CA1027109A - PROCESS FOR THE PREPARATION OF 17.alpha.-ESTERS OF 17.alpha., 21-DIHYDROXY-20-OXO STEROIDS - Google Patents

PROCESS FOR THE PREPARATION OF 17.alpha.-ESTERS OF 17.alpha., 21-DIHYDROXY-20-OXO STEROIDS

Info

Publication number
CA1027109A
CA1027109A CA178,554A CA178554A CA1027109A CA 1027109 A CA1027109 A CA 1027109A CA 178554 A CA178554 A CA 178554A CA 1027109 A CA1027109 A CA 1027109A
Authority
CA
Canada
Prior art keywords
alpha
dihydroxy
esters
preparation
oxo steroids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA178,554A
Other languages
English (en)
French (fr)
Other versions
CA178554S (en
Inventor
Gordon H. Phillipps
Graham Durrant
Brian M. Bain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Application granted granted Critical
Publication of CA1027109A publication Critical patent/CA1027109A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/005—Compounds containing elements of Groups 1 or 11 of the Periodic Table without C-Metal linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/08—Copper compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Steroid Compounds (AREA)
CA178,554A 1972-08-11 1973-08-10 PROCESS FOR THE PREPARATION OF 17.alpha.-ESTERS OF 17.alpha., 21-DIHYDROXY-20-OXO STEROIDS Expired CA1027109A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3765572A GB1440063A (en) 1972-08-11 1972-08-11 17alpha-esters of 17alpha,21-dihydroxy-20-oxo-steroids

Publications (1)

Publication Number Publication Date
CA1027109A true CA1027109A (en) 1978-02-28

Family

ID=10398029

Family Applications (1)

Application Number Title Priority Date Filing Date
CA178,554A Expired CA1027109A (en) 1972-08-11 1973-08-10 PROCESS FOR THE PREPARATION OF 17.alpha.-ESTERS OF 17.alpha., 21-DIHYDROXY-20-OXO STEROIDS

Country Status (16)

Country Link
US (1) US3891631A (es)
JP (1) JPS5752359B2 (es)
BE (1) BE803461A (es)
CA (1) CA1027109A (es)
CH (1) CH590884A5 (es)
DE (1) DE2340591A1 (es)
DK (1) DK135998B (es)
ES (1) ES417738A1 (es)
FR (1) FR2205508B1 (es)
GB (1) GB1440063A (es)
IE (1) IE38312B1 (es)
IL (1) IL42942A (es)
LU (1) LU68212A1 (es)
NL (1) NL7311072A (es)
SE (1) SE387951B (es)
ZA (2) ZA735452B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1516095A (en) * 1974-07-31 1978-06-28 Glaxo Lab Ltd 17,21-diesters of 17alpha,21-dihydroxy-steroids of the pregnane series
GB1593978A (en) * 1976-12-31 1981-07-22 Lark Spa Anti-inflammatory steroids
US4086254A (en) * 1977-04-13 1978-04-25 The Upjohn Company Photocleavable steroids
DE2735110A1 (de) * 1977-08-04 1979-02-15 Hoechst Ag Corticoid-17-alkylcarbonate und verfahren zu ihrer herstellung
DE2759135A1 (de) * 1977-12-30 1979-07-19 Lark Spa Neue steroidverbindungen und deren herstellung und verwendung
DE2817988A1 (de) * 1978-04-25 1979-11-08 Hoechst Ag Corticoid 17-alkylcarbonate und verfahren zu deren herstellung
JPS58161340A (ja) * 1982-03-19 1983-09-24 Hitachi Ltd 製品移送装置
AU558725B2 (en) * 1983-09-07 1987-02-05 Mitsubishi Kasei Corporation Corticoid derivatives
JPH0527014Y2 (es) * 1985-10-31 1993-07-08
DE3637806A1 (de) * 1986-11-06 1988-05-19 Hoechst Ag Verfahren zur herstellung von prednisolon-17-ethylcarbonat durch umlagerung von prednisolon-21-ethylcarbonat
FR2683530B1 (fr) * 1991-11-08 1994-01-21 Roussel Uclaf Nouveau procede de preparation de derives 20-oxo 17 alpha, 21-dihydroxyles du pregnane et nouveaux intermediaires.
US6858596B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6777399B2 (en) * 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
DK1305329T4 (da) * 2000-08-05 2015-06-15 Glaxo Group Ltd 6alpha, 9alpha-difluor-17alpha-(2-furanylcarboxyl)oxy-11beta-hydroxy-16alpha-methyl-3-oxo-androst-1,4-dien-17-carbothiosyre-S-fluormethylester som et antiinflammatorisk middel
GB0019172D0 (en) * 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6759398B2 (en) * 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
PL366937A1 (en) * 2001-04-30 2005-02-07 Glaxo Group Limited Anti-inflammatory 17.beta.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.alpha
AU2002356759A1 (en) * 2001-12-01 2003-06-17 Glaxo Group Limited 17.alpha. -cyclic esters of 16-methylpregnan-3,20-dione as anti-inflammatory agents
US20050175545A1 (en) * 2002-02-04 2005-08-11 Keith Biggadike Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist
GB0202635D0 (en) * 2002-02-05 2002-03-20 Glaxo Wellcome Mfg Pte Ltd Formulation containing novel anti-inflammatory androstane derivative
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
GB0615108D0 (en) * 2006-07-28 2006-09-06 Glaxo Group Ltd Novel formulations
CN103739647B (zh) * 2008-05-28 2017-06-09 雷沃根生物医药有限公司 用于治疗疾病的NF‑κB的非激素甾体调节剂
EP2556083A4 (en) 2010-04-05 2013-12-04 Validus Biopharma Inc NONHORMONAL STEROID MODULATORS OF NF-KAPPA-B FOR DISEASE TREATMENT
WO2017004205A1 (en) 2015-06-29 2017-01-05 Reveragen Biopharma, Inc. NON-HORMONAL STEROID MODULATORS OF NF-κB FOR TREATMENT OF DISEASE
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3255218A (en) * 1962-03-28 1966-06-07 Schering Corp 17(20)-enol-21-aldehydes of the pregnane series
US3780177A (en) * 1967-06-16 1973-12-18 Warner Lambert Co 17-butyrate,21-ester derivatives of 6alpha,9alpha-difluoroprednisolone,compositions and use
IT1034011B (it) * 1969-06-26 1979-09-10 Vister Vismara Terapeutici S P Processo per la prapratzione di 17 monoesteri di 17 a 21 diossisteroidi per idrolisi die corpispondenti 17 21 ortoesteri ciclici a ph control lato

