CA1032541A - 5,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolines and process for preparing same - Google Patents

5,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolines and process for preparing same

Info

Publication number
CA1032541A
CA1032541A CA239,977A CA239977A CA1032541A CA 1032541 A CA1032541 A CA 1032541A CA 239977 A CA239977 A CA 239977A CA 1032541 A CA1032541 A CA 1032541A
Authority
CA
Canada
Prior art keywords
tetrahydroisoquinolines
trimethoxybenzyl
dihydroxy
preparing same
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA239,977A
Other languages
English (en)
French (fr)
Inventor
Norihide Umino
Masanori Sato
Katsuo Ikezawa
Muneyoshi Ikezaki
Kunihiko Irie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Application granted granted Critical
Publication of CA1032541A publication Critical patent/CA1032541A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
CA239,977A 1974-11-20 1975-11-18 5,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolines and process for preparing same Expired CA1032541A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP49134734A JPS5247474B2 (de) 1974-11-20 1974-11-20

Publications (1)

Publication Number Publication Date
CA1032541A true CA1032541A (en) 1978-06-06

Family

ID=15135331

Family Applications (1)

Application Number Title Priority Date Filing Date
CA239,977A Expired CA1032541A (en) 1974-11-20 1975-11-18 5,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolines and process for preparing same

Country Status (12)

Country Link
US (1) US4054659A (de)
JP (1) JPS5247474B2 (de)
BE (1) BE835744A (de)
CA (1) CA1032541A (de)
CH (2) CH621341A5 (de)
CS (1) CS190503B2 (de)
DK (1) DK143197C (de)
FR (1) FR2291753A1 (de)
GB (1) GB1487457A (de)
HU (1) HU170648B (de)
NL (1) NL166469C (de)
SE (1) SE424638B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5817465B2 (ja) * 1977-09-02 1983-04-07 田辺製薬株式会社 テトラヒドロイソキノリン誘導体の製法
JPS5484035A (en) * 1977-12-16 1979-07-04 Tanabe Seiyaku Co Ltd Anti-allergic agent
JP2001518468A (ja) * 1997-09-30 2001-10-16 モレキュラー デザインズ インターナショナル，インコーポレイテッド β３アドレナリン受容体拮抗薬、拮抗薬合成物およびこれらの応用方法
DK1362844T3 (da) 2001-01-26 2008-04-14 Btg Int Ltd Benzylaminanalog
US6593341B2 (en) 2001-03-29 2003-07-15 Molecular Design International, Inc. β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same
US6596734B1 (en) 2002-10-11 2003-07-22 Molecular Design International, Inc. Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3873704A (en) * 1970-12-17 1975-03-25 Tanabe Seiyaku Co Novel tetrahydroisoquinoline compounds in a pharmaceutical composition
JPS5734275B2 (de) * 1973-07-30 1982-07-22

Also Published As

Publication number Publication date
DK143197C (da) 1981-11-23
SE7513013L (sv) 1976-05-21
JPS5170770A (de) 1976-06-18
FR2291753B1 (de) 1978-11-10
NL166469C (nl) 1981-08-17
DE2551924A1 (de) 1976-05-26
AU8671375A (en) 1977-03-17
DK143197B (da) 1981-07-20
CS190503B2 (en) 1979-05-31
CH623039A5 (de) 1981-05-15
FR2291753A1 (fr) 1976-06-18
SE424638B (sv) 1982-08-02
DE2551924B2 (de) 1977-05-26
US4054659A (en) 1977-10-18
NL166469B (nl) 1981-03-16
CH621341A5 (de) 1981-01-30
DK487375A (da) 1976-05-21
GB1487457A (en) 1977-09-28
BE835744A (fr) 1976-03-16
NL7513517A (nl) 1976-05-24
HU170648B (de) 1977-07-28
JPS5247474B2 (de) 1977-12-02

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