BRPI1014835A8 - Composição de células hepáticas encapsuladas - Google Patents

Composição de células hepáticas encapsuladas

Info

Publication number
BRPI1014835A8
BRPI1014835A8 BRPI1014835A BRPI1014835A BRPI1014835A8 BR PI1014835 A8 BRPI1014835 A8 BR PI1014835A8 BR PI1014835 A BRPI1014835 A BR PI1014835A BR PI1014835 A BRPI1014835 A BR PI1014835A BR PI1014835 A8 BRPI1014835 A8 BR PI1014835A8
Authority
BR
Brazil
Prior art keywords
liver cells
composition
encapsulated liver
encapsulated
amount
Prior art date
Application number
BRPI1014835A
Other languages
English (en)
Portuguese (pt)
Inventor
Aleksandrova Krasimira
Pediaditakis Peter
Salisbury Jo
Rüdinger Wolfgang
Original Assignee
Cytonet Gmbh & Co Kg
Promethera Biosciences Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytonet Gmbh & Co Kg, Promethera Biosciences Sa filed Critical Cytonet Gmbh & Co Kg
Publication of BRPI1014835A2 publication Critical patent/BRPI1014835A2/pt
Publication of BRPI1014835A8 publication Critical patent/BRPI1014835A8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Inorganic Chemistry (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BRPI1014835A 2009-04-27 2010-04-27 Composição de células hepáticas encapsuladas BRPI1014835A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/430,330 US20100272816A1 (en) 2009-04-27 2009-04-27 Microcapsules comprising liver cells and erythropoietin, methods for preparing said microcapsules and methods for treating a patient comprising applying said microcapsules to the patient
PCT/EP2010/002563 WO2010124837A2 (en) 2009-04-27 2010-04-27 Encapsulated liver cell composition

Publications (2)

Publication Number Publication Date
BRPI1014835A2 BRPI1014835A2 (pt) 2016-04-12
BRPI1014835A8 true BRPI1014835A8 (pt) 2018-02-14

Family

ID=42790675

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1014835A BRPI1014835A8 (pt) 2009-04-27 2010-04-27 Composição de células hepáticas encapsuladas

Country Status (26)

Country Link
US (3) US20100272816A1 (ko)
EP (1) EP2424510B1 (ko)
JP (1) JP5702771B2 (ko)
KR (1) KR101372384B1 (ko)
CN (2) CN103638002B (ko)
AU (1) AU2010243888C1 (ko)
BR (1) BRPI1014835A8 (ko)
CL (1) CL2011002689A1 (ko)
CY (1) CY1114464T1 (ko)
DK (1) DK2424510T3 (ko)
ES (1) ES2431297T3 (ko)
HK (1) HK1165278A1 (ko)
HR (1) HRP20130963T1 (ko)
IL (1) IL215887A (ko)
MX (1) MX2011010993A (ko)
NZ (1) NZ595511A (ko)
PL (1) PL2424510T3 (ko)
PT (1) PT2424510E (ko)
RS (1) RS52989B (ko)
RU (2) RU2564924C2 (ko)
SG (1) SG175792A1 (ko)
SI (1) SI2424510T1 (ko)
SM (1) SMT201300111B (ko)
UA (1) UA99686C2 (ko)
WO (1) WO2010124837A2 (ko)
ZA (1) ZA201106817B (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106134070B (zh) * 2014-07-25 2018-05-22 积水化学工业株式会社 一种包括二次电池的发电装置
WO2016183231A1 (en) 2015-05-12 2016-11-17 Baker Group, LLP Method and system for a bioartificial organ
RU2618989C1 (ru) * 2016-03-09 2017-05-11 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Способ лечения печеночной недостаточности
CN108138134B (zh) * 2016-09-14 2019-05-10 四川蓝光英诺生物科技股份有限公司 人工组织前体及制备其的方法
US11439731B2 (en) 2016-09-14 2022-09-13 Revotek Co., Ltd. Artificial tissue progenitor and method for preparing the same
WO2018093069A1 (ko) * 2016-11-15 2018-05-24 광주과학기술원 세포 3d 배양 방법
CN113573746A (zh) * 2019-03-20 2021-10-29 公立大学法人横滨市立大学 包覆固定剂

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5455790A (en) 1977-10-05 1979-05-04 Tomoyuki Tajima Production of erythropoetin
JPS6045849B2 (ja) 1980-08-25 1985-10-12 林原 健 ヒトエリトロポエチンの製造方法
NZ210501A (en) 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
US4956128A (en) * 1984-05-25 1990-09-11 Connaught Laboratories Limited Droplet generation
IL77081A (en) 1984-12-04 1999-10-28 Genetics Inst AND sequence encoding human erythropoietin, a process for its preparation and a pharmacological preparation of human erythropoietin
US5084350A (en) * 1990-02-16 1992-01-28 The Royal Institution For The Advance Of Learning (Mcgill University) Method for encapsulating biologically active material including cells
HUT73876A (en) 1993-04-29 1996-10-28 Abbott Lab Erythropoietin analog compositions and methods
IL110669A (en) 1993-08-17 2008-11-26 Kirin Amgen Inc Erythropoietin analogs
RU94030310A (ru) * 1994-08-16 1996-08-10 Молдавский научно-исследовательский институт профилактической и клинической медицины МЗ Республики Молдова (MD) Способ культивирования клеток человека и животных
US6281015B1 (en) * 1994-12-16 2001-08-28 Children's Medical Center Corp. Localized delivery of factors enhancing survival of transplanted cells
JP2006506971A (ja) 2002-07-19 2006-03-02 ヴェスタ セラピューティクス，インコーポレーテッド 肝性幹／前駆細胞を含む生存能のあるヒト肝臓細胞を得る方法
AU2004309083B2 (en) 2003-12-30 2010-11-11 Augustinus Bader Tissue regeneration method
CA2561725A1 (en) * 2004-03-30 2005-10-13 Fac8Cell Pty Limited Culture and use of cells that secrete liver secretory factors
RU2429864C2 (ru) 2005-10-21 2011-09-27 Ливинг Селл Продактс Пти Лимитед Система инкапсуляции

