SE396079B - Forfarande for framstellning av nya anti-inflammatoriska steroider tillhorande androstan-serien - Google Patents

Forfarande for framstellning av nya anti-inflammatoriska steroider tillhorande androstan-serien

Info

Publication number
SE396079B
SE396079B SE7310070A SE7310070A SE396079B SE 396079 B SE396079 B SE 396079B SE 7310070 A SE7310070 A SE 7310070A SE 7310070 A SE7310070 A SE 7310070A SE 396079 B SE396079 B SE 396079B
Authority
SE
Sweden
Prior art keywords
procedure
production
new anti
inflammatory steroids
belonging
Prior art date
Application number
SE7310070A
Other languages
English (en)
Swedish (sv)
Inventor
G H Phillipps
P J May
B M Bain
E A Woollett
Original Assignee
Glaxo Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Lab Ltd filed Critical Glaxo Lab Ltd
Publication of SE396079B publication Critical patent/SE396079B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SE7310070A 1972-07-19 1973-07-18 Forfarande for framstellning av nya anti-inflammatoriska steroider tillhorande androstan-serien SE396079B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3383472A GB1438940A (en) 1972-07-19 1972-07-19 17beta-haloalkoxycarbonyl-17alpha-oxysteroids

Publications (1)

Publication Number Publication Date
SE396079B true SE396079B (sv) 1977-09-05

Family

ID=10358062

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7310070A SE396079B (sv) 1972-07-19 1973-07-18 Forfarande for framstellning av nya anti-inflammatoriska steroider tillhorande androstan-serien

Country Status (18)

Country Link
US (1) US3856828A (xx)
JP (1) JPS5750800B2 (xx)
AU (1) AU473714B2 (xx)
BE (1) BE802481R (xx)
CA (1) CA1034565A (xx)
CH (1) CH619968A5 (xx)
DE (1) DE2336633A1 (xx)
DK (1) DK133158C (xx)
ES (1) ES417012A2 (xx)
FR (1) FR2192840B2 (xx)
GB (1) GB1438940A (xx)
IE (1) IE37925B1 (xx)
IL (1) IL42779A (xx)
LU (1) LU68039A1 (xx)
NL (1) NL7309992A (xx)
PH (1) PH14795A (xx)
SE (1) SE396079B (xx)
ZA (1) ZA734896B (xx)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0143764A1 (en) * 1983-11-18 1985-06-05 Aktiebolaget Draco Novel androstane-17 beta-carboxylic acid esters, a process and intermediates for their preparation, composition and method for the treatment of inflammatory conditions
EP0197018A1 (en) * 1985-04-04 1986-10-08 Aktiebolaget Draco 16,17-Acetal-substituted androstane-17-beta-carboxylic-acid esters, process for their preparation and pharmaceutical compound containing them
EP0200692A1 (en) * 1985-04-04 1986-11-05 Aktiebolaget Draco Androstane-17-beta-carboxylic-acid esters, process for their preparation and pharmaceutical compound containing them

