CA1050460A - Production of antibiotic mm 13902 by streptomyces - Google Patents
Production of antibiotic mm 13902 by streptomycesInfo
- Publication number
- CA1050460A CA1050460A CA223,313A CA223313A CA1050460A CA 1050460 A CA1050460 A CA 1050460A CA 223313 A CA223313 A CA 223313A CA 1050460 A CA1050460 A CA 1050460A
- Authority
- CA
- Canada
- Prior art keywords
- pharmaceutically acceptable
- salt
- atcc
- acceptable salt
- substantially pure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- FQQFFZPBGYGDSX-NJFHWYBASA-N epithienamycin E Chemical compound C1C(S\C=C\NC(C)=O)=C(C(O)=O)N2C(=O)[C@@H]([C@@H](OS(O)(=O)=O)C)[C@H]21 FQQFFZPBGYGDSX-NJFHWYBASA-N 0.000 title claims abstract description 92
- 238000004519 manufacturing process Methods 0.000 title abstract description 10
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- 150000003839 salts Chemical class 0.000 claims abstract description 59
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- 238000000034 method Methods 0.000 claims description 52
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 24
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 24
- 241000894007 species Species 0.000 claims description 22
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 18
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G11/00—Antibiotics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
- C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB13856/74A GB1489235A (en) | 1974-03-28 | 1974-03-28 | Antibiotics |
| AU45499/79A AU530414B2 (en) | 1974-03-28 | 1979-03-29 | Antibiotic mm13902 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1050460A true CA1050460A (en) | 1979-03-13 |
Family
ID=25627229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA223,313A Expired CA1050460A (en) | 1974-03-28 | 1975-03-27 | Production of antibiotic mm 13902 by streptomyces |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS582675B2 (xx) |
| AT (1) | AT345454B (xx) |
| AU (2) | AU499459B2 (xx) |
| BE (1) | BE827332A (xx) |
| CA (1) | CA1050460A (xx) |
| CH (1) | CH626628A5 (xx) |
| DE (1) | DE2513854C2 (xx) |
| FR (1) | FR2265399B1 (xx) |
| GB (1) | GB1489235A (xx) |
| LU (1) | LU72155A1 (xx) |
| NL (1) | NL7503672A (xx) |
| OA (1) | OA05204A (xx) |
| SE (1) | SE7503536L (xx) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7704040A (nl) * | 1976-04-28 | 1977-11-01 | Merck & Co Inc | Werkwijze voor het bereiden van nieuwe anti- biotica. |
| NL7712091A (nl) * | 1976-11-17 | 1978-05-19 | Merck & Co Inc | Werkwijze ter bereiding van een nieuw antibiotisch middel. |
| US4446146A (en) * | 1978-07-26 | 1984-05-01 | Beecham Group Limited | β-Lactam containing compounds, their preparation and use |
| DE2966446D1 (en) * | 1978-09-09 | 1984-01-05 | Beecham Group Plc | Beta-lactam compounds, their preparation and use |
| US4530791A (en) * | 1979-04-16 | 1985-07-23 | Kowa Co., Ltd. | β-Lactam antibiotics |
| JPS6029668A (ja) * | 1983-07-28 | 1985-02-15 | Hino Motors Ltd | 経済運転ガイド装置 |
| WO2006003151A1 (en) * | 2004-06-30 | 2006-01-12 | Dsm Ip Assets B.V. | Product comprising a beta-lactam antibiotic |
-
1974
- 1974-03-28 GB GB13856/74A patent/GB1489235A/en not_active Expired
-
1975
- 1975-03-25 AT AT228475A patent/AT345454B/de not_active IP Right Cessation
- 1975-03-26 SE SE7503536*1A patent/SE7503536L/xx unknown
- 1975-03-27 AU AU79599/75A patent/AU499459B2/en not_active Ceased
- 1975-03-27 NL NL7503672A patent/NL7503672A/xx not_active Application Discontinuation
- 1975-03-27 CH CH400175A patent/CH626628A5/de not_active IP Right Cessation
- 1975-03-27 CA CA223,313A patent/CA1050460A/en not_active Expired
- 1975-03-27 LU LU72155A patent/LU72155A1/xx unknown
- 1975-03-27 FR FR7509611A patent/FR2265399B1/fr not_active Expired
- 1975-03-27 DE DE2513854A patent/DE2513854C2/de not_active Expired
- 1975-03-28 BE BE154898A patent/BE827332A/xx not_active IP Right Cessation
- 1975-03-28 JP JP50038464A patent/JPS582675B2/ja not_active Expired
- 1975-04-29 OA OA55487A patent/OA05204A/xx unknown
-
1979
- 1979-03-29 AU AU45499/79A patent/AU530414B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AT345454B (de) | 1978-09-25 |
| FR2265399A1 (xx) | 1975-10-24 |
| SE7503536L (sv) | 1975-09-29 |
| AU499459B2 (en) | 1979-04-26 |
| JPS50140692A (xx) | 1975-11-11 |
| ATA228475A (de) | 1978-01-15 |
| DE2513854A1 (de) | 1975-10-02 |
| NL7503672A (nl) | 1975-09-30 |
| AU530414B2 (en) | 1983-07-14 |
| FR2265399B1 (xx) | 1978-08-04 |
| JPS582675B2 (ja) | 1983-01-18 |
| DE2513854C2 (de) | 1984-04-19 |
| CH626628A5 (en) | 1981-11-30 |
| LU72155A1 (xx) | 1975-08-20 |
| GB1489235A (en) | 1977-10-19 |
| AU7959975A (en) | 1976-09-30 |
| BE827332A (fr) | 1975-09-29 |
| AU4549979A (en) | 1981-05-14 |
| OA05204A (fr) | 1981-02-28 |
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