BRPI1012993A2 - "uso de um anticorpo anti-tau ps422 para o tratamento de doenças do cérebro" - Google Patents

"uso de um anticorpo anti-tau ps422 para o tratamento de doenças do cérebro"

Info

Publication number
BRPI1012993A2
BRPI1012993A2 BRPI1012993A BRPI1012993A BRPI1012993A2 BR PI1012993 A2 BRPI1012993 A2 BR PI1012993A2 BR PI1012993 A BRPI1012993 A BR PI1012993A BR PI1012993 A BRPI1012993 A BR PI1012993A BR PI1012993 A2 BRPI1012993 A2 BR PI1012993A2
Authority
BR
Brazil
Prior art keywords
tau
antibody
treatment
brain disease
brain
Prior art date
Application number
BRPI1012993A
Other languages
English (en)
Inventor
Bohrmann Bernd
Grueninger Fiona
Krell Hans-Willi
Ozmen Laurence
Schraeml Michael
Mundigl Olaf
Offner Sonja
Goepfert Ulrich
Lifke Valeria
Huber Walter
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI1012993A2 publication Critical patent/BRPI1012993A2/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711Alzheimer's disease; Amyloid plaque core protein
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3053Skin, nerves, brain
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/40Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/55Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
BRPI1012993A 2009-06-10 2010-06-08 "uso de um anticorpo anti-tau ps422 para o tratamento de doenças do cérebro" BRPI1012993A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09007656 2009-06-10
EP09008487 2009-06-30
PCT/EP2010/003437 WO2010142423A2 (en) 2009-06-10 2010-06-08 Use of an anti-tau ps422 antibody for the treatment of brain diseases

Publications (1)

Publication Number Publication Date
BRPI1012993A2 true BRPI1012993A2 (pt) 2018-01-16

Family

ID=42753372

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1012993A BRPI1012993A2 (pt) 2009-06-10 2010-06-08 "uso de um anticorpo anti-tau ps422 para o tratamento de doenças do cérebro"

Country Status (23)

Country Link
US (2) US8609097B2 (pt)
EP (1) EP2440578B1 (pt)
JP (2) JP2012529275A (pt)
KR (1) KR101429367B1 (pt)
CN (1) CN102459333B (pt)
AR (1) AR077016A1 (pt)
AU (1) AU2010257799B2 (pt)
BR (1) BRPI1012993A2 (pt)
CA (1) CA2762594C (pt)
CL (1) CL2011003122A1 (pt)
CO (1) CO6450613A2 (pt)
CR (1) CR20110606A (pt)
EC (1) ECSP11011514A (pt)
HK (1) HK1166331A1 (pt)
IL (1) IL216509A0 (pt)
MA (1) MA33339B1 (pt)
MX (1) MX2011012837A (pt)
NZ (1) NZ596187A (pt)
PE (1) PE20120543A1 (pt)
RU (1) RU2536247C2 (pt)
SG (1) SG176754A1 (pt)
TW (1) TW201103560A (pt)
WO (1) WO2010142423A2 (pt)

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Also Published As

Publication number Publication date
JP2017031176A (ja) 2017-02-09
EP2440578B1 (en) 2017-03-08
NZ596187A (en) 2013-11-29
JP2012529275A (ja) 2012-11-22
CA2762594A1 (en) 2010-12-16
CL2011003122A1 (es) 2012-07-20
AR077016A1 (es) 2011-07-27
EP2440578A2 (en) 2012-04-18
ECSP11011514A (es) 2012-01-31
PE20120543A1 (es) 2012-05-23
CN102459333B (zh) 2015-07-15
RU2536247C2 (ru) 2014-12-20
US9290567B2 (en) 2016-03-22
WO2010142423A3 (en) 2011-05-26
AU2010257799A1 (en) 2011-12-01
IL216509A0 (en) 2012-02-29
US8609097B2 (en) 2013-12-17
KR101429367B1 (ko) 2014-08-11
MA33339B1 (fr) 2012-06-01
CR20110606A (es) 2012-01-12
US20110059093A1 (en) 2011-03-10
CN102459333A (zh) 2012-05-16
MX2011012837A (es) 2011-12-16
RU2011152816A (ru) 2013-07-20
WO2010142423A2 (en) 2010-12-16
TW201103560A (en) 2011-02-01
SG176754A1 (en) 2012-01-30
AU2010257799B2 (en) 2013-10-17
HK1166331A1 (en) 2012-10-26
CA2762594C (en) 2017-02-28
US20130310541A1 (en) 2013-11-21
JP6513617B2 (ja) 2019-05-15
CO6450613A2 (es) 2012-05-31
KR20120024952A (ko) 2012-03-14

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