EP2331519A4 - IMPROVING THE SYNTHESIS OF HEXAHYDRODIBENZOPYRANONES - Google Patents

IMPROVING THE SYNTHESIS OF HEXAHYDRODIBENZOPYRANONES

Info

Publication number
EP2331519A4
EP2331519A4 EP09809161A EP09809161A EP2331519A4 EP 2331519 A4 EP2331519 A4 EP 2331519A4 EP 09809161 A EP09809161 A EP 09809161A EP 09809161 A EP09809161 A EP 09809161A EP 2331519 A4 EP2331519 A4 EP 2331519A4
Authority
EP
European Patent Office
Prior art keywords
hexahydrodibenzopyranones
improved synthesis
synthesis
improved
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09809161A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP2331519A1 (en
Inventor
Valeriy Mikaylo
Subakar Paramanantham
Ilya Avrutov
Martyn A Brown
Zemin Li
Natalie Lazarowych
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Actavis Laboratories UT Inc
Original Assignee
Actavis Laboratories UT Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actavis Laboratories UT Inc filed Critical Actavis Laboratories UT Inc
Publication of EP2331519A1 publication Critical patent/EP2331519A1/en
Publication of EP2331519A4 publication Critical patent/EP2331519A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP09809161A 2008-08-28 2009-08-28 IMPROVING THE SYNTHESIS OF HEXAHYDRODIBENZOPYRANONES Withdrawn EP2331519A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9249508P 2008-08-28 2008-08-28
CA002638940A CA2638940C (en) 2008-08-28 2008-09-22 Improved synthesis of hexahydrodibenzopyranones
PCT/CA2009/001207 WO2010022520A1 (en) 2008-08-28 2009-08-28 Improved synthesis of hexahydrodibenzopyranones

Publications (2)

Publication Number Publication Date
EP2331519A1 EP2331519A1 (en) 2011-06-15
EP2331519A4 true EP2331519A4 (en) 2011-10-12

Family

ID=40091252

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09809161A Withdrawn EP2331519A4 (en) 2008-08-28 2009-08-28 IMPROVING THE SYNTHESIS OF HEXAHYDRODIBENZOPYRANONES

Country Status (11)

Country Link
US (1) US8258322B2 (pt)
EP (1) EP2331519A4 (pt)
JP (1) JP2012500811A (pt)
CN (1) CN102131795A (pt)
AU (1) AU2009287327A1 (pt)
BR (1) BRPI0913167A2 (pt)
CA (1) CA2638940C (pt)
MX (1) MX2011002115A (pt)
NZ (1) NZ591180A (pt)
WO (1) WO2010022520A1 (pt)
ZA (1) ZA201101308B (pt)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4054582A (en) * 1976-07-06 1977-10-18 Eli Lilly And Company Process for converting cis-hexahydrodibenzo[b,d]pyran-9-ones to trans-hexahydrodibenzo[b,d]-pyran-9-ones

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3507885A (en) 1966-03-25 1970-04-21 Hoffmann La Roche 3-alkyl-6h-dibenzo(b,d)pyrans
GB1579137A (en) * 1976-07-06 1980-11-12 Lilly Co Eli 5-isopropylidene-2,6-methano-3,4,5,6-tetrahydro-2h-1-benzoxocins
US4054583A (en) * 1976-07-06 1977-10-18 Eli Lilly And Company Process for converting 2,7-dihydroxy-5-isopropylidene-9-substituted-2,6-methano-3,4,5,6-tetrahydro-2H-1-benzoxocin to trans-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo(b,d)pyran-9-one
GB1582564A (en) 1976-07-06 1981-01-14 Lilly Co Eli Dibenzopyrans
CA1096390A (en) 1976-07-06 1981-02-24 Edward R. Lavagnino PROCESS FOR PREPARING DL-CIS-1-HYDROXY-3-SUBSTITUTED- 6,6-DIMETHYL-6,6.alpha.,7,8,10,10.alpha.-HEXAHYDRO-9H- DIBENZO(B,D,)PYRAN-9-ONES
CA1088083A (en) * 1976-07-06 1980-10-21 Charles W. Ryan Process for preparing cis-hexahydrodibenzopyranones
US4171315A (en) * 1978-03-31 1979-10-16 Eli Lilly And Company Preparation of cis-hexahydrodibenzopyranones
JPS5841296A (ja) * 1981-09-04 1983-03-10 Seiko Instr & Electronics Ltd 磁気軸受を応用した小型軸流分子ポンプ
US4395560A (en) * 1982-05-24 1983-07-26 Eli Lilly And Company Preparation of 6a,10a-trans-hexahydrodibenzopyranones
HU194858B (en) * 1982-12-03 1988-03-28 Chinoin Gyogyszer Es Vegyeszet Process for producing dibenzo/b,d/pirane derivatives and pharmaceutical compositions containing them
US5475170A (en) * 1994-06-27 1995-12-12 Albermarle Corporation Haloalkylation process
ES2264230T3 (es) * 1998-04-06 2006-12-16 Dsm Ip Assets B.V. Procedimiento par ala obtencion de d,1-alfa-tocoferol, en un disolvente de carbonato y en presencia de un catalizador de acido conteniendo azufre.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4054582A (en) * 1976-07-06 1977-10-18 Eli Lilly And Company Process for converting cis-hexahydrodibenzo[b,d]pyran-9-ones to trans-hexahydrodibenzo[b,d]-pyran-9-ones

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2010022520A1 *

Also Published As

Publication number Publication date
EP2331519A1 (en) 2011-06-15
US8258322B2 (en) 2012-09-04
CA2638940C (en) 2009-09-15
NZ591180A (en) 2012-07-27
ZA201101308B (en) 2011-11-30
US20100056811A1 (en) 2010-03-04
JP2012500811A (ja) 2012-01-12
CA2638940A1 (en) 2008-12-02
AU2009287327A1 (en) 2010-03-04
WO2010022520A1 (en) 2010-03-04
BRPI0913167A2 (pt) 2015-07-28
WO2010022520A8 (en) 2010-06-10
MX2011002115A (es) 2011-05-23
CN102131795A (zh) 2011-07-20

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