CA1015355A - PROCESS FOR PREPARING 6-(.alpha.-(AMIDINO- AND IMIDOYLAMINOALKANOYLAMINO)-ARACYLAMINO) PENICILLANIC ACIDS - Google Patents

PROCESS FOR PREPARING 6-(.alpha.-(AMIDINO- AND IMIDOYLAMINOALKANOYLAMINO)-ARACYLAMINO) PENICILLANIC ACIDS

Info

Publication number
CA1015355A
CA1015355A CA177,719A CA177719A CA1015355A CA 1015355 A CA1015355 A CA 1015355A CA 177719 A CA177719 A CA 177719A CA 1015355 A CA1015355 A CA 1015355A
Authority
CA
Canada
Prior art keywords
imidoylaminoalkanoylamino
aracylamino
amidino
alpha
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA177,719A
Other languages
English (en)
Other versions
CA177719S (en
Inventor
Ernest S. Hamanaka
John G. Stam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of CA1015355A publication Critical patent/CA1015355A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/66—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA177,719A 1972-08-02 1973-07-31 PROCESS FOR PREPARING 6-(.alpha.-(AMIDINO- AND IMIDOYLAMINOALKANOYLAMINO)-ARACYLAMINO) PENICILLANIC ACIDS Expired CA1015355A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27706472A 1972-08-02 1972-08-02

Publications (1)

Publication Number Publication Date
CA1015355A true CA1015355A (en) 1977-08-09

Family

ID=23059254

Family Applications (1)

Application Number Title Priority Date Filing Date
CA177,719A Expired CA1015355A (en) 1972-08-02 1973-07-31 PROCESS FOR PREPARING 6-(.alpha.-(AMIDINO- AND IMIDOYLAMINOALKANOYLAMINO)-ARACYLAMINO) PENICILLANIC ACIDS

Country Status (30)

Country Link
JP (1) JPS5318039B2 (ja)
AR (1) AR206879A1 (ja)
AT (1) AT327382B (ja)
AU (1) AU472676B2 (ja)
BE (1) BE803094A (ja)
BG (1) BG25798A3 (ja)
CA (1) CA1015355A (ja)
CH (1) CH574447A5 (ja)
CS (1) CS168459B2 (ja)
DD (1) DD106849A5 (ja)
DE (1) DE2338389A1 (ja)
DK (1) DK137047B (ja)
EG (1) EG10896A (ja)
ES (1) ES417461A1 (ja)
FI (1) FI56840C (ja)
FR (1) FR2194415B1 (ja)
GB (1) GB1418656A (ja)
HU (1) HU167653B (ja)
IE (1) IE37961B1 (ja)
IL (1) IL42820A (ja)
LU (1) LU68143A1 (ja)
NL (1) NL7310696A (ja)
NO (1) NO144831C (ja)
PH (1) PH12770A (ja)
PL (1) PL96500B1 (ja)
RO (2) RO68719A2 (ja)
SE (1) SE415977B (ja)
SU (2) SU576944A3 (ja)
YU (1) YU36966B (ja)
ZA (1) ZA735236B (ja)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4024130A (en) * 1975-03-31 1977-05-17 Pfizer Inc. Process for the manufacture of alkali metal salts of 6-[2-phenyl-2-(imidoylaminoalkanoylamino)acetamido]penicillanic acids
US4073780A (en) * 1976-06-03 1978-02-14 Pfizer Inc. 4-Pyridylformimidoylglycyl-D-phenylglycine

Also Published As

Publication number Publication date
SE415977B (sv) 1980-11-17
RO63748A (fr) 1979-01-15
DK137047C (ja) 1978-08-07
DD106849A5 (ja) 1974-07-05
HU167653B (ja) 1975-11-28
PL96500B1 (pl) 1977-12-31
AR206879A1 (es) 1976-08-31
DK137047B (da) 1978-01-09
JPS4945089A (ja) 1974-04-27
EG10896A (en) 1976-07-31
AT327382B (de) 1976-01-26
JPS5318039B2 (ja) 1978-06-13
IE37961L (en) 1974-02-02
LU68143A1 (ja) 1974-02-11
ZA735236B (en) 1974-07-31
CH574447A5 (ja) 1976-04-15
NO144831B (no) 1981-08-10
DE2338389A1 (de) 1974-02-28
RO68719A2 (ro) 1980-08-15
IE37961B1 (en) 1977-11-23
YU208673A (en) 1982-02-25
FR2194415A1 (ja) 1974-03-01
ATA680773A (de) 1975-04-15
IL42820A (en) 1977-06-30
PH12770A (en) 1979-08-17
BG25798A3 (en) 1978-12-12
AU5843373A (en) 1975-01-30
GB1418656A (en) 1975-12-24
BE803094A (fr) 1974-02-01
YU36966B (en) 1984-08-31
FR2194415B1 (ja) 1976-12-31
NL7310696A (ja) 1974-02-05
ES417461A1 (es) 1976-03-01
NO144831C (no) 1981-11-18
CS168459B2 (ja) 1976-06-29
AU472676B2 (en) 1976-06-03
SU576944A3 (ru) 1977-10-15
IL42820A0 (en) 1973-10-25
FI56840B (fi) 1979-12-31
FI56840C (fi) 1980-04-10
SU576945A3 (ru) 1977-10-15

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