BRPI0918526B1 - Forma cristalina polimórfica anidra de acil sulfonamidas, seu processo de preparação, uso e composição farmacêutica que a compreende - Google Patents

Forma cristalina polimórfica anidra de acil sulfonamidas, seu processo de preparação, uso e composição farmacêutica que a compreende Download PDF

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Publication number
BRPI0918526B1
BRPI0918526B1 BRPI0918526-7A BRPI0918526A BRPI0918526B1 BR PI0918526 B1 BRPI0918526 B1 BR PI0918526B1 BR PI0918526 A BRPI0918526 A BR PI0918526A BR PI0918526 B1 BRPI0918526 B1 BR PI0918526B1
Authority
BR
Brazil
Prior art keywords
compound
acid
hiv
polymorphic
crystalline form
Prior art date
Application number
BRPI0918526-7A
Other languages
English (en)
Portuguese (pt)
Inventor
James Prentice Davidson
Michael Martin
Fei Pang
Margaret Wong
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Priority to BR122021020475-6A priority Critical patent/BR122021020475B1/pt
Priority to BR122021020474-8A priority patent/BR122021020474B1/pt
Publication of BRPI0918526A2 publication Critical patent/BRPI0918526A2/pt
Publication of BRPI0918526B1 publication Critical patent/BRPI0918526B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/51—Y being a hydrogen or a carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/42—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
BRPI0918526-7A 2008-09-09 2009-08-31 Forma cristalina polimórfica anidra de acil sulfonamidas, seu processo de preparação, uso e composição farmacêutica que a compreende BRPI0918526B1 (pt)

Priority Applications (2)

Application Number Priority Date Filing Date Title
BR122021020475-6A BR122021020475B1 (pt) 2008-09-09 2009-08-31 Polimorfos de acil sulfonamidas, seu uso, seu processo de preparação e composição farmacêutica que os compreende
BR122021020474-8A BR122021020474B1 (pt) 2008-09-09 2009-08-31 Polimorfos de acil sulfonamidas, seu uso, seu processo de preparação e composição farmacêutica que os compreende

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9536408P 2008-09-09 2008-09-09
US61/095,364 2008-09-09
PCT/EP2009/061185 WO2010028968A2 (en) 2008-09-09 2009-08-31 Polymorphs of acyl sulfonamides

Publications (2)

Publication Number Publication Date
BRPI0918526A2 BRPI0918526A2 (pt) 2015-12-01
BRPI0918526B1 true BRPI0918526B1 (pt) 2022-02-15

Family

ID=41664548

Family Applications (3)

Application Number Title Priority Date Filing Date
BRPI0918526-7A BRPI0918526B1 (pt) 2008-09-09 2009-08-31 Forma cristalina polimórfica anidra de acil sulfonamidas, seu processo de preparação, uso e composição farmacêutica que a compreende
BR122021020474-8A BR122021020474B1 (pt) 2008-09-09 2009-08-31 Polimorfos de acil sulfonamidas, seu uso, seu processo de preparação e composição farmacêutica que os compreende
BR122021020475-6A BR122021020475B1 (pt) 2008-09-09 2009-08-31 Polimorfos de acil sulfonamidas, seu uso, seu processo de preparação e composição farmacêutica que os compreende

Family Applications After (2)

Application Number Title Priority Date Filing Date
BR122021020474-8A BR122021020474B1 (pt) 2008-09-09 2009-08-31 Polimorfos de acil sulfonamidas, seu uso, seu processo de preparação e composição farmacêutica que os compreende
BR122021020475-6A BR122021020475B1 (pt) 2008-09-09 2009-08-31 Polimorfos de acil sulfonamidas, seu uso, seu processo de preparação e composição farmacêutica que os compreende

Country Status (16)

Country Link
US (1) US8063103B2 (cg-RX-API-DMAC7.html)
EP (1) EP2334638B1 (cg-RX-API-DMAC7.html)
JP (6) JP5989339B2 (cg-RX-API-DMAC7.html)
KR (7) KR102437499B1 (cg-RX-API-DMAC7.html)
CN (1) CN102143943B (cg-RX-API-DMAC7.html)
AU (1) AU2009290988B2 (cg-RX-API-DMAC7.html)
BR (3) BRPI0918526B1 (cg-RX-API-DMAC7.html)
CA (5) CA3086566C (cg-RX-API-DMAC7.html)
EA (1) EA019340B1 (cg-RX-API-DMAC7.html)
ES (1) ES2706875T3 (cg-RX-API-DMAC7.html)
IL (4) IL299322B2 (cg-RX-API-DMAC7.html)
MX (1) MX2011002319A (cg-RX-API-DMAC7.html)
PL (1) PL2334638T3 (cg-RX-API-DMAC7.html)
TR (1) TR201818979T4 (cg-RX-API-DMAC7.html)
UA (1) UA107561C2 (cg-RX-API-DMAC7.html)
WO (1) WO2010028968A2 (cg-RX-API-DMAC7.html)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2644156C1 (ru) 2017-02-28 2018-02-08 Александр Васильевич Иващенко Пролекарство ингибитора NS5B HCV полимеразы, способ его получения и применения
RU2665383C9 (ru) * 2017-06-22 2019-07-23 Общество с ограниченной ответственностью "Вириом" Фармацевтическая наносуспензия для терапии ВИЧ-инфекции
RU2662160C9 (ru) 2017-07-03 2018-10-22 Александрович Иващенко Андрей Комбинированный лекарственный препарат для терапии вирусных инфекций
RU2716257C1 (ru) 2019-04-30 2020-03-11 Андрей Александрович Иващенко Активный компонент, фармацевтическая композиция и лекарственный препарат для терапии ВИЧ и СПИДа
RU2717101C1 (ru) 2019-06-03 2020-03-18 Андрей Александрович Иващенко Анелированные 9-гидрокси-1,8-диоксо-1,3,4,8-тетрагидро-2Н-пиридо[1,2-a]пиразин-7-карбоксамиды - ингибиторы интегразы ВИЧ, способы их получения и применения

