CA1036493A - Method of detecting antigens or antibodies - Google Patents
Method of detecting antigens or antibodiesInfo
- Publication number
- CA1036493A CA1036493A CA210,357A CA210357A CA1036493A CA 1036493 A CA1036493 A CA 1036493A CA 210357 A CA210357 A CA 210357A CA 1036493 A CA1036493 A CA 1036493A
- Authority
- CA
- Canada
- Prior art keywords
- receptacles
- antigen
- antibody
- pair
- receptacle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000427 antigen Substances 0.000 title claims abstract description 86
- 102000036639 antigens Human genes 0.000 title claims abstract description 86
- 108091007433 antigens Proteins 0.000 title claims abstract description 86
- 238000000034 method Methods 0.000 title claims abstract description 44
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 13
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 13
- 239000013642 negative control Substances 0.000 claims abstract description 12
- 230000005855 radiation Effects 0.000 claims abstract description 12
- 239000002198 insoluble material Substances 0.000 claims abstract description 6
- 239000011248 coating agent Substances 0.000 claims abstract description 3
- 238000000576 coating method Methods 0.000 claims abstract description 3
- 208000006454 hepatitis Diseases 0.000 claims description 18
- 231100000283 hepatitis Toxicity 0.000 claims description 18
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- -1 polyethylene Polymers 0.000 claims description 4
- 230000002285 radioactive effect Effects 0.000 claims description 3
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 claims description 2
- 239000000020 Nitrocellulose Substances 0.000 claims description 2
- 239000004698 Polyethylene Substances 0.000 claims description 2
- 239000004743 Polypropylene Substances 0.000 claims description 2
- 239000004793 Polystyrene Substances 0.000 claims description 2
- 239000011324 bead Substances 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims description 2
- 239000011521 glass Substances 0.000 claims description 2
- 229920001220 nitrocellulos Polymers 0.000 claims description 2
- 229920000573 polyethylene Polymers 0.000 claims description 2
- 229920001155 polypropylene Polymers 0.000 claims description 2
- 229920002223 polystyrene Polymers 0.000 claims description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 2
- 229910052740 iodine Inorganic materials 0.000 claims 2
- 239000011630 iodine Substances 0.000 claims 2
- FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 claims 1
- 229940079938 nitrocellulose Drugs 0.000 claims 1
- 238000010532 solid phase synthesis reaction Methods 0.000 abstract 1
- 239000000523 sample Substances 0.000 description 23
- 239000007790 solid phase Substances 0.000 description 21
- 239000000243 solution Substances 0.000 description 8
- 238000003127 radioimmunoassay Methods 0.000 description 7
- 210000002966 serum Anatomy 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 239000002953 phosphate buffered saline Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000011067 equilibration Methods 0.000 description 3
- 210000002381 plasma Anatomy 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 2
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 239000012857 radioactive material Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 238000004435 EPR spectroscopy Methods 0.000 description 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
- 208000031220 Hemophilia Diseases 0.000 description 1
- 208000009292 Hemophilia A Diseases 0.000 description 1
- 241000700721 Hepatitis B virus Species 0.000 description 1
