BRPI0922630A2 - "(r)-3-(e)-2-(pirrolidin-33-il)vinil)-5-(tetra-hidropiran-4-ilóxi)piridina, seus sais, suas sínteses e seus usos como ligantes para receptores acetilcolinérgico nicotínicos" - Google Patents

"(r)-3-(e)-2-(pirrolidin-33-il)vinil)-5-(tetra-hidropiran-4-ilóxi)piridina, seus sais, suas sínteses e seus usos como ligantes para receptores acetilcolinérgico nicotínicos"

Info

Publication number
BRPI0922630A2
BRPI0922630A2 BRPI0922630A BRPI0922630A BRPI0922630A2 BR PI0922630 A2 BRPI0922630 A2 BR PI0922630A2 BR PI0922630 A BRPI0922630 A BR PI0922630A BR PI0922630 A BRPI0922630 A BR PI0922630A BR PI0922630 A2 BRPI0922630 A2 BR PI0922630A2
Authority
BR
Brazil
Prior art keywords
tetrahydropyran
yloxy
syntheses
pyrrolidin
pyridine
Prior art date
Application number
BRPI0922630A
Other languages
English (en)
Inventor
Daniel Yohannes
Gary Maurice Dull
Gregory J Gatto
John Genus
Joseph Pike Mitchener Jr
Julio A Munoz
Nikolai Fedorov
Philip S Hammond
Pieter Albert Otten
Scott R Breining
Srinivisa Rao Akireddy
Timothy J Cuthbertson
Original Assignee
Targacept Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Targacept Inc filed Critical Targacept Inc
Publication of BRPI0922630A2 publication Critical patent/BRPI0922630A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Pyridine Compounds (AREA)
BRPI0922630A 2008-12-01 2009-11-30 "(r)-3-(e)-2-(pirrolidin-33-il)vinil)-5-(tetra-hidropiran-4-ilóxi)piridina, seus sais, suas sínteses e seus usos como ligantes para receptores acetilcolinérgico nicotínicos" BRPI0922630A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11888508P 2008-12-01 2008-12-01
PCT/US2009/066092 WO2010065449A1 (en) 2008-12-01 2009-11-30 (r) -3- (e) -2- (pyrr0lidin-3-yl) vinyl) -5- (tetrahydr0pyran-4-yl0xy) pyridine, its salts, its synthesis and its use as ligand for nicotinic acetylcholinergic receptors

Publications (1)

Publication Number Publication Date
BRPI0922630A2 true BRPI0922630A2 (pt) 2016-01-05

Family

ID=41549744

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0922152-2A BRPI0922152A2 (pt) 2008-12-01 2009-11-30 Compostos
BRPI0922630A BRPI0922630A2 (pt) 2008-12-01 2009-11-30 "(r)-3-(e)-2-(pirrolidin-33-il)vinil)-5-(tetra-hidropiran-4-ilóxi)piridina, seus sais, suas sínteses e seus usos como ligantes para receptores acetilcolinérgico nicotínicos"

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI0922152-2A BRPI0922152A2 (pt) 2008-12-01 2009-11-30 Compostos

Country Status (28)

Country Link
US (3) US8633227B2 (pt)
EP (3) EP2358670B1 (pt)
JP (2) JP5698673B2 (pt)
KR (2) KR20110094318A (pt)
CN (2) CN102232072B (pt)
AR (1) AR074239A1 (pt)
AU (2) AU2009322628A1 (pt)
BR (2) BRPI0922152A2 (pt)
CA (2) CA2744197A1 (pt)
CL (2) CL2009002145A1 (pt)
CO (1) CO6382158A2 (pt)
EA (1) EA021054B1 (pt)
EC (1) ECSP11011135A (pt)
ES (1) ES2403022T3 (pt)
HK (1) HK1157778A1 (pt)
IL (2) IL212796A0 (pt)
MX (2) MX2011005712A (pt)
MY (1) MY159040A (pt)
NZ (1) NZ593058A (pt)
PE (1) PE20100467A1 (pt)
RU (1) RU2507197C2 (pt)
SA (1) SA109300715B1 (pt)
SG (2) SG171432A1 (pt)
TW (1) TW201024283A (pt)
UA (1) UA106217C2 (pt)
UY (1) UY32278A (pt)
WO (2) WO2010065447A2 (pt)
ZA (1) ZA201103497B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9145396B2 (en) 2008-12-01 2015-09-29 Targacept, Inc. Synthesis and novel salt forms of (R)-5-((E)-2-pyrrolidin-3ylvinyl)pyrimidine
WO2010065443A1 (en) * 2008-12-01 2010-06-10 Targacept, Inc. Synthesis and novel salt forms of (r)-5-((e)-2-(pyrrolidin-3-ylvinyl)pyrimidine
WO2013116371A1 (en) * 2012-01-30 2013-08-08 Roar Biomedical Inc. Ex vivo plasma enzyme activity assay using inhibitors as a negative control
AP2015008579A0 (en) 2013-02-05 2015-07-31 Purdue Pharma Lp Tamper resistant pharmaceutical formulations
US20160262372A1 (en) * 2015-03-13 2016-09-15 Cornell Kunz Extermination Treatment Appliance And Method
KR102485299B1 (ko) 2016-04-07 2023-01-06 오이스터 포인트 파마 인코포레이티드 안구 장애의 치료 방법