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3943124A (en) * 1970-12-17 1976-03-09 Gordon Hanley Phillipps Chemical compounds
US3989686A (en) * 1972-06-15 1976-11-02 Glaxo Laboratories Limited Anaesthetic steroids of the androstane series and process for preparing same
GB1514476A (en) * 1974-08-30 1978-06-14 Glaxo Lab Ltd Alkyl and haloalkyl androst-4-ene and androsta-1,4-diene-17beta-carboxylates
US4093721A (en) * 1974-08-30 1978-06-06 Glaxo Laboratories Limited Pharmaceutical compositions of 6α,9α-difluoro-androst-4-ene-17β-carboxylates and derivatives thereof
DK118776A (da) * 1975-03-21 1976-09-22 Schering Ag Pregnansyrederivater
CH628355A5 (de) * 1976-02-24 1982-02-26 Ciba Geigy Ag Verfahren zur herstellung neuer androstadien-17beta-carbonsaeuren und ihrer ester und salze.
IT1114534B (it) * 1978-02-08 1986-01-27 Glaxo Group Ltd Steroide anti-infiammatorio della serie dell'androstano composizioni che lo contengono e procedimento per produrlo
US4187301A (en) * 1978-04-05 1980-02-05 Syntex (U.S.A.) Inc. 17 Beta-thiocarboxylic acid esters of 6 alpha, 6 beta-difluoro-3-oxoandrost-4-enes
US4188385A (en) * 1978-04-05 1980-02-12 Syntex (U.S.A.) Inc. Thioetianic acid derivatives
US4252729A (en) * 1978-05-12 1981-02-24 Hoffmann-La Roche Inc. Steroids and process for their manufacture
AU544517B2 (en) * 1980-02-15 1985-06-06 Glaxo Group Limited Androstane carbothioates
SE449106B (sv) * 1980-07-10 1987-04-06 Otsuka Pharma Co Ltd Steroid med anti-inflammatorisk verkan samt komposition innehallande denna
US4996335A (en) * 1980-07-10 1991-02-26 Nicholas S. Bodor Soft steroids having anti-inflammatory activity
US4710495A (en) * 1980-07-10 1987-12-01 Otsuka Pharmaceutical Co., Ltd. Soft steroids having anti-inflammatory activity
PT73772B (en) * 1980-10-06 1983-10-14 Glaxo Group Ltd Topically administrable pharmaceutical compositions containing anti-inflammatory steroids
US4686214A (en) * 1985-10-30 1987-08-11 Alcon Laboratories, Inc. Anti-inflammatory compounds for ophthalmic use
WO1989003390A1 (en) * 1987-10-13 1989-04-20 Bodor Nicholas S Soft steroids having anti-inflammatory activity
US5981517A (en) * 1996-05-09 1999-11-09 Soft Drugs, Inc. Androstene derivatives
GB0015876D0 (en) * 2000-06-28 2000-08-23 Novartis Ag Organic compounds
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
DK1305329T4 (da) * 2000-08-05 2015-06-15 Glaxo Group Ltd 6alpha, 9alpha-difluor-17alpha-(2-furanylcarboxyl)oxy-11beta-hydroxy-16alpha-methyl-3-oxo-androst-1,4-dien-17-carbothiosyre-S-fluormethylester som et antiinflammatorisk middel
US6777400B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6858593B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6787532B2 (en) 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
GB0019172D0 (en) * 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6759398B2 (en) * 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
US6858596B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
PL366937A1 (en) * 2001-04-30 2005-02-07 Glaxo Group Limited Anti-inflammatory 17.beta.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.alpha
GB0125259D0 (en) * 2001-10-20 2001-12-12 Glaxo Group Ltd Novel compounds
AU2003202044A1 (en) * 2002-01-15 2003-09-09 Glaxo Group Limited 17.alpha-cycloalkyl/cycloylkenyl esters of alkyl-or haloalkyl-androst-4-en-3-on-11.beta.,17.alpha.-diol 17.beta.-carboxylates as anti-inflammatory agents
WO2003062259A2 (en) * 2002-01-21 2003-07-31 Glaxo Group Limited Non-aromatic 17.alpha.-esters of androstane-17.beta.-carboxylate esters as anti-inflammatory agents
GB0202216D0 (en) * 2002-01-31 2002-03-20 Glaxo Group Ltd Novel compounds
US20050175545A1 (en) * 2002-02-04 2005-08-11 Keith Biggadike Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist
GB0202635D0 (en) * 2002-02-05 2002-03-20 Glaxo Wellcome Mfg Pte Ltd Formulation containing novel anti-inflammatory androstane derivative
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
GB0225287D0 (en) * 2002-10-30 2002-12-11 Glaxo Group Ltd Novel compounds
DE602004008083T2 (de) * 2003-06-19 2008-04-24 Nicholas S. Gainsville Bodor Verstärkung der aktivität und/oder wirkdauer von ausgewählten entzündungshemmenden steroiden
GB0316290D0 (en) * 2003-07-11 2003-08-13 Glaxo Group Ltd Novel compounds
WO2006072599A2 (en) * 2005-01-10 2006-07-13 Glaxo Group Limited Androstane 17-alpha carbonate derivatives for use in the treatment of allergic and inflammatory conditions
US20090124588A1 (en) * 2005-01-10 2009-05-14 Glaxo Group Limited Androstane 17-Alpha-Carbonate for Use in the Treatment of Inflammatory and Allergic Conditions
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
US20070245924A1 (en) * 2006-04-20 2007-10-25 Hofmann Michael A Reduced abrasion of titanium dioxide pigments produced from the chloride process
GB0615108D0 (en) * 2006-07-28 2006-09-06 Glaxo Group Ltd Novel formulations
HUE034570T2 (en) 2010-10-27 2018-02-28 Hovione Int Ltd Electrophilic reagents for mono-gene methylation, their preparation and use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3636010A (en) * 1968-12-23 1972-01-18 Ciba Geigy Corp Esters of steroid-17-carboxylic acids
GB1384372A (en) * 1971-01-20 1975-02-19 Glaxo Lab Ltd Dereivatives of 17alpha-hydroxyandrost-4-ene-17beta-carboxylic acids

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0143764A1 (en) * 1983-11-18 1985-06-05 Aktiebolaget Draco Novel androstane-17 beta-carboxylic acid esters, a process and intermediates for their preparation, composition and method for the treatment of inflammatory conditions
US4820700A (en) * 1983-11-18 1989-04-11 Aktiebolaget Draco Novel androstane-17β-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions
EP0197018A1 (en) * 1985-04-04 1986-10-08 Aktiebolaget Draco 16,17-Acetal-substituted androstane-17-beta-carboxylic-acid esters, process for their preparation and pharmaceutical compound containing them
EP0200692A1 (en) * 1985-04-04 1986-11-05 Aktiebolaget Draco Androstane-17-beta-carboxylic-acid esters, process for their preparation and pharmaceutical compound containing them
EP0355859A1 (en) * 1985-04-04 1990-02-28 Aktiebolaget Draco Process for the preparation of intermediates for 11-beta,16-alpha,17-alpha,21-tetrahydroxypregna-3,20-dione 16-alpha,17-alpha-acetals and 21-esters thereof
US4950659A (en) * 1985-04-04 1990-08-21 Aktiebolaget Draco 16,17-acetalsubstituted androstane-17β-carboxylic acid esters prossessing high binding affinity to the glucocorticosteroid receptor

Also Published As

Publication number Publication date
JPS4980058A (xx) 1974-08-02
ES417012A2 (es) 1976-04-16
FR2192840A2 (xx) 1974-02-15
LU68039A1 (xx) 1973-09-26
US3856828A (en) 1974-12-24
AU5825273A (en) 1975-01-23
DK133158C (da) 1976-09-06
ZA734896B (en) 1974-12-24
IE37925L (en) 1974-01-19
DE2336633A1 (de) 1974-01-31
GB1438940A (en) 1976-06-09
AU473714B2 (en) 1976-07-01
BE802481R (fr) 1974-01-18
NL7309992A (xx) 1974-01-22
CA1034565A (en) 1978-07-11
JPS5750800B2 (xx) 1982-10-28
IL42779A (en) 1977-04-29
DK133158B (da) 1976-03-29
CH619968A5 (xx) 1980-10-31
PH14795A (en) 1981-12-09
FR2192840B2 (xx) 1976-12-24
IE37925B1 (en) 1977-11-09

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