- 102000002265 Human Growth Hormone Human genes 0.000 description 1
- 108010000521 Human Growth Hormone Proteins 0.000 description 1
- 239000000854 Human Growth Hormone Substances 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- HRNLUBSXIHFDHP-UHFFFAOYSA-N N-(2-aminophenyl)-4-[[[4-(3-pyridinyl)-2-pyrimidinyl]amino]methyl]benzamide Chemical compound NC1=CC=CC=C1NC(=O)C(C=C1)=CC=C1CNC1=NC=CC(C=2C=NC=CC=2)=N1 HRNLUBSXIHFDHP-UHFFFAOYSA-N 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 238000010420 art technique Methods 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 125000006501 nitrophenyl group Chemical group 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/804—Radioisotope, e.g. radioimmunoassay
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/819—Multifunctional antigen or antibody
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/82—Hepatitis associated antigens and antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/410,066 US3949064A (en) | 1973-10-26 | 1973-10-26 | Method of detecting antigens or antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1036493A true CA1036493A (en) | 1978-08-15 |
Family
ID=23623067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA210,357A Expired CA1036493A (en) | 1973-10-26 | 1974-09-30 | Method of detecting antigens or antibodies |
Country Status (15)
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4172117A (en) * | 1974-05-20 | 1979-10-23 | Biotest-Serum-Institut Gmbh | Method for the simultaneous measurement of antigens and their antibodies by solid-phase radioimmunoassay |
| US4225784A (en) * | 1976-06-17 | 1980-09-30 | Smith Kline Instruments, Inc. | Covalently bound biological substances to plastic materials and use in radioassay |
| AT343822B (de) * | 1976-08-20 | 1978-06-26 | Immuno Ag | Radioimmunologisches verfahren und einrichtung zur bestimmung von antigenen |
| JPS604422B2 (ja) * | 1976-10-07 | 1985-02-04 | 持田製薬株式会社 | 抗原の定量方法 |
| USRE34394E (en) * | 1978-01-23 | 1993-09-28 | Baxter Diagnostics Inc. | Method and composition for double receptor, specific binding assays |
| JPS608745B2 (ja) * | 1978-02-14 | 1985-03-05 | 三洋化成工業株式会社 | 免疫活性物質−つや消しガラス複合体，その製造法及び該複合体を含有してなる測定試薬 |
| US4242322A (en) * | 1978-06-07 | 1980-12-30 | Electro-Nucleonics Laboratories, Inc. | Methods and materials for detecting antigens and antibodies |
| US4393040A (en) * | 1981-03-24 | 1983-07-12 | Lopapa Institute, Inc. | In-vitro diagnostic method for detection of acetylsalicylic acid ingestion |
| US4994373A (en) | 1983-01-27 | 1991-02-19 | Enzo Biochem, Inc. | Method and structures employing chemically-labelled polynucleotide probes |
| PH21409A (en) * | 1983-07-21 | 1987-10-15 | Scripps Clinic Res | Synthetic polypeptides and pharmaceutical composition containing the same |
| US5242798A (en) * | 1983-07-21 | 1993-09-07 | Scripps Clinic And Research Foundation | Synthetic polypeptides corresponding to portions of proteinoids translated from brain-specific mRNAs, receptors, methods and diagnostics using the same |
| DE3586772T2 (de) * | 1984-07-24 | 1993-03-04 | Coselco Mimotopes Pty Ltd | Verfahren zur bestimmung von mimotopen. |
| US5182082A (en) * | 1991-01-23 | 1993-01-26 | Becton, Dickinson And Company | Multiple aliquot device for distributing a liquid solution into a well |
| US5877028A (en) * | 1991-05-29 | 1999-03-02 | Smithkline Diagnostics, Inc. | Immunochromatographic assay device |
| US6168956B1 (en) | 1991-05-29 | 2001-01-02 | Beckman Coulter, Inc. | Multiple component chromatographic assay device |
| US5998220A (en) * | 1991-05-29 | 1999-12-07 | Beckman Coulter, Inc. | Opposable-element assay devices, kits, and methods employing them |
| US5348867A (en) * | 1991-11-15 | 1994-09-20 | George Georgiou | Expression of proteins on bacterial surface |
| US5698686A (en) * | 1994-10-20 | 1997-12-16 | Arch Development Corporation | Yeast telomerase compositions |
| US5807552A (en) * | 1995-08-04 | 1998-09-15 | Board Of Regents, The University Of Texas System | Compositions for conferring immunogenicity to a substance and uses thereof |
| US5736343A (en) * | 1995-08-18 | 1998-04-07 | Landry; Donald | Detection of organic compounds through regulation of antibody-catalyzed reactions |
| US6689757B1 (en) | 1996-02-12 | 2004-02-10 | M.L. Laboratories Plc | Methods for vaccination and vaccines therefor |
| US20020034732A1 (en) * | 1997-07-30 | 2002-03-21 | Daniel J. Capon | Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening |
| US6610838B1 (en) | 1997-09-10 | 2003-08-26 | Symbicom Aktiebolag | P13 antigens from Borrelia |
| JP2002529112A (ja) * | 1998-11-17 | 2002-09-10 | ボード・オヴ・リージェンツ，ザ・ユニヴァーシティ・オヴ・テキサス・システム | Ｈｉｖ特異的ｔ細胞誘導 |
| WO2002036777A1 (en) * | 2000-11-02 | 2002-05-10 | The National University Of Singapore | aopB GENE, PROTEIN, HOMOLOGS, FRAGMENTS AND VARIANTS THEREOF, AND THEIR USE FOR CELL SURFACE DISPLAY |
| EP2292762A3 (en) | 2002-12-20 | 2012-12-12 | Board of Regents, The University of Texas System | VMP-like sequences of pathogenic Borrelia species and strains |
| CN1820020B (zh) * | 2003-05-06 | 2010-04-28 | 技术持有有限公司 | Sars-冠状病毒病毒样颗粒以及应用方法 |
| EP1635765B1 (en) | 2003-05-23 | 2013-07-17 | Board Of Regents, The University Of Texas System | Structure based and combinatorially selected oligonucleoside phosphorothioate and phosphorodithioate aptamer targeting ap-1 transcription factors |
| EP2368569A3 (en) | 2006-01-18 | 2012-05-02 | University Of Chicago | Compositions and methods related to staphylococcal bacterium proteins |
| MX2009008140A (es) * | 2007-02-02 | 2009-10-26 | Baylor Res Inst | Vacunas a base de antigeno dirigido a dcir expresado en celulas que presentan antigeno. |
| TWI422594B (zh) | 2007-02-02 | 2014-01-11 | Baylor Res Inst | 經由樹狀細胞去唾液酸糖蛋白受體（ｄｃ-ａｓｇｐｒ）接合抗原呈現細胞之藥劑 |
| BRPI0807344A2 (pt) | 2007-02-02 | 2014-05-20 | Baylor Res Inst | Antígenos multivariáveis complexados com anticorpo monoclonal humanizado de direcionamento |
| BRPI0807563A2 (pt) | 2007-02-23 | 2014-07-01 | Baylor Res Inst | Ativação de células apresentando antígeno humano através de receptor-1 (lox-1) de ldl oxidado semelhante a lectina de célula dendrítica |
| CA2717656A1 (en) * | 2007-02-23 | 2008-08-28 | Baylor Research Institute | Activation of human antigen-presenting cells through clec-6 |
| CN101679949B (zh) | 2007-02-23 | 2015-08-19 | 贝勒研究院 | 通过dectin-1激活人抗原呈递细胞的治疗性应用 |
| WO2009059328A2 (en) * | 2007-11-02 | 2009-05-07 | The Johns Hopkins University | Multi- component l2 vaccine for prevention of human papillomavirus infection |
| ES2685823T3 (es) * | 2008-07-16 | 2018-10-11 | Baylor Research Institute | Anticuerpos antagonistas anti-CD40 |
| US20110262477A1 (en) | 2008-10-06 | 2011-10-27 | University Of Chicago | Compositions and Methods Related to Bacterial EAP, EMP, and/or ADSA Proteins |
| WO2011127032A1 (en) | 2010-04-05 | 2011-10-13 | University Of Chicago | Compositions and methods related to protein a (spa) antibodies as an enhancer of immune response |
| SI3281947T1 (sl) | 2009-04-03 | 2020-07-31 | The University Of Chicago | Sestave in metode v zvezi z variantami proteina A (SPA) |