Also Published As

Publication number Publication date
GB1440063A (en) 1976-06-23
DK135998C (es) 1977-12-27
NL7311072A (es) 1974-02-13
AU5914373A (en) 1975-02-13
FR2205508B1 (es) 1978-09-15
JPS4985062A (es) 1974-08-15
IE38312L (en) 1974-02-11
CH590884A5 (es) 1977-08-31
ES417738A1 (es) 1976-06-16
SE387951B (sv) 1976-09-20
ZA735453B (en) 1974-10-30
DK135998B (da) 1977-07-25
LU68212A1 (es) 1973-10-16
DE2340591A1 (de) 1974-03-07
IE38312B1 (en) 1978-02-15
BE803461A (fr) 1974-02-11
IL42942A0 (en) 1973-11-28
US3891631A (en) 1975-06-24
IL42942A (en) 1977-05-31
JPS5752359B2 (es) 1982-11-06
ZA735452B (en) 1974-07-31
FR2205508A1 (es) 1974-05-31

Similar Documents

Publication Publication Date Title
CA1027109A (en) PROCESS FOR THE PREPARATION OF 17.alpha.-ESTERS OF 17.alpha., 21-DIHYDROXY-20-OXO STEROIDS
CA1021318A (en) 11,11-alkylidene steroids
CA972744A (en) PROCESS FOR THE PREPARATION OF 3.alpha.-HYDROXYSTEROIDS
CA1006519A (en) Certain scopolammonium compounds and process for the preparation thereof
CA1026326A (en) PROCESS FOR THE PREPARATION OF .alpha.-6-DEOXYTETRACYCLINES
CA953708A (en) PROCESS FOR THE PREPARATION OF 6.alpha.-METHYL-19-NOR-PREGNENES
CA1014559A (en) Amino-imidazo and amino-pyrazolo-isoquinolines and process for the preparation thereof
CA1013736A (fr) Procede de preparation de nouveaux 2,2-dimethyle steroides
CA1027973A (en) Process for the preparation of 1,2-dichloroethane
CA951310A (en) METHOD FOR THE PREPARATION OF 2.alpha.,3.alpha.-EPITHIO-5.alpha.-STEROIDS
CA983016A (en) Process for the preparation of 6-azido-4,6-pregnadienes
CA966506A (en) Process for the isomerization of 5-vinylbicyclo(2.2.1)hept-2-enes
CA928301A (en) 3 .alpha. . 5 .alpha. -PROPANO-PIPERIDINES AND PROCESS FOR THE PREPARATION THEREOF
CA916138A (en) PROCESS FOR THE PREPARATION OF 21-ACYLOXY-5-PREGNENE-3.beta., 17.alpha.-DIOL-20-ONES
CA900971A (en) PROCESS FOR THE PREPARATION OF 17.alpha.-MONOESTERS OF 11.beta., 17.alpha., 21-TRIHYDROXYSTEROIDS
CA914152A (en) 9.alpha.-FLUORO-16-FLUOROMETHYLENEPREDNISOLONE-21-ENANTHATE AND PROCESS FOR THE PREPARATION THEREOF
CA908158A (en) PROCESS FOR THE PREPARATION OF 17.alpha.-ALKYL STEROIDS
CA893729A (en) Process for the preparation of p-hydroxy-butyrophenone and its 2,3-dichloroderivatives
CA960649A (en) METHOD FOR THE PREPARATION OF 2.alpha.,3.alpha.-EPITHIO-5.alpha.-STEROIDS
CA908159A (en) DI-EPOXIDE PROCESS FOR THE PREPARATION OF 9.alpha.-FLUORO-16-METHYLENE-PREDNISOLONE OR -PREDNISONE, AND 21 ESTERS THEREOF
CA898802A (en) PROCESS FOR THE PREPARATION OF 17.alpha.-DIHYDROEQUILENIN AND RELATED COMPOUNDS
CA894243A (en) Process for the preparation of 9-pyridylalkyl-1,2,8,9-tetraazaphenale nes
CA835427A (en) Process for the preparation of 1,1,-chlorofluoroethane
CA845742A (en) Process for the preparation of 1,1,1-trifluoro-2-bromo-2-chloroethane
AU492089B2 (en) Novel 11,11-alkylidene steroids