CA1056685A - Active agent dispenser and process for making same - Google Patents

Active agent dispenser and process for making same

Info

Publication number
CA1056685A
CA1056685A CA239,459A CA239459A CA1056685A CA 1056685 A CA1056685 A CA 1056685A CA 239459 A CA239459 A CA 239459A CA 1056685 A CA1056685 A CA 1056685A
Authority
CA
Canada
Prior art keywords
active agent
dispenser
lamina
drug
core
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA239,459A
Other languages
English (en)
French (fr)
Inventor
Robert M. Gale
Richard W. Baker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of CA1056685A publication Critical patent/CA1056685A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA239,459A 1974-11-14 1975-11-12 Active agent dispenser and process for making same Expired CA1056685A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US523720A US3926188A (en) 1974-11-14 1974-11-14 Laminated drug dispenser

Publications (1)

Publication Number Publication Date
CA1056685A true CA1056685A (en) 1979-06-19

Family

ID=24086191

Family Applications (1)

Application Number Title Priority Date Filing Date
CA239,459A Expired CA1056685A (en) 1974-11-14 1975-11-12 Active agent dispenser and process for making same

Country Status (10)

Country Link
US (1) US3926188A (show.php)
JP (1) JPS6059203B2 (show.php)
CA (1) CA1056685A (show.php)
CH (1) CH634226A5 (show.php)
DE (1) DE2549856C2 (show.php)
FR (1) FR2290891A1 (show.php)
GB (1) GB1477813A (show.php)
IT (1) IT1050619B (show.php)
MX (2) MX158867A (show.php)
SE (1) SE439432B (show.php)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4182330A (en) * 1977-07-25 1980-01-08 Alza Corporation Means for administering amphipathic medicament
US4304232A (en) * 1979-03-14 1981-12-08 Alza Corporation Unit system having multiplicity of means for dispensing useful agent
AR221964A1 (es) * 1979-09-12 1981-03-31 Lilly Co Eli Dispositivo para rumiantes
US4314557A (en) * 1980-05-19 1982-02-09 Alza Corporation Dissolution controlled active agent dispenser
JPS5770816A (en) * 1980-10-17 1982-05-01 Ono Pharmaceut Co Ltd Multilayered film preparation of prostagladin of prolonged action
DE3115763A1 (de) * 1981-04-18 1982-11-04 Edgar Dr.med. 6238 Hofheim Lenhard Medizinische depotsonde zur lokalen protrahierten wirkstoffreisetzung
US4370313A (en) * 1981-10-26 1983-01-25 Eaton Laboratories, Inc. Nitrofurantoin dosage form
JPS58134019A (ja) * 1982-02-05 1983-08-10 Ono Pharmaceut Co Ltd プロスタグランジン含有持続放出型三層状フイルム製剤及びその製造方法
US4571039A (en) * 1983-04-15 1986-02-18 Stanley Poler Eye-medicating contact-lens construction
US4639244A (en) * 1983-05-03 1987-01-27 Nabil I. Rizk Implantable electrophoretic pump for ionic drugs and associated methods
US4564364A (en) * 1983-05-26 1986-01-14 Alza Corporation Active agent dispenser
US4601893A (en) * 1984-02-08 1986-07-22 Pfizer Inc. Laminate device for controlled and prolonged release of substances to an ambient environment and method of use
US4863445A (en) * 1984-07-30 1989-09-05 Baxter Travenol Laboratories, Inc. Assembly for inhibiting microbial growth in collected fluid
US4627851A (en) * 1984-10-26 1986-12-09 Alza Corporation Colonic-therapeutic delivery system
US4693895A (en) * 1984-10-26 1987-09-15 Alza Corporation Colon delivery system
CH667001A5 (de) * 1985-09-03 1988-09-15 Hugo Degen Untermatratze.
US4880633A (en) * 1986-03-12 1989-11-14 Merck & Co., Inc. Transdermal drug delivery system
US4938759A (en) * 1986-09-02 1990-07-03 Alza Corporation Transdermal delivery device having a rate controlling adhesive