| US10080799B2 (en) | 2010-02-12 | 2018-09-25 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods and compositions related to glycoprotein-immunoglobulin fusions |
| US8821894B2 (en) | 2010-07-02 | 2014-09-02 | The University Of Chicago | Compositions and methods related to protein A (SpA) variants |
| US9095540B2 (en) | 2010-09-09 | 2015-08-04 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens |
| US9567346B2 (en) | 2010-10-29 | 2017-02-14 | Life Technologies Corporation | Biotin derivatives |
| US8945588B2 (en) | 2011-05-06 | 2015-02-03 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides |
| BR112014026861A2 (pt) | 2012-04-26 | 2018-05-15 | Univ Chicago | antígenos de estafilococos coagulase e métodos de seu uso |
| US9701719B2 (en) | 2012-09-27 | 2017-07-11 | Research Development Foundation | Attenuated Chikungunya virus |
| WO2014138696A1 (en) | 2013-03-07 | 2014-09-12 | University Of Maryland, Baltimore | Immunotherapeutic potential of modified lipooligosaccharides/lipid a |
| CA3185180A1 (en) | 2014-05-16 | 2015-11-19 | Baylor Research Institute | Methods and compositions for treating autoimmune and inflammatory conditions |
| US10662226B2 (en) | 2016-10-28 | 2020-05-26 | The Regents of the University of Caiifomia | Synthetic beta-amyloid peptides capable of forming stable antigenic oligomers |
| US11413336B2 (en) | 2018-03-23 | 2022-08-16 | Board Of Regents, The University Of Texas System | Coccidioides antigens and methods of their use |
| US11548938B2 (en) | 2018-08-21 | 2023-01-10 | Quidel Corporation | DbpA antibodies and uses thereof |
| US20220175920A1 (en) | 2019-03-27 | 2022-06-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Recombinant proteins with cd40 activating properties |
| US20230034677A1 (en) | 2019-11-21 | 2023-02-02 | INSERM (Institut National de la Santé et la Recherche (Médicale) | Novel immunotherapies targeting pd-1 with anti-pd-1/il-15 immunocytokines |
| WO2021178637A1 (en) | 2020-03-05 | 2021-09-10 | Iowa State University Research Foundation, Inc. | IMMUNOGENIC AND VACCINE COMPOSITIONS AGAINST SARS-CoV-2 |
| JP2023525140A (ja) | 2020-05-13 | 2023-06-14 | アンセルム（アンスティチュート・ナシオナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシェルシュ・メディカル） | Ｏｘ４０活性化特性を有する組換えタンパク質 |
| EP4469079A1 (en) | 2022-01-28 | 2024-12-04 | Pfizer Inc. | Coronavirus antigen variants |
| WO2025017036A1 (en) | 2023-07-17 | 2025-01-23 | Institut National de la Santé et de la Recherche Médicale | Alphavirus nsp3 helical tubular scaffolds |
| WO2025027492A1 (en) | 2023-07-31 | 2025-02-06 | Pfizer Inc. | Coronavirus antigen variants |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE337223B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1967-05-23 | 1971-08-02 | Pharmacia Ab | |
| SE343210B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1967-12-20 | 1972-03-06 | Pharmacia Ab | |
| US3646346A (en) * | 1968-12-26 | 1972-02-29 | Pharmacia Ab | Antibody-coated tube system for radioimmunoassay |
| US3867517A (en) * | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
-
1973
- 1973-10-26 US US05/410,066 patent/US3949064A/en not_active Expired - Lifetime
-
1974
- 1974-09-23 IL IL45707A patent/IL45707A/en unknown
- 1974-09-25 ZA ZA00746098A patent/ZA746098B/xx unknown
- 1974-09-27 GB GB4199674A patent/GB1436934A/en not_active Expired
- 1974-09-28 JP JP49112223A patent/JPS5762020B2/ja not_active Expired
- 1974-09-30 AU AU73787/74A patent/AU476619B2/en not_active Expired
- 1974-09-30 CA CA210,357A patent/CA1036493A/en not_active Expired
- 1974-10-01 LU LU71027A patent/LU71027A1/xx unknown
- 1974-10-03 BE BE149173A patent/BE820660A/xx unknown
