BRPI0918868B8 - compostos moduladores do receptor de nmda e composições compreendendo os mesmos - Google Patents
compostos moduladores do receptor de nmda e composições compreendendo os mesmosInfo
- Publication number
- BRPI0918868B8 BRPI0918868B8 BRPI0918868A BRPI0918868A BRPI0918868B8 BR PI0918868 B8 BRPI0918868 B8 BR PI0918868B8 BR PI0918868 A BRPI0918868 A BR PI0918868A BR PI0918868 A BRPI0918868 A BR PI0918868A BR PI0918868 B8 BRPI0918868 B8 BR PI0918868B8
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- nmda receptor
- compositions
- same
- modulating compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 3
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 title abstract 2
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 title abstract 2
- 238000009472 formulation Methods 0.000 abstract 2
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 abstract 1
- 230000036592 analgesia Effects 0.000 abstract 1
- 230000001149 cognitive effect Effects 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000001990 intravenous administration Methods 0.000 abstract 1
- 230000013016 learning Effects 0.000 abstract 1
- 208000004296 neuralgia Diseases 0.000 abstract 1
- 208000021722 neuropathic pain Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9808808P | 2008-09-18 | 2008-09-18 | |
| US61/098,088 | 2008-09-18 | ||
| PCT/US2009/057401 WO2010033757A1 (en) | 2008-09-18 | 2009-09-18 | Nmda receptor modulators and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0918868A2 BRPI0918868A2 (pt) | 2018-05-22 |
| BRPI0918868B1 BRPI0918868B1 (pt) | 2020-07-21 |
| BRPI0918868B8 true BRPI0918868B8 (pt) | 2021-05-25 |
Family
ID=42039880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0918868A BRPI0918868B8 (pt) | 2008-09-18 | 2009-09-18 | compostos moduladores do receptor de nmda e composições compreendendo os mesmos |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US20110306586A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2331571B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5702288B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101769999B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN102186883B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2009293164B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0918868B8 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2740628C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2553968T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL211802A (cg-RX-API-DMAC7.html) |
| MX (1) | MX2011003015A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2515615C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010033757A1 (cg-RX-API-DMAC7.html) |
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| JP2008188285A (ja) * | 2007-02-06 | 2008-08-21 | Bridgestone Corp | バックパッド及び車両用シート |
| WO2010033757A1 (en) | 2008-09-18 | 2010-03-25 | Naurex, Inc. | Nmda receptor modulators and uses thereof |
| US8951968B2 (en) | 2009-10-05 | 2015-02-10 | Northwestern University | Methods of treating depression and other related diseases |
| KR101692275B1 (ko) * | 2010-02-11 | 2017-01-04 | 노오쓰웨스턴 유니버시티 | ２차 구조 안정화된 ｎｍｄａ 수용체 조절제 및 그의 용도 |
| BR112012020142A2 (pt) * | 2010-02-11 | 2020-08-18 | Northwestern University | moduladores do receptor de nmda com estrutura secundária estabilizada e usos dos mesmos. |
| US9737531B2 (en) | 2012-07-12 | 2017-08-22 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
| US10583138B2 (en) | 2012-07-12 | 2020-03-10 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
| EP3679931A3 (en) * | 2011-04-27 | 2020-10-14 | Northwestern University | Methods of treating alzheimer's disease, huntington's disease, autism, and other disorders |
| MX375286B (es) * | 2013-01-29 | 2025-03-06 | Aptinyx Inc | Moduladores de receptores nmda de espiro-lactama y sus usos. |
| ES2935352T3 (es) * | 2013-01-29 | 2023-03-06 | Aptinyx Inc | Moduladores de receptores NMDA de espiro-lactama y sus usos |
| CN105026401A (zh) * | 2013-01-29 | 2015-11-04 | 诺雷克斯股份有限公司 | 螺-内酰胺nmda受体调节剂及其用途 |
| JP6419087B2 (ja) * | 2013-01-29 | 2018-11-07 | アプティニックス インコーポレイテッド | スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用 |
| BR112015018094A2 (pt) * | 2013-01-29 | 2017-07-18 | Naurex Inc | moduladores de receptor nmda de espiro-lactama e usos dos mesmos |
| JP6603668B2 (ja) * | 2013-10-28 | 2019-11-06 | ノーレックス インコーポレイテッド | Ｎｍｄａ受容体モジュレーター及びプロドラッグ、塩、並びにこれらの使用 |
| WO2016014982A1 (en) * | 2014-07-24 | 2016-01-28 | Naurex, Inc. | N-methyl-d-aspartate receptor modulators and methods of making and using same |
| CN104546809B (zh) * | 2015-01-13 | 2018-08-24 | 西安力邦制药有限公司 | 3,3’,5,5’-四异丙基-4,4’-二联苯酚在预防及治疗缺血性脑卒中中的应用 |