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998032742A1 (en) * 1997-01-23 1998-07-30 Yamanouchi Pharmaceutical Co., Ltd. Novel amide derivatives and medicinal compositions thereof
US7625949B2 (en) 2004-04-23 2009-12-01 Roche Palo Alto Llc Methods for treating retroviral infections
RU2389719C3 (ru) * 2004-04-23 2018-04-18 Ф.Хоффманн-Ля Рош Аг Ненуклеозидные ингибиторы обратной транскриптазы
US7166738B2 (en) * 2004-04-23 2007-01-23 Roche Palo Alto Llc Non-nucleoside reverse transcriptase inhibitors
US7618981B2 (en) * 2004-05-06 2009-11-17 Cytokinetics, Inc. Imidazopyridinyl-benzamide anti-cancer agents
KR100925900B1 (ko) * 2005-04-28 2009-11-09 화이자 리미티드 아미노산 유도체
WO2009018233A1 (en) * 2007-07-30 2009-02-05 Ardea Biosciences, Inc. Derivatives of n-(arylamino) sulfonamides including polymorphs as inhibitors of mek as well as compositions, methods of use and methods for preparing the same
CA2625047A1 (en) * 2005-10-19 2007-04-26 F. Hoffmann-La Roche Ag Phenyl-acetamide nnrt inhibitors
CN101959502A (zh) * 2008-03-04 2011-01-26 弗·哈夫曼-拉罗切有限公司 制备浓缩胶束水溶液的方法

Also Published As

Publication number Publication date
AU2009290988B2 (en) 2016-01-28
IL299322B1 (en) 2024-06-01
KR20210108499A (ko) 2021-09-02
CA2949912A1 (en) 2010-03-18
CA3086566C (en) 2025-09-02
EA019340B1 (ru) 2014-02-28
CN102143943A (zh) 2011-08-03
TR201818979T4 (tr) 2019-01-21
CA2735192C (en) 2017-02-28
CA3059552C (en) 2021-03-16
JP2019194229A (ja) 2019-11-07
JP2021176894A (ja) 2021-11-11
US20100063154A1 (en) 2010-03-11
KR20220120723A (ko) 2022-08-30
ES2706875T3 (es) 2019-04-01
KR20110053234A (ko) 2011-05-19
KR101678700B1 (ko) 2016-11-22
EA201100451A1 (ru) 2011-10-31
WO2010028968A2 (en) 2010-03-18
KR20160092049A (ko) 2016-08-03
KR20180110237A (ko) 2018-10-08
KR20180001582A (ko) 2018-01-04
IL211353A (en) 2016-04-21
CA3003213C (en) 2021-07-20
IL264118A (en) 2019-02-28
IL299322A (en) 2023-02-01
JP2012502075A (ja) 2012-01-26
EP2334638B1 (en) 2018-11-21
CA3059552A1 (en) 2010-03-18
KR101822319B1 (ko) 2018-01-25
IL244350A0 (en) 2016-05-01
KR102437499B1 (ko) 2022-08-29
JP2023082131A (ja) 2023-06-13
AU2009290988A1 (en) 2010-03-18
CA3003213A1 (en) 2010-03-18
JP2018058862A (ja) 2018-04-12
BRPI0918526A2 (pt) 2015-12-01
JP2016172741A (ja) 2016-09-29
CN102143943B (zh) 2014-03-12
KR102560207B1 (ko) 2023-07-27
BR122021020475B1 (pt) 2022-06-07
IL299322B2 (en) 2024-10-01
JP6450340B2 (ja) 2019-01-09
US8063103B2 (en) 2011-11-22
CA2949912C (en) 2019-12-03
CA2735192A1 (en) 2010-03-18
JP5989339B2 (ja) 2016-09-07
EP2334638A2 (en) 2011-06-22
PL2334638T3 (pl) 2019-04-30
CA3086566A1 (en) 2010-03-18
KR20230113420A (ko) 2023-07-28
BR122021020474B1 (pt) 2022-06-07
MX2011002319A (es) 2011-04-05
WO2010028968A3 (en) 2010-06-10
IL211353A0 (en) 2011-05-31
UA107561C2 (xx) 2015-01-26

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO EM FUNCAO DA REVOGACAO DO ART. 229-C DA LEI NO 9.279, DE 1996, POR FORCA DA LEI NO 14.195, DE 2021

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 31/08/2009, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.