- 1974-10-15 FR FR7434561A patent/FR2249334B1/fr not_active Expired
- 1974-10-15 NL NL7413552A patent/NL7413552A/xx not_active Application Discontinuation
- 1974-10-24 DE DE2450523A patent/DE2450523C3/de not_active Expired
- 1974-10-24 BR BR8886/74A patent/BR7408886A/pt unknown
- 1974-10-25 SE SE7413484A patent/SE7413484L/xx not_active Application Discontinuation
- 1974-10-26 ES ES431413A patent/ES431413A1/es not_active Expired
-
1978
- 1978-03-13 US US05/885,829 patent/USRE29955E/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5762020B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1982-12-27 |
| LU71027A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-04-17 |
| FR2249334A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-05-23 |
| IL45707A0 (en) | 1974-11-29 |
| AU476619B2 (en) | 1976-09-30 |
| US3949064A (en) | 1976-04-06 |
| DE2450523C3 (de) | 1978-06-22 |
| DE2450523B2 (de) | 1976-10-07 |
| ES431413A1 (es) | 1976-10-16 |
| FR2249334B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1977-03-25 |
| BR7408886A (pt) | 1976-05-04 |
| USRE29955E (en) | 1979-04-03 |
| DE2450523A1 (de) | 1975-05-22 |
| NL7413552A (nl) | 1975-04-29 |
| ZA746098B (en) | 1975-11-26 |
| SE7413484L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-04-28 |
| GB1436934A (en) | 1976-05-26 |
| BE820660A (fr) | 1975-02-03 |
| IL45707A (en) | 1977-01-31 |
| JPS5075095A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-06-20 |
| AU7378774A (en) | 1976-04-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA1036493A (en) | Method of detecting antigens or antibodies | |
| Clark et al. | Enzyme-linked immunosorbent assay (ELISA): theoretical and practical aspects | |
| US4020151A (en) | Method for quantitation of antigens or antibodies on a solid surface | |
| CA1179940A (en) | Solid phase system for ligand assay | |
| US3966897A (en) | Medium for use in bioassay and method of using same | |
| US4242096A (en) | Immunoassay for antigens | |
| EP0267317B1 (en) | Method for the detection of proteins and viruses | |
| US4338094A (en) | Macroencapsulated immunosorbent assay technique | |
| EP0427984A1 (en) | Articles for use in enzyme immuno-assay techniques, and methods of making and using such articles | |
| EP0122695B1 (en) | Immunoassay for antigens employing supported binder | |
| US4865997A (en) | Assay for ligands by separating bound and free tracer from sample | |
| GB1564579A (en) | Specific binding assay method ans test kit employing polyvinyl alcohol as separating agent | |
| US4012494A (en) | Direct radioimmunoassay for antigens and their antibodies | |
| CA1340575C (en) | Article for performing immunological assays utilizing organic dyes and mehtods for producing and utilizing same | |
| CA1142852A (en) | Method for determining the contents of biological fluids and means therefor | |
| CA2008100A1 (en) | Method for the determination of immunologically detectable substance | |
| JPH0224559A (ja) | 免疫学的に検出可能な物質の測定法、反応容器及びイムノアツセイ原理による方法における種々のパラメーターの測定法 | |
| US4399229A (en) | Rapid radioimmunoassay product and method of making and using same | |
| JPS5915861A (ja) | 免疫分析用材料 | |
| GB1597556A (en) | Device for use in immunoassays | |
| US4727023A (en) | Preparations for use in solid phase immunoassays comprising monoclonal antibodies covalently embedded in their immobilized hybridoma cells | |
| CA1059901A (en) | Direct radioimmunoassay for antigens and their antibodies | |
| EP0080108A1 (en) | Diagnostic reagent and use thereof | |
| JPS6318704B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | ||
| CA1163460A (en) | Immunoassay for antigens |