Also Published As

Publication number Publication date
US9517247B2 (en) 2016-12-13
SI2424510T1 (sl) 2013-11-29
CN103638002A (zh) 2014-03-19
KR101372384B1 (ko) 2014-03-12
WO2010124837A2 (en) 2010-11-04
CN103638002B (zh) 2016-05-18
RS52989B (en) 2014-02-28
AU2010243888C1 (en) 2014-01-23
KR20120014171A (ko) 2012-02-16
IL215887A0 (en) 2012-01-31
JP2012524739A (ja) 2012-10-18
SG175792A1 (en) 2011-12-29
RU2500390C2 (ru) 2013-12-10
PL2424510T3 (pl) 2013-12-31
US20120093937A1 (en) 2012-04-19
NZ595511A (en) 2013-02-22
CN102413820B (zh) 2013-09-25
CY1114464T1 (el) 2016-10-05
US8535923B2 (en) 2013-09-17
PT2424510E (pt) 2013-10-14
CL2011002689A1 (es) 2012-04-27
ES2431297T3 (es) 2013-11-25
JP5702771B2 (ja) 2015-04-15
DK2424510T3 (da) 2013-10-07
ZA201106817B (en) 2012-11-28
RU2564924C2 (ru) 2015-10-10
RU2011148106A (ru) 2013-06-10
SMT201300111B (it) 2013-11-08
AU2010243888A1 (en) 2011-10-27
EP2424510B1 (en) 2013-07-17
MX2011010993A (es) 2011-11-02
AU2010243888B2 (en) 2013-08-22
WO2010124837A3 (en) 2011-02-10
US20140017305A1 (en) 2014-01-16
BRPI1014835A2 (pt) 2016-04-12
US20100272816A1 (en) 2010-10-28
HRP20130963T1 (hr) 2013-11-22
CN102413820A (zh) 2012-04-11
IL215887A (en) 2016-05-31
UA99686C2 (ru) 2012-09-10
RU2013143436A (ru) 2015-03-27
EP2424510A2 (en) 2012-03-07
HK1165278A1 (en) 2012-10-05

Similar Documents

Publication Publication Date Title
BRPI1014835A8 (pt) Composição de células hepáticas encapsuladas
BR112013014706A2 (pt) composição elastomérica, apresentando uma dispersão muito boa da carga na matriz elastomérica
SG10201809901SA (en) Generating Pluripotent Cells De Novo
BRPI0920956A2 (pt) Cultura de células-tronco pluripotentes em microveículos
EP2352190A4 (en) Positive active material with improved high voltage properties
BRPI0909622A2 (pt) controle temporal in vivo de enzimas de degradação de matriz ativáveis
DK3354665T5 (da) Modificerede alginater til celleindkapsling og celleterapi
BRPI0812037A2 (pt) Variantes de uma alfa-amilase com níveis de produção aperfeiçoados em processos de fermentação
AP2016009448A0 (en) Antibodies to matrix metalloproteinase 9
BR112013014707A2 (pt) composição elastomérica, apresentando uma dispersão muito boa da carga na matriz elastomérica
BR112014032201A2 (pt) eletrodo de enzima
DE102009001310A8 (de) Anzeigedisplay mit einer Aktivmatrix von Elektrobenetzungszellen
BRPI0822351A2 (pt) célula flutuante com filtro de macrófitas em flutuação e ilha que compreende uma pluralidade de células flutuantes com filtro de macrófitos em flutuação.
BR112013012481A2 (pt) composições e artigos contendo um líquido ativo em uma matriz polimérica e métodos de preparar e usar os mesmos
EA201390592A1 (ru) Аллели 1-d-дезоксиксилулозо-5-фосфат синтазы, ответственные за усиленный биосинтез терпенов
ZA201203983B (en) Fexofenadine microcapsules and compositions containing them
BR112012029946A2 (pt) encapsulação de ingredientes em matriz de lactose para formar encapsulados ativos
BR112015005782A2 (pt) variantes de enzima com propriedades aprimoradas de éster-sintase
BRPI1010684A2 (pt) método para determinar o potencial cardiorregenerativo de células mamíferas
EP2635305A4 (en) IMPROVEMENT OF PATHOGENIC TH17 MEMORY LANGUAGES
FR2989222B1 (fr) Materiau d'encapsulation de cellules photovoltaiques
FI20095355A0 (fi) Regeneroituva aktiivinen matriisi ja sen käytöt
MY153067A (en) Encapsulated liver cell composition
GB2502731A (en) Encapsulated arrays of electronic switching devices
TH124821B (th) องค์ประกอบเซลล์ตับที่ถูกห่อหุ้ม (Encapsulated Liver Cell Composition)

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 3A ANUIDADE.

B08G Application fees: restoration [chapter 8.7 patent gazette]
B25A Requested transfer of rights approved

Owner name: PROMETHERA BIOSCIENCES SA (BE)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL