DK133158B - Analogifremgangsmade til fremstilling af 3-oxo-17alfa-acyloxyandrost-4-en-17beta-carboxylsyreestere - Google Patents

Analogifremgangsmade til fremstilling af 3-oxo-17alfa-acyloxyandrost-4-en-17beta-carboxylsyreestere

Info

Publication number
DK133158B
DK133158B DK397073AA DK397073A DK133158B DK 133158 B DK133158 B DK 133158B DK 397073A A DK397073A A DK 397073AA DK 397073 A DK397073 A DK 397073A DK 133158 B DK133158 B DK 133158B
Authority
DK
Denmark
Prior art keywords
acyloxyandrost
17alfa
17beta
oxo
production
Prior art date
Application number
DK397073AA
Other languages
English (en)
Other versions
DK133158C (da
Inventor
G H Phillipps
P J May
B M Bain
E A Woollett
Original Assignee
Glaxo Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Lab Ltd filed Critical Glaxo Lab Ltd
Publication of DK133158B publication Critical patent/DK133158B/da
Application granted granted Critical
Publication of DK133158C publication Critical patent/DK133158C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK397073A 1972-07-19 1973-07-18 Analogifremgangsmade til fremstilling af 3-oxo-17alfa-acyloxyandrost-4-en-17beta-carboxylsyreestere DK133158C (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3383472A GB1438940A (en) 1972-07-19 1972-07-19 17beta-haloalkoxycarbonyl-17alpha-oxysteroids

Publications (2)

Publication Number Publication Date
DK133158B true DK133158B (da) 1976-03-29
DK133158C DK133158C (da) 1976-09-06

Family

ID=10358062

Family Applications (1)

Application Number Title Priority Date Filing Date
DK397073A DK133158C (da) 1972-07-19 1973-07-18 Analogifremgangsmade til fremstilling af 3-oxo-17alfa-acyloxyandrost-4-en-17beta-carboxylsyreestere

Country Status (18)