| EP3383429B1 (en) | 2015-11-30 | 2020-10-14 | INSERM - Institut National de la Santé et de la Recherche Médicale | Nmdar antagonists for the treatment of tumor angiogenesis |
| KR102128675B1 (ko) * | 2016-05-19 | 2020-06-30 | 앱티닉스 인크. | 스피로-락탐 nmda 수용체 조정제 및 그의 용도 |
| WO2017201285A1 (en) | 2016-05-19 | 2017-11-23 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| KR102503590B1 (ko) | 2016-08-01 | 2023-02-24 | 앱티닉스 인크. | 스피로-락탐 nmda 수용체 조정제 및 그의 용도 |
| SG11201900551WA (en) | 2016-08-01 | 2019-02-27 | Aptinyx Inc | Spiro-lactam nmda receptor modulators and uses thereof |
| CA3031563C (en) | 2016-08-01 | 2023-12-05 | Aptinyx Inc. | Spiro-lactam nmda modulators and methods of using same |
| EA201990424A1 (ru) | 2016-08-01 | 2019-08-30 | Аптиникс Инк. | Спиролактамовые модуляторы nmda-рецептора и их применение |
| JP2019527235A (ja) | 2016-08-01 | 2019-09-26 | アプティニックス インコーポレイテッド | スピロ−ラクタム及びビス−スピロ−ラクタムｎｍｄａ受容体修飾因子及びその使用 |
| MX393950B (es) | 2017-06-12 | 2025-03-24 | Glytech Llc | Composicion y metodo para el tratamiento de la depresion y psicosis en humanos |
| PE20211455A1 (es) * | 2018-01-31 | 2021-08-05 | Aptinyx Inc | Moduladores del receptor nmda espiro-lactama y usos de los mismos |
| WO2019152696A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| SG11202007256PA (en) | 2018-01-31 | 2020-08-28 | Aptinyx Inc | Spiro-lactam nmda receptor modulators and uses thereof |
| WO2019152685A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and methods of using same |
| BR112021026380A2 (pt) * | 2019-06-24 | 2022-05-10 | Naurex Inc | Formas sólidas de (s)-2-((2s,3r)-1-amino-3-hidróxi-1-oxobutan-2-il)-1-oxo-2,5-diazaespiro[3.4]octano-5-carboxilato de terc-butila e métodos de preparação das mesmas |
| CN114269338B (zh) * | 2019-06-24 | 2025-02-18 | 诺雷克斯股份有限公司 | 生产二氮杂螺内酰胺化合物的方法和中间体 |
| US12012413B2 (en) | 2019-11-11 | 2024-06-18 | Tenacia Biotechnology (Hong Kong) Co., Limited | Methods of treating painful diabetic peripheral neuropathy |
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2009
- 2009-09-18 WO PCT/US2009/057401 patent/WO2010033757A1/en not_active Ceased
- 2009-09-18 AU AU2009293164A patent/AU2009293164B2/en not_active Ceased
- 2009-09-18 KR KR1020117008824A patent/KR101769999B1/ko not_active Expired - Fee Related
- 2009-09-18 CN CN200980141061.7A patent/CN102186883B/zh not_active Expired - Fee Related
- 2009-09-18 CA CA2740628A patent/CA2740628C/en active Active
- 2009-09-18 MX MX2011003015A patent/MX2011003015A/es active IP Right Grant
- 2009-09-18 BR BRPI0918868A patent/BRPI0918868B8/pt not_active IP Right Cessation
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- 2009-09-18 JP JP2011527977A patent/JP5702288B2/ja not_active Expired - Fee Related
- 2009-09-18 RU RU2011114982/04A patent/RU2515615C2/ru active
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2011
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- 2011-03-18 US US13/051,237 patent/US20110306586A1/en not_active Abandoned
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2013
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2014
- 2014-12-23 US US14/580,803 patent/US9802946B2/en not_active Expired - Fee Related
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2017
- 2017-10-17 US US15/785,603 patent/US10906913B2/en not_active Expired - Fee Related
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- 2020-12-04 US US17/111,657 patent/US20210332061A1/en not_active Abandoned
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|---|---|
| US20150336969A1 (en) | 2015-11-26 |
| US20150105364A1 (en) | 2015-04-16 |
| AU2009293164A1 (en) | 2010-03-25 |
| JP2012503008A (ja) | 2012-02-02 |
| US20210332061A1 (en) | 2021-10-28 |
| CA2740628A1 (en) | 2010-03-25 |
| BRPI0918868A2 (pt) | 2018-05-22 |
| CN102186883A (zh) | 2011-09-14 |
| WO2010033757A1 (en) | 2010-03-25 |
| AU2009293164B2 (en) | 2015-07-09 |
| US9512133B2 (en) | 2016-12-06 |
| US9802946B2 (en) | 2017-10-31 |
| US10906913B2 (en) | 2021-02-02 |
| CN102186883B (zh) | 2016-08-03 |
| IL211802A (en) | 2017-03-30 |
| US20110306586A1 (en) | 2011-12-15 |
| BRPI0918868B1 (pt) | 2020-07-21 |
| EP2331571A1 (en) | 2011-06-15 |
| MX2011003015A (es) | 2011-11-18 |
| US20190077807A1 (en) | 2019-03-14 |
| KR101769999B1 (ko) | 2017-08-21 |
| JP5702288B2 (ja) | 2015-04-15 |
| EP2331571A4 (en) | 2012-06-20 |
| ES2553968T3 (es) | 2015-12-15 |
| IL211802A0 (en) | 2011-06-30 |
| EP2331571B1 (en) | 2015-08-26 |
| RU2011114982A (ru) | 2012-10-27 |
| RU2515615C2 (ru) | 2014-05-20 |
| KR20110076941A (ko) | 2011-07-06 |
| CA2740628C (en) | 2018-05-01 |
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