CA1034565A - ANDROSTANE-17.beta.-CARBOXYLIC ACIDS DERIVATIVES - Google Patents

ANDROSTANE-17.beta.-CARBOXYLIC ACIDS DERIVATIVES

Info

Publication number
CA1034565A
CA1034565A CA176,804A CA176804A CA1034565A CA 1034565 A CA1034565 A CA 1034565A CA 176804 A CA176804 A CA 176804A CA 1034565 A CA1034565 A CA 1034565A
Authority
CA
Canada
Prior art keywords
androstane
beta
carboxylic acids
acids derivatives
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA176,804A
Other languages
English (en)
French (fr)
Other versions
CA176804S (en
Inventor
Brian M. Bain
Gordon H. Phillipps
Peter J. May
Edward A. Woollett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Application granted granted Critical
Publication of CA1034565A publication Critical patent/CA1034565A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA176,804A 1972-07-19 1973-07-18 ANDROSTANE-17.beta.-CARBOXYLIC ACIDS DERIVATIVES Expired CA1034565A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3383472A GB1438940A (en) 1972-07-19 1972-07-19 17beta-haloalkoxycarbonyl-17alpha-oxysteroids

Publications (1)

Publication Number Publication Date
CA1034565A true CA1034565A (en) 1978-07-11

Family

ID=10358062

Family Applications (1)

Application Number Title Priority Date Filing Date
CA176,804A Expired CA1034565A (en) 1972-07-19 1973-07-18 ANDROSTANE-17.beta.-CARBOXYLIC ACIDS DERIVATIVES

Country Status (18)

