CA1063101A - Process for the preparation of a new alkoxylated steroid - Google Patents
Process for the preparation of a new alkoxylated steroidInfo
- Publication number
- CA1063101A CA1063101A CA262,304A CA262304A CA1063101A CA 1063101 A CA1063101 A CA 1063101A CA 262304 A CA262304 A CA 262304A CA 1063101 A CA1063101 A CA 1063101A
- Authority
- CA
- Canada
- Prior art keywords
- alpha
- triène
- estra
- les
- éthynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003431 steroids Chemical class 0.000 title 1
- 230000009471 action Effects 0.000 claims abstract description 3
- HLCRYAZDZCJZFG-BDXSIMOUSA-N (8s,9s,13s,14s)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene Chemical compound C1CC2=CC=CC=C2[C@@H]2[C@@H]1[C@@H]1CCC[C@@]1(C)CC2 HLCRYAZDZCJZFG-BDXSIMOUSA-N 0.000 claims description 4
- 206010067572 Oestrogenic effect Diseases 0.000 abstract 1
- 230000002280 anti-androgenic effect Effects 0.000 abstract 1
- 229940046836 anti-estrogen Drugs 0.000 abstract 1
- 230000001833 anti-estrogenic effect Effects 0.000 abstract 1
- 239000000051 antiandrogen Substances 0.000 abstract 1
- 230000002054 antogonadotrophic effect Effects 0.000 abstract 1
- -1 benzyl halide Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000328 estrogen antagonist Substances 0.000 abstract 1
- 230000001076 estrogenic effect Effects 0.000 abstract 1
- 230000001766 physiological effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 4
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 210000002307 prostate Anatomy 0.000 description 3
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 1
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 240000007817 Olea europaea Species 0.000 description 1
- 244000299461 Theobroma cacao Species 0.000 description 1
- 235000005764 Theobroma cacao ssp. cacao Nutrition 0.000 description 1
- 235000005767 Theobroma cacao ssp. sphaerocarpum Nutrition 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- KCXMKQUNVWSEMD-UHFFFAOYSA-N benzyl chloride Chemical compound ClCC1=CC=CC=C1 KCXMKQUNVWSEMD-UHFFFAOYSA-N 0.000 description 1
- 235000001046 cacaotero Nutrition 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0096—Alkynyl derivatives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7529934A FR2326197A2 (fr) | 1975-09-30 | 1975-09-30 | Nouveau steroide alcoxyle, son procede de preparation et son application comme medicament |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1063101A true CA1063101A (en) | 1979-09-25 |
Family
ID=9160655
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA262,304A Expired CA1063101A (en) | 1975-09-30 | 1976-09-29 | Process for the preparation of a new alkoxylated steroid |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE846718R (en:Method) |
| CA (1) | CA1063101A (en:Method) |
| CH (1) | CH616690A5 (en:Method) |
| FR (1) | FR2326197A2 (en:Method) |
| GB (1) | GB1512761A (en:Method) |
| ZA (1) | ZA765706B (en:Method) |
-
1975
- 1975-09-30 FR FR7529934A patent/FR2326197A2/fr active Granted
-
1976
- 1976-09-23 ZA ZA765706A patent/ZA765706B/xx unknown
- 1976-09-29 BE BE171054A patent/BE846718R/xx active
- 1976-09-29 CA CA262,304A patent/CA1063101A/en not_active Expired
- 1976-09-30 CH CH1237676A patent/CH616690A5/fr not_active IP Right Cessation
- 1976-09-30 GB GB40568/76A patent/GB1512761A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH616690A5 (en) | 1980-04-15 |
| FR2326197B2 (en:Method) | 1979-09-14 |
| FR2326197A2 (fr) | 1977-04-29 |
| GB1512761A (en) | 1978-06-01 |
| ZA765706B (en) | 1977-10-26 |
| BE846718R (fr) | 1977-03-29 |
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