CA1042345A - Oxygen-transferable emulsion - Google Patents

Oxygen-transferable emulsion

Info

Publication number
CA1042345A
CA1042345A CA191,662A CA191662A CA1042345A CA 1042345 A CA1042345 A CA 1042345A CA 191662 A CA191662 A CA 191662A CA 1042345 A CA1042345 A CA 1042345A
Authority
CA
Canada
Prior art keywords
acid
perfluoro
compound
emulsion
emulsion according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA191,662A
Other languages
English (en)
French (fr)
Inventor
Kazumasa Yokoyama
Ryoichiro Murashima
Ryozo Watanabe
Koichi Yamanouchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Green Cross Corp Japan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Green Cross Corp Japan filed Critical Green Cross Corp Japan
Application granted granted Critical
Publication of CA1042345A publication Critical patent/CA1042345A/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026Blood substitute; Oxygen transporting formulations; Plasma extender
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/02Halogenated hydrocarbons

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CA191,662A 1973-10-05 1974-02-04 Oxygen-transferable emulsion Expired CA1042345A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11204773A JPS5331209B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1973-10-05 1973-10-05

Publications (1)

Publication Number Publication Date
CA1042345A true CA1042345A (en) 1978-11-14

Family

ID=14576675

Family Applications (1)

Application Number Title Priority Date Filing Date
CA191,662A Expired CA1042345A (en) 1973-10-05 1974-02-04 Oxygen-transferable emulsion

Country Status (12)

Country Link
US (1) US3962439A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS5331209B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) AT333962B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU471724B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1042345A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH598749A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE2404564C3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK137433B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2246262B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB1445925A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL159007B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SE (1) SE403433B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