US5344656A (en) * 1986-09-12 1994-09-06 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US4908027A (en) * 1986-09-12 1990-03-13 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US4841968A (en) * 1986-09-26 1989-06-27 Southern Research Institute Antithrombotic/thrombolytic suture and methods of making and using the same
US4830860A (en) * 1986-10-30 1989-05-16 Pfizer Inc. Stressed polymeric device for controlled release of a substance to an ambient environment
JPS63143581A (ja) * 1986-12-05 1988-06-15 Nissha Printing Co Ltd ホログラム成型品
US4892778A (en) * 1987-05-27 1990-01-09 Alza Corporation Juxtaposed laminated arrangement
EP0303306B1 (en) * 1987-08-08 1993-03-10 Akzo N.V. Contraceptive implant
DK530787D0 (da) * 1987-10-09 1987-10-09 Bukh Meditec Indretning til indfoering i en legemshulhed
US5071645A (en) * 1987-10-19 1991-12-10 Ppg Industries, Inc. Process of producing an active agent delivery device
US4959208A (en) * 1987-10-19 1990-09-25 Ppg Industries, Inc. Active agent delivery device
US5035886A (en) * 1987-10-19 1991-07-30 Ppg Industries, Inc. Active agent delivery device
US4781924A (en) 1987-11-09 1988-11-01 Alza Corporation Transdermal drug delivery device
US4906475A (en) * 1988-02-16 1990-03-06 Paco Pharmaceutical Services Estradiol transdermal delivery system
US5004610A (en) * 1988-06-14 1991-04-02 Alza Corporation Subsaturated nicotine transdermal therapeutic system
GB8815968D0 (en) * 1988-07-05 1988-08-10 Pfizer Ltd Veterinary devices
US5053227A (en) * 1989-03-22 1991-10-01 Cygnus Therapeutic Systems Skin permeation enhancer compositions, and methods and transdermal systems associated therewith
US5059426A (en) * 1989-03-22 1991-10-22 Cygnus Therapeutic Systems Skin permeation enhancer compositions, and methods and transdermal systems associated therewith
US4973468A (en) * 1989-03-22 1990-11-27 Cygnus Research Corporation Skin permeation enhancer compositions
US5124157A (en) 1989-08-18 1992-06-23 Cygnus Therapeutic Systems Method and device for administering dexmedetomidine transdermally
US5217718A (en) * 1989-08-18 1993-06-08 Cygnus Therapeutic Systems Method and device for administering dexmedetomidine transdermally
US5508038A (en) * 1990-04-16 1996-04-16 Alza Corporation Polyisobutylene adhesives for transdermal devices
HUT69680A (en) * 1990-08-09 1995-09-28 Endocon Inc Implant and apparatus for delivering multiple drug and process for production of theese
JPH0444601U (show.php) * 1990-08-22 1992-04-15
JPH0444666U (show.php) * 1990-08-22 1992-04-15
US5538735A (en) * 1993-02-19 1996-07-23 Ahn; Sam S. Method of making a drug delivery system using hollow fibers
JP3720386B2 (ja) * 1993-12-27 2005-11-24 住友製薬株式会社 薬物放出制御製剤
US5466233A (en) * 1994-04-25 1995-11-14 Escalon Ophthalmics, Inc. Tack for intraocular drug delivery and method for inserting and removing same
US5660848A (en) * 1994-11-02 1997-08-26 The Population Council, Center For Biomedical Research Subdermally implantable device
EP1284137B1 (en) * 2000-05-26 2010-12-01 TAKADA, Kanji Nonoral preparation having three-layer structure
US20020148138A1 (en) * 2001-04-06 2002-10-17 Egan Brian A. Smart tread boot covers
EP2316394B1 (en) 2001-06-12 2016-11-23 The Johns Hopkins University Reservoir device for intraocular drug delivery
US7306580B2 (en) * 2003-04-16 2007-12-11 Cook Incorporated Medical device with therapeutic agents
US20070043332A1 (en) * 2003-07-10 2007-02-22 Galen (Chemiclas) Liimited Intravaginal drug delivery devices
CN1882338A (zh) * 2003-09-18 2006-12-20 马库赛特公司 经巩膜递送
US20050244465A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Drug delivery systems and methods for treatment of an eye
