BRPI0913167A2 - Síntese aprimorada de hexahidrodibenzopiranonas - Google Patents

Síntese aprimorada de hexahidrodibenzopiranonas

Info

Publication number
BRPI0913167A2
BRPI0913167A2 BRPI0913167-1A BRPI0913167A BRPI0913167A2 BR PI0913167 A2 BRPI0913167 A2 BR PI0913167A2 BR PI0913167 A BRPI0913167 A BR PI0913167A BR PI0913167 A2 BRPI0913167 A2 BR PI0913167A2
Authority
BR
Brazil
Prior art keywords
hexahydrodibenzopyranones
enhanced synthesis
synthesis
enhanced
Prior art date
Application number
BRPI0913167-1A
Other languages
English (en)
Inventor
Valery Mikaylo
Subakar Paramanantham
Ilya Avrutov
Martyn A Brown
Zemin Li
Natalie Lazarowych
Original Assignee
Watson Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Watson Lab filed Critical Watson Lab
Publication of BRPI0913167A2 publication Critical patent/BRPI0913167A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BRPI0913167-1A 2008-08-28 2009-08-28 Síntese aprimorada de hexahidrodibenzopiranonas BRPI0913167A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9249508P 2008-08-28 2008-08-28
CA002638940A CA2638940C (en) 2008-08-28 2008-09-22 Improved synthesis of hexahydrodibenzopyranones
PCT/CA2009/001207 WO2010022520A1 (en) 2008-08-28 2009-08-28 Improved synthesis of hexahydrodibenzopyranones

Publications (1)

Publication Number Publication Date
BRPI0913167A2 true BRPI0913167A2 (pt) 2015-07-28

Family

ID=40091252

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0913167-1A BRPI0913167A2 (pt) 2008-08-28 2009-08-28 Síntese aprimorada de hexahidrodibenzopiranonas

Country Status (11)

Country Link
US (1) US8258322B2 (pt)
EP (1) EP2331519A4 (pt)
JP (1) JP2012500811A (pt)
CN (1) CN102131795A (pt)
AU (1) AU2009287327A1 (pt)
BR (1) BRPI0913167A2 (pt)
CA (1) CA2638940C (pt)
MX (1) MX2011002115A (pt)
NZ (1) NZ591180A (pt)
WO (1) WO2010022520A1 (pt)
ZA (1) ZA201101308B (pt)

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3507885A (en) 1966-03-25 1970-04-21 Hoffmann La Roche 3-alkyl-6h-dibenzo(b,d)pyrans
US4054582A (en) * 1976-07-06 1977-10-18 Eli Lilly And Company Process for converting cis-hexahydrodibenzo[b,d]pyran-9-ones to trans-hexahydrodibenzo[b,d]-pyran-9-ones
US4054583A (en) * 1976-07-06 1977-10-18 Eli Lilly And Company Process for converting 2,7-dihydroxy-5-isopropylidene-9-substituted-2,6-methano-3,4,5,6-tetrahydro-2H-1-benzoxocin to trans-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo(b,d)pyran-9-one
GB1582564A (en) 1976-07-06 1981-01-14 Lilly Co Eli Dibenzopyrans
CA1096390A (en) * 1976-07-06 1981-02-24 Edward R. Lavagnino PROCESS FOR PREPARING DL-CIS-1-HYDROXY-3-SUBSTITUTED- 6,6-DIMETHYL-6,6.alpha.,7,8,10,10.alpha.-HEXAHYDRO-9H- DIBENZO(B,D,)PYRAN-9-ONES
GB1579137A (en) 1976-07-06 1980-11-12 Lilly Co Eli 5-isopropylidene-2,6-methano-3,4,5,6-tetrahydro-2h-1-benzoxocins
CA1088083A (en) * 1976-07-06 1980-10-21 Charles W. Ryan Process for preparing cis-hexahydrodibenzopyranones
US4171315A (en) * 1978-03-31 1979-10-16 Eli Lilly And Company Preparation of cis-hexahydrodibenzopyranones
JPS5841296A (ja) * 1981-09-04 1983-03-10 Seiko Instr & Electronics Ltd 磁気軸受を応用した小型軸流分子ポンプ
US4395560A (en) * 1982-05-24 1983-07-26 Eli Lilly And Company Preparation of 6a,10a-trans-hexahydrodibenzopyranones
HU194858B (en) * 1982-12-03 1988-03-28 Chinoin Gyogyszer Es Vegyeszet Process for producing dibenzo/b,d/pirane derivatives and pharmaceutical compositions containing them
US5475170A (en) * 1994-06-27 1995-12-12 Albermarle Corporation Haloalkylation process
EP0949255B1 (en) * 1998-04-06 2006-05-24 DSM IP Assets B.V. Process for manufacturing d, l-alpha-tocopherol in a carbonate solvent and in the presence of a sulphur-containing acid catalyst

Also Published As

Publication number Publication date
CA2638940A1 (en) 2008-12-02
AU2009287327A1 (en) 2010-03-04
CA2638940C (en) 2009-09-15
US20100056811A1 (en) 2010-03-04
ZA201101308B (en) 2011-11-30
CN102131795A (zh) 2011-07-20
EP2331519A1 (en) 2011-06-15
JP2012500811A (ja) 2012-01-12
NZ591180A (en) 2012-07-27
MX2011002115A (es) 2011-05-23
WO2010022520A1 (en) 2010-03-04
WO2010022520A8 (en) 2010-06-10
US8258322B2 (en) 2012-09-04
EP2331519A4 (en) 2011-10-12

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2344 DE 08-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.