Country Link
US (1) US3856828A (bg)
JP (1) JPS5750800B2 (bg)
AU (1) AU473714B2 (bg)
BE (1) BE802481R (bg)
CA (1) CA1034565A (bg)
CH (1) CH619968A5 (bg)
DE (1) DE2336633A1 (bg)
DK (1) DK133158C (bg)
ES (1) ES417012A2 (bg)
FR (1) FR2192840B2 (bg)
GB (1) GB1438940A (bg)
IE (1) IE37925B1 (bg)
IL (1) IL42779A (bg)
LU (1) LU68039A1 (bg)
NL (1) NL7309992A (bg)
PH (1) PH14795A (bg)
SE (1) SE396079B (bg)
ZA (1) ZA734896B (bg)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3943124A (en) * 1970-12-17 1976-03-09 Gordon Hanley Phillipps Chemical compounds
US3989686A (en) * 1972-06-15 1976-11-02 Glaxo Laboratories Limited Anaesthetic steroids of the androstane series and process for preparing same
GB1514476A (en) * 1974-08-30 1978-06-14 Glaxo Lab Ltd Alkyl and haloalkyl androst-4-ene and androsta-1,4-diene-17beta-carboxylates
US4093721A (en) * 1974-08-30 1978-06-06 Glaxo Laboratories Limited Pharmaceutical compositions of 6α,9α-difluoro-androst-4-ene-17β-carboxylates and derivatives thereof
DK118776A (da) * 1975-03-21 1976-09-22 Schering Ag Pregnansyrederivater
CH628355A5 (de) * 1976-02-24 1982-02-26 Ciba Geigy Ag Verfahren zur herstellung neuer androstadien-17beta-carbonsaeuren und ihrer ester und salze.
IT1114534B (it) * 1978-02-08 1986-01-27 Glaxo Group Ltd Steroide anti-infiammatorio della serie dell'androstano composizioni che lo contengono e procedimento per produrlo
US4188385A (en) * 1978-04-05 1980-02-12 Syntex (U.S.A.) Inc. Thioetianic acid derivatives
US4187301A (en) * 1978-04-05 1980-02-05 Syntex (U.S.A.) Inc. 17 Beta-thiocarboxylic acid esters of 6 alpha, 6 beta-difluoro-3-oxoandrost-4-enes
US4252729A (en) * 1978-05-12 1981-02-24 Hoffmann-La Roche Inc. Steroids and process for their manufacture
NZ196260A (en) * 1980-02-15 1983-11-30 Glaxo Group Ltd Androstane carbothioates anti-inflammatory compositions
SE449106B (sv) * 1980-07-10 1987-04-06 Otsuka Pharma Co Ltd Steroid med anti-inflammatorisk verkan samt komposition innehallande denna
US4996335A (en) * 1980-07-10 1991-02-26 Nicholas S. Bodor Soft steroids having anti-inflammatory activity
US4710495A (en) * 1980-07-10 1987-12-01 Otsuka Pharmaceutical Co., Ltd. Soft steroids having anti-inflammatory activity
CH649923A5 (de) * 1980-10-06 1985-06-28 Glaxo Group Ltd Topisch verabreichbare pharmazeutische zusammensetzungen, enthaltend anti-inflammatorische steroide.
SE8306370D0 (sv) * 1983-11-18 1983-11-18 Draco Ab Novel androstane-17beta-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions
SE8501693D0 (sv) * 1985-04-04 1985-04-04 Draco Ab Novel 16,17-acetalsubstituted androstane-17beta-carboxylic acid esters
IL78144A0 (en) * 1985-04-04 1986-07-31 Draco Ab Novel androstane-17beta-carboxylic acid esters
US4686214A (en) * 1985-10-30 1987-08-11 Alcon Laboratories, Inc. Anti-inflammatory compounds for ophthalmic use
WO1989003390A1 (en) * 1987-10-13 1989-04-20 Bodor Nicholas S Soft steroids having anti-inflammatory activity
US5981517A (en) * 1996-05-09 1999-11-09 Soft Drugs, Inc. Androstene derivatives
GB0015876D0 (en) * 2000-06-28 2000-08-23 Novartis Ag Organic compounds
US6787532B2 (en) 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6777400B2 (en) * 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
WO2002012265A1 (en) * 2000-08-05 2002-02-14 Glaxo Group Limited 6.ALPHA., 9.ALPHA.-DIFLUORO-17.ALPHA.-`(2-FURANYLCARBOXYL) OXY!-11.BETA.-HYDROXY-16.ALPHA.-METHYL-3-OXO-ANDROST-1,4,-DIENE-17-CARBOTHIOIC ACID S-FLUOROMETHYL ESTER AS AN ANTI-INFLAMMATORY AGENT
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
US6858596B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
GB0019172D0 (en) 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
US6858593B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
SI1383786T1 (sl) 2001-04-30 2009-02-28 Glaxo Group Ltd Protivnetni 17.beta-karbotioatestrski derivati androstana s ciklično estrsko skupino na položaju 17.alfa
GB0125259D0 (en) * 2001-10-20 2001-12-12 Glaxo Group Ltd Novel compounds
WO2003072592A1 (en) * 2002-01-15 2003-09-04 Glaxo Group Limited 17.alpha-cycloalkyl/cycloylkenyl esters of alkyl-or haloalkyl-androst-4-en-3-on-11.beta.,17.alpha.-diol 17.beta.-carboxylates as anti-inflammatory agents
WO2003062259A2 (en) * 2002-01-21 2003-07-31 Glaxo Group Limited Non-aromatic 17.alpha.-esters of androstane-17.beta.-carboxylate esters as anti-inflammatory agents
GB0202216D0 (en) * 2002-01-31 2002-03-20 Glaxo Group Ltd Novel compounds
US20050175545A1 (en) * 2002-02-04 2005-08-11 Keith Biggadike Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist
GB0202635D0 (en) * 2002-02-05 2002-03-20 Glaxo Wellcome Mfg Pte Ltd Formulation containing novel anti-inflammatory androstane derivative
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
GB0225287D0 (en) * 2002-10-30 2002-12-11 Glaxo Group Ltd Novel compounds
WO2004112800A1 (en) * 2003-06-19 2004-12-29 Bodor Nicholas S Enhancement of activity and/or duration of action of selected anti-inflammatory steroids
GB0316290D0 (en) 2003-07-11 2003-08-13 Glaxo Group Ltd Novel compounds
US20090124588A1 (en) * 2005-01-10 2009-05-14 Glaxo Group Limited Androstane 17-Alpha-Carbonate for Use in the Treatment of Inflammatory and Allergic Conditions
ATE517908T1 (de) * 2005-01-10 2011-08-15 Glaxo Group Ltd Androstan-17-alpha-carbonat-derivate zur verwendung bei der behandlung allergischer und entzündlicher zustände
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
US20070245924A1 (en) * 2006-04-20 2007-10-25 Hofmann Michael A Reduced abrasion of titanium dioxide pigments produced from the chloride process
GB0615108D0 (en) * 2006-07-28 2006-09-06 Glaxo Group Ltd Novel formulations
US9290446B2 (en) 2010-10-27 2016-03-22 Hovione Inter Limited Electrophilic reagents for monohalomethylation, their preparation and their uses

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3636010A (en) * 1968-12-23 1972-01-18 Ciba Geigy Corp Esters of steroid-17-carboxylic acids
GB1384372A (en) * 1971-01-20 1975-02-19 Glaxo Lab Ltd Dereivatives of 17alpha-hydroxyandrost-4-ene-17beta-carboxylic acids

Also Published As

Publication number Publication date
DK133158B (da) 1976-03-29
DK133158C (da) 1976-09-06
IL42779A (en) 1977-04-29
ES417012A2 (es) 1976-04-16
AU473714B2 (en) 1976-07-01
FR2192840A2 (bg) 1974-02-15
PH14795A (en) 1981-12-09
LU68039A1 (bg) 1973-09-26
DE2336633A1 (de) 1974-01-31
JPS4980058A (bg) 1974-08-02
CH619968A5 (bg) 1980-10-31
ZA734896B (en) 1974-12-24
AU5825273A (en) 1975-01-23
SE396079B (sv) 1977-09-05
IE37925B1 (en) 1977-11-09
IE37925L (en) 1974-01-19
BE802481R (fr) 1974-01-18
GB1438940A (en) 1976-06-09
FR2192840B2 (bg) 1976-12-24
US3856828A (en) 1974-12-24
JPS5750800B2 (bg) 1982-10-28
NL7309992A (bg) 1974-01-22

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