DE102004050457A1 (de) * 2004-10-12 2006-04-13 Capsulution Nanoscience Ag Segmentierte Vorrichtung für die verzögerte Freisetzung von Molekülen in tangentialer Richtung durch dünne Filme und Anwendungen derselben
HUE027352T2 (en) 2005-02-09 2016-09-28 Santen Pharmaceutical Co Ltd Liquid formulations for the treatment of diseases or conditions
US8663639B2 (en) 2005-02-09 2014-03-04 Santen Pharmaceutical Co., Ltd. Formulations for treating ocular diseases and conditions
BRPI0707612B8 (pt) 2006-02-09 2021-05-25 Macusight Inc vaso lacrado e formulações líquidas contidas no mesmo
AU2007230964B2 (en) 2006-03-23 2012-07-19 Santen Pharmaceutical Co., Ltd. Formulations and methods for vascular permeability-related diseases or conditions
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
PL2391419T3 (pl) 2009-01-29 2019-12-31 Forsight Vision4, Inc. Dostarczanie leku do tylnego odcinka
EP4108216A1 (en) 2009-06-03 2022-12-28 Forsight Vision5, Inc. Anterior segment drug delivery
US20110066141A1 (en) * 2009-09-11 2011-03-17 Cook Incorporated Implantable medical device having an anti-gastric distress agent
US20110098797A1 (en) * 2009-10-23 2011-04-28 Cleek Robert L Drug eluting composite
US9504771B2 (en) 2009-11-09 2016-11-29 W. L. Gore & Associates, Inc. Drug eluting composite
US9320890B2 (en) * 2009-11-09 2016-04-26 W. L. Gore & Associates, Inc. Drug eluting composite
US10166142B2 (en) 2010-01-29 2019-01-01 Forsight Vision4, Inc. Small molecule delivery with implantable therapeutic device
PL2547332T3 (pl) 2010-03-16 2019-07-31 Titan Pharmaceuticals, Inc. Heterogeniczne wyroby wszczepialne do podaży leku
EP2600876B1 (en) 2010-08-05 2015-04-29 Forsight Vision4, Inc. Combined drug delivery methods and apparatus
CN103209664A (zh) 2010-08-05 2013-07-17 弗赛特影像4股份有限公司 可植入的治疗装置
CA2807535C (en) 2010-08-05 2019-03-19 Forsight Vision4, Inc. Injector apparatus and method for drug delivery
US20140031769A1 (en) 2010-11-19 2014-01-30 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
WO2013003620A2 (en) 2011-06-28 2013-01-03 Forsight Vision4, Inc. Diagnostic methods and apparatus
KR102071083B1 (ko) 2011-09-14 2020-01-29 포사이트 비젼5, 인크. 안내 삽입물 장치 및 방법
LT2755600T (lt) 2011-09-16 2021-04-26 Forsight Vision4, Inc. Skysčio pakeitimo aparatas
EP2765999A4 (en) * 2011-10-14 2015-04-01 Purdue Research Foundation EASY MULTILAYER UNIT WITH PRESENT FUNCTIONS AND COMBINATIONS
PT2911623T (pt) 2012-10-26 2019-11-21 Forsight Vision5 Inc Sistema oftálmico para libertação prolongada de fármaco no olho
WO2014152959A1 (en) 2013-03-14 2014-09-25 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
WO2014160884A1 (en) 2013-03-28 2014-10-02 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
CA2957548A1 (en) 2014-08-08 2016-02-11 Forsight Vision4, Inc. Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
US10226419B2 (en) * 2014-09-08 2019-03-12 ProMed Pharma, LLC Methods for manufacturing implants
WO2016077371A1 (en) 2014-11-10 2016-05-19 Forsight Vision4, Inc. Expandable drug delivery devices and method of use
WO2016168141A1 (en) 2015-04-13 2016-10-20 Forsight Vision5, Inc. Ocular insert composition of semi-crystalline or crystalline pharmaceutically active agent
EP3377009B1 (en) 2015-11-20 2020-10-28 ForSight Vision4, Inc. Porous structures for extended release drug delivery devices
CN113017981B (zh) 2016-04-05 2023-07-25 弗赛特影像4股份有限公司 药物递送装置
WO2019103906A1 (en) 2017-11-21 2019-05-31 Forsight Vision4, Inc. Fluid exchange apparatus for expandable port delivery system and methods of use
USD1033637S1 (en) 2022-01-24 2024-07-02 Forsight Vision4, Inc. Fluid exchange device

