BRPI0923644A2 - composto derivado de retinoide, composição farmacêutica, usos do referido composto, e processos para síntese do mesmo e para a preparação de uma composição farmacêutica - Google Patents

composto derivado de retinoide, composição farmacêutica, usos do referido composto, e processos para síntese do mesmo e para a preparação de uma composição farmacêutica

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Publication number
BRPI0923644A2
BRPI0923644A2 BRPI0923644A BRPI0923644A BRPI0923644A2 BR PI0923644 A2 BRPI0923644 A2 BR PI0923644A2 BR PI0923644 A BRPI0923644 A BR PI0923644A BR PI0923644 A BRPI0923644 A BR PI0923644A BR PI0923644 A2 BRPI0923644 A2 BR PI0923644A2
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BR
Brazil
Prior art keywords
pharmaceutical composition
compound
synthesizing
preparing
processes
Prior art date
Application number
BRPI0923644A
Other languages
English (en)
Inventor
Claudio Pisano
Domenico Alloatti
Gianfranco Battistuzzi
Giuseppe Giannini
Sabrina Dallavalle
Tiziana Brunetti
Walter Cabri
Original Assignee
Sigma Tau Ind Famaceutiche Riunite S P A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Sigma Tau Ind Famaceutiche Riunite S P A filed Critical Sigma Tau Ind Famaceutiche Riunite S P A
Publication of BRPI0923644A2 publication Critical patent/BRPI0923644A2/pt

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    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
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    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
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BRPI0923644A 2008-12-24 2009-12-21 composto derivado de retinoide, composição farmacêutica, usos do referido composto, e processos para síntese do mesmo e para a preparação de uma composição farmacêutica BRPI0923644A2 (pt)

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EP08172883 2008-12-24
PCT/EP2009/067667 WO2010072727A1 (en) 2008-12-24 2009-12-21 New retinoid derivatives endowed with cytotoxic and/or antiangiogenic properties

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BRPI0923644A2 true BRPI0923644A2 (pt) 2016-01-19

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US (1) US8530517B2 (pt)
EP (1) EP2367781B1 (pt)
JP (1) JP4933683B1 (pt)
KR (1) KR20110101129A (pt)
CN (1) CN102224127A (pt)
AR (1) AR075495A1 (pt)
AU (1) AU2009331515A1 (pt)
BR (1) BRPI0923644A2 (pt)
CA (1) CA2740928A1 (pt)
EA (1) EA201170885A1 (pt)
IL (1) IL212733A0 (pt)
MX (1) MX2011006413A (pt)
NZ (1) NZ592330A (pt)
SG (1) SG171713A1 (pt)
TW (1) TW201031402A (pt)
WO (1) WO2010072727A1 (pt)
ZA (1) ZA201104641B (pt)

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EP3301085A1 (en) 2016-09-29 2018-04-04 Biogem S.Ca.R.L. Retinoid derivatives with antitumor activity
US11364216B2 (en) 2016-09-29 2022-06-21 Biogem S.C. A R.L. Retinoid derivatives with antitumor activity
WO2022229017A1 (en) 2021-04-27 2022-11-03 Biogem S.C.A R.L. Adamantyl retinoid derivative with anticancer activity

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ITRM20010464A1 (it) * 2001-07-31 2003-01-31 Sigma Tau Ind Farmaceuti Derivati retinoidi ad attivita' antiangiogenica, antitumorale e pro-apoptotica.
JP4092915B2 (ja) * 2002-01-16 2008-05-28 日本ゼオン株式会社 シクロペンタノールの製造方法
ITRM20050248A1 (it) * 2005-05-20 2006-11-21 Sigma Tau Ind Farmaceuti Uso acido adamantil metossidifenil propenoico per il trattamento di patologie cutanee.
CA2607207C (en) * 2005-06-28 2015-01-20 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Biphenyl and naphthyl-phenyl hydroxamic acid derivatives
WO2007071605A1 (en) 2005-12-19 2007-06-28 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. The use of st1898 for the treatment of restenosis
WO2008077772A2 (en) 2006-12-22 2008-07-03 Sigma-Tau Industrie Farmaceutiche Riunite Spa Combination of a retinoid and a platinum anticancer agent

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MX2011006413A (es) 2011-07-12
JP4933683B1 (ja) 2012-05-16
TW201031402A (en) 2010-09-01
EA201170885A1 (ru) 2011-12-30
KR20110101129A (ko) 2011-09-15
NZ592330A (en) 2013-05-31
AR075495A1 (es) 2011-04-06
JP2012513965A (ja) 2012-06-21
ZA201104641B (en) 2012-03-28
CN102224127A (zh) 2011-10-19
US20110312965A1 (en) 2011-12-22
EP2367781A1 (en) 2011-09-28
AU2009331515A1 (en) 2010-07-01
CA2740928A1 (en) 2010-07-01
WO2010072727A1 (en) 2010-07-01
IL212733A0 (en) 2011-07-31
SG171713A1 (en) 2011-07-28
US8530517B2 (en) 2013-09-10
EP2367781B1 (en) 2013-10-02

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