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SK94393A3 (en) * 1992-09-11 1994-08-10 Thomae Gmbh Dr K Cyclic derivatives of urea, process for their production and their pharmaceutical agents with the content of those
IL107184A (en) 1992-10-09 1997-08-14 Abbott Lab Heterocyclic ether compounds that enhance cognitive function
US5852041A (en) 1993-04-07 1998-12-22 Sibia Neurosciences, Inc. Substituted pyridines useful as modulators of acethylcholine receptors
US5597919A (en) 1995-01-06 1997-01-28 Dull; Gary M. Pyrimidinyl or Pyridinyl alkenyl amine compounds
US5604231A (en) 1995-01-06 1997-02-18 Smith; Carr J. Pharmaceutical compositions for prevention and treatment of ulcerative colitis
JP3745433B2 (ja) * 1995-02-02 2006-02-15 第一製薬株式会社 複素環式化合物
US5585388A (en) 1995-04-07 1996-12-17 Sibia Neurosciences, Inc. Substituted pyridines useful as modulators of acetylcholine receptors
US5583140A (en) 1995-05-17 1996-12-10 Bencherif; Merouane Pharmaceutical compositions for the treatment of central nervous system disorders
IL118279A (en) 1995-06-07 2006-10-05 Abbott Lab Compounds 3 - Pyridyloxy (or Thio) Alkyl Heterocyclic Pharmaceutical Compositions Containing Them and Their Uses for Preparing Drugs to Control Synaptic Chemical Transmission
ID22045A (id) * 1996-09-13 1999-08-26 Schering Corp Senyawa-senyawa trisiklik yang berguna untuk penghambatan fungsi protein-g dan untuk pengobatan penyakit-penyakit proliferatif
TW492957B (en) * 1996-11-07 2002-07-01 Novartis Ag N-substituted 2-cyanopyrrolidnes
ZA9711092B (en) 1996-12-11 1999-07-22 Smithkline Beecham Corp Novel compounds.
JPH1171345A (ja) * 1997-08-30 1999-03-16 Nippon Nohyaku Co Ltd 光学活性なピロリジン誘導体及びその中間体並びにそれらの製造法
US6310043B1 (en) 1998-08-07 2001-10-30 Governors Of The University Of Alberta Treatment of bacterial infections
GB9821503D0 (en) 1998-10-02 1998-11-25 Novartis Ag Organic compounds
WO2002004402A1 (fr) * 2000-07-11 2002-01-17 Banyu Pharmaceutical Co., Ltd. Derives d'ester
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Also Published As

Publication number Publication date
BRPI0922152A2 (pt) 2015-08-18
CL2009002145A1 (es) 2010-04-30
EP2358670B1 (en) 2012-10-24
AU2009322628A1 (en) 2010-06-10
UA106217C2 (en) 2014-08-11
CN102232072B (zh) 2014-09-24
TW201024283A (en) 2010-07-01
CN102227406B (zh) 2013-07-31
JP2012510473A (ja) 2012-05-10
EP2358670A2 (en) 2011-08-24
CN102227406A (zh) 2011-10-26
MX2011005713A (es) 2011-06-17
JP2012510472A (ja) 2012-05-10
RU2011127004A (ru) 2013-01-10
IL212799A0 (en) 2011-07-31
WO2010065447A2 (en) 2010-06-10
US8633227B2 (en) 2014-01-21
NZ593058A (en) 2013-06-28
JP5698673B2 (ja) 2015-04-08
SG171876A1 (en) 2011-07-28
SG171432A1 (en) 2011-07-28
MY159040A (en) 2016-12-15
EP2896619A1 (en) 2015-07-22
CN102232072A (zh) 2011-11-02
PE20100467A1 (es) 2010-08-03
JP5615836B2 (ja) 2014-10-29
EP2358705A1 (en) 2011-08-24
EA201170736A1 (ru) 2011-12-30
ECSP11011135A (es) 2011-07-29
KR20110094318A (ko) 2011-08-23
WO2010065449A1 (en) 2010-06-10
UY32278A (es) 2011-06-30
SA109300715B1 (ar) 2014-06-25
KR20110094100A (ko) 2011-08-19
WO2010065447A3 (en) 2010-07-22
RU2507197C2 (ru) 2014-02-20
US20140107163A1 (en) 2014-04-17
AU2009322630A1 (en) 2010-06-10
IL212796A0 (en) 2011-07-31
ES2403022T3 (es) 2013-05-13
CA2744197A1 (en) 2010-06-10
US20110269975A1 (en) 2011-11-03
MX2011005712A (es) 2011-06-17
AR074239A1 (es) 2010-12-29
HK1157778A1 (en) 2012-07-06
CO6382158A2 (es) 2012-02-15
US20120015983A1 (en) 2012-01-19
US8153821B2 (en) 2012-04-10
CL2009002146A1 (es) 2010-04-30
ZA201103497B (en) 2012-01-25
IL212799A (en) 2013-12-31
CA2744191A1 (en) 2010-06-10
EA021054B1 (ru) 2015-03-31

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2386 DE 27-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.