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB906422A (en) * 1958-05-02 1962-09-19 Wellcome Found Improvements in and relating to prolonged acting pharmaceutical preparations
US2928770A (en) * 1958-11-28 1960-03-15 Frank M Bardani Sustained action pill
US3416530A (en) * 1966-03-02 1968-12-17 Richard A. Ness Eyeball medication dispensing tablet
US3854480A (en) * 1969-04-01 1974-12-17 Alza Corp Drug-delivery system
US3630200A (en) * 1969-06-09 1971-12-28 Alza Corp Ocular insert
US3618604A (en) * 1969-06-09 1971-11-09 Alza Corp Ocular insert
US3625214A (en) * 1970-05-18 1971-12-07 Alza Corp Drug-delivery device
US3832252A (en) * 1970-09-29 1974-08-27 T Higuchi Method of making a drug-delivery device
US3797485A (en) * 1971-03-26 1974-03-19 Alza Corp Novel drug delivery device for administering drug into blood circulation in blood vessel
US3851648A (en) * 1973-10-11 1974-12-03 Mead Johnson & Co Zero-order release device

Also Published As

Publication number Publication date
US3926188A (en) 1975-12-16
FR2290891A1 (fr) 1976-06-11
SE439432B (sv) 1985-06-17
DE2549856C2 (de) 1985-01-03
JPS5170807A (show.php) 1976-06-18
DE2549856A1 (de) 1976-05-20
IT1050619B (it) 1981-03-20
MX158868A (es) 1989-03-27
CH634226A5 (de) 1983-01-31
FR2290891B1 (show.php) 1978-11-10
SE7512744L (sv) 1977-05-15
MX158867A (es) 1989-03-27
JPS6059203B2 (ja) 1985-12-24
GB1477813A (en) 1977-06-29

Similar Documents

Publication Publication Date Title
CA1056685A (en) Active agent dispenser and process for making same
CA1047403A (en) Process for making a monolithic drug delivery device
US4177256A (en) Osmotic bursting drug delivery device
AU670410B2 (en) Transdermal drug delivery device using a membrane-protected microporous membrane to achieve delayed onset
US4911707A (en) Monolithic user-activated transdermal therapeutic system
US4917676A (en) User-activated transdermal therapeutic system
US3995631A (en) Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient
CA1133853A (en) Article for the dispensing of volatiles
US5273755A (en) Transdermal drug delivery device using a polymer-filled microporous membrane to achieve delayed onset
US4976966A (en) Delayed release osmotically driven fluid dispenser
FI95539B (fi) Transdermaalinen järjestelmä, sen valmistusmenetelmä ja käyttö
DE60201815T2 (de) Vorrichtung zur verabreichung von medikamenten in die atemwege
US5254346A (en) Occlusive body for administering a physiologically active substance
CA1078734A (en) Controlled release article
US4445641A (en) Controlled-release dispenser
CA2133598C (en) Non-occlusive adhesive patch for applying medication to the skin
US4830860A (en) Stressed polymeric device for controlled release of a substance to an ambient environment
CA1084839A (en) Active agent delivery systems made from certain segmented copolyesters
DE19620534A1 (de) Verfahren zur Kontrolle der exothermen Reaktion einer exothermen Verbindung, der exothermen Verbindung, einer exothermen Vorrichtung und einer Applikationskompresse
WO1995015158A1 (de) Wirkstoffhaltiges pflaster
JPH03505044A (ja) プリントされた皮膚透過性薬剤投与具
EP0093262A1 (en) Article for the dispersion of a volatile substance and an article of manufacture comprising a plurality of said articles
AU614728B2 (en) User-activated transdermal therapeutic systems
EP0384267A2 (de) Therapeutisches System zur verzögerten und gesteuerten transdermalen oder transmucosalen Verabreichung von Wirkstoffen
CA1083041A (en) Sustained release drug delivery device and process for making same