BRPI0914807A2 - Processo para a preparação de compostos inibidores de rho-quinase - Google Patents

Processo para a preparação de compostos inibidores de rho-quinase

Info

Publication number
BRPI0914807A2
BRPI0914807A2 BRPI0914807A BRPI0914807A BRPI0914807A2 BR PI0914807 A2 BRPI0914807 A2 BR PI0914807A2 BR PI0914807 A BRPI0914807 A BR PI0914807A BR PI0914807 A BRPI0914807 A BR PI0914807A BR PI0914807 A2 BRPI0914807 A2 BR PI0914807A2
Authority
BR
Brazil
Prior art keywords
compounds
rho
preparation
kinase inhibitors
inhibitors compounds
Prior art date
Application number
BRPI0914807A
Other languages
English (en)
Inventor
She Jin
Bryan Decamp Jonathan
S Watson Paul
J Slade David
Original Assignee
Inspire Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inspire Pharmaceuticals Inc filed Critical Inspire Pharmaceuticals Inc
Publication of BRPI0914807A2 publication Critical patent/BRPI0914807A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/78—Benzoic acid esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

PROCESSO PARA A PREPARAÇÃO DE COMPOSTOS INIBIDORES DE RHO-QUINASE. A presente invenção refere-se processos de sintéticos de alto rendimento práticos para preparar compostos de Fórmula geral III, IV, V, VII, VIII, IX, X, XII, XIV e XV. Tais compostos são úteis como produtos finais ou podem ser usados como intermediários e ainda ser modificados para preparar outros produtos desejados, tais como inibidores da rhoquinase. A presente invenção também refere-se a certos novos compostos e / ou novas formas sólidas de certos compostos.
BRPI0914807A 2008-06-18 2009-05-21 Processo para a preparação de compostos inibidores de rho-quinase BRPI0914807A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7369508P 2008-06-18 2008-06-18
PCT/US2009/044889 WO2009154940A1 (en) 2008-06-18 2009-05-21 Process for the preparation of rho-kinase inhibitor compounds

Publications (1)

Publication Number Publication Date
BRPI0914807A2 true BRPI0914807A2 (pt) 2017-08-22

Family

ID=41434376

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0914807A BRPI0914807A2 (pt) 2008-06-18 2009-05-21 Processo para a preparação de compostos inibidores de rho-quinase

Country Status (11)

Country Link
US (1) US8158796B2 (pt)
EP (1) EP2291077A4 (pt)
JP (1) JP2011524909A (pt)
KR (1) KR20110018370A (pt)
CN (1) CN102065689A (pt)
AU (1) AU2009260628A1 (pt)
BR (1) BRPI0914807A2 (pt)
CA (1) CA2726611A1 (pt)
MX (1) MX2010013952A (pt)
RU (1) RU2011101572A (pt)
WO (1) WO2009154940A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100008968A1 (en) * 2008-06-26 2010-01-14 Lampe John W Method for treating cardiovascular diseases using rho kinase inhibitor compounds
EP2597953A4 (en) * 2010-07-27 2013-12-25 Inspire Pharmaceuticals Inc METHOD FOR THE TREATMENT OF EYE DISEASES USING KINASE-INHIBITOR COMPOUNDS IN PRODRUG FORMS
WO2012030938A1 (en) * 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Salts of lorcaserin with optically active acids

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003264427A1 (en) * 2002-09-12 2004-04-30 Kirin Beer Kabushiki Kaisha Isoquinoline derivatives having kinasae inhibitory activity and drugs containing the same
CA2530389A1 (en) 2003-07-02 2005-01-13 Biofocus Discovery Limited Pyrazine and pyridine derivatives as rho kinase inhibitors
US20070004771A1 (en) 2003-10-06 2007-01-04 Glaxo Group Limited Preparation of 1,6,7-trisubstituted azabenzimidazoles as kinase inhibitors
US7759342B2 (en) * 2005-01-13 2010-07-20 Signal Pharmaceuticals, Llc Methods of treatment and prevention using haloaryl substituted aminopurines
US8071779B2 (en) 2006-12-18 2011-12-06 Inspire Pharmaceuticals, Inc. Cytoskeletal active rho kinase inhibitor compounds, composition and use

Also Published As

Publication number Publication date
JP2011524909A (ja) 2011-09-08
US8158796B2 (en) 2012-04-17
CN102065689A (zh) 2011-05-18
EP2291077A1 (en) 2011-03-09
AU2009260628A1 (en) 2009-12-23
RU2011101572A (ru) 2012-07-27
KR20110018370A (ko) 2011-02-23
EP2291077A4 (en) 2011-05-25
MX2010013952A (es) 2011-02-18
US20100022775A1 (en) 2010-01-28
CA2726611A1 (en) 2009-12-23
WO2009154940A1 (en) 2009-12-23

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Legal Events

Date Code Title Description
B15I Others concerning applications: loss of priority
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2435 DE 05-09-2017 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.