Country Link
US (1) US3856828A (da)
JP (1) JPS5750800B2 (da)
AU (1) AU473714B2 (da)
BE (1) BE802481R (da)
CA (1) CA1034565A (da)
CH (1) CH619968A5 (da)
DE (1) DE2336633A1 (da)
DK (1) DK133158C (da)
ES (1) ES417012A2 (da)
FR (1) FR2192840B2 (da)
GB (1) GB1438940A (da)
IE (1) IE37925B1 (da)
IL (1) IL42779A (da)
LU (1) LU68039A1 (da)
NL (1) NL7309992A (da)
PH (1) PH14795A (da)
SE (1) SE396079B (da)
ZA (1) ZA734896B (da)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
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US3943124A (en) * 1970-12-17 1976-03-09 Gordon Hanley Phillipps Chemical compounds
US3989686A (en) * 1972-06-15 1976-11-02 Glaxo Laboratories Limited Anaesthetic steroids of the androstane series and process for preparing same
US4093721A (en) * 1974-08-30 1978-06-06 Glaxo Laboratories Limited Pharmaceutical compositions of 6α,9α-difluoro-androst-4-ene-17β-carboxylates and derivatives thereof
GB1514476A (en) * 1974-08-30 1978-06-14 Glaxo Lab Ltd Alkyl and haloalkyl androst-4-ene and androsta-1,4-diene-17beta-carboxylates
DK118776A (da) * 1975-03-21 1976-09-22 Schering Ag Pregnansyrederivater
CH628355A5 (de) * 1976-02-24 1982-02-26 Ciba Geigy Ag Verfahren zur herstellung neuer androstadien-17beta-carbonsaeuren und ihrer ester und salze.
IT1114534B (it) * 1978-02-08 1986-01-27 Glaxo Group Ltd Steroide anti-infiammatorio della serie dell'androstano composizioni che lo contengono e procedimento per produrlo
US4188385A (en) * 1978-04-05 1980-02-12 Syntex (U.S.A.) Inc. Thioetianic acid derivatives
US4187301A (en) * 1978-04-05 1980-02-05 Syntex (U.S.A.) Inc. 17 Beta-thiocarboxylic acid esters of 6 alpha, 6 beta-difluoro-3-oxoandrost-4-enes
US4252729A (en) * 1978-05-12 1981-02-24 Hoffmann-La Roche Inc. Steroids and process for their manufacture
DE3153379C2 (da) * 1980-02-15 1992-11-19 Glaxo Group Ltd., London, Gb
SE449106B (sv) * 1980-07-10 1987-04-06 Otsuka Pharma Co Ltd Steroid med anti-inflammatorisk verkan samt komposition innehallande denna
US4996335A (en) * 1980-07-10 1991-02-26 Nicholas S. Bodor Soft steroids having anti-inflammatory activity
US4710495A (en) * 1980-07-10 1987-12-01 Otsuka Pharmaceutical Co., Ltd. Soft steroids having anti-inflammatory activity
PT73772B (en) * 1980-10-06 1983-10-14 Glaxo Group Ltd Topically administrable pharmaceutical compositions containing anti-inflammatory steroids
SE8306370D0 (sv) * 1983-11-18 1983-11-18 Draco Ab Novel androstane-17beta-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions
SE8501693D0 (sv) * 1985-04-04 1985-04-04 Draco Ab Novel 16,17-acetalsubstituted androstane-17beta-carboxylic acid esters
IL78144A0 (en) * 1985-04-04 1986-07-31 Draco Ab Novel androstane-17beta-carboxylic acid esters
US4686214A (en) * 1985-10-30 1987-08-11 Alcon Laboratories, Inc. Anti-inflammatory compounds for ophthalmic use
ATE90355T1 (de) * 1987-10-13 1993-06-15 Nicholas S Bodor Weiche steroide mit anti-entzuendungswirkung.
US5981517A (en) * 1996-05-09 1999-11-09 Soft Drugs, Inc. Androstene derivatives
GB0015876D0 (en) * 2000-06-28 2000-08-23 Novartis Ag Organic compounds
US6777399B2 (en) * 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
GB0019172D0 (en) 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6858596B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6787532B2 (en) 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
US6777400B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
AP1422A (en) * 2000-08-05 2005-06-05 Glaxo Group Ltd 6.Alpha.,9.alpha.-difluoro-17.alpha.-'(2-furanylcarboxyl)oxy!-11.beta.-hydroxy-16.alpha.-methyl-3-oxo-androst-1,4,-diene-17-carbothioic acid s-fluoromethyl ester as an anti-inflammatory agent.
US6759398B2 (en) * 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
US6858593B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
CN1302007C (zh) 2001-04-30 2007-02-28 葛兰素集团有限公司 具有抗炎性的在17.α位上具有环酯基的雄甾烷的17.β.－硫代羧酸酯衍生物
GB0125259D0 (en) * 2001-10-20 2001-12-12 Glaxo Group Ltd Novel compounds
AU2003202044A1 (en) * 2002-01-15 2003-09-09 Glaxo Group Limited 17.alpha-cycloalkyl/cycloylkenyl esters of alkyl-or haloalkyl-androst-4-en-3-on-11.beta.,17.alpha.-diol 17.beta.-carboxylates as anti-inflammatory agents
WO2003062259A2 (en) * 2002-01-21 2003-07-31 Glaxo Group Limited Non-aromatic 17.alpha.-esters of androstane-17.beta.-carboxylate esters as anti-inflammatory agents
GB0202216D0 (en) * 2002-01-31 2002-03-20 Glaxo Group Ltd Novel compounds
US20050175545A1 (en) * 2002-02-04 2005-08-11 Keith Biggadike Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist
GB0202635D0 (en) * 2002-02-05 2002-03-20 Glaxo Wellcome Mfg Pte Ltd Formulation containing novel anti-inflammatory androstane derivative
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
GB0225287D0 (en) * 2002-10-30 2002-12-11 Glaxo Group Ltd Novel compounds
WO2004112800A1 (en) * 2003-06-19 2004-12-29 Bodor Nicholas S Enhancement of activity and/or duration of action of selected anti-inflammatory steroids
GB0316290D0 (en) * 2003-07-11 2003-08-13 Glaxo Group Ltd Novel compounds
WO2006072599A2 (en) * 2005-01-10 2006-07-13 Glaxo Group Limited Androstane 17-alpha carbonate derivatives for use in the treatment of allergic and inflammatory conditions
US20090124588A1 (en) * 2005-01-10 2009-05-14 Glaxo Group Limited Androstane 17-Alpha-Carbonate for Use in the Treatment of Inflammatory and Allergic Conditions
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
US20070245924A1 (en) * 2006-04-20 2007-10-25 Hofmann Michael A Reduced abrasion of titanium dioxide pigments produced from the chloride process
GB0615108D0 (en) * 2006-07-28 2006-09-06 Glaxo Group Ltd Novel formulations
PT2632896T (pt) 2010-10-27 2017-06-26 Hovione Int Ltd Reagentes eletrofílicos para monohalometilação, sua preparação e suas utilizações

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3636010A (en) * 1968-12-23 1972-01-18 Ciba Geigy Corp Esters of steroid-17-carboxylic acids
GB1384372A (en) * 1971-01-20 1975-02-19 Glaxo Lab Ltd Dereivatives of 17alpha-hydroxyandrost-4-ene-17beta-carboxylic acids

Also Published As

Publication number Publication date
JPS4980058A (da) 1974-08-02
US3856828A (en) 1974-12-24
AU473714B2 (en) 1976-07-01
DK133158C (da) 1976-09-06
DE2336633A1 (de) 1974-01-31
CA1034565A (en) 1978-07-11
CH619968A5 (da) 1980-10-31
JPS5750800B2 (da) 1982-10-28
FR2192840A2 (da) 1974-02-15
IE37925B1 (en) 1977-11-09
ZA734896B (en) 1974-12-24
FR2192840B2 (da) 1976-12-24
GB1438940A (en) 1976-06-09
SE396079B (sv) 1977-09-05
LU68039A1 (da) 1973-09-26
AU5825273A (en) 1975-01-23
PH14795A (en) 1981-12-09
IE37925L (en) 1974-01-19
ES417012A2 (es) 1976-04-16
NL7309992A (da) 1974-01-22
IL42779A (en) 1977-04-29
BE802481R (fr) 1974-01-18

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