BRPI0910097A2 - métodos para triar quanto a um alelo defeituoso de um gene que codifica enzima remediável pela administração de cofator, para detectar uma predisposição a uma deficiência de enzima dependente de cofator, para identificar e/ou caracterizar uma deficiência de enzima dentro uma via metabólica em um paciente, para tratar uma deficiência metabólica de enzima em um paciente, para triar quanto ao risco de uma condição ou doença associadas com o metabolismo de foliato/homocisteína aberrante, para triar quanto ao potencial de resposta quimioterapêutica e para triar quanto à toxidade quimioterapêutica, kit para avaliar deficiências de enzima remediáveis em uma via metabólica, ácido nucleico isolado, arranjo para detectar um alelo defeituoso de um gene na via metabólica do foliato/homocisteína - Google Patents
métodos para triar quanto a um alelo defeituoso de um gene que codifica enzima remediável pela administração de cofator, para detectar uma predisposição a uma deficiência de enzima dependente de cofator, para identificar e/ou caracterizar uma deficiência de enzima dentro uma via metabólica em um paciente, para tratar uma deficiência metabólica de enzima em um paciente, para triar quanto ao risco de uma condição ou doença associadas com o metabolismo de foliato/homocisteína aberrante, para triar quanto ao potencial de resposta quimioterapêutica e para triar quanto à toxidade quimioterapêutica, kit para avaliar deficiências de enzima remediáveis em uma via metabólica, ácido nucleico isolado, arranjo para detectar um alelo defeituoso de um gene na via metabólica do foliato/homocisteínaInfo
- Publication number
- BRPI0910097A2 BRPI0910097A2 BRPI0910097A BRPI0910097A BRPI0910097A2 BR PI0910097 A2 BRPI0910097 A2 BR PI0910097A2 BR PI0910097 A BRPI0910097 A BR PI0910097A BR PI0910097 A BRPI0910097 A BR PI0910097A BR PI0910097 A2 BRPI0910097 A2 BR PI0910097A2
- Authority
- BR
- Brazil
- Prior art keywords
- enzyme
- screen
- metabolic pathway
- foliate
- cofactor
- Prior art date
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/6895—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/142—Toxicological screening, e.g. expression profiles which identify toxicity
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/37—Assays involving biological materials from specific organisms or of a specific nature from fungi
- G01N2333/39—Assays involving biological materials from specific organisms or of a specific nature from fungi from yeasts
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pathology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Food Science & Technology (AREA)
- Psychiatry (AREA)
- General Physics & Mathematics (AREA)
- Ophthalmology & Optometry (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4002008P | 2008-03-27 | 2008-03-27 | |
PCT/US2009/038703 WO2009121044A1 (en) | 2008-03-27 | 2009-03-27 | Impaired alleles of genes involved in metabolic pathways and methods for detecting and using the same |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0910097A2 true BRPI0910097A2 (pt) | 2015-12-15 |
Family
ID=41114354
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0910097A BRPI0910097A2 (pt) | 2008-03-27 | 2009-03-27 | métodos para triar quanto a um alelo defeituoso de um gene que codifica enzima remediável pela administração de cofator, para detectar uma predisposição a uma deficiência de enzima dependente de cofator, para identificar e/ou caracterizar uma deficiência de enzima dentro uma via metabólica em um paciente, para tratar uma deficiência metabólica de enzima em um paciente, para triar quanto ao risco de uma condição ou doença associadas com o metabolismo de foliato/homocisteína aberrante, para triar quanto ao potencial de resposta quimioterapêutica e para triar quanto à toxidade quimioterapêutica, kit para avaliar deficiências de enzima remediáveis em uma via metabólica, ácido nucleico isolado, arranjo para detectar um alelo defeituoso de um gene na via metabólica do foliato/homocisteína |
Country Status (12)
Country | Link |
---|---|
US (1) | US20090281061A1 (pt) |
EP (1) | EP2276857A4 (pt) |
JP (1) | JP2011519267A (pt) |
KR (1) | KR20100134067A (pt) |
CN (1) | CN102027134A (pt) |
AU (1) | AU2009228015A1 (pt) |
BR (1) | BRPI0910097A2 (pt) |
CA (1) | CA2719733A1 (pt) |
IL (1) | IL208456A0 (pt) |
MX (1) | MX2010010476A (pt) |
RU (1) | RU2010143882A (pt) |
WO (1) | WO2009121044A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115579056B (zh) * | 2022-08-24 | 2024-05-31 | 南方医科大学南方医院 | 一组用于评估精神分裂症分子分型的基因群及其诊断产品和应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9410620D0 (en) * | 1994-05-26 | 1994-07-13 | Univ Mcgill | cDNA for human mehylenetetrahydrofolate reductase |
-
2009
- 2009-03-27 MX MX2010010476A patent/MX2010010476A/es not_active Application Discontinuation
- 2009-03-27 WO PCT/US2009/038703 patent/WO2009121044A1/en active Application Filing
- 2009-03-27 BR BRPI0910097A patent/BRPI0910097A2/pt not_active IP Right Cessation
- 2009-03-27 CN CN200980117301XA patent/CN102027134A/zh active Pending
- 2009-03-27 KR KR1020107023846A patent/KR20100134067A/ko not_active Application Discontinuation
- 2009-03-27 AU AU2009228015A patent/AU2009228015A1/en not_active Abandoned
- 2009-03-27 JP JP2011502127A patent/JP2011519267A/ja not_active Withdrawn
- 2009-03-27 US US12/413,506 patent/US20090281061A1/en not_active Abandoned
- 2009-03-27 EP EP09724590A patent/EP2276857A4/en not_active Withdrawn
- 2009-03-27 RU RU2010143882/10A patent/RU2010143882A/ru not_active Application Discontinuation
- 2009-03-27 CA CA2719733A patent/CA2719733A1/en not_active Abandoned
-
2010
- 2010-10-03 IL IL208456A patent/IL208456A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP2276857A4 (en) | 2012-01-25 |
WO2009121044A8 (en) | 2010-11-04 |
JP2011519267A (ja) | 2011-07-07 |
KR20100134067A (ko) | 2010-12-22 |
CA2719733A1 (en) | 2009-10-01 |
IL208456A0 (en) | 2010-12-30 |
CN102027134A (zh) | 2011-04-20 |
AU2009228015A1 (en) | 2009-10-01 |
EP2276857A1 (en) | 2011-01-26 |
WO2009121044A1 (en) | 2009-10-01 |
MX2010010476A (es) | 2010-11-25 |
US20090281061A1 (en) | 2009-11-12 |
RU2010143882A (ru) | 2012-05-10 |
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