 1980-07-24 JP JP10146380A patent/JPS5726625A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5247912A (en) * | 1975-10-09 | 1977-04-16 | Minnesota Mining & Mfg | Solid serum albumin circles and its production |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5597802A (en) * | 1990-06-07 | 1997-01-28 | Genentech, Inc. | Method of formulating IGF-I with growth hormone |
US5681814A (en) * | 1990-06-07 | 1997-10-28 | Genentech, Inc. | Formulated IGF-I Composition |
US5192743A (en) * | 1992-01-16 | 1993-03-09 | Genentech, Inc. | Reconstitutable lyophilized protein formulation |
FR2810336A1 (en) * | 2000-06-19 | 2001-12-21 | Prod Oenologiques J Laffort & | METHOD FOR MANUFACTURING AN ADJUSTED CLARIFICATION PRODUCT OF A WINE AND CLARIFICATION PRODUCT OBTAINED |
EP1167513A1 (en) * | 2000-06-19 | 2002-01-02 | Produits Oenologiques J. Laffort & Cie (Société Anonyme) | Preparation of a fining or clarifying agent and product obtained |
Also Published As
Publication number | Publication date |
---|---|
JPH0217527B2 (en) | 1990-04-20 |
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