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JPS5835485B2 (ja) * 1976-02-03 1983-08-03 株式会社ミドリ十字 酸素運搬輸液
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US4252827A (en) * 1979-05-23 1981-02-24 The Green Cross Corporation Oxygen-transferable fluorocarbon emulsion
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US4830849A (en) * 1980-04-14 1989-05-16 Thomas Jefferson University Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4795423A (en) * 1980-04-14 1989-01-03 Thomas Jefferson University Oxygenated perfluorinated perfusion of the ocular globe to treat ischemic retinopathy
US4758431A (en) * 1980-04-14 1988-07-19 Thomas Jefferson University Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4378797A (en) * 1980-04-14 1983-04-05 Thomas Jefferson University Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4369127A (en) * 1980-07-21 1983-01-18 Instrumentation Laboratory Inc. Blood gas control
JPS5832829A (ja) * 1981-08-22 1983-02-25 Green Cross Corp:The 血管造影剤
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US4461717A (en) * 1982-03-19 1984-07-24 Sun Tech, Inc. Stable gas-carrying compositions
FR2523956A1 (fr) * 1982-03-26 1983-09-30 Ugine Kuhlmann Bis-(perfluoroalkyl)-1,2-ethenes ramifies, leur preparation et leur utilisation comme transporteurs d'oxygene convertisseur electromecanique
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US4530926A (en) * 1982-06-29 1985-07-23 The Green Cross Corporation Perfluorotricyclic amines as oxygen carriers
US4497829A (en) * 1982-07-27 1985-02-05 The University Of Pennsylvania Process for preparing perfluorochemical emulsion artificial blood
US4423077A (en) * 1982-07-27 1983-12-27 The University Of Pennsylvania Perfluorochemical emulsion artificial blood
US4397870A (en) * 1982-07-27 1983-08-09 The University Of Pennsylvania Process for prolonging retention of emulsion particles in the bloodstream
US4542147A (en) * 1982-08-07 1985-09-17 The Green Cross Corporation Perfluoro-1-azatricyclic amine compound
WO1984000686A1 (en) * 1982-08-17 1984-03-01 Sun Tech Inc Perfluorocarbon emulsions and their preparation and use in therapy
JPS5939870A (ja) * 1982-08-30 1984-03-05 Green Cross Corp:The フルオロカ−ボン乳化製剤
JPS5946218A (ja) * 1982-09-09 1984-03-15 Green Cross Corp:The フルオロカ−ボン乳化製剤
JPS5967229A (ja) * 1982-10-08 1984-04-16 Green Cross Corp:The 超音波診断造影剤
JPS59112936A (ja) * 1982-12-21 1984-06-29 Green Cross Corp:The ペルフルオロエ−テル化合物及びその製造法
US4534978A (en) * 1982-12-28 1985-08-13 The Green Cross Corporation Perfluorocycloamines
JPS59175421A (ja) * 1983-03-24 1984-10-04 Tetsuzou Agishi 血液浄化剤
US4530936A (en) * 1983-07-08 1985-07-23 Farmacon Research Corporation Composition and method for inhibiting the absorption of nutritional elements from the upper intestinal tract
SE8406634D0 (sv) * 1984-12-27 1984-12-27 Andreas Leonhardt Die verwendung von silicon-emulsionen als gastreger fur freie und immobilisierte biologische zellen
US4931472A (en) * 1985-09-17 1990-06-05 Biomed Technology, Inc. Fluorinated triethylenediamine as an oxygen transport agent
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US4865836A (en) * 1986-01-14 1989-09-12 Fluoromed Pharmaceutical, Inc. Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport
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ES2054658T3 (es) * 1986-01-24 1994-08-16 Childrens Hosp Medical Center Metodo para la preparacion de una emulsion fisiologicamente aceptable.
US5684050A (en) * 1986-01-24 1997-11-04 Hemagen/Pfc Stable emulsions of highly fluorinated organic compounds
US4769241A (en) * 1986-09-23 1988-09-06 Alpha Therapeutic Corporation Apparatus and process for oxygenation of liquid state dissolved oxygen-carrying formulation
US4929317A (en) * 1986-12-01 1990-05-29 Tokuyama Soda Kabushiki Kaisha Process for preparation of perfluoro organic compounds
US4781676A (en) * 1987-02-20 1988-11-01 Air Products And Chemicals, Inc. Interstitial administration of perfluorochemical emulsions for reoxygenation of hypoxic tumor cells
US4895876A (en) * 1987-03-20 1990-01-23 Air Products And Chemicals, Inc. Concentrated stable fluorochemical aqueous emulsions containing triglycerides
US4866096A (en) * 1987-03-20 1989-09-12 Air Products And Chemicals, Inc. Stable fluorochemical aqueous emulsions
US4956390A (en) * 1987-08-25 1990-09-11 Air Products And Chemicals, Inc. Gas transport employing perfluorobutyldecalin
US5061484A (en) * 1988-03-11 1991-10-29 Alpha Therapeutic Corporation Perfluorochemical emulsion with stabilized vesicles
WO1989008459A1 (en) * 1988-03-11 1989-09-21 Alpha Therapeutic Corporation Perfluorochemical emulsion with stabilized vesicles
US5171755A (en) * 1988-04-29 1992-12-15 Hemagen/Pfc Emulsions of highly fluorinated organic compounds
US5518731A (en) * 1990-09-27 1996-05-21 Allergan, Inc. Nonaqueous fluorinated drug delivery vehicle suspensions
US6458376B1 (en) 1990-09-27 2002-10-01 Allergan, Inc. Nonaqueous fluorinated drug delivery suspensions
US5827222A (en) * 1990-10-10 1998-10-27 Life Resuscitation Technologies, Inc. Method of treating at least one of brain and associated nervous tissue injury
US5146014A (en) * 1991-07-02 1992-09-08 Air Products And Chemicals, Inc. Perfluoroethyldimethyl cyclohexane
AU2441592A (en) * 1991-08-08 1993-03-02 Leigh D. Segel Fluorocarbon blood substitute
US5216032A (en) * 1991-09-30 1993-06-01 The University Of North Carolina At Chapel Hill Selective aortic arch perfusion using perfluorochemical and alpha adrenergic agonist to treat cardiac arrest
US5403575A (en) * 1991-12-12 1995-04-04 Hemagen/Pfc Highly fluorinated, chloro-substituted organic compound-containing emulsions and methods of using them
US5846516A (en) * 1992-06-03 1998-12-08 Alliance Pharmaceutial Corp. Perfluoroalkylated amphiphilic phosphorus compounds: preparation and biomedical applications
US5595687A (en) * 1992-10-30 1997-01-21 Thomas Jefferson University Emulsion stability
US5437633A (en) * 1994-03-30 1995-08-01 The University Of North Carolina At Chapel Hill Selective aortic arch perfusion
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US5658962A (en) 1994-05-20 1997-08-19 Minnesota Mining And Manufacturing Company Omega-hydrofluoroalkyl ethers, precursor carboxylic acids and derivatives thereof, and their preparation and application
US5502094A (en) * 1994-05-20 1996-03-26 Minnesota Mining And Manufacturing Company Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods for use
US5614170A (en) * 1994-11-30 1997-03-25 Hemagen/Pfc Paramagnetic complexes of N-alkyl-N-hydroxylamides of organic acids and emulsions containing same for magnetic resonance imaging (MRI)
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US5678570A (en) * 1995-04-14 1997-10-21 The University Of North Carolina At Chapel Hill Method of treating cardiac arrest
US5716318A (en) * 1995-04-14 1998-02-10 The University Of North Carolina At Chapel Hill Method of treating cardiac arrest and apparatus for same
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US6679859B1 (en) 1997-10-24 2004-01-20 Alliance Pharmaceutical Corp. Amelioration of ischemic damage using synthetic oxygen carriers
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US6977140B1 (en) * 1998-09-29 2005-12-20 Organ Recovery Systems, Inc. Method for maintaining and/or restoring viability of organs
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US7749693B2 (en) * 1998-09-29 2010-07-06 Lifeline Scientific, Inc. Method of determining that an organ is not suitable for transplantation and using it for testing substances
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US20100055067A1 (en) * 2008-08-26 2010-03-04 Snu R&Db Foundation Perfluorocarbon conjugate as a blood substitute
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CH604490A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1970-09-05 1978-09-15 Green Cross Corp
JPS4861616A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1971-12-06 1973-08-29

Also Published As

Publication number Publication date
DE2404564C3 (de) 1981-09-03
NL159007B (nl) 1979-01-15
JPS5331209B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1978-09-01
AU6520074A (en) 1975-08-07
DK137433C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1978-08-21
SE403433B (sv) 1978-08-21
DE2404564A1 (de) 1975-04-17
DK88174A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1975-05-20
GB1445925A (en) 1976-08-11
US3962439A (en) 1976-06-08
FR2246262A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1975-05-02
SE7400989L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1975-04-07
NL7402664A (nl) 1975-04-08
DE2404564B2 (de) 1980-08-21
FR2246262B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1977-11-04
CH598749A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1978-05-12
AT333962B (de) 1976-12-27
ATA78374A (de) 1976-04-15
AU471724B2 (en) 1976-04-29
DK137433B (da) 1978-03-06
JPS5069219A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1975-06-10

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